{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T23:13:35Z","timestamp":1788995615806,"version":"build-2803163510"},"reference-count":24,"publisher":"Japanese Circulation Society","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2018,11,24]]},"DOI":"10.1253\/circj.cj-18-0636","type":"journal-article","created":{"date-parts":[[2018,10,15]],"date-time":"2018-10-15T22:29:32Z","timestamp":1539642572000},"page":"3076-3081","source":"Crossref","is-referenced-by-count":45,"title":["Nocturnal Hypoxemia, But Not Sleep Apnea, Is Associated With a Poor Prognosis in Patients With Pulmonary Arterial Hypertension"],"prefix":"10.1253","volume":"82","author":[{"given":"Mika","family":"Nagaoka","sequence":"first","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Kyorin University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayumi","family":"Goda","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Kyorin University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaori","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Kyorin University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanako","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Kyorin University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayumi","family":"Finger","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Kyorin University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takumi","family":"Inami","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Kyorin University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Soejima","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Kyorin University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toru","family":"Satoh","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Medicine, Kyorin University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Bradley TD, Floras JS. Sleep apnea and heart failure. Part I: Obstructive sleep apnea. <i>Circulation<\/i> 2003; 107: 1671\u20131678.","DOI":"10.1161\/01.CIR.0000061757.12581.15"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Bradley TD, Floras JS. Sleep apnea and heart failure. Part II: Central sleep apnea. <i>Circulation<\/i> 2003; 107: 1822\u20131826.","DOI":"10.1161\/01.CIR.0000061758.05044.64"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Bradley TD, Hall MJ, Ando S, Floras JS. Hemodynamic effects of simulated obstructive apneas in humans with and without heart failure. <i>Chest<\/i> 2001; 119: 1827\u20131835.","DOI":"10.1378\/chest.119.6.1827"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Javaheri S. Sleep disorders in systolic heart failure: A prospective study of 100 male patients. The final report. <i>Int J Cardiol<\/i> 2006; 106: 21\u201328.","DOI":"10.1016\/j.ijcard.2004.12.068"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Javaheri S, Javaheri A. Sleep apnea, heart failure, and pulmonary hypertension. <i>Curr Heart Fail Rep<\/i> 2013; 10: 315\u2013320.","DOI":"10.1007\/s11897-013-0167-3"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Brij SO, Peacock AJ. Cellular responses to hypoxia in the pulmonary circulation. <i>Thorax<\/i> 1998; 53: 1075\u20131079.","DOI":"10.1136\/thx.53.12.1075"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Dumas JP, Bardou M, Goirand F, Dumas M. Hypoxic pulmonary vasoconstriction. <i>Gen Pharmacol<\/i> 1999; 33: 289\u2013297.","DOI":"10.1016\/S0306-3623(99)00026-9"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Schulz R, Baseler G, Ghofrani HA, Grimminger F, Olschewski H, Seeger W. Nocturnal periodic breathing in primary pulmonary hypertension. <i>Eur Respir J<\/i> 2002; 19: 658\u2013663.","DOI":"10.1183\/09031936.02.00225102"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Ulrich S, Fischler M, Speich R, Bloch KE. Sleep-related breathing disorders in patients with pulmonary hypertension. <i>Chest<\/i> 2008; 133: 1375\u20131380.","DOI":"10.1378\/chest.07-3035"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Minai OA, Pandya CM, Golish JA, Avecillas JF, McCarthy K, Marlow S, et al. Predictors of nocturnal oxygen desaturation in pulmonary arterial hypertension. <i>Chest<\/i> 2007; 131: 109\u2013117.","DOI":"10.1378\/chest.06-1378"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Minic M, Granton JT, Ryan CM. Sleep disordered breathing in group 