{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T16:04:41Z","timestamp":1758816281842},"reference-count":33,"publisher":"Japanese Circulation Society","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2021,12,24]]},"DOI":"10.1253\/circj.cj-20-1300","type":"journal-article","created":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T22:11:45Z","timestamp":1625004705000},"page":"49-57","source":"Crossref","is-referenced-by-count":9,"title":["Exercise-Based Cardiac Rehabilitation Improves Exercise Capacity Regardless of the Response to Cardiac Resynchronization Therapy in Patients With Heart Failure and Reduced Ejection Fraction"],"prefix":"10.1253","volume":"86","author":[{"given":"Kayo","family":"Misumi","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"},{"name":"Department of Cardiology and Department of Emergency and Critical Care Medicine, Saiseikai Utsunomiya Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Nakanishi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Miura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Date","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuo","family":"Tokeshi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leon","family":"Kumasaka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Arakawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Nakao","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigefumi","family":"Fukui","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanobu","family":"Yanase","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruo","family":"Noguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Kusano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichi","family":"Goto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center"},{"name":"Yoka Municipal Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Yancy CW, Jessup M, Bozkurt B, Butler J, Casey DE, Drazner MH, et al. 2013 ACCF\/AHA guideline for the management of heart failure: A report of the American College of Cardiology Foundation\/American Heart Association task force on practice guidelines. <i>Circulation<\/i> 2013; 128: 240\u2013327.","DOI":"10.1161\/CIR.0b013e31829e8776"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Yasuda S, Miyamoto Y, Ogawa H. Current status of cardiovascular medicine in the aging society of Japan. <i>Circulation<\/i> 2018; 138: 965\u2013967.","DOI":"10.1161\/CIRCULATIONAHA.118.035858"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Upshaw JN, Konstam MA, van Klaveren D, Noubary F, Huggins GS, Kent DM. Multistate model to predict heart failure hospitalizations and all-cause mortality in outpatients with heart failure with reduced ejection fraction. <i>Circ Heart Fail<\/i> 2016; 9: e003146.","DOI":"10.1161\/CIRCHEARTFAILURE.116.003146"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, et al. Cardiac resynchronization in chronic heart failure. <i>N Engl J Med<\/i> 2002; 346: 1845\u20131853.","DOI":"10.1056\/NEJMoa013168"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Bax JJ, Abraham T, Barold SS, Breithardt OA, Fung JW, Garrigue S, et al. Cardiac resynchronization therapy: Part 1--issues before device implantation. <i>J Am Coll Cardiol<\/i> 2005; 46: 2153\u20132167.","DOI":"10.1016\/j.jacc.2005.09.019"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. McAlister F, Ezekowitz J, Hooton N, Vandermeer B, Spooner C, Dryden DM, et al. Cardiac resynchronization therapy for patients with left ventricular systolic dysfunction: A systematic review. <i>JAMA<\/i> 2007; 297: 2502\u20132514.","DOI":"10.1001\/jama.297.22.2502"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Cleland JJGF, Daubert JCJ, Erdmann E, Freemantle N, Gras D, Kappenberger L, et al. The effect of cardiac resynchronization on morbidity and mortality in heart failure. <i>N Engl J Med<\/i> 2005; 352: 1539\u20131549.","DOI":"10.1056\/NEJMoa050496"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Goldenberg I, Kutyifa V, Klein HU, Cannom DS, Brown MW, Dan A, et al. Survival with cardiac-resynchronization therapy in mild heart failure. <i>N Engl J Med<\/i> 2014; 370: 1694\u20131701.","DOI":"10.1056\/NEJMoa1401426"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Mastenbroek MH, Van\u2019t Sant J, Versteeg H, Cramer