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Ozsolak F, Milos PM. RNA sequencing: Advances, challenges and opportunities. <i>Nat Rev Genet<\/i> 2011; 12: 87\u201398.","DOI":"10.1038\/nrg2934"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. <i>Cell<\/i> 1993; 75: 843\u2013854.","DOI":"10.1016\/0092-8674(93)90529-Y"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Ambros V. The functions of animal microRNAs. <i>Nature<\/i> 2004; 431: 350\u2013355.","DOI":"10.1038\/nature02871"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Ono K, Kuwabara Y, Han J. MicroRNAs and cardiovascular diseases. <i>FEBS J<\/i> 2011; 278: 1619\u20131633.","DOI":"10.1111\/j.1742-4658.2011.08090.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hon CC, Ramilowski JA, Harshbarger J, Bertin N, Rackham OJ, Gough J, et al. An atlas of human long non-coding RNAs with accurate 5\u2019 ends. <i>Nature<\/i> 2017; 543: 199\u2013204.","DOI":"10.1038\/nature21374"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Nelson BR, Makarewich CA, Anderson DM, Winders BR, Troupes CD, Wu F, et al. A peptide encoded by a transcript annotated as long noncoding rna enhances serca activity in muscle. <i>Science<\/i> 2016; 351: 271\u2013275.","DOI":"10.1126\/science.aad4076"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kong L, Zhang Y, Ye ZQ, Liu XQ, Zhao SQ, Wei L, et al. Cpc: Assess the protein-coding potential of transcripts using sequence features and support vector machine. <i>Nucleic Acids Res<\/i> 2007; 35: W345\u2013W349.","DOI":"10.1093\/nar\/gkm391"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Wang L, Park HJ, Dasari S, Wang S, Kocher JP, Li W. Cpat: Coding-potential assessment tool using an alignment-free logistic regression model. <i>Nucleic Acids Res<\/i> 2013; 41: e74.","DOI":"10.1093\/nar\/gkt006"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Sun L, Luo H, Bu D, Zhao G, Yu K, Zhang C, et al. Utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts. <i>Nucleic Acids Res<\/i> 2013; 41: e166.","DOI":"10.1093\/nar\/gkt646"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Chu C, Qu K, Zhong FL, Artandi SE, Chang HY. Genomic maps of long noncoding RNA occupancy reveal principles of RNA-chromatin interactions. <i>Mol Cell<\/i> 2011; 44: 667\u2013678.","DOI":"10.1016\/j.molcel.2011.08.027"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Simon MD, Wang CI, Kharchenko PV, West JA, Chapman BA, Alekseyenko AA, et al. The genomic binding sites of a noncoding RNA. <i>Proc Natl Acad Sci USA<\/i> 2011; 108: 20497\u201320502.","DOI":"10.1073\/pnas.1113536108"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Engreitz JM, Pandya-Jones A, McDonel P, Shishkin A, Sirokman K, Surka C, et al. The Xist lncRNA exploits three-dimensional genome architecture to spread across the X chromosome. <i>Science<\/i> 2013; 341: 1237973.","DOI":"10.1126\/science.1237973"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Chu C, Zhang QC, da Rocha ST, Flynn RA, Bharadwaj M, Calabrese JM, et al. Systematic discovery of Xist RNA binding proteins. <i>Cell<\/i> 2015; 161: 404\u2013416.","DOI":"10.1016\/j.cell.2015.03.025"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. West JA, Davis CP, Sunwoo H, Simon MD, Sadreyev RI, Wang PI, et al. The long noncoding RNAs neat1 and malat1 bind active chromatin sites. <i>Mol Cell<\/i> 2014; 55: 791\u2013802.","DOI":"10.1016\/j.molcel.2014.07.012"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Helwak A, Tollervey