{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T16:44:59Z","timestamp":1791391499039,"version":"4.3.3"},"reference-count":38,"publisher":"Japanese Circulation Society","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2018]]},"DOI":"10.1253\/circj.cj-17-0820","type":"journal-article","created":{"date-parts":[[2017,9,26]],"date-time":"2017-09-26T18:10:02Z","timestamp":1506449402000},"page":"502-508","source":"Crossref","is-referenced-by-count":73,"title":["Association of Epicardial, Visceral, and Subcutaneous Fat With Cardiometabolic Diseases"],"prefix":"10.1253","volume":"82","author":[{"given":"Fumi","family":"Sato","sequence":"first","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"},{"name":"Department of Cardiology, KKR Otemae Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norikazu","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"},{"name":"Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Cardiology, KKR Otemae Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Namazui","sequence":"additional","affiliation":[{"name":"Department of Cardiology, KKR Otemae Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Fukuda","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Natsukawa","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"},{"name":"Senri Critical Care Medical Center, Osaka Saiseikai Senri Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Nagao","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Murai","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"},{"name":"Department of Internal Medicine, Kawasaki Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Masuda","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshimitsu","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Obata","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Fujishima","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Nishizawa","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tohru","family":"Funahashi","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"},{"name":"Department of Metabolism and Atherosclerosis, Graduate School of Medicine, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iichiro","family":"Shimomura","sequence":"additional","affiliation":[{"name":"Department of Metabolic Medicine, Graduate School of Medicine, Osaka University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Matsuzawa Y. Therapy Insight: Adipocytokines in metabolic syndrome and related cardiovascular disease. <i>Nat Clin Pract Cardiovasc Med<\/i> 2006; 3: 35\u201342.","DOI":"10.1038\/ncpcardio0380"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Shimomura I, Funahashi T, Takahashi M, Maeda K, Kotani K, Nakamura T, et al. Enhanced expression of PAI-1 in visceral fat: Possible contributor to vascular disease in obesity. <i>Nat Med<\/i> 1996; 2: 800\u2013803.","DOI":"10.1038\/nm0796-800"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J, et al. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. <i>Biochem Biophys Res Commun<\/i> 1999; 257: 79\u201383.","DOI":"10.1006\/bbrc.1999.0255"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Matsuzawa Y, Funahashi T, Kihara S, Shimomura I. Adiponectin and metabolic syndrome. <i>Arterioscler Thromb Vasc Biol<\/i> 2004; 24: 29\u201333.","DOI":"10.1161\/01.ATV.0000099786.99623.EF"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Funahashi T, Matsuzawa Y. Adiponectin and the cardiometabolic syndrome: An epidemiological perspective. <i>Best Pract Res Clin Endocrinol Metab<\/i> 2014; 28: 93\u2013106.","DOI":"10.1016\/j.beem.2013.09.002"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Fujioka S, Matsuzawa Y, Tokunaga K, Tarui S. Contribution of intra-abdominal fat accumulation to the impairment of glucose and lipid metabolism in human obesity. <i>Metabolism<\/i> 1987; 36: 54\u201359.","DOI":"10.1016\/0026-0495(87)90063-1"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hiuge-Shimizu A, Kishida K, Funahashi T, Ishizaka Y, Oka R, Okada M, et al. Absolute value of visceral fat area measured on computed tomography scans and obesity-related cardiovascular risk factors in large-scale Japanese general population (the VACATION-J study). <i>Ann Med<\/i> 2012; 44: 82\u201392.","DOI":"10.3109\/07853890.2010.526138"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Obata Y, Maeda N, Yamada Y, Yamamoto K, Nakamura S, Yamaoka M, et al. Impact of visceral fat on gene expression profile in peripheral blood cells in obese Japanese subjects. <i>Cardiovasc Diabetol<\/i> 2016; 15: 159.","DOI":"10.1186\/s12933-016-0479-1"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Bertaso AG, Bertol D, Duncan BB, Foppa M. Epicardial fat: Definition, measurements and systematic review of main