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Writing Group Members, Mozaffarian D, Benjamin EJ, Go AS, Arnett DK, Blaha MJ, Cushman M, et al. Heart disease and stroke statistics-2016 update: A report from the American Heart Association. <i>Circulation<\/i> 2016; 133: e38\u2013e360."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Thygesen K, Alpert JS, Jaffe AS, Chaitman BR, Bax JJ, Morrow DA, et al. Fourth universal definition of myocardial infarction (2018). <i>Glob Heart<\/i> 2018; 13: 305\u2013338.","DOI":"10.1016\/j.gheart.2018.08.004"},{"key":"3","unstructured":"3. Dehmer GJ, Smith KJ. Drug-eluting coronary artery stents. <i>Am Fam Physician<\/i> 2009; 80: 1245\u20131251."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. <i>Nature<\/i> 2005; 438: 967\u2013974.","DOI":"10.1038\/nature04483"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Stewart DJ, Kutryk MJ, Fitchett D, Freeman M, Camack N, Su Y, et al. VEGF gene therapy fails to improve perfusion of ischemic myocardium in patients with advanced coronary disease: Results of the NORTHERN trial. <i>Mol Ther<\/i> 2009; 17: 1109\u20131115.","DOI":"10.1038\/mt.2009.70"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Thamsborg G, Florescu A, Oturai P, Fallentin E, Tritsaris K, Dissing S. Treatment of knee osteoarthritis with pulsed electromagnetic fields: A randomized, double-blind, placebo-controlled study. <i>Osteoarthritis Cartilage<\/i> 2005; 13: 575\u2013581.","DOI":"10.1016\/j.joca.2005.02.012"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Luo Q, Li SS, He C, He H, Yang L, Deng L. Pulse electromagnetic fields effects on serum E2 levels, chondrocyte apoptosis, and matrix metalloproteinase-13 expression in ovariectomized rats. <i>Rheumatol Int<\/i> 2009; 29: 927\u2013935.","DOI":"10.1007\/s00296-008-0782-6"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Zhou J, Chen S, Guo H, Xia L, Liu H, Qin Y, et al. Pulsed electromagnetic field stimulates osteoprotegerin and reduces RANKL expression in ovariectomized rats. <i>Rheumatol Int<\/i> 2013; 33: 1135\u20131141.","DOI":"10.1007\/s00296-012-2499-9"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Chalidis B, Sachinis N, Assiotis A, Maccauro G. Stimulation of bone formation and fracture healing with pulsed electromagnetic fields: Biologic responses and clinical implications. <i>Int J Immunopathol Pharmacol<\/i> 2011; 24(1 Suppl 2): 17\u201320.","DOI":"10.1177\/03946320110241S204"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Kim SS, Shin HJ, Eom DW, Huh JR, Woo Y, Kim H, et al. Enhanced expression of neuronal nitric oxide synthase and phospholipase C-gamma1 in regenerating murine neuronal cells by pulsed electromagnetic field. <i>Exp Mol Med<\/i> 2002; 34: 53\u201359.","DOI":"10.1038\/emm.2002.8"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Cheing GL, Li X, Huang L, Kwan RL, Cheung KK. Pulsed electromagnetic fields (PEMF) promote early wound healing and myofibroblast proliferation in diabetic rats. <i>Bioelectromagnetics<\/i> 2014; 35: 161\u2013169.","DOI":"10.1002\/bem.21832"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Delle Monache S, Alessandro R, Iorio R, Gualtieri G, Colonna R. Extremely low frequency electromagnetic fields (ELF-EMFs) induce in vitro angiogenesis process in human endothelial cells. <i>Bioelectromagnetics<\/i> 2008; 29: 640\u2013648.","DOI":"10.1002\/bem.20430"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Pan Y, Dong Y, Hou W, Ji Z, Zhi K, Yin Z, et al. Effects of PEMF on microcirculation and angiogenesis in a model of acute hindlimb ischemia in diabetic rats. <i>Bioelectromagnetics<\/i> 2013; 34: 180\u2013188.","DOI":"10.1002\/bem.21755"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Ahn D, Cheng L, Moon C, Spurgeon H, Lakatta EG, Talan MI. Induction of myocardial infarcts of a predictable size and location by branch pattern probability-assisted coronary ligation in C57BL\/6 mice. <i>Am J Physiol Heart Circ Physiol<\/i> 2004; 286: H1201\u2013H1207.","DOI":"10.1152\/ajpheart.00862.2003"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Gao E, Lei YH, Shang X, Huang ZM, Zuo L, Boucher M, et al. A novel and efficient model of coronary artery ligation and myocardial infarction in the mouse. <i>Circ Res<\/i> 2010; 107: 1445\u20131453.","DOI":"10.1161\/CIRCRESAHA.110.223925"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Karam R, Healy BP, Wicker P. Coronary reserve is depressed in postmyocardial infarction reactive cardiac hypertrophy. <i>Circulation<\/i> 1990; 81: 238\u2013246.","DOI":"10.1161\/01.CIR.81.1.238"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Shiojima I, Sato K, Izumiya Y, Schiekofer S, Ito M, Liao R, et al. Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. <i>J Clin Invest<\/i> 2005; 115: 2108\u20132118.","DOI":"10.1172\/JCI24682"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Gupta R, Tongers J, Losordo DW. Human studies of angiogenic gene therapy. <i>Circ Res<\/i> 2009; 105: 724\u2013736.","DOI":"10.1161\/CIRCRESAHA.109.200386"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Guo M, Shi JH, Wang PL, Shi DZ. Angiogenic growth factors for coronary artery disease: Current status and prospects. <i>J Cardiovasc Pharmacol Ther<\/i> 2018; 23: 130\u2013141.","DOI":"10.1177\/1074248417735399"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Sutton MG, Sharpe N. Left ventricular remodeling after myocardial infarction: Pathophysiology and therapy. <i>Circulation<\/i> 2000; 101: 2981\u20132988.","DOI":"10.1161\/01.CIR.101.25.2981"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Katz MG, Fargnoli AS, Kendle AP, Hajjar RJ, Bridges CR. Gene therapy in cardiac surgery: Clinical trials, challenges, and perspectives. <i>Ann Thorac Surg<\/i> 2016; 101: 2407\u20132416.","DOI":"10.1016\/j.athoracsur.2015.12.004"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Callaghan MJ, Chang EI, Seiser N, Aarabi S, Ghali S, Kinnucan ER, et al. Pulsed electromagnetic fields accelerate normal and diabetic wound healing by increasing endogenous FGF-2 release. <i>Plast Reconstr Surg<\/i> 2008; 121: 130\u2013141.","DOI":"10.1097\/01.prs.0000293761.27219.84"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Tepper OM, Callaghan MJ, Chang EI, Galiano RD, Bhatt KA, Baharestani S, et al. Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2. <i>Faseb J<\/i> 2004; 18: 1231\u20131233.","DOI":"10.1096\/fj.03-0847fje"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Yen-Patton GP, Patton WF, Beer DM, Jacobson BS. Endothelial cell response to pulsed electromagnetic fields: Stimulation of growth rate and angiogenesis in vitro. <i>J Cell Physiol<\/i> 1988; 134: 37\u201346.","DOI":"10.1002\/jcp.1041340105"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Bussolino F, Mantovani A, Persico G. Molecular mechanisms of blood vessel formation. <i>Trends Biochem Sci<\/i> 1997; 22: 251\u2013256.","DOI":"10.1016\/S0968-0004(97)01074-8"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Koch S, Tugues S, Li X, Gualandi L, Claesson-Welsh L. Signal transduction by vascular endothelial growth factor receptors. <i>Biochem J<\/i> 2011; 437: 169\u2013183.","DOI":"10.1042\/BJ20110301"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Potente M, Carmeliet P. The link between angiogenesis and endothelial metabolism. <i>Annu Rev Physiol<\/i> 2017; 79: 43\u201366.","DOI":"10.1146\/annurev-physiol-021115-105134"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Hart FX. Integrins may serve as mechanical transducers for low-frequency electric fields. <i>Bioelectromagnetics<\/i> 2006; 27: 505\u2013508.","DOI":"10.1002\/bem.20236"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Schmidt C, Pommerenke H, Durr F, Nebe B, Rychly J. Mechanical stressing of integrin receptors induces enhanced tyrosine phosphorylation of cytoskeletally anchored proteins. <i>J Biol Chem<\/i> 1998; 273: 5081\u20135085.","DOI":"10.1074\/jbc.273.9.5081"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Sulik GL, Soong