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Effects of sex on coronary microvascular dysfunction and cardiac outcomes. <i>Circulation<\/i> 2014; 129: 2518\u20132527.","DOI":"10.1161\/CIRCULATIONAHA.113.008507"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Suwaidi JA, Hamasaki S, Higano ST, Nishimura RA, Holmes DR Jr, Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. <i>Circulation<\/i> 2000; 101: 948\u2013954.","DOI":"10.1161\/01.CIR.101.9.948"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Murthy VL, Naya M, Foster CR, Hainer J, Gaber M, Di Carli G, et al. Improved cardiac risk assessment with noninvasive measures of coronary flow reserve. <i>Circulation<\/i> 2011; 124: 2215\u20132224.","DOI":"10.1161\/CIRCULATIONAHA.111.050427"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Pepine CJ, Anderson RD, Sharaf BL, Reis SE, Smith KM, Handberg EM, et al. Coronary microvascular reactivity to adenosine predicts adverse outcome in women evaluated for suspected ischemia: Results from the National Heart, Lung and Blood Institute WISE (Women\u2019s Ischemia Syndrome Evaluation) study. <i>J Am Coll Cardiol<\/i> 2010; 55: 2825\u20132832.","DOI":"10.1016\/j.jacc.2010.01.054"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Taqueti VR, Hachamovitch R, Murthy VL, Naya M, Foster CR, Hainer J, et al. Global coronary flow reserve is associated with adverse cardiovascular events independently of luminal angiographic severity and modifies the effect of early revascularization. <i>Circulation<\/i> 2015; 131: 19\u201327.","DOI":"10.1161\/CIRCULATIONAHA.114.011939"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Murthy VL, Naya M, Foster CR, Gaber M, Hainer J, Klein J, et al. Association between coronary vascular dysfunction and cardiac mortality in patients with and without diabetes mellitus. <i>Circulation<\/i> 2012; 126: 1858\u20131868.","DOI":"10.1161\/CIRCULATIONAHA.112.120402"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Serruys PW, di Mario C, Piek J, Schroeder E, Vrints C, Probst P, et al. Prognostic value of intracoronary flow velocity and diameter stenosis in assessing the short- and long-term outcomes of coronary balloon angioplasty: The DEBATE study (Doppler Endpoints Balloon Angioplasty Trial Europe). <i>Circulation<\/i> 1997; 96: 3369\u20133377.","DOI":"10.1161\/01.CIR.96.10.3369"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Fukushima K, Javadi MS, Higuchi T, Lautamaki R, Merrill J, Nekolla SG, et al. Prediction of short-term cardiovascular events using quantification of global myocardial flow reserve in patients referred for clinical 82Rb PET perfusion imaging. <i>J Nucl Med<\/i> 2011; 52: 726\u2013732.","DOI":"10.2967\/jnumed.110.081828"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Hasdai D, Gibbons RJ, Holmes DR Jr, Higano ST, Lerman A. Coronary endothelial dysfunction in humans is associated with myocardial perfusion defects. <i>Circulation<\/i> 1997; 96: 3390\u20133395.","DOI":"10.1161\/01.CIR.96.10.3390"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Zeiher AM, Krause T, Schachinger V, Minners J, Moser E. Impaired endothelium-dependent vasodilation of coronary resistance vessels is associated with exercise-induced myocardial ischemia. <i>Circulation<\/i> 1995; 91: 2345\u20132352.","DOI":"10.1161\/01.CIR.91.9.2345"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Phan A, Shufelt C, Merz CN. Persistent chest pain and no obstructive coronary artery disease. <i>JAMA<\/i> 2009; 301: 1468\u20131474.","DOI":"10.1001\/jama.2009.425"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Camici PG, Crea F. Coronary microvascular dysfunction. <i>N Engl J Med<\/i> 2007; 356: 830\u2013840.","DOI":"10.1056\/NEJMra061889"},{"key":"15","unstructured":"15. Farrehi PM, Bernstein SJ, Rasak M, Dabbous SA, Stomel RJ, Eagle KA, et al. Frequency of negative coronary arteriographic findings in patients with chest pain is related to community practice patterns. <i>Am J Manag Care<\/i> 2002; 8: 643\u2013648."},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Bradley SM, Maddox TM, Stanislawski MA, O\u2019Donnell CI, Grunwald GK, Tsai TT, et al. Normal coronary rates for elective angiography in the Veterans Affairs healthcare system: Insights from the VA CART program (Veterans Affairs Clinical Assessment Reporting and Tracking). <i>J Am Coll Cardiol<\/i> 2014; 63: 417\u2013426.","DOI":"10.1016\/j.jacc.2013.09.055"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hasdai D, Holmes DR Jr, Higano ST, Burnett JC Jr, Lerman A. Prevalence of coronary blood flow reserve abnormalities among patients with nonobstructive coronary artery disease and chest pain. <i>Mayo Clin Proc<\/i> 1998; 73: 1133\u20131140.","DOI":"10.4065\/73.12.1133"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Sade LE, Eroglu S, Bozbas H, Ozbicer S, Hayran M, Haberal A, et al. Relation between epicardial fat thickness and coronary flow reserve in women with chest pain and angiographically normal coronary