1 pulmonary arterial hypertension. <i>J Clin Sleep Med<\/i> 2014; 10: 277\u2013283.","DOI":"10.5664\/jcsm.3528"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Jilwan FN, Escourrou P, Garcia G, Jais X, Humbert M, Roisman G. High occurrence of hypoxemic sleep respiratory disorders in precapillary pulmonary hypertension and mechanisms. <i>Chest<\/i> 2013; 143: 47\u201355.","DOI":"10.1378\/chest.11-3124"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Dumitrascu R, Tiede H, Eckermann J, Mayer K, Reichenberger F, Ghofrani HA, et al. Sleep apnea in precapillary pulmonary hypertension. <i>Sleep Med<\/i> 2013; 14: 247\u2013251.","DOI":"10.1016\/j.sleep.2012.11.013"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Rafanan AL, Golish JA, Dinner DS, Hague LK, Arroliga AC. Nocturnal hypoxemia is common in primary pulmonary hypertension. <i>Chest<\/i> 2001; 120: 894\u2013899.","DOI":"10.1378\/chest.120.3.894"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Wang H, Parker JD, Newton GE, Floras JS, Mak S, Chiu KL, et al. Influence of obstructive sleep apnea on mortality in patients with heart failure. <i>J Am Coll Cardiol<\/i> 2007; 49: 1625\u20131631.","DOI":"10.1016\/j.jacc.2006.12.046"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Roebuck T, Solin P, Kaye DM, Bergin P, Bailey M, Naughton MT. Increased long-term mortality in heart failure due to sleep apnoea is not yet proven. <i>Eur Respir J<\/i> 2004; 23: 735\u2013740.","DOI":"10.1183\/09031936.04.00060404"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Minai OA, Ricaurte B, Kaw R, Hammel J, Mansour M, McCarthy K, et al. Frequency and impact of pulmonary hypertension in patients with obstructive sleep apnea syndrome. <i>Am J Cardiol<\/i> 2009; 104: 1300\u20131306.","DOI":"10.1016\/j.amjcard.2009.06.048"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Buda AJ, Pinsky MR, Ingels NB Jr, Daughters GT 2nd, Stinson EB, Alderman EL. Effect of intrathoracic pressure on left ventricular performance. <i>N Engl J Med<\/i> 1979; 301: 453\u2013459.","DOI":"10.1056\/NEJM197908303010901"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Iturriaga R, Del Rio R, Idiaquez J, Somers VK. Carotid body chemoreceptors, sympathetic neural activation, and cardiometabolic disease. <i>Biol Res<\/i> 2016; 49: 13.","DOI":"10.1186\/s40659-016-0073-8"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Hildenbrand FF, Bloch KE, Speich R, Ulrich S. Daytime measurements underestimate nocturnal oxygen desaturations in pulmonary arterial and chronic thromboembolic pulmonary hypertension. <i>Respiration<\/i> 2012; 84: 477\u2013484.","DOI":"10.1159\/000341182"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Atwood CW Jr, McCrory D, Garcia JG, Abman SH, Ahearn GS. Pulmonary artery hypertension and sleep-disordered breathing: ACCP evidence-based clinical practice guidelines. <i>Chest<\/i> 2004; 126(Suppl): 72S\u201377S.","DOI":"10.1378\/chest.126.1_suppl.72S"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Ismail K, Roberts K, Manning P, Manley C, Hill NS. OSA and pulmonary hypertension: Time for a new look. <i>Chest<\/i> 2015; 147: 847\u2013861.","DOI":"10.1378\/chest.14-0614"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Prisco DL, Sica AL, Talwar A, Narasimhan M, Omonuwa K, Hakimisefat B, et al. Correlation of pulmonary hypertension severity with metrics of comorbid sleep-disordered breathing. <i>Sleep Breath<\/i> 2011; 15: 633\u2013639.","DOI":"10.1007\/s11325-010-0411-y"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Poms AD, Turner M, Farber HW, Meltzer LA, McGoon MD. Comorbid conditions and outcomes in patients with pulmonary arterial hypertension: A REVEAL registry analysis. <i>Chest<\/i> 2013; 144: 169\u2013176.","DOI":"10.1378\/chest.11-3241"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/82\/12\/82_CJ-18-0636\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,26]],"date-time":"2019-10-26T19:21:56Z","timestamp":1572117716000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/82\/12\/82_CJ-18-0636\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,24]]},"references-count":24,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2018]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-18-0636","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,24]]}}}