D. Mapping the miRNA interactome by cross-linking ligation and sequencing of hybrids (clash). <i>Nat Protoc<\/i> 2014; 9: 711\u2013728.","DOI":"10.1038\/nprot.2014.043"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Spitale RC, Crisalli P, Flynn RA, Torre EA, Kool ET, Chang HY. RNA shape analysis in living cells. <i>Nat Chem Biol<\/i> 2013; 9: 18\u201320.","DOI":"10.1038\/nchembio.1131"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Hsu PD, Lander ES, Zhang F. Development and applications of CRISPR-Cas9 for genome engineering. <i>Cell<\/i> 2014; 157: 1262\u20131278.","DOI":"10.1016\/j.cell.2014.05.010"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Gilbert LA, Larson MH, Morsut L, Liu Z, Brar GA, Torres SE, et al. Crispr-mediated modular RNA-guided regulation of transcription in eukaryotes. <i>Cell<\/i> 2013; 154: 442\u2013451.","DOI":"10.1016\/j.cell.2013.06.044"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Tanenbaum ME, Gilbert LA, Qi LS, Weissman JS, Vale RD. A protein-tagging system for signal amplification in gene expression and fluorescence imaging. <i>Cell<\/i> 2014; 159: 635\u2013646.","DOI":"10.1016\/j.cell.2014.09.039"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Guttman M, Donaghey J, Carey BW, Garber M, Grenier JK, Munson G, et al. LincRNAs act in the circuitry controlling pluripotency and differentiation. <i>Nature<\/i> 2011; 477: 295\u2013300.","DOI":"10.1038\/nature10398"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Klattenhoff CA, Scheuermann JC, Surface LE, Bradley RK, Fields PA, Steinhauser ML, et al. Braveheart, a long noncoding RNA required for cardiovascular lineage commitment. <i>Cell<\/i> 2013; 152: 570\u2013583.","DOI":"10.1016\/j.cell.2013.01.003"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Xue Z, Hennelly S, Doyle B, Gulati AA, Novikova IV, Sanbonmatsu KY, et al. A G-rich motif in the lncRNA Braveheart interacts with a zinc-finger transcription factor to specify the cardiovascular lineage. <i>Mol Cell<\/i> 2016; 64: 37\u201350.","DOI":"10.1016\/j.molcel.2016.08.010"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Grote P, Wittler L, Hendrix D, Koch F, Wahrisch S, Beisaw A, et al. The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. <i>Dev Cell<\/i> 2013; 24: 206\u2013214.","DOI":"10.1016\/j.devcel.2012.12.012"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ong CT, Corces VG. Enhancer function: New insights into the regulation of tissue-specific gene expression. <i>Nat Rev Genet<\/i> 2011; 12: 283\u2013293.","DOI":"10.1038\/nrg2957"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Orom UA, Derrien T, Beringer M, Gumireddy K, Gardini A, Bussotti G, et al. Long noncoding RNAs with enhancer-like function in human cells. <i>Cell<\/i> 2010; 143: 46\u201358.","DOI":"10.1016\/j.cell.2010.09.001"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Wamstad JA, Alexander JM, Truty RM, Shrikumar A, Li F, Eilertson KE, et al. Dynamic and coordinated epigenetic regulation of developmental transitions in the cardiac lineage. <i>Cell<\/i> 2012; 151: 206\u2013220.","DOI":"10.1016\/j.cell.2012.07.035"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Li W, Notani D, Rosenfeld MG. Enhancers as non-coding RNA transcription units: Recent insights and future perspectives. <i>Nat Rev Genet<\/i> 2016; 17: 207\u2013223.","DOI":"10.1038\/nrg.2016.4"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Ounzain S, Pezzuto I, Micheletti R, Burdet F, Sheta R, Nemir M, et