arteries. <i>Atherosclerosis<\/i> 2009; 204: 580\u2013585.","DOI":"10.1016\/j.atherosclerosis.2008.09.038"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Reis SE, Holubkov R, Conrad Smith AJ, Kelsey SF, Sharaf BL, Reichek N, et al. Coronary microvascular dysfunction is highly prevalent in women with chest pain in the absence of coronary artery disease: Results from the NHLBI WISE study. <i>Am Heart J<\/i> 2001; 141: 735\u2013741.","DOI":"10.1067\/mhj.2001.114198"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Sara JD, Widmer RJ, Matsuzawa Y, Lennon RJ, Lerman LO, Lerman A. Prevalence of coronary microvascular dysfunction among patients with chest pain and nonobstructive coronary artery disease. <i>JACC Cardiovasc Interv<\/i> 2015; 8: 1445\u20131453.","DOI":"10.1016\/j.jcin.2015.06.017"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Patel MR, Peterson ED, Dai D, Brennan JM, Redberg RF, Anderson HV, et al. Low diagnostic yield of elective coronary angiography. <i>N Engl J Med<\/i> 2010; 362: 886\u2013895.","DOI":"10.1056\/NEJMoa0907272"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Jespersen L, Hvelplund A, Abildstrom SZ, Pedersen F, Galatius S, Madsen JK, et al. Stable angina pectoris with no obstructive coronary artery disease is associated with increased risks of major adverse cardiovascular events. <i>Eur Heart J<\/i> 2012; 33: 734\u2013744.","DOI":"10.1093\/eurheartj\/ehr331"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Bugiardini R, Bairey Merz CN. Angina with \u201cnormal\u201d coronary arteries: A changing philosophy. <i>JAMA<\/i> 2005; 293: 477\u2013484.","DOI":"10.1001\/jama.293.4.477"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Britten MB, Zeiher AM, Schachinger V. Microvascular dysfunction in angiographically normal or mildly diseased coronary arteries predicts adverse cardiovascular long-term outcome. <i>Coron Artery Dis<\/i> 2004; 15: 259\u2013264.","DOI":"10.1097\/01.mca.0000134590.99841.81"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. <i>Circulation<\/i> 2000; 101: 1899\u20131906.","DOI":"10.1161\/01.CIR.101.16.1899"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Gulati M, Cooper-DeHoff RM, McClure C, Johnson BD, Shaw LJ, Handberg EM, et al. Adverse cardiovascular outcomes in women with nonobstructive coronary artery disease: A report from the Women\u2019s Ischemia Syndrome evaluation study and the St James Women Take Heart project. <i>Arch Intern Med<\/i> 2009; 169: 843\u2013850.","DOI":"10.1001\/archinternmed.2009.50"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Halcox JP, Schenke WH, Zalos G, Mincemoyer R, Prasad A, Waclawiw MA, et al. Prognostic value of coronary vascular endothelial dysfunction. <i>Circulation<\/i> 2002; 106: 653\u2013658.","DOI":"10.1161\/01.CIR.0000025404.78001.D8"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. von Mering GO, Arant CB, Wessel TR, McGorray SP, Bairey Merz CN, Sharaf BL, et al. Abnormal coronary vasomotion as a prognostic indicator of cardiovascular events in women: Results from the National Heart, Lung, and Blood Institute-sponsored Women\u2019s Ischemia Syndrome Evaluation (WISE). <i>Circulation<\/i> 2004; 109: 722\u2013725.","DOI":"10.1161\/01.CIR.0000115525.92645.16"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Patel B, Fisher M. Therapeutic advances in myocardial microvascular resistance: Unravelling the enigma. <i>Pharmacol Ther<\/i> 2010; 127: 131\u2013147.","DOI":"10.1016\/j.pharmthera.2010.04.014"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Kuo L, Davis MJ, Chilian WM. Longitudinal gradients for endothelium-dependent and -independent vascular responses in the coronary microcirculation. <i>Circulation<\/i> 1995; 92: 518\u2013525.","DOI":"10.1161\/01.CIR.92.3.518"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Camici PG, Olivotto I, Rimoldi OE. The coronary circulation and blood flow in left ventricular hypertrophy. <i>J Mol Cell Cardiol<\/i> 2012; 52: 857\u2013864.","DOI":"10.1016\/j.yjmcc.2011.08.028"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Schindler TH, Hornig B, Buser PT, Olschewski M, Magosaki N, Pfisterer M, et al. Prognostic value of abnormal vasoreactivity of epicardial coronary arteries to sympathetic stimulation in patients with normal coronary angiograms. <i>Arterioscler Thromb Vasc Biol<\/i> 2003; 23: 495\u2013501.","DOI":"10.1161\/01.ATV.0000057571.03012.F4"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Herrmann J, Kaski JC, Lerman A. Coronary microvascular dysfunction in the clinical setting: From mystery to reality. <i>Eur Heart J<\/i> 2012; 33: 2771\u20132782b.","DOI":"10.1093\/eurheartj\/ehs246"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Lanza GA, Crea F. Primary coronary microvascular dysfunction: Clinical presentation, pathophysiology, and management. <i>Circulation<\/i> 2010; 121: 2317\u20132325.","DOI":"10.1161\/CIRCULATIONAHA.109.900191"},{"key":"35","unstructured":"35. Kanatsuka H, Eastham CL, Marcus ML, Lamping KG. Effects of nitroglycerin on the coronary microcirculation in normal and ischemic myocardium. <i>J Cardiovasc Pharmacol<\/i> 1992; 19: 755\u2013763."