MJ, Doevendans PA, Pedersen SS, et al. Relationship between reverse remodeling and cardiopulmonary exercise capacity in heart failure patients undergoing cardiac resynchronization therapy. <i>J Card Fail<\/i> 2016; 22: 385\u2013394.","DOI":"10.1016\/j.cardfail.2015.08.342"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Solomon SD, Foster E, Bourgoun M, Shah A, Viloria E, Brown MW, et al. effect of cardiac resynchronization therapy on reverse remodeling and relation to outcome: Multicenter automatic defibrillator implantation trial: Cardiac resynchronization therapy. <i>Circulation<\/i> 2010; 122: 985\u2013992.","DOI":"10.1161\/CIRCULATIONAHA.110.955039"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Birnie DH, Tang AS. The problem of non-response to cardiac resynchronization therapy. <i>Curr Opin Cardiol<\/i> 2006; 21: 20\u201326.","DOI":"10.1097\/01.hco.0000198983.93755.99"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Reuter S, Garrigue S, Barold SS, Jais P, Hocini M, Haissaguerre M, et al. Comparison of characteristics in responders versus nonresponders with biventricular pacing for drug-resistant congestive heart failure. <i>Am J Cardiol<\/i> 2002; 89: 346\u2013350.","DOI":"10.1016\/S0002-9149(01)02240-8"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Sagar VA, Davies EJ, Briscoe S, Coats AJS, Dalal HM, Lough F, et al. Exercise-based rehabilitation for heart failure: Systematic review and meta-analysis. <i>Open Heart<\/i> 2015; 2: e000163.","DOI":"10.1136\/openhrt-2014-000163"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. O\u2019Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, et al. Efficacy and safety of exercise training in patients with chronic heart failure. <i>JAMA<\/i> 2009; 301: 1439\u20131450.","DOI":"10.1001\/jama.2009.454"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Ismail H, McFarlane JR, Nojoumian AH, Dieberg G, Smart NA. Clinical outcomes and cardiovascular responses to different exercise training intensities in patients with heart failure: A systematic review and meta-analysis. <i>JACC Heart Fail<\/i> 2013; 1: 514\u2013522.","DOI":"10.1016\/j.jchf.2013.08.006"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Patwala AY, Woods PR, Sharp L, Goldspink DF, Tan LB, Wright DJ. Maximizing patient benefit from cardiac resynchronization therapy with the addition of structured exercise training: A randomized controlled study. <i>J Am Coll Cardiol<\/i> 2009; 53: 2332\u20132339.","DOI":"10.1016\/j.jacc.2009.02.063"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, et al. 2016 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) developed with the special contribution of the Heart Failure Association (HFA) of the ESC. <i>Eur Heart J<\/i> 2016; 37: 2129\u20132200.","DOI":"10.1093\/eurheartj\/ehw128"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Tsutsui H, Isobe M, Ito H, Ito H, Okumura K, Ono M, et al. JCS 2017\/JHFS 2017 guideline on diagnosis and treatment of acute and chronic heart failure: Digest version. <i>Circ J<\/i> 2019; 83: 2084\u20132184.","DOI":"10.1253\/circj.CJ-19-0342"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Takaya Y, Kumasaka R, Arakawa T, Ohara T, Nakanishi M, Noguchi T, et al. Impact of cardiac rehabilitation on renal function in patients with and without chronic kidney disease after acute myocardial infarction. <i>Circ J<\/i> 2014; 78: 377\u2013384.","DOI":"10.1253\/circj.CJ-13-0779"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Itoh H, Koike A, Taniguchi K, Marumo F. Severity and pathophysiology of heart failure on the basis of anaerobic threshold (AT) and related parameters. <i>Jpn Circ J<\/i> 1989; 53: 146\u2013154.","DOI":"10.1253\/jcj.53.146"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, et al. Recommendations for chamber quantification: A report from the American Society of Echocardiography\u2019s Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography. <i>J Am Soc Echocardiogr<\/i> 2015; 28: 1440\u20131463.","DOI":"10.1016\/j.echo.2005.10.005"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Kanda Y. Investigation of the freely available easy-to-use software \u201cEZR\u201d for medical statistics. <i>Bone Marrow Transplant<\/i> 2013; 48: 