al. Functional importance of cardiac enhancer-associated noncoding RNAs in heart development and disease. <i>J Mol Cell Cardiol<\/i> 2014; 76: 55\u201370.","DOI":"10.1016\/j.yjmcc.2014.08.009"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Ounzain S, Micheletti R, Arnan C, Plaisance I, Cecchi D, Schroen B, et al. Carmen, a human super enhancer-associated long noncoding RNA controlling cardiac specification, differentiation and homeostasis. <i>J Mol Cell Cardiol<\/i> 2015; 89: 98\u2013112.","DOI":"10.1016\/j.yjmcc.2015.09.016"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Lee JH, Gao C, Peng G, Greer C, Ren S, Wang Y, et al. Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts. <i>Circ Res<\/i> 2011; 109: 1332\u20131341.","DOI":"10.1161\/CIRCRESAHA.111.249433"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Wang Z, Zhang XJ, Ji YX, Zhang P, Deng KQ, Gong J, et al. The long noncoding RNA Chaer defines an epigenetic checkpoint in cardiac hypertrophy. <i>Nat Med<\/i> 2016; 22: 1131\u20131139.","DOI":"10.1038\/nm.4179"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Han P, Li W, Lin CH, Yang J, Shang C, Nuernberg ST, et al. A long noncoding RNA protects the heart from pathological hypertrophy. <i>Nature<\/i> 2014; 514: 102\u2013106.","DOI":"10.1038\/nature13596"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Hang CT, Yang J, Han P, Cheng HL, Shang C, Ashley E, et al. Chromatin regulation by Brg1 underlies heart muscle development and disease. <i>Nature<\/i> 2010; 466: 62\u201367.","DOI":"10.1038\/nature09130"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Viereck J, Kumarswamy R, Foinquinos A, Xiao K, Avramopoulos P, Kunz M, et al. Long noncoding RNA Chast promotes cardiac remodeling. <i>Sci Transl Med<\/i> 2016; 8: 326ra322.","DOI":"10.1126\/scitranslmed.aaf1475"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Wang K, Liu F, Zhou LY, Long B, Yuan SM, Wang Y, et al. The long noncoding RNA Chrf regulates cardiac hypertrophy by targeting mir-489. <i>Circ Res<\/i> 2014; 114: 1377\u20131388.","DOI":"10.1161\/CIRCRESAHA.114.302476"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Zhang Y, Xia J, Li Q, Yao Y, Eades G, Gernapudi R, et al. Nrf2\/long noncoding RNA ROR signaling regulates mammary stem cell expansion and protects against estrogen genotoxicity. <i>J Biol Chem<\/i> 2014; 289: 31310\u201331318.","DOI":"10.1074\/jbc.M114.604868"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Jiang F, Zhou X, Huang J. Long non-coding RNA-Ror mediates the reprogramming in cardiac hypertrophy. <i>PLoS One<\/i> 2016; 11: e0152767.","DOI":"10.1371\/journal.pone.0152767"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Liu L, An X, Li Z, Song Y, Li L, Zuo S, et al. The h19 long noncoding RNA is a novel negative regulator of cardiomyocyte hypertrophy. <i>Cardiovasc Res<\/i> 2016; 111: 56\u201365.","DOI":"10.1093\/cvr\/cvw078"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Wang K, Liu CY, Zhou LY, Wang JX, Wang M, Zhao B, et al. Apf lncRNA regulates autophagy and myocardial infarction by targeting mir-188-3p. <i>Nat Commun<\/i> 2015; 6: 6779.","DOI":"10.1038\/ncomms7779"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Wang K, Long B, Zhou LY, Liu F, Zhou QY, Liu CY, et al. Carl lncRNA inhibits anoxia-induced mitochondrial fission and apoptosis in cardiomyocytes by impairing mir-539-dependent phb2 downregulation. <i>Nat Commun<\/i> 2014; 5: 3596.","DOI":"10.1038\/ncomms4596"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Merkwirth