},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Gulati M, Shaw LJ, Bairey Merz CN. Myocardial ischemia in women: Lessons from the NHLBI WISE study. <i>Clin Cardiol<\/i> 2012; 35: 141\u2013148.","DOI":"10.1002\/clc.21966"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Mygind ND, Michelsen MM, Pena A, Frestad D, Dose N, Aziz A, et al. Coronary microvascular function and cardiovascular risk factors in women with angina pectoris and no obstructive coronary artery disease: The iPOWER study. <i>J Am Heart Assoc<\/i> 2016; 5: e003064.","DOI":"10.1161\/JAHA.115.003064"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Sara JD, Sugrue A, Kremen V, Qiang B, Sapir Y, Attia ZI, et al. Electrocardiographic predictors of coronary microvascular dysfunction in patients with non-obstructive coronary artery disease: Utility of a novel T wave analysis program. <i>Int J Cardiol<\/i> 2016; 203: 601\u2013606.","DOI":"10.1016\/j.ijcard.2015.10.228"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Ong P, Athanasiadis A, Hill S, Schaufele T, Mahrholdt H, Sechtem U. Coronary microvascular dysfunction assessed by intracoronary ACh provocation testing is a frequent cause of ischemia and angina in patients with exercise-induced electrocardiographic changes and unobstructed coronary arteries. <i>Clin Cardiol<\/i> 2014; 37: 462\u2013467.","DOI":"10.1002\/clc.22282"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Loffler AI, Bourque JM. Coronary microvascular dysfunction, microvascular angina, and management. <i>Curr Cardiol Rep<\/i> 2016; 18: 1.","DOI":"10.1007\/s11886-015-0682-9"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Cullen JH, Horsfield MA, Reek CR, Cherryman GR, Barnett DB, Samani NJ. A myocardial perfusion reserve index in humans using first-pass contrast-enhanced magnetic resonance imaging. <i>J Am Coll Cardiol<\/i> 1999; 33: 1386\u20131394.","DOI":"10.1016\/S0735-1097(99)00004-2"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Panting JR, Gatehouse PD, Yang GZ, Grothues F, Firmin DN, Collins P, et al. Abnormal subendocardial perfusion in cardiac syndrome X detected by cardiovascular magnetic resonance imaging. <i>N Engl J Med<\/i> 2002; 346: 1948\u20131953.","DOI":"10.1056\/NEJMoa012369"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Wohrle J, Nusser T, Merkle N, Kestler HA, Grebe OC, Marx N, et al. Myocardial perfusion reserve in cardiovascular magnetic resonance: Correlation to coronary microvascular dysfunction. <i>J Cardiovasc Magn Reson<\/i> 2006; 8: 781\u2013787.","DOI":"10.1080\/10976640600737649"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Sharif B, Dharmakumar R, LaBounty T, Arsanjani R, Shufelt C, Thomson L, et al. Towards elimination of the dark-rim artifact in first-pass myocardial perfusion MRI: Removing Gibbs ringing effects using optimized radial imaging. <i>Magn Reson Med<\/i> 2014; 72: 124\u2013136.","DOI":"10.1002\/mrm.24913"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Doyle M, Weinberg N, Pohost GM, Bairey Merz CN, Shaw LJ, Sopko G, et al. Prognostic value of global MR myocardial perfusion imaging in women with suspected myocardial ischemia and no obstructive coronary disease: Results from the NHLBI-sponsored WISE (Women\u2019s Ischemia Syndrome Evaluation) study. <i>JACC Cardiovasc Imaging<\/i> 2010; 3: 1030\u20131036.","DOI":"10.1016\/j.jcmg.2010.07.008"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Freed BH, Narang A, Bhave NM, Czobor P, Mor-Avi V, Zaran ER, et al. Prognostic value of normal regadenoson stress perfusion cardiovascular magnetic resonance. <i>J Cardiovasc Magn Reson<\/i> 2013; 15: 108.","DOI":"10.1186\/1532-429X-15-108"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Des Prez RD, Shaw LJ, Gillespie RL, Jaber WA, Noble GL, Soman P, et al. Cost-effectiveness of myocardial perfusion imaging: A summary of the currently available literature. <i>J Nucl Cardiol<\/i> 2005; 12: 750\u2013759.","DOI":"10.1016\/j.nuclcard.2005.10.001"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. McCrohon JA, Lyne JC, Rahman SL, Lorenz CH, Underwood SR, Pennell DJ. Adjunctive role of cardiovascular magnetic resonance in the assessment of patients with inferior attenuation on myocardial perfusion spect. <i>J Cardiovasc Magn Reson<\/i> 2005; 7: 377\u2013382.","DOI":"10.1081\/JCMR-200053627"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Prior JO, Allenbach G, Valenta I, Kosinski M, Burger C, Verdun FR, et al. Quantification of myocardial blood flow with 82Rb positron emission tomography: Clinical validation with 15O-water. <i>Eur J Nucl Med Mol Imaging<\/i> 2012; 39: 1037\u20131047.","DOI":"10.1007\/s00259-012-2082-3"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Valenta I, Dilsizian V, Quercioli A, Ruddy TD, Schindler TH. Quantitative PET\/CT measures of myocardial flow reserve and atherosclerosis