outcomes. <i>Arq Bras Cardiol<\/i> 2013; 101: e18\u2013e28.","DOI":"10.5935\/abc.20130138"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Examination Committee of Criteria for \u2018Obesity Disease\u2019 in Japan, Japan Society for the Study of Obesity. New criteria for \u2018obesity disease\u2019 in Japan. <i>Circ J<\/i> 2002; 66: 987\u2013992.","DOI":"10.1253\/circj.66.987"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Committee of the Japan Diabetes Society on the Diagnostic Criteria of Diabetes Mellitus, Seino Y, Nanjo K, Tajima N, Kadowaki T, Kashiwagi A, Araki E, et al. Report of the Committee on the Classification and Diagnostic Criteria of Diabetes Mellitus. <i>J Diabetes Investig<\/i> 2010; 1: 212\u2013228.","DOI":"10.1111\/j.2040-1124.2010.00074.x"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Yamanaka H; Japanese Society of Gout and Nucleic Acid Metabolism. Japanese guideline for the management of hyperuricemia and gout: Second edition. <i>Nucleosides Nucleotides Nucleic Acids<\/i> 2011; 30: 1018\u20131029.","DOI":"10.1080\/15257770.2011.596496"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Japanese Society of Nephrology. Evidence-based practice guideline for the treatment of CKD. <i>Clin Exp Nephrol<\/i> 2009; 13: 537\u2013566.","DOI":"10.1007\/s10157-009-0237-8"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Matsuzawa Y. Metabolic syndrome: Definition and diagnostic criteria in Japan. <i>J Jpn Soc Int Med<\/i> 2005; 94: 188\u2013203.","DOI":"10.5551\/jat.12.301"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Agatston AS, Janowitz WR, Hildner FJ, Zusmer NR, Viamonte M Jr, Detrano R. Quantification of coronary artery calcium using ultrafast computed tomography. <i>J Am Coll Cardiol<\/i> 1990; 15: 827\u2013832.","DOI":"10.1016\/0735-1097(90)90282-T"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Yoshizumi T, Nakamura T, Yamane M, Islam AH, Menju M, Yamasaki K, et al. Abdominal fat: Standardized technique for measurement at CT. <i>Radiology<\/i> 1999; 211: 283\u2013286.","DOI":"10.1148\/radiology.211.1.r99ap15283"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Rosito GA, Massaro JM, Hoffmann U, Ruberg FL, Mahabadi AA, Vasan RS, et al. Pericardial fat, visceral abdominal fat, cardiovascular disease risk factors, and vascular calcification in a community-based sample: The Framingham Heart Study. <i>Circulation<\/i> 2008; 117: 605\u2013613.","DOI":"10.1161\/CIRCULATIONAHA.107.743062"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Mahabadi AA, Massaro JM, Rosito GA, Levy D, Murabito JM, Wolf PA, et al. Association of pericardial fat, intrathoracic fat, and visceral abdominal fat with cardiovascular disease burden: The Framingham Heart Study. <i>Eur Heart J<\/i> 2009; 30: 850\u2013856.","DOI":"10.1093\/eurheartj\/ehn573"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Liu J, Fox CS, Hickson D, Sarpong D, Ekunwe L, May WD, et al. Pericardial adipose tissue, atherosclerosis, and cardiovascular disease risk factors: The Jackson heart study. <i>Diabetes Care<\/i> 2010; 33: 1635\u20131639.","DOI":"10.2337\/dc10-0245"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Greif M, Becker A, von Ziegler F, Lebherz C, Lehrke M, Broedl UC, et al. Pericardial adipose tissue determined by dual source CT is a risk factor for coronary atherosclerosis. <i>Arterioscler Thromb Vasc Biol<\/i> 2009; 29: 781\u2013786.","DOI":"10.1161\/ATVBAHA.108.180653"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Harada PH, Canziani ME, Lima LM, Kamimura M, Rochitte CE, Lemos MM, et al. Pericardial fat is associated with coronary artery calcification in non-dialysis dependent chronic kidney disease patients. <i>PLoS One<\/i> 2014; 9: e114358.","DOI":"10.1371\/journal.pone.0114358"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Tsushima H, Yamamoto H, Kitagawa T, Urabe Y, Tatsugami F, Awai K, et al. Association of epicardial and abdominal visceral adipose tissue with coronary atherosclerosis in patients with a coronary artery calcium score of zero. <i>Circ J<\/i> 2015; 79: 1084\u20131091.","DOI":"10.1253\/circj.CJ-14-1169"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Oikawa M, Owada T, Yamauchi H, Misaka T, Machii H, Yamaki T, et al. Epicardial adipose tissue reflects the presence of coronary artery disease: Comparison with abdominal visceral adipose tissue. <i>Biomed Res Int<\/i> 2015; 2015: 483982.","DOI":"10.1155\/2015\/483982"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Maeda N, Funahashi T, Shimomura I. Cardiovascular-metabolic impact of adiponectin and aquaporin. <i>Endocr J<\/i> 2013; 60: 251\u2013259.","DOI":"10.1507\/endocrj.EJ13-0016"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Maeda N, Takahashi M, Funahashi T, Kihara S, Nishizawa H, Kishida K, et al. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein. <i>Diabetes<\/i> 2001; 50: 2094\u20132099.","DOI":"10.2337\/diabetes.50.9.2094"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Iacobellis G, Pistilli D, Gucciardo M, Leonetti F, Miraldi F, Brancaccio G, et al. Adiponectin expression in human epicardial adipose tissue in vivo is lower in patients with coronary artery disease. <i>Cytokine<\/i> 2005; 29: 251\u2013255.","DOI":"10.1016\/j.cyto.2004.11.002"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Mori T, Koyama Y, Maeda N, Nakamura Y, Fujishima Y, Matsuda K, et al. Ultrastructural localization of adiponectin protein in vasculature of normal and atherosclerotic mice. <i>Sci Rep<\/i> 2014; 4: 4895.","DOI":"10.1038\/srep04895"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Matsuda K, Fujishima Y, Maeda N, Mori T, Hirata A, Sekimoto R, et al. Positive feedback regulation between adiponectin and T-cadherin impacts adiponectin levels in tissue and plasma of male mice. <i>Endocrinology<\/i> 2015; 156: 934\u2013946.","DOI":"10.1210\/en.2014-1618"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Fujishima Y, Maeda N, Matsuda K, Masuda S, Mori T, Fukuda S, et al. Adiponectin association with T-cadherin protects against neointima proliferation and atherosclerosis. <i>FASEB J<\/i> 2017; 31: 1571\u20131583.","DOI":"10.1096\/fj.201601064R"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Imanishi Y, Miyagawa S, Maeda N, Fukushima S, Kitagawa-Sakakida S, Daimon T, et al. Induced adipocyte cell-sheet ameliorates cardiac dysfunction in a mouse myocardial infarction model: A novel drug delivery system for heart failure. <i>Circulation<\/i> 2011; 124: S10\u2013S17.","DOI":"10.1161\/CIRCULATIONAHA.110.009993"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Kamata S, Miyagawa S, Fukushima S, Imanishi Y, Saito A, Maeda N, et al. Targeted delivery of adipocytokines into the heart by induced adipocyte cell-sheet transplantation yields immune tolerance and functional recovery in autoimmune-associated myocarditis in rats. <i>Circ J<\/i> 2015; 79: 169\u2013179.","DOI":"10.1253\/circj.CJ-14-0840"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Shimabukuro M, Hirata Y, Tabata M, Dagvasumberel M, Sato H, Kurobe H, et al. Epicardial adipose tissue volume and adipocytokine imbalance are strongly linked to human coronary atherosclerosis. <i>Arterioscler Thromb Vasc Biol<\/i> 2013; 33: 1077\u20131084.","DOI":"10.1161\/ATVBAHA.112.300829"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Matsuzawa Y, Shimomura I, Nakamura T, Keno Y, Kotani K, Tokunaga K. Pathophysiology and pathogenesis of visceral fat obesity. <i>Obes Res<\/i> 1995; 3: 187S\u2013194S.","DOI":"10.1002\/j.1550-8528.1995.tb00462.x"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Fox CS, Massaro JM, Hoffmann U, Pou KM, Maurovich-Horvat P, Liu CY, et al. Abdominal visceral and subcutaneous adipose tissue compartments: Association with metabolic risk factors in the Framingham Heart Study. <i>Circulation<\/i> 2007; 116: 39\u201348.","DOI":"10.1161\/CIRCULATIONAHA.106.675355"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Preis SR, Massaro JM, Robins SJ, Hoffmann U, Vasan RS, Irlbeck T, et al. Abdominal subcutaneous and visceral adipose tissue and insulin resistance in the Framingham heart study. <i>Obesity (Silver Spring)<\/i> 2010; 18: 2191\u20132198.","DOI":"10.1038\/oby.2010.59"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Jung CH, Kim BY, Kim KJ, Jung SH, Kim CH, Kang SK, et al. Contribution of subcutaneous abdominal fat on ultrasonography to carotid atherosclerosis in patients with type 2 diabetes mellitus. <i>Cardiovasc Diabetol<\/i> 2014; 13: 67.","DOI":"10.1186\/1475-2840-13-67"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. J\u00f8rgensen ME, Borch-Johnsen K, Stolk R, Bjerregaard P. Fat distribution and glucose intolerance among Greenland Inuit. <i>Diabetes Care<\/i> 2013; 36: 2988\u20132994.","DOI":"10.2337\/dc12-2703"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Ryd\u00e9n M, Andersson DP, Bergstr\u00f6m IB, Arner P. Adipose tissue and metabolic alterations: Regional differences in fat cell size and number matter, but differently: A cross-sectional study. <i>J Clin Endocrinol Metab<\/i> 2014; 99: E1870\u2013E1876.","DOI":"10.1210\/jc.2014-1526"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/82\/2\/82_CJ-17-0820\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T20:22:04Z","timestamp":1570134124000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/82\/2\/82_CJ-17-0820\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-17-0820","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018]]}}}