HK, Chang PC, Parkinson WC, Elner SG, Elner VM. Effects of steady electric fields on human retinal pigment epithelial cell orientation and migration in culture. <i>Acta Ophthalmol (Copenh)<\/i> 1992; 70: 115\u2013122.","DOI":"10.1111\/j.1755-3768.1992.tb02102.x"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Han J, Yan XL, Han QH, Li Y, Zhu J, Hui YN. Electric fields contribute to directed migration of human retinal pigment epithelial cells via interaction between F-actin and beta1 integrin. <i>Curr Eye Res<\/i> 2009; 34: 438\u2013446.","DOI":"10.1080\/02713680902879033"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Hatanaka K, Ito K, Shindo T, Kagaya Y, Ogata T, Eguchi K, et al. Molecular mechanisms of the angiogenic effects of low-energy shock wave therapy: Roles of mechanotransduction. <i>Am J Physiol Cell Physiol<\/i> 2016; 311: C378\u2013C385.","DOI":"10.1152\/ajpcell.00152.2016"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Shindo T, Ito K, Ogata T, Hatanaka K, Kurosawa R, Eguchi K, et al. Low-intensity pulsed ultrasound enhances angiogenesis and ameliorates left ventricular dysfunction in a mouse model of acute myocardial infarction. <i>Arterioscler Thromb Vasc Biol<\/i> 2016; 36: 1220\u20131229.","DOI":"10.1161\/ATVBAHA.115.306477"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Scully KM, Skowronska-Krawczyk D, Krawczyk M, Merkurjev D, Taylor H, Livolsi A, et al. Epithelial cell integrin beta1 is required for developmental angiogenesis in the pituitary gland. <i>Proc Natl Acad Sci USA<\/i> 2016; 113: 13408\u201313413.","DOI":"10.1073\/pnas.1614970113"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Malan D, Wenzel D, Schmidt A, Geisen C, Raible A, Bolck B, et al. Endothelial beta1 integrins regulate sprouting and network formation during vascular development. <i>Development<\/i> 2010; 137: 993\u20131002.","DOI":"10.1242\/dev.045377"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Nishida T, Shimokawa H, Oi K, Tatewaki H, Uwatoku T, Abe K, et al. Extracorporeal cardiac shock wave therapy markedly ameliorates ischemia-induced myocardial dysfunction in pigs in vivo. <i>Circulation<\/i> 2004; 110: 3055\u20133061.","DOI":"10.1161\/01.CIR.0000148849.51177.97"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Abe Y, Ito K, Hao K, Shindo T, Ogata T, Kagaya Y, et al. Extracorporeal low-energy shock-wave therapy exerts anti-inflammatory effects in a rat model of acute myocardial infarction. <i>Circ J<\/i> 2014; 78: 2915\u20132925.","DOI":"10.1253\/circj.CJ-14-0230"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Uwatoku T, Ito K, Abe K, Oi K, Hizume T, Sunagawa K, et al. Extracorporeal cardiac shock wave therapy improves left ventricular remodeling after acute myocardial infarction in pigs. <i>Coron Artery Dis<\/i> 2007; 18: 397\u2013404.","DOI":"10.1097\/MCA.0b013e328089f19b"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Kagaya Y, Ito K, Takahashi J, Matsumoto Y, Shiroto T, Tsuburaya R, et al. Low-energy cardiac shockwave therapy to suppress left ventricular remodeling in patients with acute myocardial infarction: A first-in-human study. <i>Coron Artery Dis<\/i> 2018; 29: 294\u2013300.","DOI":"10.1097\/MCA.0000000000000577"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Hanawa K, Ito K, Aizawa K, Shindo T, Nishimiya K, Hasebe Y, et al. Low-intensity pulsed ultrasound induces angiogenesis and ameliorates left ventricular dysfunction in a porcine model of chronic myocardial ischemia. <i>PLoS One<\/i> 2014; 9: e104863.","DOI":"10.1371\/journal.pone.0104863"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Yuan Y, Wei L, Li F, Guo W, Li W, Luan R, et al. Pulsed magnetic field induces angiogenesis and improves cardiac function of surgically induced infarcted myocardium in Sprague-Dawley rats. <i>Cardiology<\/i> 2010; 117: 57\u201363.","DOI":"10.1159\/000321459"},{"key":"42","unstructured":"42. Hao CN, Huang JJ, Shi YQ, Cheng XW, Li HY, Zhou L, et al. 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