for cardiac risk assessment and predicting adverse patient outcomes. <i>Curr Cardiol Rep<\/i> 2013; 15: 344.","DOI":"10.1007\/s11886-012-0344-0"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Marroquin OC, Holubkov R, Edmundowicz D, Rickens C, Pohost G, Buchthal S, et al. Heterogeneity of microvascular dysfunction in women with chest pain not attributable to coronary artery disease: Implications for clinical practice. <i>Am Heart J<\/i> 2003; 145: 628\u2013635.","DOI":"10.1067\/mhj.2003.95"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Plank F, Friedrich G, Dichtl W, Klauser A, Jaschke W, Franz WM, et al. The diagnostic and prognostic value of coronary CT angiography in asymptomatic high-risk patients: A cohort study. <i>Open Heart<\/i> 2014; 1: e000096.","DOI":"10.1136\/openhrt-2014-000096"},{"key":"53","doi-asserted-by":"crossref","unstructured":"53. Dimitrow PP. Transthoracic Doppler echocardiography: Noninvasive diagnostic window for coronary flow reserve assessment. <i>Cardiovasc Ultrasound<\/i> 2003; 1: 4.","DOI":"10.1186\/1476-7120-1-4"},{"key":"54","doi-asserted-by":"crossref","unstructured":"54. Saraste M, Koskenvuo J, Knuuti J, Toikka J, Laine H, Niemi P, et al. Coronary flow reserve: Measurement with transthoracic Doppler echocardiography is reproducible and comparable with positron emission tomography. <i>Clin Physiol<\/i> 2001; 21: 114\u2013122.","DOI":"10.1046\/j.1365-2281.2001.00296.x"},{"key":"55","doi-asserted-by":"crossref","unstructured":"55. Caiati C, Montaldo C, Zedda N, Montisci R, Ruscazio M, Lai G, et al. Validation of a new noninvasive method (contrast-enhanced transthoracic second harmonic echo Doppler) for the evaluation of coronary flow reserve: Comparison with intracoronary Doppler flow wire. <i>J Am Coll Cardiol<\/i> 1999; 34: 1193\u20131200.","DOI":"10.1016\/S0735-1097(99)00342-3"},{"key":"56","doi-asserted-by":"crossref","unstructured":"56. Vogel R, Indermuhle A, Reinhardt J, Meier P, Siegrist PT, Namdar M, et al. The quantification of absolute myocardial perfusion in humans by contrast echocardiography: Algorithm and validation. <i>J Am Coll Cardiol<\/i> 2005; 45: 754\u2013762.","DOI":"10.1016\/j.jacc.2004.11.044"},{"key":"57","doi-asserted-by":"crossref","unstructured":"57. Murray KJ. Cyclic AMP and mechanisms of vasodilation. <i>Pharmacol Ther<\/i> 1990; 47: 329\u2013345.","DOI":"10.1016\/0163-7258(90)90060-F"},{"key":"58","unstructured":"58. Blaise GA, Stewart DJ, Guerard MJ. Acetylcholine stimulates release of endothelium-derived relaxing factor in coronary arteries of human organ donors. <i>Can J Cardiol<\/i> 1993; 9: 813\u2013820."},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Wei J, Mehta PK, Shufelt C, Yang Y, Gill E, Kahlon R, et al. Diastolic dysfunction measured by cardiac magnetic resonance imaging in women with signs and symptoms of ischemia but no obstructive coronary artery disease. <i>Int J Cardiol<\/i> 2016; 220: 775\u2013780.","DOI":"10.1016\/j.ijcard.2016.06.198"},{"key":"60","doi-asserted-by":"crossref","unstructured":"60. Lerman A, Zeiher AM. Endothelial function: Cardiac events. <i>Circulation<\/i> 2005; 111: 363\u2013368.","DOI":"10.1161\/01.CIR.0000153339.27064.14"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Wei J, Mehta PK, Johnson BD, Samuels B, Kar S, Anderson RD, et al. Safety of coronary reactivity testing in women with no obstructive coronary artery disease: Results from the NHLBI-sponsored WISE (Women\u2019s Ischemia Syndrome Evaluation) study. <i>JACC Cardiovasc Interv<\/i> 2012; 5: 646\u2013653.","DOI":"10.1016\/j.jcin.2012.01.023"},{"key":"62","doi-asserted-by":"crossref","unstructured":"62. Kaufmann PA, Gnecchi-Ruscone T, di Terlizzi M, Schafers KP, Luscher TF, Camici PG. Coronary heart disease in smokers: Vitamin C restores coronary microcirculatory function. <i>Circulation<\/i> 2000; 102: 1233\u20131238.","DOI":"10.1161\/01.CIR.102.11.1233"},{"key":"63","doi-asserted-by":"crossref","unstructured":"63. Lee DH, Youn HJ, Choi YS, Park CS, Park JH, Jeon HK, et al. Coronary flow reserve is a comprehensive indicator of cardiovascular risk factors in subjects with chest pain and normal coronary angiogram. <i>Circ J<\/i> 2010; 74: 1405\u20131414.","DOI":"10.1253\/circj.CJ-09-0897"},{"key":"64","doi-asserted-by":"crossref","unstructured":"64. Tona F, Serra R, Di Ascenzo L, Osto E, Scarda A, Fabris R, et al. Systemic inflammation is related to coronary microvascular dysfunction in obese patients without obstructive coronary disease. <i>Nutr Metab Cardiovasc Dis<\/i> 2014; 24: 447\u2013453.","DOI":"10.1016\/j.numecd.2013.09.021"},{"key":"65","doi-asserted-by":"crossref","unstructured":"65. Ahmari SA, Bunch TJ, Modesto K, Stussy V, Dichak A, Seward JB, et al. Impact of individual and cumulative coronary risk factors on coronary flow reserve assessed by dobutamine stress echocardiography. <i>Am J Cardiol<\/i> 2008; 101: 1694\u20131699.","DOI":"10.1016\/j.amjcard.2008.02.055"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Pitkanen