{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T05:28:46Z","timestamp":1769923726886,"version":"3.49.0"},"reference-count":34,"publisher":"Japanese Circulation Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2020,12,25]]},"DOI":"10.1253\/circj.cj-20-0786","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T22:05:20Z","timestamp":1604700320000},"page":"27-36","source":"Crossref","is-referenced-by-count":17,"title":["Monotherapy With Prasugrel After Dual-Antiplatelet Therapy for Japanese Percutaneous Coronary Intervention Patients With High Bleeding Risk\u3000\u2015 A Prospective Cohort Study (PENDULUM mono Study) \u2015"],"prefix":"10.1253","volume":"85","author":[{"given":"Masato","family":"Nakamura","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Toho University Ohashi Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Morino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Iwate Medical University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsunekazu","family":"Kakuta","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tsuchiura Kyodo General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Minamino Cardiovascular Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itaru","family":"Takamisawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sakakibara Heart Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Tanabe","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Mitsui Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Anzai","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ota Memorial Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akihiko","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sakurakai Takahashi Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazushige","family":"Kadota","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kurashiki Central Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Showa University Fujigaoka Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuzo","family":"Wakatsuki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Okayama","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Ehime Prefectural Central Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Yamashita","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Medical University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Akasaka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Wakayama Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyoshi","family":"Yokoi","sequence":"additional","affiliation":[{"name":"Cardiovascular Medicine Center, Fukuoka Sanno Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuo","family":"Nakagami","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Omihachiman Community Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiharu","family":"Higuchi","sequence":"additional","affiliation":[{"name":"Cardiovascular Division, Osaka Police Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junichi","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Tokyo Women\u2019s Medical University Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Iwate Prefectural Ofunato Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Harada","sequence":"additional","affiliation":[{"name":"Medical Science Department, Daiichi Sankyo Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Medical Science Department, Daiichi Sankyo Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Takita","sequence":"additional","affiliation":[{"name":"Data Intelligence Department, Daiichi Sankyo Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raisuke","family":"Iijima","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Toho University Ohashi Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Murakami","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics, School of Medicine, Toho University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Cardiology & Catheterization Laboratories, Shonan Kamakura General Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Kimura K, Kimura T, Ishihara M, Nakagawa Y, Nakao K, Miyauchi K, et al; on behalf of the Japanese Circulation Society Joint Working Group. JCS 2018 guideline on diagnosis and treatment of acute coronary syndrome. <i>Circ J<\/i> 2019; 83: 1085\u20131196.","DOI":"10.1253\/circj.CJ-19-0133"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Mehran R, Baber U, Sharma SK, Cohen DJ, Angiolillo DJ, Briguori C, et al. Ticagrelor with or without aspirin in high-risk patients after PCI. <i>N Engl J Med<\/i> 2019; 381: 2032\u20132042.","DOI":"10.1056\/NEJMoa1908419"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Palmerini T, Benedetto U, Bacchi-Reggiani L, Della Riva D, Biondi-Zoccai G, Feres F, et al. Mortality in patients treated with extended duration dual antiplatelet therapy after drug-eluting stent implantation: A pairwise and Bayesian network meta-analysis of randomised trials. <i>Lancet<\/i> 2015; 385: 2371\u20132382.","DOI":"10.1016\/S0140-6736(15)60263-X"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Toyota T, Shiomi H, Morimoto T, Natsuaki M, Kimura T. Short versus prolonged dual antiplatelet therapy (DAPT) duration after coronary stent