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Amsterdam EA, Wenger NK, Brindis RG, Casey DE Jr, Ganiats TG, Holmes DR Jr, et al. 2014 AHA\/ACC guideline for the management of patients with non-ST-elevation acute coronary syndromes: Executive summary. A report of the American College of Cardiology\/American Heart Association Task Force on Practice Guidelines. <i>Circulation<\/i> 2014; 130: 2354\u20132394.","DOI":"10.1161\/CIR.0000000000000133"},{"key":"2","unstructured":"2. O\u2019Gara PT, Kushner FG, Ascheim DD, Casey DE Jr, Chung MK, de Lemos JA, et al. 2013 ACCF\/AHA guideline for the management of ST-elevation myocardial infarction: A report of the American College of Cardiology Foundation\/American Heart Association Task Force on Practice Guidelines. <i>J Am Coll Cardiol<\/i> 2013; 61: e78\u2013e140."},{"key":"#cr-split#-3.1","unstructured":"3. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the Management of Acute Myocardial Infarction in Patients Presenting with ST-segment Elevation of the European Society of Cardiology (ESC). <i>Eur Heart J<\/i> 2018"},{"key":"#cr-split#-3.2","unstructured":"3. Ibanez B, James S, Agewall S, Antunes MJ, Bucciarelli-Ducci C, Bueno H, et al. 2017 ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the Management of Acute Myocardial Infarction in Patients Presenting with ST-segment Elevation of the European Society of Cardiology"},{"key":"#cr-split#-3.3","unstructured":"(ESC). <i>Eur Heart J<\/i> 2018; 39: 119-177."},{"key":"#cr-split#-4.1","doi-asserted-by":"crossref","unstructured":"4. Roffi M, Patrono C, Collet JP, Mueller C, Valgimigli M, Andreotti F, et al. 2015 ESC guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC). <i>Eur Heart J<\/i> 2016","DOI":"10.1093\/eurheartj\/ehv320"},{"key":"#cr-split#-4.2","doi-asserted-by":"crossref","unstructured":"4. 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II: Morbidity results. <i>JAMA<\/i> 1983; 250: 2814\u20132819.","DOI":"10.1001\/jama.250.20.2814"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Norwegian Multicenter Study Group. Timolol-induced reduction in mortality and reinfarction in patients surviving acute myocardial infarction. <i>N Engl J Med<\/i> 1981; 304: 801\u2013807.","DOI":"10.1056\/NEJM198104023041401"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Yusuf S, Peto R, Lewis J, Collins R, Sleight P. Beta blockade during and after myocardial infarction: An overview of the randomized trials. <i>Prog Cardiovasc Dis<\/i> 1985; 27: 335\u2013371.","DOI":"10.1016\/S0033-0620(85)80003-7"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Choo EH, Chang K, Ahn Y, Jeon DS, Lee JM, Kim DB, et al. Benefit of beta-blocker treatment for patients with acute myocardial infarction and preserved systolic function after percutaneous coronary intervention. <i>Heart<\/i> 2014; 100: 492\u2013499.","DOI":"10.1136\/heartjnl-2013-305137"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Yang JH, Hahn JY, Song YB, Choi SH, Choi JH, Lee SH, et al. Association of beta-blocker therapy at discharge with clinical outcomes in patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. <i>JACC Cardiovasc Interv<\/i> 2014; 7: 592\u2013601.","DOI":"10.1016\/j.jcin.2013.12.206"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Goldberger JJ, Bonow RO, Cuffe M, Liu L, Rosenberg Y, Shah PK, et al. Effect of beta-blocker dose on survival after acute myocardial infarction. <i>J Am Coll Cardiol<\/i> 2015; 66: 1431\u20131441.","DOI":"10.1016\/j.jacc.2015.07.047"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Huang BT, Huang FY, Zuo ZL, Liao YB, Heng Y, Wang PJ, et al. Meta-analysis of relation between oral beta-blocker therapy and outcomes in patients with acute myocardial infarction who underwent percutaneous coronary intervention. <i>Am J Cardiol<\/i> 2015; 115: 1529\u20131538.","DOI":"10.1016\/j.amjcard.2015.02.057"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Puymirat E, Riant E, Aissoui N, Soria A, Ducrocq G, Coste P, et al. \u03b2 blockers and mortality after myocardial infarction in patients without heart failure: Multicentre prospective cohort study. <i>BMJ<\/i> 2016; 354: i4801.","DOI":"10.1136\/bmj.i4801"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Dondo TB, Hall M, West RM, Jernberg T, Lindahl B, Bueno H, et al. 