OP, Nuutila P, Raitakari OT, Ronnemaa T, Koskinen PJ, Iida H, et al. Coronary flow reserve is reduced in young men with IDDM. <i>Diabetes<\/i> 1998; 47: 248\u2013254.","DOI":"10.2337\/diab.47.2.248"},{"key":"67","doi-asserted-by":"crossref","unstructured":"67. Moreau P, d\u2019Uscio LV, Luscher TF. Structure and reactivity of small arteries in aging. <i>Cardiovasc Res<\/i> 1998; 37: 247\u2013253.","DOI":"10.1016\/S0008-6363(97)00225-3"},{"key":"68","doi-asserted-by":"crossref","unstructured":"68. Sicari R, Rigo F, Cortigiani L, Gherardi S, Galderisi M, Picano E. Additive prognostic value of coronary flow reserve in patients with chest pain syndrome and normal or near-normal coronary arteries. <i>Am J Cardiol<\/i> 2009; 103: 626\u2013631.","DOI":"10.1016\/j.amjcard.2008.10.033"},{"key":"69","doi-asserted-by":"crossref","unstructured":"69. Tuccillo B, Accadia M, Rumolo S, Iengo R, D\u2019Andrea A, Granata G, et al. Factors predicting coronary flow reserve impairment in patients evaluated for chest pain: An ultrasound study. <i>J Cardiovasc Med (Hagerstown)<\/i> 2008; 9: 251\u2013255.","DOI":"10.2459\/JCM.0b013e32820588dd"},{"key":"70","doi-asserted-by":"crossref","unstructured":"70. Schwartzkopff B, Motz W, Frenzel H, Vogt M, Knauer S, Strauer BE. Structural and functional alterations of the intramyocardial coronary arterioles in patients with arterial hypertension. <i>Circulation<\/i> 1993; 88: 993\u20131003.","DOI":"10.1161\/01.CIR.88.3.993"},{"key":"71","doi-asserted-by":"crossref","unstructured":"71. Rizzoni D, Palombo C, Porteri E, Muiesan ML, Kozakova M, La Canna G, et al. Relationships between coronary flow vasodilator capacity and small artery remodelling in hypertensive patients. <i>J Hypertens<\/i> 2003; 21: 625\u2013631.","DOI":"10.1097\/00004872-200303000-00030"},{"key":"72","unstructured":"72. Yokoyama I, Murakami T, Ohtake T, Momomura S, Nishikawa J, Sasaki Y, et al. Reduced coronary flow reserve in familial hypercholesterolemia. <i>J Nucl Med<\/i> 1996; 37: 1937\u20131942."},{"key":"73","doi-asserted-by":"crossref","unstructured":"73. Dayanikli F, Grambow D, Muzik O, Mosca L, Rubenfire M, Schwaiger M. Early detection of abnormal coronary flow reserve in asymptomatic men at high risk for coronary artery disease using positron emission tomography. <i>Circulation<\/i> 1994; 90: 808\u2013817.","DOI":"10.1161\/01.CIR.90.2.808"},{"key":"74","doi-asserted-by":"crossref","unstructured":"74. Tamai O, Matsuoka H, Itabe H, Wada Y, Kohno K, Imaizumi T. Single LDL apheresis improves endothelium-dependent vasodilatation in hypercholesterolemic humans. <i>Circulation<\/i> 1997; 95: 76\u201382.","DOI":"10.1161\/01.CIR.95.1.76"},{"key":"75","doi-asserted-by":"crossref","unstructured":"75. Wessel TR, Arant CB, McGorray SP, Sharaf BL, Reis SE, Kerensky RA, et al. Coronary microvascular reactivity is only partially predicted by atherosclerosis risk factors or coronary artery disease in women evaluated for suspected ischemia: Results from the NHLBI Women\u2019s Ischemia Syndrome Evaluation (WISE). <i>Clin Cardiol<\/i> 2007; 30: 69\u201374.","DOI":"10.1002\/clc.19"},{"key":"76","doi-asserted-by":"crossref","unstructured":"76. Ishimori ML, Martin R, Berman DS, Goykhman P, Shaw LJ, Shufelt C, et al. Myocardial ischemia in the absence of obstructive coronary artery disease in systemic lupus erythematosus. <i>JACC Cardiovasc Imaging<\/i> 2011; 4: 27\u201333.","DOI":"10.1016\/j.jcmg.2010.09.019"},{"key":"77","doi-asserted-by":"crossref","unstructured":"77. Caliskan M, Erdogan D, Gullu H, Yilmaz S, Gursoy Y, Yildirir A, et al. Impaired coronary microvascular and left ventricular diastolic functions in patients with ankylosing spondylitis. <i>Atherosclerosis<\/i> 2008; 196: 306\u2013312.","DOI":"10.1016\/j.atherosclerosis.2006.11.003"},{"key":"78","doi-asserted-by":"crossref","unstructured":"78. Recio-Mayoral A, Mason JC, Kaski JC, Rubens MB, Harari OA, Camici PG. Chronic inflammation and coronary microvascular dysfunction in patients without risk factors for coronary artery disease. <i>Eur Heart J<\/i> 2009; 30: 1837\u20131843.","DOI":"10.1093\/eurheartj\/ehp205"},{"key":"79","doi-asserted-by":"crossref","unstructured":"79. Caliskan Z, Keles N, Gokturk HS, Ozdil K, Aksu F, Ozturk O, et al. Is activation in inflammatory bowel diseases associated with further impairment of coronary microcirculation? <i>Int J Cardiol<\/i> 2016; 223: 176\u2013181.","DOI":"10.1016\/j.ijcard.2016.08.141"},{"key":"80","doi-asserted-by":"crossref","unstructured":"80. Vianello F, Cella G, Osto E, Ballin A, Famoso G, Tellatin S, et al. Coronary microvascular dysfunction due to essential thrombocythemia and policythemia vera: The missing piece in the puzzle of their increased cardiovascular risk? <i>Am J Hematol<\/i> 2015; 90: 109\u2013113.","DOI":"10.1002\/ajh.23881"},{"key":"81","doi-asserted-by":"crossref","unstructured":"81. Kemp HG Jr, Vokonas PS, Cohn PF, Gorlin R. The anginal syndrome associated with normal coronary arteriograms: Report of