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Compound heterozygosity for mutations (W156X and R225 W) in SCN5A associated with severe cardiac conduction disturbances and degenerative changes in the conduction system. <i>Circ Res<\/i> 2003; 92: 159\u2013168."},{"key":"10","unstructured":"10. Frigo G, Rampazzo A, Bauce B, Pilichou K, Beffagna G, Danieli GA, et al. Homozygous SCN5A mutation in Brugada syndrome with monomorphic ventricular tachycardia and structural heart abnormalities. <i>Europace<\/i> 2007; 9: 391\u2013397."},{"key":"11","unstructured":"11. McNair WP, Ku L, Taylor MR, Fain PR, Dao D, Wolfel E, et al. SCN5A mutation associated with dilated cardiomyopathy, conduction disorder, and arrhythmia. <i>Circulation<\/i> 2004; 110: 2163\u20132167."},{"key":"12","unstructured":"12. Olson TM, Michels VV, Ballew JD, Reyna SP, Karst ML, Herron KJ, et al. Sodium channel mutations and susceptibility to heart failure and atrial fibrillation. <i>JAMA<\/i> 2005; 293: 447\u2013454."},{"key":"13","unstructured":"13. 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Okita K, Yamakawa T, Matsumura Y, Sato Y, Amano N, Watanabe A, et al. An efficient nonviral method to generate integration-free human-induced pluripotent stem cells from cord blood and peripheral blood cells. <i>Stem Cells<\/i> 2013; 31: 458\u2013466."},{"key":"18","unstructured":"18. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. <i>Cell<\/i> 2006; 126: 663\u2013676."},{"key":"19","unstructured":"19. Sasaki K, Makiyama T, Yoshida Y, Wuriyanghai Y, Kamakura T, Nishiuchi S, et al. Patient-specific human induced pluripotent stem cell model assessed with electrical pacing validates S107 as a potential therapeutic agent for catecholaminergic polymorphic ventricular tachycardia. <i>PLoS One<\/i> 2016; 11: e0164795."},{"key":"20","unstructured":"20. Yang L, Soonpaa MH, Adler ED, Roepke TK, Kattman SJ, Kennedy M, et al. Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. <i>Nature<\/i> 2008; 453: 524\u2013528."},{"key":"21","unstructured":"21. Dubois NC, Craft AM, Sharma P, Elliott DA, Stanley EG, Elefanty AG, et al. SIRPA is a specific cell-surface marker for isolating cardiomyocytes derived from human pluripotent stem cells. <i>Nat Biotechnol<\/i> 2011; 29: 1011\u20131018."},{"key":"22","unstructured":"22. Miki K, Endo K, Takahashi S, Funakoshi S, Takei I, Katayama S, et al. Efficient detection and purification of cell populations using synthetic microRNA switches. <i>Cell Stem Cell<\/i> 2015; 16: 699\u2013711."},{"key":"23","unstructured":"23. Horie T, Baba O, Kuwabara Y, Chujo Y, Watanabe S, Kinoshita M, et al. MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE\u2212\/\u2212 mice. <i>J Am Heart Assoc<\/i> 2012; 1: e003376."},{"key":"24","unstructured":"24. Lee YK, Ng KM, Lai WH, Chan YC, Lau YM, Lian Q, et al. Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes. <i>Stem Cell Rev<\/i> 2011; 7: 976\u2013986."},{"key":"25","unstructured":"25. Abe K, Machida T, Sumitomo N, Yamamoto H, Ohkubo K, Watanabe I, et al. Sodium channelopathy underlying familial sick sinus syndrome with early onset and predominantly male characteristics. <i>Circ Arrhythm Electrophysiol<\/i> 2014; 7: 511\u2013517."},{"key":"26","unstructured":"26. Huttner IG, Trivedi G, Jacoby A, Mann SA, Vandenberg JI, Fatkin D. A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death. <i>J Mol Cell Cardiol<\/i> 2013; 61: 123\u2013132."},{"key":"27","unstructured":"27. van Bemmelen MX, Rougier JS, Gavillet B, Apotheloz F, Daidie D, Tateyama M, et al. Cardiac voltage-gated sodium channel Nav1.5 is regulated by Nedd4-2 mediated ubiquitination. <i>Circ Res<\/i> 2004; 95: 284\u2013291."},{"key":"28","unstructured":"28. Detta N, Frisso G, Salvatore F. The multi-faceted aspects of the complex cardiac Nav1.5 protein in membrane function and pathophysiology. <i>Biochim Biophys Acta<\/i> 2015; 1854: 1502\u20131509."},{"key":"29","unstructured":"29. Chakrabarti S, Wu X, Yang Z, Wu L, Yong SL, Zhang C, et al. MOG1 rescues defective trafficking of Na(v)1.5 mutations in Brugada syndrome and sick sinus syndrome. <i>Circ Arrhythm Electrophysiol<\/i> 2013; 6: 392\u2013401."},{"key":"30","unstructured":"30. Rougier JS, Gavillet B, Abriel H. Proteasome inhibitor (MG132) rescues Nav1.5 protein content and the cardiac sodium current in dystrophin-deficient mdx (5cv) mice. <i>Front Physiol<\/i> 2013; 4: 51."},{"key":"31","unstructured":"31. Gavillet B, Rougier JS, Domenighetti AA, Behar R, Boixel C, Ruchat P, et al. Cardiac sodium channel Nav1.5 is regulated by a multiprotein complex composed of syntrophins and dystrophin. <i>Circ Res<\/i> 2006; 99: 407\u2013414."},{"key":"32","unstructured":"32. Hu D, Barajas-Martinez H, Pfeiffer R, Dezi F, Pfeiffer J, Buch T, et al. Mutations in SCN10A are responsible for a large fraction of cases of Brugada syndrome. <i>J Am Coll Cardiol<\/i> 2014; 64: 66\u201379."},{"key":"33","unstructured":"33. Nguyen TP, Wang DW, Rhodes TH, George AL Jr. Divergent biophysical defects caused by mutant sodium channels in dilated cardiomyopathy with arrhythmia. <i>Circ Res<\/i> 2008; 102: 364\u2013371."},{"key":"34","unstructured":"34. Leblanc N, Hume JR. Sodium current-induced release of calcium from cardiac sarcoplasmic reticulum. <i>Science<\/i> 1990; 248: 372\u2013376."},{"key":"35","unstructured":"35. Royer A, van Veen TA, Le Bouter S, Marionneau C, Griol-Charhbili V, Leoni AL, et al. Mouse model of SCN5A-linked hereditary Lenegre\u2019s disease: Age-related conduction slowing and myocardial fibrosis. <i>Circulation<\/i> 2005; 111: 1738\u20131746."},{"key":"36","unstructured":"36. Nademanee K, Raju H, de Noronha SV, Papadakis M, Robinson L, Rothery S, et al. Fibrosis, Connexin-43, and conduction abnormalities in the Brugada syndrome. <i>J Am Coll Cardiol<\/i> 2015; 66: 1976\u20131986."},{"key":"37","unstructured":"37. Hao X, Zhang Y, Zhang X, Nirmalan M, Davies L, Konstantinou D, et al. TGF-beta1-mediated fibrosis and ion channel remodeling are key mechanisms in producing the sinus node dysfunction associated with SCN5A deficiency and aging. <i>Circ Arrhythm Electrophysiol<\/i> 2011; 4: 397\u2013406."},{"key":"38","unstructured":"38. Kamakura T, Makiyama T, Sasaki K, Yoshida Y, Wuriyanghai Y, Chen J, et al. 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