implantation: A comparison between the DAPT study and 9 other trials evaluating DAPT duration. <i>PLoS One<\/i> 2017; 12: e0174502.","DOI":"10.1371\/journal.pone.0174502"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Baber U, Mehran R, Giustino G, Cohen DJ, Henry TD, Sartori S, et al. Coronary thrombosis and major bleeding after PCI with drug-eluting stents: Risk scores from PARIS. <i>J Am Coll Cardiol<\/i> 2016; 67: 2224\u20132234.","DOI":"10.1016\/j.jacc.2016.02.064"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Costa F, van Klaveren D, James S, Heg D, R\u00e4ber L, Feres F, et al. Derivation and validation of the predicting bleeding complications in patients undergoing stent implantation and subsequent dual antiplatelet therapy (PRECISE-DAPT) score: A pooled analysis of individual-patient datasets from clinical trials. <i>Lancet<\/i> 2017; 389: 1025\u20131034.","DOI":"10.1016\/S0140-6736(17)30397-5"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Yeh RW, Secemsky EA, Kereiakes DJ, Normand SL, Gershlick AH, Cohen DJ, et al. Development and validation of a prediction rule for benefit and harm of dual antiplatelet therapy beyond 1 year after percutaneous coronary intervention. <i>JAMA<\/i> 2016; 315: 1735\u20131749.","DOI":"10.1001\/jama.2016.3775"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Neumann FJ, Sousa-Uva M, Ahlsson A, Alfonso F, Banning AP, Benedetto U, et al. 2018 ESC\/EACTS guidelines on myocardial revascularization. <i>Eur Heart J<\/i> 2019; 40: 87\u2013165.","DOI":"10.1093\/eurheartj\/ehy855"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Johnson JA, Caudle KE, Gong L, Whirl-Carrillo M, Stein CM, Scott SA, et al. Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline for pharmacogenetics-guided warfarin dosing: 2017 update. <i>Clin Pharmacol Ther<\/i> 2017; 102: 397\u2013404.","DOI":"10.1002\/cpt.668"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Capodanno D, Mehran R, Valgimigli M, Baber U, Windecker S, Vranckx P, et al. Aspirin-free strategies in cardiovascular disease and cardioembolic stroke prevention. <i>Nat Rev Cardiol<\/i> 2018; 15: 480\u2013496.","DOI":"10.1038\/s41569-018-0049-1"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Watanabe H, Domei T, Morimoto T, Natsuaki M, Shiomi H, Toyota T, et al. Effect of 1-month dual antiplatelet therapy followed by clopidogrel vs. 12-month dual antiplatelet therapy on cardiovascular and bleeding events in patients receiving PCI: The STOPDAPT-2 randomized clinical trial. <i>JAMA<\/i> 2019; 321: 2414\u20132427.","DOI":"10.1001\/jama.2019.8145"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Cavallari LH, Obeng AO. Genetic determinants of P2Y(12) inhibitors and clinical implications. <i>Interv Cardiol Clin<\/i> 2017; 6: 141\u2013149.","DOI":"10.1016\/j.iccl.2016.08.010"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Urban P, Mehran R, Colleran R, Angiolillo DJ, Byrne RA, Capodanno D, et al. Defining high bleeding risk in patients undergoing percutaneous coronary intervention. <i>Circulation<\/i> 2019; 140: 240\u2013261.","DOI":"10.1161\/CIRCULATIONAHA.119.040167"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Nakamura M, Kadota K, Nakao K, Nakagawa Y, Shite J, Yokoi H, et al. High bleeding risk and clinical outcomes in East Asian patients undergoing percutaneous coronary intervention: The PENDULUM Registry. <i>EuroIntervention<\/i>, doi:10.4244\/EIJ-D-20-00345.","DOI":"10.4244\/EIJ-D-20-00345"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Ikeda Y, Shimada K, Teramoto T, Uchiyama S, Yamazaki T, Oikawa S, et al. Low-dose aspirin for primary prevention of cardiovascular events in Japanese patients 60 years or older with atherosclerotic risk factors: A randomized clinical trial. <i>JAMA<\/i> 2014; 312: 2510\u20132520.","DOI":"10.1001\/jama.2014.15690"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. CAPRIE Steering Committee. A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). <i>Lancet<\/i> 1996; 348: 1329\u20131339.","DOI":"10.1016\/S0140-6736(96)09457-3"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Dewilde WJM, Oirbans T, Verheugt FWA, Kelder JC, De Smet BJGL, Herrman JP, et al. Use of clopidogrel with or without aspirin in patients taking oral anticoagulant therapy and undergoing percutaneous coronary intervention: An open-label, randomised, controlled trial. <i>Lancet<\/i> 2013; 381: 1107\u20131115.","DOI":"10.1016\/S0140-6736(12)62177-1"},{"key":"18","unstructured":"18. Bayaspirin 100 mg package insert (in Japanese). https:\/\/www.info.pmda.go.jp\/go\/pack\/3399007H1021_1_18\/ (accessed August 21, 2020)."},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJGM, Lip GYH. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: The Euro Heart Survey. <i>CHEST<\/i> 2010; 138: 1093\u20131100.","DOI":"10.1378\/chest.10-0134"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J, et al. Standardized bleeding definitions for cardiovascular clinical trials: A consensus report from the Bleeding Academic Research Consortium. <i>Circulation<\/i> 2011; 123: 2736\u20132747.","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Valgimigli M, Campo G, Monti M, Vranckx P, Percoco G, Tumscitz C, et al. Short- versus long-term duration of dual-antiplatelet therapy after coronary stenting: A randomized multicenter trial. <i>Circulation<\/i> 2012; 125: 2015\u20132026.","DOI":"10.1161\/CIRCULATIONAHA.111.071589"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Konishi H, Miyauchi K, Tsuboi S, Ogita M, Naito R, Dohi T, et al. Impact of the HAS-BLED score on long-term outcomes after percutaneous coronary intervention. <i>Am J Cardiol<\/i> 2015; 116: 527\u2013531.","DOI":"10.1016\/j.amjcard.2015.05.015"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Nakamura M, Kimura K, Kimura T, Ishihara M, Otsuka F, Kozuma K, et al. JCS 2020 guideline focused update on antithrombotic therapy in patients with coronary artery disease. <i>Circ J<\/i> 2020; 84: 831\u2013865.","DOI":"10.1253\/circj.CJ-19-1109"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Natsuaki M, Morimoto T, Shiomi H, Yamaji K, Watanabe H, Shizuta S, et al. Application of the Academic Research Consortium high bleeding risk criteria in an all-comers registry of percutaneous coronary intervention. <i>Circ Cardiovasc Interv<\/i> 2019; 12: e008307.","DOI":"10.1161\/CIRCINTERVENTIONS.119.008307"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Watanabe H, Domei T, Morimoto T, Natsuaki M, Shiomi H, Toyota T, et al. Details on the effect of very short dual antiplatelet therapy after drug-eluting stent implantation in patients with high bleeding risk: Insight from the STOPDAPT-2 trial. <i>Cardiovasc Interv Ther<\/i>, doi:10.1007\/s12928-020-00651-9.","DOI":"10.1007\/s12928-020-00651-9"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Nakamura M, Kadota K, Takahashi A, Kanda J, Anzai H, Ishii Y, et al. Relationship between platelet reactivity and ischemic and bleeding events after percutaneous coronary intervention in East Asian patients: 1-year results of the PENDULUM Registry. <i>J Am Heart Assoc<\/i> 2020; 9: e015439.","DOI":"10.1161\/JAHA.119.015439"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Fujii K, Kubo T, Otake H, Nakazawa G, Sonoda S, Hibi K, et al. Expert consensus statement for quantitative measurement and morphological assessment of optical coherence tomography. <i>Cardiovasc Interv Ther<\/i> 2020; 35: 13\u201318.","DOI":"10.1007\/s12928-019-00626-5"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Saito Y, Kobayashi Y, Fujii K, Sonoda S, Tsujita K, Hibi K, et al. Clinical expert consensus document on standards for measurements and assessment of intravascular ultrasound from the Japanese Association of Cardiovascular Intervention and Therapeutics. <i>Cardiovasc Interv Ther<\/i> 2020; 35: 1\u201312.","DOI":"10.1007\/s12928-019-00625-6"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Ueki Y, B\u00e4r S, Losdat S, Otsuka T, Zanchin C, Zanchin T, et al. Validation of the Academic Research Consortium for High Bleeding Risk (ARC-HBR) in patients undergoing percutaneous coronary intervention and comparison with contemporary bleeding risk scores. <i>EuroIntervention<\/i> 2020; 16: 371\u2013379.","DOI":"10.4244\/EIJ-D-20-00052"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Cao D, Mehran R, Dangas G, Baber U, Sartori S, Chandiramani R, et al. Validation of the Academic Research Consortium High Bleeding Risk definition in contemporary PCI patients. <i>J Am Coll Cardiol<\/i> 2020; 75: 2711\u20132722.","DOI":"10.1016\/j.jacc.2020.03.070"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Natsuaki M, Morimoto T, Yamaji K, Watanabe H, Yoshikawa Y, Shiomi H, et al. Prediction of thrombotic and bleeding events after percutaneous coronary intervention: CREDO-Kyoto thrombotic and bleeding risk scores. <i>J Am Heart Assoc<\/i> 2018; 7: e008708.","DOI":"10.1161\/JAHA.118.008708"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Astor BC, Coresh J, Heiss G, Pettitt D, Sarnak MJ. Kidney function and anemia as risk factors for coronary heart disease and mortality: The Atherosclerosis Risk in Communities (ARIC) Study. <i>Am Heart J<\/i> 2006; 151: 492\u2013500.","DOI":"10.1016\/j.ahj.2005.03.055"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Virani SA, Khosla A, Levin A. Chronic kidney disease, heart failure and anemia. <i>Can J Cardiol<\/i> 2008; 24(Suppl B): 22B\u201324B.","DOI":"10.1016\/S0828-282X(08)71026-2"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Go AS, Yang J, Ackerson LM, Lepper K, Robbins S, Massie BM, et al. Hemoglobin level, chronic kidney disease, and the risks of death and hospitalization in adults with chronic heart failure: The Anemia in Chronic Heart Failure: Outcomes and Resource Utilization (ANCHOR) Study. <i>Circulation<\/i> 2006; 113: 2713\u20132723.","DOI":"10.1161\/CIRCULATIONAHA.105.577577"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/85\/1\/85_CJ-20-0786\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T04:22:04Z","timestamp":1653711724000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/85\/1\/85_CJ-20-0786\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,25]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-20-0786","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,25]]},"article-number":"CJ-20-0786"}}