a six year experience. <i>Am J Med<\/i> 1973; 54: 735\u2013742.","DOI":"10.1016\/0002-9343(73)90060-0"},{"key":"82","doi-asserted-by":"crossref","unstructured":"82. Marinescu MA, Loffler AI, Ouellette M, Smith L, Kramer CM, Bourque JM. Coronary microvascular dysfunction, microvascular angina, and treatment strategies. <i>JACC Cardiovasc Imaging<\/i> 2015; 8: 210\u2013220.","DOI":"10.1016\/j.jcmg.2014.12.008"},{"key":"83","doi-asserted-by":"crossref","unstructured":"83. Mizuno R, Fujimoto S, Saito Y, Okamoto Y. Optimal antihypertensive level for improvement of coronary microvascular dysfunction: The lower, the better? <i>Hypertension<\/i> 2012; 60: 326\u2013332.","DOI":"10.1161\/HYPERTENSIONAHA.111.189209"},{"key":"84","doi-asserted-by":"crossref","unstructured":"84. Jadhav S, Ferrell W, Greer IA, Petrie JR, Cobbe SM, Sattar N. Effects of metformin on microvascular function and exercise tolerance in women with angina and normal coronary arteries: A randomized, double-blind, placebo-controlled study. <i>J Am Coll Cardiol<\/i> 2006; 48: 956\u2013963.","DOI":"10.1016\/j.jacc.2006.04.088"},{"key":"85","doi-asserted-by":"crossref","unstructured":"85. Lim TK, Choy AJ, Khan F, Belch JJ, Struthers AD, Lang CC. Therapeutic development in cardiac syndrome X: A need to target the underlying pathophysiology. <i>Cardiovasc Ther<\/i> 2009; 27: 49\u201358.","DOI":"10.1111\/j.1755-5922.2008.00070.x"},{"key":"86","doi-asserted-by":"crossref","unstructured":"86. Anand SS, Islam S, Rosengren A, Franzosi MG, Steyn K, Yusufali AH, et al. Risk factors for myocardial infarction in women and men: Insights from the Interheart study. <i>Eur Heart J<\/i> 2008; 29: 932\u2013940.","DOI":"10.1093\/eurheartj\/ehn018"},{"key":"87","doi-asserted-by":"crossref","unstructured":"87. Stampfer MJ, Hu FB, Manson JE, Rimm EB, Willett WC. Primary prevention of coronary heart disease in women through diet and lifestyle. <i>N Engl J Med<\/i> 2000; 343: 16\u201322.","DOI":"10.1056\/NEJM200007063430103"},{"key":"88","doi-asserted-by":"crossref","unstructured":"88. Parikh P, McDaniel MC, Ashen MD, Miller JI, Sorrentino M, Chan V, et al. Diets and cardiovascular disease: An evidence-based assessment. <i>J Am Coll Cardiol<\/i> 2005; 45: 1379\u20131387.","DOI":"10.1016\/j.jacc.2004.11.068"},{"key":"89","doi-asserted-by":"crossref","unstructured":"89. Pizzi C, Manfrini O, Fontana F, Bugiardini R. Angiotensin-converting enzyme inhibitors and 3-hydroxy-3-methylglutaryl coenzyme a reductase in cardiac syndrome X: Role of superoxide dismutase activity. <i>Circulation<\/i> 2004; 109: 53\u201358.","DOI":"10.1161\/01.CIR.0000100722.34034.E4"},{"key":"90","doi-asserted-by":"crossref","unstructured":"90. Pauly DF, Johnson BD, Anderson RD, Handberg EM, Smith KM, Cooper-DeHoff RM, et al. In women with symptoms of cardiac ischemia, nonobstructive coronary arteries, and microvascular dysfunction, angiotensin-converting enzyme inhibition is associated with improved microvascular function: A double-blind randomized study from the National Heart, Lung and Blood Institute Women\u2019s Ischemia Syndrome Evaluation (WISE). <i>Am Heart J<\/i> 2011; 162: 678\u2013684.","DOI":"10.1016\/j.ahj.2011.07.011"},{"key":"91","doi-asserted-by":"crossref","unstructured":"91. Schwartzkopff B, Brehm M, Mundhenke M, Strauer BE. Repair of coronary arterioles after treatment with perindopril in hypertensive heart disease. <i>Hypertension<\/i> 2000; 36: 220\u2013225.","DOI":"10.1161\/01.HYP.36.2.220"},{"key":"92","doi-asserted-by":"crossref","unstructured":"92. Bavry AA, Handberg EM, Huo T, Lerman A, Quyyumi AA, Shufelt C, et al. Aldosterone inhibition and coronary endothelial function in women without obstructive coronary artery disease: An ancillary study of the National Heart, Lung, and Blood Institute-sponsored Women\u2019s Ischemia Syndrome Evaluation. <i>Am Heart J<\/i> 2014; 167: 826\u2013832.","DOI":"10.1016\/j.ahj.2014.01.017"},{"key":"93","doi-asserted-by":"crossref","unstructured":"93. Garg R, Rao AD, Baimas-George M, Hurwitz S, Foster C, Shah RV, et al. Mineralocorticoid receptor blockade improves coronary microvascular function in individuals with type 2 diabetes. <i>Diabetes<\/i> 2015; 64: 236\u2013242.","DOI":"10.2337\/db14-0670"},{"key":"94","doi-asserted-by":"crossref","unstructured":"94. Oestreicher EM, Martinez-Vasquez D, Stone JR, Jonasson L, Roubsanthisuk W, Mukasa K, et al. Aldosterone and not plasminogen activator inhibitor-1 is a critical mediator of early angiotensin II\/NG-nitro-l-arginine methyl ester-induced myocardial injury. <i>Circulation<\/i> 2003; 108: 2517\u20132523.","DOI":"10.1161\/01.CIR.0000097000.51723.6F"},{"key":"95","doi-asserted-by":"crossref","unstructured":"95. Farquharson CA, Struthers AD. Aldosterone induces acute endothelial dysfunction in vivo in humans: Evidence for an aldosterone-induced vasculopathy. <i>Clin Sci (Lond)<\/i> 2002; 103: 425\u2013431.","DOI":"10.1042\/cs1030425"},{"key":"96","doi-asserted-by":"crossref","unstructured":"96. Lanza GA, Colonna G, Pasceri V, Maseri A. Atenolol versus amlodipine versus isosorbide-5-mononitrate on anginal symptoms in syndrome X. <i>Am J Cardiol<\/i> 1999; 84: 854\u2013856, A858.","DOI":"10.1016\/S0002-9149(99)00450-6"},{"key":"97","unstructured":"97. Leonardo F, Fragasso G, Rossetti E, Dabrowski P, Pagnotta P, Rosano GM, et al. Comparison of trimetazidine with atenolol in patients with syndrome X: Effects on diastolic function and exercise tolerance. <i>Cardiologia<\/i> 1999; 44: 1065\u20131069."