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Hindricks G, Potpara T, Dagres N, Arbelo E, Bax JJ, Blomstrom-Lundqvist C, et al. 2020 ESC Guidelines for the diagnosis and management of atrial fibrillation developed in collaboration with the European Association of Cardio-Thoracic Surgery (EACTS): The Task Force for the diagnosis and management of atrial fibrillation of the European Society of Cardiology (ESC) developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESC. <i>Eur Heart J<\/i> 2021; 42: 373\u2013498.","DOI":"10.1093\/eurheartj\/ehab648"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. January CT, Wann LS, Calkins H, Chen LY, Cigarroa JE, Cleveland JC Jr, et al. 2019 AHA\/ACC\/HRS Focused Update of the 2014 AHA\/ACC\/HRS Guideline for the Management of Patients With Atrial Fibrillation: A Report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines and the Heart Rhythm Society in Collaboration With the Society of Thoracic Surgeons. <i>Circulation<\/i> 2019; 140: e125\u2013e151.","DOI":"10.1161\/CIR.0000000000000665"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Cheng X, Hu Q, Gao L, Liu J, Qin S, Zhang D. Sex-related differences in catheter ablation of atrial fibrillation: A systematic review and meta-analysis. <i>Europace<\/i> 2019; 21: 1509\u20131518.","DOI":"10.1093\/europace\/euz179"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Tanaka N, Inoue K, Kobori A, Kaitani K, Morimoto T, Kurotobi T, et al. Sex differences in atrial fibrillation ablation outcomes: Insights from a large-scale multicentre registry. <i>Europace<\/i> 2020; 22: 1345\u20131357.","DOI":"10.1093\/europace\/euaa104"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Akoum N, Mahnkopf C, Kholmovski EG, Brachmann J, Marrouche NF. Age and sex differences in atrial fibrosis among patients with atrial fibrillation. <i>Europace<\/i> 2018; 20: 1086\u20131092.","DOI":"10.1093\/europace\/eux260"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Odening KE, Deiss S, Dilling-Boer D, Didenko M, Eriksson U, Nedios S, et al. Mechanisms of sex differences in atrial fibrillation: Role of hormones and differences in electrophysiology, structure, function, and remodelling. <i>Europace<\/i> 2019; 21: 366\u2013376.","DOI":"10.1093\/europace\/euy215"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Takigawa M, Kuwahara T, Takahashi A, Watari Y, Okubo K, Takahashi Y, et al. Differences in catheter ablation of paroxysmal atrial fibrillation between males and females. <i>Int J Cardiol<\/i> 2013; 168: 1984\u20131991.","DOI":"10.1016\/j.ijcard.2012.12.101"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Huo Y, Gaspar T, Pohl M, Sitzy J, Richter U, Neudeck S, et al. Prevalence and predictors of low voltage zones in the left atrium in patients with atrial fibrillation. <i>Europace<\/i> 2018; 20: 956\u2013962.","DOI":"10.1093\/europace\/eux082"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Yamaguchi T, Tsuchiya T, Fukui A, Kawano Y, Otsubo T, Takahashi Y, et al. Impact of the extent of low-voltage zone on outcomes after voltage-based catheter ablation for persistent atrial fibrillation. <i>J Cardiol<\/i> 2018; 72: 427\u2013433.","DOI":"10.1016\/j.jjcc.2018.04.010"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Inamura Y, Nitta J, Inaba O, Sato A, Takamiya T, Murata K, et al. Presence of non-pulmonary vein foci in patients with atrial fibrillation undergoing standard ablation of pulmonary vein isolation: Clinical characteristics and long-term ablation outcome. <i>Int J Cardiol Heart Vasc<\/i> 2021; 32: 100717.","DOI":"10.1016\/j.ijcha.2021.100717"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Dohi T, Nakatani D, Inoue K, Hikoso S, Oka T, Hayashi K, et al. Effect of Extensive Ablation on Recurrence in Patients with Persistent Atrial Fibrillation Treated with Pulmonary Vein Isolation (EARNEST-PVI) trial: Design and rationale. <i>J Cardiol<\/i> 2019; 74: 164\u2013168.","DOI":"10.1016\/j.jjcc.2019.01.010"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Inoue K, Hikoso S, Masuda M, Furukawa Y, Hirata A, Egami Y, et al. Pulmonary vein isolation alone vs. more extensive ablation with defragmentation and linear ablation of