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Redfield MM, Jacobsen SJ, Burnett JC Jr, Mahoney DW, Bailey KR, Rodeheffer RJ. Burden of systolic and diastolic ventricular dysfunction in the community: Appreciating the scope of the heart failure epidemic. <i>JAMA<\/i> 2003; 289: 194\u2013202.","DOI":"10.1001\/jama.289.2.194"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Kane GC, Karon BL, Mahoney DW, Redfield MM, Roger VL, Burnett JC Jr, et al. Progression of left ventricular diastolic dysfunction and risk of heart failure. <i>JAMA<\/i> 2011; 306: 856\u2013863.","DOI":"10.1001\/jama.2011.1201"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Jeong EM, Dudley SC Jr. Diastolic dysfunction. <i>Circ J<\/i> 2015; 79: 470\u2013477.","DOI":"10.1253\/circj.CJ-15-0064"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Reed AL, Tanaka A, Sorescu D, Liu H, Jeong EM, Sturdy M, et al. Diastolic dysfunction is associated with cardiac fibrosis in the senescence-accelerated mouse. <i>Am J Physiol Heart Circ Physiol<\/i> 2011; 301: H824\u2013H831.","DOI":"10.1152\/ajpheart.00407.2010"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hedger MP, de Kretser DM. The activins and their binding protein, follistatin-Diagnostic and therapeutic targets in inflammatory disease and fibrosis. <i>Cytokine Growth Factor Rev<\/i> 2013; 24: 285\u2013295.","DOI":"10.1016\/j.cytogfr.2013.03.003"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Engelse MA, Neele JM, van Achterberg TA, van Aken BE, van Schaik RH, Pannekoek H, et al. Human activin-A is expressed in the atherosclerotic lesion and promotes the contractile phenotype of smooth muscle cells. <i>Circ Res<\/i> 1999; 85: 931\u2013939.","DOI":"10.1161\/01.RES.85.10.931"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Michel U, Ebert S, Phillips D, Nau R. Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia. <i>Eur J Endocrinol<\/i> 2003; 148: 559\u2013564.","DOI":"10.1530\/eje.0.1480559"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Yndestad A, Ueland T, Oie E, Florholmen G, Halvorsen B, Attramadal H, et al. Elevated levels of activin A in heart failure: Potential role in myocardial remodeling. <i>Circulation<\/i> 2004; 109: 1379\u20131385.","DOI":"10.1161\/01.CIR.0000120704.97934.41"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Miyoshi T, Hirohata S, Uesugi T, Hirota M, Ohnishi H, Nogami K, et al. Relationship between activin A level and infarct size in patients with acute myocardial infarction undergoing successful primary coronary intervention. <i>Clin Chim Acta<\/i> 2009; 401: 3\u20137.","DOI":"10.1016\/j.cca.2008.10.027"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Yndestad A, Larsen KO, Oie E, Ueland T, Smith C, Halvorsen B, et al. Elevated levels of activin A in clinical and experimental pulmonary hypertension. <i>J Appl Physiol<\/i> 2009; 106: 1356\u20131364.","DOI":"10.1152\/japplphysiol.90719.2008"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Fukushima N, Matsuura K, Akazawa H, Honda A, Nagai T, Takahashi T, et al. A crucial role of activin A-mediated growth hormone suppression in mouse and human heart failure. <i>PLoS One<\/i> 2011; 6: e27901.","DOI":"10.1371\/journal.pone.0027901"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Yong HE, Murthi P, Wong MH, Kalionis B, Cartwright JE, Brennecke SP, et al. Effects of normal and high circulating concentrations of activin A on vascular endothelial cell functions and vasoactive factor production. <i>Pregnancy Hypertens<\/i> 2015; 5: 346\u2013353.","DOI":"10.1016\/j.preghy.2015.09.006"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Tsai YL, Chang CC, Liu LK, Huang PH, Chen LK, Lin SJ. The Association between serum activin a levels and hypertension in the elderly: A cross-sectional analysis from I-Lan Longitudinal Aging Study. <i>Am J Hypertens<\/i> 2018; 31: 369\u2013374.","DOI":"10.1093\/ajh\/hpx185"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, et al. A new equation to estimate glomerular filtration rate. <i>Ann Intern Med<\/i> 2009; 150: 604\u2013612.","DOI":"10.7326\/0003-4819-150-9-200905050-00006"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Wachtell K, Bella JN, Liebson PR, Gerdts E, Dahlof B, Aalto T, et al. Impact of different partition values on prevalences of left ventricular hypertrophy and concentric geometry in a large hypertensive population: The LIFE study. <i>Hypertension<\/i> 2000; 35: 6\u201312.","DOI":"10.1161\/01.HYP.35.1.6"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Roman MJ, Pickering TG, Schwartz JE, Pini R, Devereux RB. Relation of arterial structure and function to left ventricular geometric patterns in hypertensive adults. <i>J Am Coll Cardiol<\/i> 1996; 28: 751\u2013756.","DOI":"10.1016\/0735-1097(96)00225-2"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Nagueh SF, Appleton CP, Gillebert TC, Marino PN, Oh JK, Smiseth OA, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography. <i>Eur J Echocardiogr<\/i> 2009; 10: 165\u2013193.","DOI":"10.1093\/ejechocard\/jep007"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Okamoto Y, Fujita S, Morita H, Kizawa S, Ito T, Sakane K, et al. Association between circulating FGF23, alpha-Klotho, and left ventricular diastolic dysfunction among patients with preserved ejection fraction. <i>Heart Vessels<\/i> 2016; 31: 66\u201373.","DOI":"10.1007\/s00380-014-0581-9"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Kusunose K, Yamada H, Nishio S, Tomita N, Niki T, Yamaguchi K, et al. Clinical utility of single-beat E\/e\u2019 obtained by simultaneous recording of flow and tissue Doppler velocities in atrial fibrillation with preserved systolic function. <i>JACC Cardiovasc Imaging<\/i> 2009; 2: 1147\u20131156.","DOI":"10.1016\/j.jcmg.2009.05.013"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE, Drazner MH, et al. 2013 ACCF\/AHA Guideline for the management of heart failure: Executive summary: A report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines. <i>J Am Coll Cardiol<\/i> 2013; 62: 1495\u20131539.","DOI":"10.1016\/j.jacc.2013.05.020"},{"key":"21","unstructured":"21. Lin JF, Hsu SY, Teng MS, Wu S, Hsieh CA, Jang SJ, et al. 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