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Ieda M, Fukuda K, Hisaka Y, Kimura K, Kawaguchi H, Fujita J, et al. Endothelin-1 regulates cardiac sympathetic innervation in the rodent heart by controlling nerve growth factor expression. <i>J Clin Invest<\/i> 2004; 113: 876\u2013884.","DOI":"10.1172\/JCI200419480"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Ieda M, Kanazawa H, Ieda Y, Kimura K, Matsumura K, Tomita Y, et al. Nerve growth factor is critical for cardiac sensory innervation and rescues neuropathy in diabetic hearts. <i>Circulation<\/i> 2006; 114: 2351\u20132363.","DOI":"10.1161\/CIRCULATIONAHA.106.627588"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Ieda M, Kanazawa H, Kimura K, Hattori F, Ieda Y, Taniguchi M, et al. Sema3a maintains normal heart rhythm through sympathetic innervation patterning. <i>Nat Med<\/i> 2007; 13: 604\u2013612.","DOI":"10.1038\/nm1570"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Ieda M, Tsuchihashi T, Ivey KN, Ross RS, Hong TT, Shaw RM, et al. Cardiac fibroblasts regulate myocardial proliferation through beta1 integrin signaling. <i>Dev Cell<\/i> 2009; 16: 233\u2013244.","DOI":"10.1016\/j.devcel.2008.12.007"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Ieda M, Fu JD, Delgado-Olguin P, Vedantham V, Hayashi Y, Bruneau BG, et al. Direct reprogramming of fibroblasts into functional cardiomyocytes by defined factors. <i>Cell<\/i> 2010; 142: 375\u2013386.","DOI":"10.1016\/j.cell.2010.07.002"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Inagawa K, Miyamoto K, Yamakawa H, Muraoka N, Sadahiro T, Umei T, et al. Induction of cardiomyocyte-like cells in infarct hearts by gene transfer of Gata4, Mef2c, and Tbx5. <i>Circ Res<\/i> 2012; 111: 1147\u20131156.","DOI":"10.1161\/CIRCRESAHA.112.271148"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Wada R, Muraoka N, Inagawa K, Yamakawa H, Miyamoto K, Sadahiro T, et al. Induction of human cardiomyocyte-like cells from fibroblasts by defined factors. <i>Proc Natl Acad Sci USA<\/i> 2013; 110: 12667\u201312672.","DOI":"10.1073\/pnas.1304053110"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Muraoka N, Yamakawa H, Miyamoto K, Sadahiro T, Umei T, Isomi M, et al. MiR-133 promotes cardiac reprogramming by directly repressing Snai1 and silencing fibroblast signatures. <i>EMBO J<\/i> 2014; 33: 1565\u20131581.","DOI":"10.15252\/embj.201387605"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Yamakawa H, Muraoka N, Miyamoto K, Sadahiro T, Isomi M, Haginiwa S, et al. Fibroblast growth factors and vascular endothelial growth factor promote cardiac reprogramming under defined conditions. <i>Stem Cell Rep<\/i> 2015; 5: 1128\u20131142.","DOI":"10.1016\/j.stemcr.2015.10.019"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Minamisawa M, Izawa A, Motoki H, Kashima Y, Hioki H, Abe N, et al. Prognostic significance of neuroadrenergic dysfunction for cardiovascular events in patients with acute myocardial infarction. <i>Circ J<\/i> 2015; 79: 2238\u20132245.","DOI":"10.1253\/circj.CJ-15-0265"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Kimura K, Ieda M, Fukuda K. Development, maturation, and transdifferentiation of cardiac sympathetic nerves. <i>Circ Res<\/i> 2012; 110: 325\u2013336.","DOI":"10.1161\/CIRCRESAHA.111.257253"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Lockhart ST, Turrigiano GG, Birren SJ. Nerve growth factor modulates synaptic transmission between sympathetic neurons and cardiac myocytes. <i>J Neurosci<\/i> 1997; 17: 9573\u20139582.","DOI":"10.1523\/JNEUROSCI.17-24-09573.1997"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Snider WD. Functions of the neurotrophins during nervous system development: What the knockouts are teaching us. <i>Cell<\/i> 1994; 77: 627\u2013638.","DOI":"10.1016\/0092-8674(94)90048-5"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Faerman I, Faccio E, Milei J, Nu\u00f1ez R, Jadzinsky M, Fox D, et al. Autonomic neuropathy and painless myocardial infarction in diabetic patients: Histologic evidence of their relationship. <i>Diabetes<\/i> 1977; 26: 1147\u20131158.","DOI":"10.2337\/diab.26.12.1147"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Crowley C, Spencer SD, Nishimura MC, Chen KS, Pitts-Meek S, Armanini MP, et al. Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. <i>Cell<\/i> 1994; 76: 1001\u20131011.","DOI":"10.1016\/0092-8674(94)90378-6"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Schmid H, Forman LA, Cao X, Sherman PS, Stevens MJ. Heterogeneous cardiac sympathetic denervation and decreased myocardial nerve growth factor in streptozotocin-induced diabetic rats: Implications for cardiac sympathetic dysinnervation complicating diabetes. <i>Diabetes<\/i> 1999; 48: 603\u2013608.","DOI":"10.2337\/diabetes.48.3.603"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Ito M, Zipes DP. Efferent sympathetic and vagal innervation of the canine right ventricle. <i>Circulation<\/i> 1994; 90: 1459\u20131468.","DOI":"10.1161\/01.CIR.90.3.1459"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Behar O, Golden JA, Mashimo H, Schoen FJ, Fishman MC. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. <i>Nature<\/i> 1996; 383: 525\u2013528.","DOI":"10.1038\/383525a0"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Opthof T, Misier AR, Coronel R, Vermeulen JT, Verberne HJ, Frank RG, et al. Dispersion of refractoriness in canine ventricular myocardium: Effects of sympathetic stimulation. <i>Circ Res<\/i> 1991; 68: 1204\u20131215.","DOI":"10.1161\/01.RES.68.5.1204"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Cao JM, Chen LS, KenKnight BH, Ohara T, Lee MH, Tsai J, et al. Nerve sprouting and sudden cardiac death. <i>Circ Res<\/i> 2000; 86: 816\u2013821.","DOI":"10.1161\/01.RES.86.7.816"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. Nakano Y, Chayama K, Ochi H, Toshishige M, Hayashida Y, Miki D, et al. A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation. <i>PLoS Genet<\/i> 2013; 9: e1003364, doi:10.1371\/journal.pgen.1003364.","DOI":"10.1371\/journal.pgen.1003364"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Boczek NJ, Ye D, Johnson EK, Wang W, Crotti L, Tester DJ, et al. Characterization of SEMA3A-encoded semaphorin as a naturally occurring Kv4.3 protein inhibitor and its contribution to Brugada syndrome. <i>Circ Res<\/i> 2014; 115: 460\u2013469.","DOI":"10.1161\/CIRCRESAHA.115.303657"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Brunet S, Aimond F, Li H, Guo W, Eldstrom J, Fedida D, et al. Heterogeneous expression of repolarizing, voltage-gated K<sup>+<\/sup> currents in adult mouse ventricles. <i>J Physiol<\/i> 2004; 559: 103\u2013120.","DOI":"10.1113\/jphysiol.2004.063347"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ieda M, Kimura K, Kanazawa H, Fukuda K. Regulation of cardiac nerves: A new paradigm in the management of sudden cardiac death? <i>Curr Med Chem<\/i> 2008; 15: 1731\u20131736.","DOI":"10.2174\/092986708784872339"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Camelliti P, Borg TK, Kohl P. Structural and functional characterisation of cardiac fibroblasts. <i>Cardiovasc Res<\/i> 2005; 65: 40\u201351.","DOI":"10.1016\/j.cardiores.2004.08.020"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Lavine KJ, Yu K, White AC, Zhang X, Smith C, Partanen J, et al. Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo. <i>Dev Cell<\/i> 2005; 8: 85\u201395.","DOI":"10.1016\/j.devcel.2004.12.002"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Weber KT, Brilla CG. Pathological hypertrophy and cardiac interstitium: Fibrosis and renin-angiotensin-aldosterone system. <i>Circulation<\/i> 1991; 83: 1849\u20131865.","DOI":"10.1161\/01.CIR.83.6.1849"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Shai SY, Harpf AE, Babbitt CJ, Jordan MC, Fishbein MC, Chen J, et al. Cardiac myocyte-specific excision of the beta1 integrin gene results in myocardial fibrosis and cardiac failure. <i>Circ Res<\/i> 2002; 90: 458\u2013464.","DOI":"10.1161\/hh0402.105790"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. <i>Cell<\/i> 2006; 126: 663\u2013676.","DOI":"10.1016\/j.cell.2006.07.024"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Srivastava D, Ieda M. Critical factors for cardiac reprogramming. <i>Circ Res<\/i> 2012; 111: 5\u20138.","DOI":"10.1161\/CIRCRESAHA.112.271452"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Song K, Nam YJ, Luo X, Qi X, Tan W, Huang GN, et al. Heart repair by reprogramming non-myocytes with cardiac transcription factors. <i>Nature<\/i> 2012; 485: 599\u2013604.","DOI":"10.1038\/nature11139"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Qian L, Huang Y, Spencer CI, Foley A, Vedantham V, Liu L, et al. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. <i>Nature<\/i> 2012; 485: 593\u2013598.","DOI":"10.1038\/nature11044"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Fu JD, Stone NR, Liu L, Spencer CI, Qian L, Hayashi Y, et al. Direct reprogramming of human fibroblasts toward a cardiomyocyte-like state. <i>Stem Cell Rep<\/i> 2013; 1: 235\u2013247.","DOI":"10.1016\/j.stemcr.2013.07.005"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Nam YJ, Song K, Luo X, Daniel E, Lambeth K, West K, et al. Reprogramming of human fibroblasts toward a cardiac fate. <i>Proc Natl Acad Sci USA<\/i> 2013; 110: 5588\u20135593.","DOI":"10.1073\/pnas.1301019110"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Zhao Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O\u2019Rourke R, et al. High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling. <i>Nat Commun<\/i> 2015; 6: 8243.","DOI":"10.1038\/ncomms9243"},{"key":"36","doi-asserted-by":"publisher","unstructured":"36. Ifkovits JL, Addis RC, Epstein JA, Gearhart JD. Inhibition of TGFbeta signaling increases direct conversion of fibroblasts to induced cardiomyocytes. <i>PLoS One<\/i> 2014; 9: e89678, doi:10.1371\/journal.pone.0089678.","DOI":"10.1371\/journal.pone.0089678"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Fu JD, Srivastava D. Direct reprogramming of fibroblasts into cardiomyocytes for cardiac regenerative medicine. <i>Circ J<\/i> 2015; 79: 245\u2013254.","DOI":"10.1253\/circj.CJ-14-1372"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Sadahiro T, Yamanaka S, Ieda M. Direct cardiac reprogramming: Progress and challenges in basic biology and clinical applications. <i>Circ Res<\/i> 2015; 116: 1378\u20131391.","DOI":"10.1161\/CIRCRESAHA.116.305374"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Noseda M, Abreu-Paiva M, Schneider MD. 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