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Goldstein JL, Hobbs HH, Brown MS. Familial hypercholesterolemia. <i>In<\/i>: Scriver CR, Beaudet AL, Sly WS, Valle D, editors. The metabolic and molecular bases of inherited disease. New York: McGraw-Hill, 2001; 2863e913."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Mabuchi H. Half a century tales of familial hypercholesterolemia (FH) in Japan. <i>J Atheroscler Thromb<\/i> 2017; 24: 189\u2013207.","DOI":"10.5551\/jat.RV16008"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Beheshti SO, Madsen CM, Varbo A, Nordestgaard BG. Worldwide prevalence of familial hypercholesterolemia: Meta-analyses of 11 million subjects. <i>J Am Coll Cardiol<\/i> 2020; 75: 2553\u20132566.","DOI":"10.1016\/j.jacc.2020.03.057"},{"key":"4","unstructured":"4. Nordestgaard BG, Chapman MJ, Humphries SE, Ginsberg HN, Masana L, Descamps OS, et al. Familial hypercholesterolaemia is underdiagnosed and undertreated in the general population: Guidance for clinicians to prevent coronary heart disease: Consensus statement of the European Atherosclerosis Society. <i>Eur Heart J<\/i> 2013; 34: 3478\u20133490a."},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Ference BA, Majeed F, Penumetcha R, Flack JM, Brook RD. Effect of naturally random allocation to lower low-density lipoprotein cholesterol on the risk of coronary heart disease mediated by polymorphisms in NPC1L1, HMGCR, or both: A 2\u00d72 factorial Mendelian randomization study. <i>J Am Coll Cardiol<\/i> 2015; 65: 1552\u20131561.","DOI":"10.1016\/j.jacc.2015.02.020"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Ference BA, Ray KK, Catapano AL, Ference TB, Burgess S, Neff DR, et al. Mendelian randomization study of ACLY and cardiovascular disease. <i>N Engl J Med<\/i> 2019; 380: 1033\u20131042.","DOI":"10.1056\/NEJMoa1806747"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Nomura A, Emdin CA, Won HH, Peloso GM, Natarajan P, Ardissino D, et al. Heterozygous ATP-binding cassette transporter G5 gene deficiency and risk of coronary artery disease. <i>Circ Genom Precis Med<\/i> 2020; 13: 417\u2013423.","DOI":"10.1161\/CIRCGEN.119.002871"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Tada H, Usui S, Sakata K, Takamura M, Kawashiri MA. Low-density lipoprotein cholesterol level cannot be too low: Considerations from clinical trials, human genetics, and biology. <i>J Atheroscler Thromb<\/i> 2020; 27: 489\u2013498.","DOI":"10.5551\/jat.RV17040"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Tada H, Okada H, Nomura A, Nohara A, Yamagishi M, Takamura M, et al. Prognostic impact of cascade screening for familial hypercholesterolemia on cardiovascular events. <i>J Clin Lipidol<\/i> 2021; 15: 358\u2013365.","DOI":"10.1016\/j.jacl.2020.12.012"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Harada-Shiba M, Arai H, Ishigaki Y, Ishibashi S, Okamura T, Ogura M, et al. Guidelines for diagnosis and treatment of familial hypercholesterolemia 2017. <i>J Atheroscler Thromb<\/i> 2018; 25: 751\u2013770.","DOI":"10.5551\/jat.CR003"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Tada H, Kawashiri MA, Nomura A, Teramoto R, Hosomichi K, Nohara A, et al. Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease. <i>J Clin Lipidol<\/i> 2018; 12: 1436\u20131444.","DOI":"10.1016\/j.jacl.2018.08.006"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Tada H, Kawashiri MA, Nohara A, Inazu A, Mabuchi H, Yamagishi M. Impact of clinical signs and genetic diagnosis of familial hypercholesterolaemia on the prevalence of coronary artery disease in patients with severe hypercholesterolaemia. <i>Eur Heart J<\/i> 2017; 38: 1573\u20131579.","DOI":"10.1093\/eurheartj\/ehx004"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Mabuchi H, Koizumi J, Shimizu M, Takeda R. Development of coronary heart disease in familial hypercholesterolemia. <i>Circulation<\/i> 1989; 79: 225\u2013232.","DOI":"10.1161\/01.CIR.79.2.225"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Tada H, Kawashiri MA, Okada H, Teramoto R, Konno T, Yoshimuta T, et al. Assessment of coronary atherosclerosis in patients with familial hypercholesterolemia by coronary computed tomography angiography. <i>Am J Cardiol<\/i> 2015; 115: 724\u2013729.","DOI":"10.1016\/j.amjcard.2014.12.034"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Tada H, Kawashiri MA, Okada H, Nakahashi T, Sakata K, Nohara A, et al. Assessments of carotid artery plaque burden in patients with familial hypercholesterolemia. <i>Am J Cardiol<\/i> 2017; 120: 1955\u20131960.","DOI":"10.1016\/j.amjcard.2017.08.012"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Harada-Shiba M, Sugisawa T, Makino H, Abe M, Tsushima M, Yoshimasa Y, et al. Impact of statin treatment on the clinical fate of heterozygous familial hypercholesterolemia. <i>J Atheroscler Thromb<\/i> 2010; 17: 667\u2013674.","DOI":"10.5551\/jat.4143"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Wiegman A, Gidding SS, Watts GF, Chapman MJ, Ginsberg HN, Cuchel M, et al. Familial hypercholesterolaemia in children and adolescents: Gaining decades of life by optimizing detection and treatment. <i>Eur Heart J<\/i> 2015; 36: 2425\u20132437.","DOI":"10.1093\/eurheartj\/ehv157"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Gidding SS, Champagne MA, de Ferranti SD, Defesche J, Ito MK, Knowles JW, et al. The agenda for familial hypercholesterolemia: A Scientific Statement from the American Heart Association. <i>Circulation<\/i> 2015; 132: 2167\u20132192.","DOI":"10.1161\/CIR.0000000000000297"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Luirink IK, Wiegman A, Kusters DM, Hof MH, Groothoff JW, de Groot E, et al. 20-year follow-up of statins in children with familial hypercholesterolemia. <i>N Engl J Med<\/i> 2019; 381: 1547\u20131556.","DOI":"10.1056\/NEJMoa1816454"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Tada H, Kawashiri MA, Yamagishi M. Comprehensive genotyping in dyslipidemia: Mendelian dyslipidemias caused by rare variants and Mendelian randomization studies using common variants. <i>J Hum Genet<\/i> 2017; 62: 453\u2013458.","DOI":"10.1038\/jhg.2016.159"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Wilson PW, Hoeg JM, D\u2019Agostino RB, Silbershatz H, Belanger AM, Poehlmann H, et al. Cumulative effects of high cholesterol levels, high blood pressure, and cigarette smoking on carotid stenosis. <i>N Engl J Med<\/i> 1997; 337: 516\u2013522.","DOI":"10.1056\/NEJM199708213370802"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Domanski MJ, Tian X, Wu CO, Reis JP, Dey AK, Gu Y, et al. Time course of LDL cholesterol exposure and cardiovascular disease event risk. <i>J Am Coll Cardiol<\/i> 2020; 76: 1507\u20131516.","DOI":"10.1016\/j.jacc.2020.07.059"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Gallo A, Charriere S, Vimont A, Chapman MJ, Angoulvant D, Boccara F, et al. 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