persistent atrial fibrillation: The EARNEST-PVI trial. <i>Europace<\/i> 2021; 23: 565\u2013574.","DOI":"10.1093\/europace\/euaa293"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Inoue K, Sotomi Y, Masuda M, Furukawa Y, Hirata A, Egami Y, et al. Efficacy of extensive ablation for persistent atrial fibrillation with trigger-based vs. substrate-based mechanisms: A prespecified subanalysis of the EARNEST-PVI Trial. <i>Circ J<\/i> 2021; 85: 1897\u20131905.","DOI":"10.1253\/circj.CJ-21-0126"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Verma A, Novak P, Macle L, Whaley B, Beardsall M, Wulffhart Z, et al. A prospective, multicenter evaluation of ablating complex fractionated electrograms (CFEs) during atrial fibrillation (AF) identified by an automated mapping algorithm: Acute effects on AF and efficacy as an adjuvant strategy. <i>Heart Rhythm<\/i> 2008; 5: 198\u2013205.","DOI":"10.1016\/j.hrthm.2007.09.027"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Sotomi Y, Hikoso S, Nakatani D, Mizuno H, Okada K, Dohi T, et al. Sex differences in heart failure with preserved ejection fraction. <i>J Am Heart Assoc<\/i> 2021; 10: e018574.","DOI":"10.1161\/JAHA.120.018574"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Hamanaka Y, Sotomi Y, Hirata A, Kobayashi T, Ichibori Y, Makino N, et al. Persistent systemic inflammation is associated with bleeding risk in atrial fibrillation patients. <i>Circ J<\/i> 2020; 84: 411\u2013418.","DOI":"10.1253\/circj.CJ-19-1006"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Odening KE, Choi BR, Liu GX, Hartmann K, Ziv O, Chaves L, et al. Estradiol promotes sudden cardiac death in transgenic long QT type 2 rabbits while progesterone is protective. <i>Heart Rhythm<\/i> 2012; 9: 823\u2013832.","DOI":"10.1016\/j.hrthm.2012.01.009"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Baker AR, Silva NF, Quinn DW, Harte AL, Pagano D, Bonser RS, et al. Human epicardial adipose tissue expresses a pathogenic profile of adipocytokines in patients with cardiovascular disease. <i>Cardiovasc Diabetol<\/i> 2006; 5: 1.","DOI":"10.1186\/1475-2840-5-1"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Oberhauser V, Schwertfeger E, Rutz T, Beyersdorf F, Rump LC. Acetylcholine release in human heart atrium: Influence of muscarinic autoreceptors, diabetes, and age. <i>Circulation<\/i> 2001; 103: 1638\u20131643.","DOI":"10.1161\/01.CIR.103.12.1638"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Hamatani Y, Iguchi M, Ueno K, Aono Y, Esato M, Tsuji H, et al. Prognostic significance of natriuretic peptide levels in atrial fibrillation without heart failure. <i>Heart<\/i> 2021; 107: 705\u2013712.","DOI":"10.1136\/heartjnl-2020-317735"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Yamasaki H, Tada H, Sekiguchi Y, Igarashi M, Arimoto T, Machino T, et al. Prevalence and characteristics of asymptomatic excessive transmural injury after radiofrequency catheter ablation of atrial fibrillation. <i>Heart Rhythm<\/i> 2011; 8: 826\u2013832.","DOI":"10.1016\/j.hrthm.2011.01.045"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Miyazaki Y, Ueda N, Otsuka F, Miyamoto K, Noguchi T, Kusano K. Rescue percutaneous coronary intervention for sinus node dysfunction following left atrial flutter ablation. <i>HeartRhythm Case Rep<\/i> 2021; 7: 529\u2013532.","DOI":"10.1016\/j.hrcr.2021.04.015"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Kloosterman M, Chua W, Fabritz L, Al-Khalidi HR, Schotten U, Nielsen JC, et al. Sex differences in catheter ablation of atrial fibrillation: Results from AXAFA-AFNET 5. <i>Europace<\/i> 2020; 22: 1026\u20131035.","DOI":"10.1093\/europace\/euaa015"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Sotomi Y, Kikkawa T, Inoue K, Tanaka K, Toyoshima Y, Oka T, et al. Regional difference of optimal contact force to prevent acute pulmonary vein reconnection during radiofrequency catheter ablation for atrial fibrillation. <i>J Cardiovasc Electrophysiol<\/i> 2014; 25: 941\u2013947.","DOI":"10.1111\/jce.12443"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Verma A, Jiang CY, Betts TR, Chen J, Deisenhofer I, Mantovan R, et al. 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