C, Dargazanli S, Tatsuta T, Geimer S, Lower B, Wunderlich FT, et al. Prohibitins control cell proliferation and apoptosis by regulating opa1-dependent cristae morphogenesis in mitochondria. <i>Genes Dev<\/i> 2008; 22: 476\u2013488.","DOI":"10.1101\/gad.460708"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Huang ZP, Ding Y, Chen J, Wu G, Kataoka M, Hu Y, et al. Long non-coding RNAs link extracellular matrix gene expression to ischemic cardiomyopathy. <i>Cardiovasc Res<\/i> 2016; 112: 543\u2013554.","DOI":"10.1093\/cvr\/cvw201"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Micheletti R, Plaisance I, Abraham BJ, Sarre A, Ting CC, Alexanian M, et al. The long noncoding RNA Wisper controls cardiac fibrosis and remodeling. <i>Sci Transl Med<\/i> 2017; 9: eaai9118.","DOI":"10.1126\/scitranslmed.aai9118"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Chen L, Yao H, Hui JY, Ding SH, Fan YL, Pan YH, et al. Global transcriptomic study of atherosclerosis development in rats. <i>Gene<\/i> 2016; 592: 43\u201348.","DOI":"10.1016\/j.gene.2016.07.023"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Chen L, Yang W, Guo Y, Chen W, Zheng P, Zeng J, et al. Exosomal lncRNA GAS5 regulates the apoptosis of macrophages and vascular endothelial cells in atherosclerosis. <i>PLoS One<\/i> 2017; 12: e0185406.","DOI":"10.1371\/journal.pone.0185406"},{"key":"46","doi-asserted-by":"crossref","unstructured":"46. Wu G, Cai J, Han Y, Chen J, Huang ZP, Chen C, et al. LincRNA-p21 regulates neointima formation, vascular smooth muscle cell proliferation, apoptosis, and atherosclerosis by enhancing p53 activity. <i>Circulation<\/i> 2014; 130: 1452\u20131465.","DOI":"10.1161\/CIRCULATIONAHA.114.011675"},{"key":"47","doi-asserted-by":"crossref","unstructured":"47. Ballantyne MD, Pinel K, Dakin R, Vesey AT, Diver L, Mackenzie R, et al. Smooth muscle enriched long noncoding RNA (Smilr) regulates cell proliferation. <i>Circulation<\/i> 2016; 133: 2050\u20132065.","DOI":"10.1161\/CIRCULATIONAHA.115.021019"},{"key":"48","doi-asserted-by":"crossref","unstructured":"48. Samani NJ, Schunkert H. Chromosome 9p21 and cardiovascular disease: The story unfolds. <i>Circ Cardiovasc Genet<\/i> 2008; 1: 81\u201384.","DOI":"10.1161\/CIRCGENETICS.108.832527"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Folkersen L, Kyriakou T, Goel A, Peden J, Malarstig A, Paulsson-Berne G, et al. Relationship between cad risk genotype in the chromosome 9p21 locus and gene expression: Identification of eight new ANRIL splice variants. <i>PLoS One<\/i> 2009; 4: e7677.","DOI":"10.1371\/journal.pone.0007677"},{"key":"50","doi-asserted-by":"crossref","unstructured":"50. Holdt LM, Hoffmann S, Sass K, Langenberger D, Scholz M, Krohn K, et al. Alu elements in ANRIL non-coding RNA at chromosome 9p21 modulate atherogenic cell functions through trans-regulation of gene networks. <i>PLoS Genet<\/i> 2013; 9: e1003588.","DOI":"10.1371\/journal.pgen.1003588"},{"key":"51","doi-asserted-by":"crossref","unstructured":"51. Bell RD, Long X, Lin M, Bergmann JH, Nanda V, Cowan SL, et al. Identification and initial functional characterization of a human vascular cell-enriched long noncoding RNA. <i>Arterioscler Thromb Vasc Biol<\/i> 2014; 34: 1249\u20131259.","DOI":"10.1161\/ATVBAHA.114.303240"},{"key":"52","doi-asserted-by":"crossref","unstructured":"52. Michalik KM, You X, Manavski Y, Doddaballapur A, Zornig M, Braun T, et al. 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