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Kernis SJ, Harjai KJ, Stone GW, Grines LL, Boura JA, O\u2019Neill WW, et al. Does beta-blocker therapy improve clinical outcomes of acute myocardial infarction after successful primary angioplasty? <i>J Am Coll Cardiol<\/i> 2004; 43: 1773\u20131779."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Nakatani D, Sakata Y, Suna S, Usami M, Matsumoto S, Shimizu M, et al. Impact of beta blockade therapy on long-term mortality after ST-segment elevation acute myocardial infarction in the percutaneous coronary intervention era. <i>Am J Cardiol<\/i> 2013; 111: 457\u2013464.","DOI":"10.1016\/j.amjcard.2012.10.026"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Antoni ML, Boden H, Delgado V, Boersma E, Fox K, Schalij MJ, et al. Relationship between discharge heart rate and mortality in patients after acute myocardial infarction treated with primary percutaneous coronary intervention. <i>Eur Heart J<\/i> 2012; 33: 96\u2013102.","DOI":"10.1093\/eurheartj\/ehr293"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Seronde MF, Geha R, Puymirat E, Chaib A, Simon T, Berard L, et al. Discharge heart rate and mortality after acute myocardial infarction. <i>Am J Med<\/i> 2014; 127: 954\u2013962.","DOI":"10.1016\/j.amjmed.2014.06.034"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Kjekshus JK. Importance of heart rate in determining beta-blocker efficacy in acute and long-term acute myocardial infarction intervention trials. <i>Am J Cardiol<\/i> 1986; 57: 43f\u201349f.","DOI":"10.1016\/0002-9149(86)90888-X"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Cucherat M. Quantitative relationship between resting heart rate reduction and magnitude of clinical benefits in post-myocardial infarction: A meta-regression of randomized clinical trials. <i>Eur Heart J<\/i> 2007; 28: 3012\u20133019.","DOI":"10.1093\/eurheartj\/ehm489"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Ishihara M, Fujino M, Ogawa H, Yasuda S, Noguchi T, Nakao K, et al. Clinical Presentation, management and outcome of Japanese Patients with acute myocardial infarction in the troponin era: Japanese Registry of Acute Myocardial Infarction Diagnosed by Universal Definition (J-MINUET). <i>Circ J<\/i> 2015; 79: 1255\u20131262.","DOI":"10.1253\/circj.CJ-15-0217"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Ishihara M, Nakao K, Ozaki Y, Kimura K, Ako J, Noguchi T, et al. Long-term outcomes of non-ST-elevation myocardial infarction without creatine kinase elevation: The J-MINUET Study. <i>Circ J<\/i> 2017; 81: 958\u2013965.","DOI":"10.1253\/circj.CJ-17-0033"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Thygesen K, Alpert JS, Jaffe AS, Simoons ML, Chaitman BR, White HD, et al. Third universal definition of myocardial infarction. <i>J Am Coll Cardiol<\/i> 2012; 60: 1581\u20131598.","DOI":"10.1016\/j.jacc.2012.08.001"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Alpert JS, Thygesen K, Antman E, Bassand JP. Myocardial infarction redefined: A consensus document of The Joint European Society of Cardiology\/American College of Cardiology Committee for the redefinition of myocardial infarction. <i>J Am Coll Cardiol<\/i> 2000; 36: 959\u2013969.","DOI":"10.1016\/S0735-1097(00)00804-4"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Chen ZM, Pan HC, Chen YP, Peto R, Collins R, Jiang LX, et al. Early intravenous then oral metoprolol in 45,852 patients with acute myocardial infarction: Randomised placebo-controlled trial. <i>Lancet<\/i> 2005; 366: 1622\u20131632.","DOI":"10.1016\/S0140-6736(05)67661-1"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Dargie HJ. Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: The CAPRICORN randomised trial. <i>Lancet<\/i> 2001; 357: 1385\u20131390.","DOI":"10.1016\/S0140-6736(00)04560-8"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Fosbol EL, Seibaek M, Brendorp B, Moller DV, Thune JJ, Gislason GH, et al. Long-term prognostic importance of resting heart rate in patients with left ventricular dysfunction in connection with either heart failure or myocardial infarction: The DIAMOND study. <i>Int J Cardiol<\/i> 2010; 140: 279\u2013286.","DOI":"10.1016\/j.ijcard.2008.11.084"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Parodi G, Bellandi B, Valenti R, Memisha G, Giuliani G, Velluzzi S, et al. Heart rate as an independent prognostic risk factor in patients with acute myocardial infarction undergoing primary percutaneous coronary intervention. <i>Atherosclerosis<\/i> 2010; 211: 255\u2013259.","DOI":"10.1016\/j.atherosclerosis.2010.02.017"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Li J, Becker R, Rauch B, Schiele R, Schneider S, Riemer T, et al. Usefulness of heart rate to predict one-year mortality in patients with atrial fibrillation and acute myocardial infarction (from the OMEGA trial). <i>Am J Cardiol<\/i> 2013; 111: 811\u2013815.","DOI":"10.1016\/j.amjcard.2012.11.048"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Fox K, Ford I, Steg PG, Tendera M, Ferrari R, Investigators B. Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): A randomised, double-blind, placebo-controlled trial. <i>Lancet<\/i> 2008; 372: 807\u2013816.","DOI":"10.1016\/S0140-6736(08)61170-8"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Noman A, Balasubramaniam K, Das R, Ang D, Kunadian V, Ivanauskiene T, et al. Admission heart rate predicts mortality following primary percutaneous coronary intervention for ST-elevation myocardial infarction: An observational study. <i>Cardiovasc Ther<\/i> 2013; 31: 363\u2013369.","DOI":"10.1111\/1755-5922.12031"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Gheorghiade M, Colucci WS, Swedberg K. Beta-blockers in chronic heart failure. <i>Circulation<\/i> 2003; 107: 1570\u20131575.","DOI":"10.1161\/01.CIR.0000065187.80707.18"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Lee JH, Ryu HM, Bae MH, Kwon YS, Lee JH, Park Y, et al. Prognosis and natural history of drug-related bradycardia. <i>Korean Circ J<\/i> 2009; 39: 367\u2013371.","DOI":"10.4070\/kcj.2009.39.9.367"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Sagie A, Strasberg B, Kusnieck J, Sclarovsky S. Symptomatic bradycardia induced by the combination of oral diltiazem and beta blockers. <i>Clin Cardiol<\/i> 1991; 14: 314\u2013316.","DOI":"10.1002\/clc.4960140406"},{"key":"37","unstructured":"37. Lu HT, Kam J, Nordin RB, Khelae SK, Wang JM, Choy CN, et al. Beta-blocker use and risk of symptomatic bradyarrhythmias: A hospital-based case-control study. <i>J Geriatr Cardiol<\/i> 2016; 13: 749\u2013759."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Packer M, Coats AJ, Fowler MB, Katus HA, Krum H, Mohacsi P, et al. Effect of carvedilol on survival in severe chronic heart failure. <i>N Engl J Med<\/i> 2001; 344: 1651\u20131658.","DOI":"10.1056\/NEJM200105313442201"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. A randomized trial of beta-blockade in heart failure. The Cardiac Insufficiency Bisoprolol Study (CIBIS): CIBIS Investigators and Committees. <i>Circulation<\/i> 1994; 90: 1765\u20131773.","DOI":"10.1161\/01.CIR.90.4.1765"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Schneider HJ, Pfeiffer D, Hagendorff A. 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