452\u2013458.","DOI":"10.1038\/bmt.2012.244"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Hirai DM, Musch TI, Poole DC. Exercise training in chronic heart failure: Improving skeletal muscle O<sub>2<\/sub> transport and utilization. <i>Am J Physiol Heart Circ Physiol<\/i> 2015; 309: H1419\u2013H1439.","DOI":"10.1152\/ajpheart.00469.2015"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Erbs S, H\u00f6llriegel R, Linke A, Beck EB, Adams V, Gielen S, et al. Exercise training in patients with advanced chronic heart failure (NYHA IIIb) promotes restoration of peripheral vasomotor function, induction of endogenous regeneration, and improvement of left ventricular function. <i>Circ Heart Fail<\/i> 2010; 3: 486\u2013494.","DOI":"10.1161\/CIRCHEARTFAILURE.109.868992"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Downing J, Balady GJ. The role of exercise training in heart failure. <i>J Am Coll Cardiol<\/i> 2011; 58: 561\u2013569.","DOI":"10.1016\/j.jacc.2011.04.020"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Luo N, Merrill P, Parikh KS, Whellan DJ, Pi\u00f1a IL, Fiuzat M, et al. Exercise training in patients with chronic heart failure and atrial fibrillation. <i>J Am Coll Cardiol<\/i> 2017; 69: 1683\u20131691.","DOI":"10.1016\/j.jacc.2017.01.032"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Abreu A, Oliveira M, Silva Cunha P, Santa Clara H, Portugal G, Gon\u00e7alves Rodrigues I, et al. Does permanent atrial fibrillation modify response to cardiac resynchronization therapy in heart failure patients? <i>Rev Port Cardiol<\/i> 2017; 36: 687\u2013694.","DOI":"10.1016\/j.repc.2017.02.016"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Bierbauer W, Scholz U, Bermudez T, Debeer D, Coch M, Fleisch-Silvestri R, et al. Improvements in exercise capacity of older adults during cardiac rehabilitation. <i>Eur J Prev Cardiol<\/i> 2020; 27: 1747\u20131755.","DOI":"10.1177\/2047487320914736"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Vanhees L, Stevens A, Schepers D, Defoor J, Rademakers F, Fagard R. Determinants of the effects of physical training and of the complications requiring resuscitation during exercise in patients with cardiovascular disease. <i>Eur J Cardiovasc Prev Rehabil<\/i> 2004; 11: 304\u2013312.","DOI":"10.1097\/01.hjr.0000136458.44614.a2"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Nobre TS, Antunes-Correa LM, Groehs RV, Alves MJNN, Sarmento AO, Bacurau AV, et al. Exercise training improves neurovascular control and calcium cycling gene expression in patients with heart failure with cardiac resynchronization therapy. <i>Am J Physiol Heart Circ Physiol<\/i> 2016; 311: H1180\u2013H1188.","DOI":"10.1152\/ajpheart.00275.2016"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Haykowsky MJ, Liang Y, Pechter D, Jones LW, McAlister FA, Clark AM. A meta-analysis of the effect of exercise training on left ventricular remodeling in heart failure patients: The benefit depends on the type of training performed. <i>J Am Coll Cardiol<\/i> 2007; 49: 2329\u20132336.","DOI":"10.1016\/j.jacc.2007.02.055"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Zeitler EP, Piccini JP, Hellkamp AS, Whellan DJ, Jackson KP, Ellis SJ, et al. Exercise training and pacing status in patients with heart failure: Results from HF-ACTION. <i>J Card Fail<\/i> 2015; 21: 60\u201367.","DOI":"10.1016\/j.cardfail.2014.10.004"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Swank AM, Horton J, Fleg JL, Fonarow GC, Keteyian S, Goldberg L, et al. Modest increase in peak VO<sub>2<\/sub> is related to better clinical outcomes in chronic heart failure patients: Results from Heart Failure and a Controlled Trial to Investigate Outcomes of Exercise Training. <i>Circ Hear Fail<\/i> 2012; 5: 579\u2013585.","DOI":"10.1161\/CIRCHEARTFAILURE.111.965186"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/86\/1\/86_CJ-20-1300\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T04:23:33Z","timestamp":1715142213000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/86\/1\/86_CJ-20-1300\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,24]]},"references-count":33,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-20-1300","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,24]]},"article-number":"CJ-20-1300"}}