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He J, Ogden LG, Bazzano LA, Vupputuri S, Loria C, Whelton PK. Risk factors for congestive heart failure in US men and women: NHANES I epidemiologic follow-up study. <i>Arch Intern Med<\/i> 2001; 161: 996\u20131002.","DOI":"10.1001\/archinte.161.7.996"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Hausenloy DJ, Mwamure PK, Venugopal V, Harris J, Barnard M, Grundy E, et al. Effect of remote ischaemic preconditioning on myocardial injury in patients undergoing coronary artery bypass graft surgery: A randomised controlled trial. <i>Lancet<\/i> 2007; 370: 575\u2013579.","DOI":"10.1016\/S0140-6736(07)61296-3"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Hausenloy DJ, Candilio L, Evans R, Ariti C, Jenkins DP, Kolvekar S, et al. Remote ischemic preconditioning and outcomes of cardiac surgery. <i>N Engl J Med<\/i> 2015; 373: 1408\u20131417.","DOI":"10.1056\/NEJMoa1413534"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Meybohm P, Bein B, Brosteanu O, Cremer J, Gruenewald M, Stoppe C, et al. A multicenter trial of remote ischemic preconditioning for heart surgery. <i>N Engl J Med<\/i> 2015; 373: 1397\u20131407.","DOI":"10.1056\/NEJMoa1413579"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Hausenloy DJ, Kharbanda RK, Moller UK, Ramlall M, Aaroe J, Butler R, et al. Effect of remote ischaemic conditioning on clinical outcomes in patients with acute myocardial infarction (CONDI-2\/ERIC-PPCI): A single-blind randomised controlled trial. <i>Lancet<\/i> 2019; 394: 1415\u20131424.","DOI":"10.1016\/S0140-6736(19)32039-2"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Hausenloy DJ. Cardioprotection techniques: Preconditioning, postconditioning and remote conditioning (basic science). <i>Curr Pharm Des<\/i> 2013; 19: 4544\u20134563.","DOI":"10.2174\/1381612811319250004"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Cai Z, Zhong H, Bosch-Marce M, Fox-Talbot K, Wang L, Wei C, et al. Complete loss of ischaemic preconditioning-induced cardioprotection in mice with partial deficiency of HIF-1 alpha. <i>Cardiovasc Res<\/i> 2008; 77: 463\u2013470.","DOI":"10.1093\/cvr\/cvm035"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Semenza GL. Hypoxia-inducible factors in physiology and medicine. <i>Cell<\/i> 2012; 148: 399\u2013408.","DOI":"10.1016\/j.cell.2012.01.021"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Kaelin WG Jr, Ratcliffe PJ. Oxygen sensing by metazoans: The central role of the HIF hydroxylase pathway. <i>Mol Cell<\/i> 2008; 30: 393\u2013402.","DOI":"10.1016\/j.molcel.2008.04.009"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Villa JC, Chiu D, Brandes AH, Escorcia FE, Villa CH, Maguire WF, et al. Nontranscriptional role of Hif-1alpha in activation of gamma-secretase and notch signaling in breast cancer. <i>Cell Rep<\/i> 2014; 8: 1077\u20131092.","DOI":"10.1016\/j.celrep.2014.07.028"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Minamishima YA, Kaelin WG Jr. Reactivation of hepatic EPO synthesis in mice after PHD loss. <i>Science<\/i> 2010; 329: 407.","DOI":"10.1126\/science.1192811"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Provenzano R, Besarab A, Wright S, Dua S, Zeig S, Nguyen P, et al. Roxadustat (FG-4592) versus epoetin alfa for anemia in patients receiving maintenance hemodialysis: A phase 2, randomized, 6- to 19-week, open-label, active-comparator, dose-ranging, safety and exploratory efficacy study. <i>Am J Kidney Dis<\/i> 2016; 67: 912\u2013924.","DOI":"10.1053\/j.ajkd.2015.12.020"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Fujino T, Ide T, Yoshida M, Onitsuka K, Tanaka A, Hata Y, et al. Recombinant mitochondrial transcription factor A protein inhibits nuclear factor of activated T cells signaling and attenuates pathological hypertrophy of cardiac myocytes. <i>Mitochondrion<\/i> 2012; 12: 449\u2013458.","DOI":"10.1016\/j.mito.2012.06.002"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Salabei JK, Gibb AA, Hill BG. Comprehensive measurement of respiratory activity in permeabilized cells using extracellular flux analysis. <i>Nat Protoc<\/i> 2014; 9: 421\u2013438.","DOI":"10.1038\/nprot.2014.018"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Bishop T, Ratcliffe PJ. HIF hydroxylase pathways in cardiovascular physiology and medicine. <i>Circ Res<\/i> 2015; 117: 65\u201379.","DOI":"10.1161\/CIRCRESAHA.117.305109"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Semenza GL, Nejfelt MK, Chi SM, Antonarakis SE. 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