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Evidence of aortopathy in mice with haploinsufficiency of Notch1 in Nos3-null background. <i>J Cardiovasc Dev Dis<\/i> 2015; 2: 17\u201330.","DOI":"10.3390\/jcdd2010017"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Padang R, Bagnall RD, Richmond DR, Bannon PG, Semsarian C. Rare non-synonymous variations in the transcriptional activation domains of GATA5 in bicuspid aortic valve disease. <i>J Mol Cell Cardiol<\/i> 2012; 53: 277\u2013281.","DOI":"10.1016\/j.yjmcc.2012.05.009"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Foffa I, Ait Ali L, Panesi P, Mariani M, Festa P, Botto N, et al. Sequencing of NOTCH1, GATA5, TGFBR1 and TGFBR2 genes in familial cases of bicuspid aortic valve. <i>BMC Med Genet<\/i> 2013; 14: 44.","DOI":"10.1186\/1471-2350-14-44"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Qu XK, Qiu XB, Yuan F, Wang J, Zhao CM, Liu XY, et al. A novel NKX2.5 loss-of-function mutation associated with congenital bicuspid aortic valve. <i>Am J Cardiol<\/i> 2014; 114: 1891\u20131895.","DOI":"10.1016\/j.amjcard.2014.09.028"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Huang da W, Sherman BT, Lempicki RA. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. <i>Nat Protoc<\/i> 2009; 4: 44\u201357.","DOI":"10.1038\/nprot.2008.211"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Jiao J, Xiong W, Wang L, Yang J, Qiu P, Hirai H, et al. Differentiation defect in neural crest-derived smooth muscle cells in patients with aortopathy associated with bicuspid aortic valves. <i>EBioMedicine<\/i> 2016; 10: 282\u2013290.","DOI":"10.1016\/j.ebiom.2016.06.045"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Li W, Chen Q, Mills I, Sumpio BE. Involvement of S6 kinase and p38 mitogen activated protein kinase pathways in strain-induced alignment and proliferation of bovine aortic smooth muscle cells. <i>J Cell Physiol<\/i> 2003; 195: 202\u2013209.","DOI":"10.1002\/jcp.10230"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Jiao Y, Li G, Li Q, Ali R, Qin L, Li W, et al. mTOR (Mechanistic Target of Rapamycin) inhibition decreases mechanosignaling, collagen accumulation, and stiffening of the thoracic aorta in elastin-deficient mice. <i>Arterioscler Thromb Vasc Biol<\/i> 2017; 37: 1657\u20131666.","DOI":"10.1161\/ATVBAHA.117.309653"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Antoine M, Wirz W, Tag CG, Mavituna M, Emans N, Korff T, et al. Expression pattern of fibroblast growth factors (FGFs), their receptors and antagonists in primary endothelial cells and vascular smooth muscle cells. <i>Growth Factors<\/i> 2005; 23: 87\u201395.","DOI":"10.1080\/08977190500096004"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Joannes A, Brayer S, Besnard V, Marchal-Somme J, Jaillet M, Mordant P, et al. FGF9 and FGF18 in idiopathic pulmonary fibrosis promote survival and migration and inhibit myofibroblast differentiation of human lung fibroblasts in vitro. <i>Am J Physiol Lung Cell Mol Physiol<\/i> 2016; 310: L615\u2013L629.","DOI":"10.1152\/ajplung.00185.2015"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Grewal N, Gittenberger-de Groot AC, DeRuiter MC, Klautz RJ, Poelmann RE, Duim S, et al. Bicuspid aortic valve: Phosphorylation of c-Kit and downstream targets are prognostic for future aortopathy. <i>Eur J Cardiothorac Surg<\/i> 2014; 46: 831\u2013839.","DOI":"10.1093\/ejcts\/ezu319"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Liu ZJ, Xiao M, Balint K, Soma A, Pinnix CC, Capobianco AJ, et al. Inhibition of endothelial cell proliferation by Notch1 signaling is mediated by repressing MAPK and PI3K\/Akt pathways and requires MAML1. <i>FASEB J<\/i> 2006; 20: 1009\u20131011.","DOI":"10.1096\/fj.05-4880fje"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Brownstein AJ, Ziganshin BA, Kuivaniemi H, Body SC, Bale AE, Elefteriades JA. Genes associated with thoracic aortic aneurysm and dissection: An update and clinical implications. <i>Aorta (Stamford)<\/i> 2017; 5: 11\u201320.","DOI":"10.12945\/j.aorta.2017.17.003"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Arcucci A, Ruocco MR, Albano F, Granato G, Romano V, Corso G, et al. 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