},{"key":"98","doi-asserted-by":"crossref","unstructured":"98. Matsuda Y, Akita H, Terashima M, Shiga N, Kanazawa K, Yokoyama M. Carvedilol improves endothelium-dependent dilatation in patients with coronary artery disease. <i>Am Heart J<\/i> 2000; 140: 753\u2013759.","DOI":"10.1067\/mhj.2000.110093"},{"key":"99","doi-asserted-by":"crossref","unstructured":"99. Sutsch G, Oechslin E, Mayer I, Hess OM. Effect of diltiazem on coronary flow reserve in patients with microvascular angina. <i>Int J Cardiol<\/i> 1995; 52: 135\u2013143.","DOI":"10.1016\/0167-5273(95)02458-9"},{"key":"100","doi-asserted-by":"crossref","unstructured":"100. Cannon RO 3rd, Watson RM, Rosing DR, Epstein SE. Efficacy of calcium channel blocker therapy for angina pectoris resulting from small-vessel coronary artery disease and abnormal vasodilator reserve. <i>Am J Cardiol<\/i> 1985; 56: 242\u2013246.","DOI":"10.1016\/0002-9149(85)90842-2"},{"key":"101","doi-asserted-by":"crossref","unstructured":"101. Ridker PM, MacFadyen J, Libby P, Glynn RJ. Relation of baseline high-sensitivity C-reactive protein level to cardiovascular outcomes with rosuvastatin in the justification for use of statins in prevention: An intervention trial evaluating rosuvastatin (JUPITER). <i>Am J Cardiol<\/i> 2010; 106: 204\u2013209.","DOI":"10.1016\/j.amjcard.2010.03.018"},{"key":"102","doi-asserted-by":"crossref","unstructured":"102. Zhang X, Li Q, Zhao J, Li X, Sun X, Yang H, et al. Effects of combination of statin and calcium channel blocker in patients with cardiac syndrome X. <i>Coron Artery Dis<\/i> 2014; 25: 40\u201344.","DOI":"10.1097\/MCA.0000000000000054"},{"key":"103","doi-asserted-by":"crossref","unstructured":"103. Caliskan M, Erdogan D, Gullu H, Topcu S, Ciftci O, Yildirir A, et al. Effects of atorvastatin on coronary flow reserve in patients with slow coronary flow. <i>Clin Cardiol<\/i> 2007; 30: 475\u2013479.","DOI":"10.1002\/clc.20140"},{"key":"104","unstructured":"104. Eshtehardi P, McDaniel MC, Dhawan SS, Binongo JN, Krishnan SK, Golub L, et al. Effect of intensive atorvastatin therapy on coronary atherosclerosis progression, composition, arterial remodeling, and microvascular function. <i>J Invasive Cardiol<\/i> 2012; 24: 522\u2013529."},{"key":"105","doi-asserted-by":"crossref","unstructured":"105. Hasenfuss G, Maier LS. Mechanism of action of the new anti-ischemia drug ranolazine. <i>Clin Res Cardiol<\/i> 2008; 97: 222\u2013226.","DOI":"10.1007\/s00392-007-0612-y"},{"key":"106","doi-asserted-by":"crossref","unstructured":"106. Mehta PK, Goykhman P, Thomson LE, Shufelt C, Wei J, Yang Y, et al. Ranolazine improves angina in women with evidence of myocardial ischemia but no obstructive coronary artery disease. <i>JACC Cardiovasc Imaging<\/i> 2011; 4: 514\u2013522.","DOI":"10.1016\/j.jcmg.2011.03.007"},{"key":"107","doi-asserted-by":"crossref","unstructured":"107. Villano A, Di Franco A, Nerla R, Sestito A, Tarzia P, Lamendola P, et al. Effects of ivabradine and ranolazine in patients with microvascular angina pectoris. <i>Am J Cardiol<\/i> 2013; 112: 8\u201313.","DOI":"10.1016\/j.amjcard.2013.02.045"},{"key":"108","doi-asserted-by":"crossref","unstructured":"108. Bairey Merz CN, Handberg EM, Shufelt CL, Mehta PK, Minissian MB, Wei J, et al. A randomized, placebo-controlled trial of late Na current inhibition (ranolazine) in coronary microvascular dysfunction (CMD): Impact on angina and myocardial perfusion reserve. <i>Eur Heart J<\/i> 2016; 37: 1504\u20131513.","DOI":"10.1093\/eurheartj\/ehv647"},{"key":"109","doi-asserted-by":"crossref","unstructured":"109. Skalidis EI, Hamilos MI, Chlouverakis G, Zacharis EA, Vardas PE. Ivabradine improves coronary flow reserve in patients with stable coronary artery disease. <i>Atherosclerosis<\/i> 2011; 215: 160\u2013165.","DOI":"10.1016\/j.atherosclerosis.2010.11.035"},{"key":"110","unstructured":"110. Yesildag O, Yazici M, Yilmaz O, Ucar R, Sagkan O. The effect of aminophylline infusion on the exercise capacity in patients with syndrome X. <i>Acta Cardiol<\/i> 1999; 54: 335\u2013337."},{"key":"111","doi-asserted-by":"crossref","unstructured":"111. Elliott PM, Krzyzowska-Dickinson K, Calvino R, Hann C, Kaski JC. Effect of oral aminophylline in patients with angina and normal coronary arteriograms (cardiac syndrome X). <i>Heart<\/i> 1997; 77: 523\u2013526.","DOI":"10.1136\/hrt.77.6.523"},{"key":"112","doi-asserted-by":"crossref","unstructured":"112. Shi J, Wei L. Rho kinases in cardiovascular physiology and pathophysiology: The effect of fasudil. <i>J Cardiovasc Pharmacol<\/i> 2013; 62: 341\u2013354.","DOI":"10.1097\/FJC.0b013e3182a3718f"},{"key":"113","doi-asserted-by":"crossref","unstructured":"113. Mohri M, Shimokawa H, Hirakawa Y, Masumoto A, Takeshita A. Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm. <i>J Am Coll Cardiol<\/i> 2003; 41: 15\u201319.","DOI":"10.1016\/S0735-1097(02)02632-3"},{"key":"114","doi-asserted-by":"crossref","unstructured":"114. Palmer RM, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from l-arginine. <i>Nature<\/i> 1988; 333: 664\u2013666.","DOI":"10.1038\/333664a0"},{"key":"115","doi-asserted-by":"crossref","unstructured":"115. Egashira K, Hirooka Y, Kuga T, Mohri M, Takeshita A. Effects of l-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms. <i>Circulation<\/i> 1996; 94: 130\u2013134.","DOI":"10.1161\/01.CIR.94.2.130"},{"key":"116","doi-asserted-by":"crossref","unstructured":"116. Gellman J, Hare JM, Lowenstein CJ, Gerstenblith G, Coombs V, Langenberg P, et al. L-arginine ameliorates the abnormal sympathetic response of the dysfunctional human coronary microvasculature. <i>Angiology<\/i> 2004; 55: 1\u20138.","DOI":"10.1177\/000331970405500101"},{"key":"117","doi-asserted-by":"crossref","unstructured":"117. Lerman A, Burnett JC Jr, Higano ST, McKinley LJ, Holmes DR Jr. Long-term L-arginine supplementation improves small-vessel coronary endothelial function in humans. <i>Circulation<\/i> 1998; 97: 2123\u20132128.","DOI":"10.1161\/01.CIR.97.21.2123"},{"key":"118","doi-asserted-by":"crossref","unstructured":"118. Cannon RO 3rd, Quyyumi AA, Mincemoyer R, Stine AM, Gracely RH, Smith WB, et al. Imipramine in patients with chest pain despite normal coronary angiograms. <i>N Engl J Med<\/i> 1994; 330: 1411\u20131417.","DOI":"10.1056\/NEJM199405193302003"},{"key":"119","doi-asserted-by":"crossref","unstructured":"119. Cox ID, Hann CM, Kaski JC. Low dose imipramine improves chest pain but not quality of life in patients with angina and normal coronary angiograms. <i>Eur Heart J<\/i> 1998; 19: 250\u2013254.","DOI":"10.1053\/euhj.1997.0615"},{"key":"120","doi-asserted-by":"crossref","unstructured":"120. Sestito A, Lanza GA, Le Pera D, De Armas L, Sgueglia GA, Infusino F, et al. Spinal cord stimulation normalizes abnormal cortical pain processing in patients with cardiac syndrome X. <i>Pain<\/i> 2008; 139: 82\u201389.","DOI":"10.1016\/j.pain.2008.03.015"},{"key":"121","unstructured":"121. Lanza GA, Sestito A, Sandric S, Cioni B, Tamburrini G, Barollo A, et al. Spinal cord stimulation in patients with refractory anginal pain and normal coronary arteries. <i>Ital Heart J<\/i> 2001; 2: 25\u201330."},{"key":"122","doi-asserted-by":"crossref","unstructured":"122. Kitsou V, Xanthos T, Roberts R, Karlis GM, Padadimitriou L. Enhanced external counterpulsation: Mechanisms of action and clinical applications. <i>Acta Cardiol<\/i> 2010; 65: 239\u2013247.","DOI":"10.2143\/AC.65.2.2047060"},{"key":"123","doi-asserted-by":"crossref","unstructured":"123. Kronhaus KD, Lawson WE. Enhanced external counterpulsation is an effective treatment for syndrome X. <i>Int J Cardiol<\/i> 2009; 135: 256\u2013257.","DOI":"10.1016\/j.ijcard.2008.03.022"},{"key":"124","doi-asserted-by":"crossref","unstructured":"124. Asbury EA, Kanji N, Ernst E, Barbir M, Collins P. Autogenic training to manage symptomology in women with chest pain and normal coronary arteries. <i>Menopause<\/i> 2009; 16: 60\u201365.","DOI":"10.1097\/gme.0b013e318184762e"},{"key":"125","doi-asserted-by":"crossref","unstructured":"125. Samim A, Nugent L, Mehta PK, Shufelt C, Bairey Merz CN. Treatment of angina and microvascular coronary dysfunction. <i>Curr Treat Options Cardiovasc Med<\/i> 2010; 12: 355\u2013364.","DOI":"10.1007\/s11936-010-0083-8"},{"key":"126","unstructured":"126. Mehta PK, Bairey Merz CN. Treatment of angina in subjects with evidence of myocardial ischemia and no obstructive coronary artery disease. <i>In<\/i>: Bonow R, Mann D, Zipes D, Libby P, editors. Braunwald\u2019s heart disease, 9th edn. Philadelphia, PA: Elsevier, 2011 (www.expertconsult.com)."},{"key":"127","doi-asserted-by":"crossref","unstructured":"127. Cassar A, Chareonthaitawee P, Rihal CS, Prasad A, Lennon RJ, Lerman LO, et al. Lack of correlation between noninvasive stress tests and invasive coronary vasomotor dysfunction in patients with nonobstructive coronary artery disease. <i>Circ Cardiovasc Interv<\/i> 2009; 2: 237\u2013244.","DOI":"10.1161\/CIRCINTERVENTIONS.108.841056"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/81\/1\/81_CJ-16-1002\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T01:30:03Z","timestamp":1568597403000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/81\/1\/81_CJ-16-1002\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017]]},"references-count":127,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2017]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-16-1002","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017]]}}}