{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:17:18Z","timestamp":1781968638279,"version":"3.54.5"},"reference-count":43,"publisher":"Japanese Circulation Society","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2025,9,25]]},"DOI":"10.1253\/circj.cj-24-0762","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T18:07:25Z","timestamp":1750270045000},"page":"1627-1636","source":"Crossref","is-referenced-by-count":5,"title":["Contribution of Seasonal Variation and Inflammation to Increased In-Hospital Events and Early Mortality in Patients With Takotsubo Syndrome"],"prefix":"10.1253","volume":"89","author":[{"given":"Maximilien","family":"Martz","sequence":"first","affiliation":[{"name":"University of Strasbourg, Cardio-vascular Medical-Surgical Activity Center, New Civil Hospital, Strasbourg University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kensuke","family":"Matsushita","sequence":"additional","affiliation":[{"name":"University of Strasbourg, Cardio-vascular Medical-Surgical Activity Center, New Civil Hospital, Strasbourg University Hospital"},{"name":"Division of Cardiology, Yokohama City University Medical Center"},{"name":"UR 3074 Translational Cardiovascular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonin","family":"Trimaille","sequence":"additional","affiliation":[{"name":"University of Strasbourg, Cardio-vascular Medical-Surgical Activity Center, New Civil Hospital, Strasbourg University Hospital"},{"name":"UR 3074 Translational Cardiovascular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinnosuke","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"University of Strasbourg, Cardio-vascular Medical-Surgical Activity Center, New Civil Hospital, Strasbourg University Hospital"},{"name":"Division of Cardiology, Yokohama City University Medical Center"},{"name":"UR 3074 Translational Cardiovascular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taraneh","family":"Tatarcheh","sequence":"additional","affiliation":[{"name":"UR 3074 Translational Cardiovascular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin","family":"Marchandot","sequence":"additional","affiliation":[{"name":"University of Strasbourg, Cardio-vascular Medical-Surgical Activity Center, New Civil Hospital, Strasbourg University Hospital"},{"name":"UR 3074 Translational Cardiovascular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amandine","family":"Granier","sequence":"additional","affiliation":[{"name":"University of Strasbourg, Cardio-vascular Medical-Surgical Activity Center, New Civil Hospital, Strasbourg University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Loic","family":"Faucher","sequence":"additional","affiliation":[{"name":"University of Strasbourg, Cardio-vascular Medical-Surgical Activity Center, New Civil Hospital, Strasbourg University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Schini-Kerth","sequence":"additional","affiliation":[{"name":"UR 3074 Translational Cardiovascular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Ohlmann","sequence":"additional","affiliation":[{"name":"University of Strasbourg, Cardio-vascular Medical-Surgical Activity Center, New Civil Hospital, Strasbourg University Hospital"},{"name":"UR 3074 Translational Cardiovascular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Jesel","sequence":"additional","affiliation":[{"name":"University of Strasbourg, Cardio-vascular Medical-Surgical Activity Center, New Civil Hospital, Strasbourg University Hospital"},{"name":"UR 3074 Translational Cardiovascular Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Morel","sequence":"additional","affiliation":[{"name":"University of Strasbourg, Cardio-vascular Medical-Surgical Activity Center, New Civil Hospital, Strasbourg University Hospital"},{"name":"UR 3074 Translational Cardiovascular Medicine"},{"name":"Hanoi Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Ghadri JR, Kato K, Cammann VL, Gili S, Jurisic S, Di Vece D, et al. Long-term prognosis of patients with takotsubo syndrome. <i>J Am Coll Cardiol<\/i> 2018; 72: 874\u2013882.","DOI":"10.1016\/j.jacc.2018.06.016"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Lyon AR, Citro R, Schneider B, Morel O, Ghadri JR, Templin C, et al. Pathophysiology of takotsubo syndrome. <i>J Am Coll Cardiol<\/i> 2021; 77: 902\u2013921.","DOI":"10.1016\/j.jacc.2020.10.060"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Dias A, N\u00fa\u00f1ez Gil IJ, Santoro F, Madias JE, Pelliccia F, Brunetti ND, et al. Takotsubo syndrome: State-of-the-art review by an expert panel \u2013 Part 1. <i>Cardiovasc Revasc Med<\/i> 2019; 20: 70\u201379.","DOI":"10.1016\/j.carrev.2018.11.015"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Lyon AR, Rees PS, Prasad S, Poole-Wilson PA, Harding SE. Stress (takotsubo) cardiomyopathy: A novel pathophysiological hypothesis to explain catecholamine-induced acute myocardial stunning. <i>Nat Clin Pract Cardiovasc Med<\/i> 2008; 5: 22\u201329.","DOI":"10.1038\/ncpcardio1066"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Katsuumi G, Shimizu I, Yoshida Y, Hayashi Y, Ikegami R, Suda M, et al. Catecholamine-induced senescence of endothelial cells and bone marrow cells promotes cardiac dysfunction in mice. <i>Int Heart J<\/i> 2018; 59: 837\u2013844.","DOI":"10.1536\/ihj.17-313"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Morel O, Sauer F, Imperiale A, Cimarelli S, Blondet C, Jesel L, et al. Importance of inflammation and neurohumoral activation in takotsubo cardiomyopathy. <i>J Card Fail<\/i> 2009; 15: 206\u2013213.","DOI":"10.1016\/j.cardfail.2008.10.031"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Scally C, Abbas H, Ahearn T, Srinivasan J, Mezincescu A, Rudd A, et al. Myocardial and systemic inflammation in acute stress-induced (takotsubo) cardiomyopathy. <i>Circulation<\/i> 2019; 139: 1581\u20131592.","DOI":"10.1161\/CIRCULATIONAHA.118.037975"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Scally C, Rudd A, Mezincescu A, Wilson H, Srivanasan J, Horgan G, et al. Persistent long-term structural, functional, and metabolic changes after stress-induced (takotsubo) cardiomyopathy. <i>Circulation<\/i> 2018; 137: 1039\u20131048.","DOI":"10.1161\/CIRCULATIONAHA.117.031841"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Wilson HM, Cheyne L, Brown PAJ, Kerr K, Hannah A, Srinivasan J, et al. Characterization of the myocardial inflammatory response in acute stress-induced (takotsubo) cardiomyopathy. <i>JACC Basic Transl Sci<\/i> 2018; 3: 766\u2013778.","DOI":"10.1016\/j.jacbts.2018.08.006"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Lachmet-Th\u00e9baud L, Marchandot B, Matsushita K, Dagrenat C, Peillex M, Sato C, et al. Systemic inflammatory response syndrome is a major determinant of cardiovascular outcome in takotsubo syndrome. <i>Circ J<\/i> 2020; 84: 592\u2013600.","DOI":"10.1253\/circj.CJ-19-1088"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Matsushita K, Lachmet-Th\u00e9baud L, Marchandot B, Trimaille A, Sato C, Dagrenat C, et al. Incomplete recovery from takotsubo syndrome is a major determinant of cardiovascular mortality. <i>Circ J<\/i> 2021; 85: 1823\u20131831.","DOI":"10.1253\/circj.CJ-20-1116"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Dagrenat C, Von Hunolstein JJ, Matsushita K, Thebaud L, Greciano S, Tuzin N, et al. Value of cardiac biomarkers in the early diagnosis of takotsubo syndrome. <i>J Clin Med<\/i> 2020; 9: 2985.","DOI":"10.3390\/jcm9092985"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Jesel L, Berthon C, Messas N, Lim HS, M\u00e9lanie Girardey, Marzak H, et al. Atrial arrhythmias in takotsubo cardiomyopathy: Incidence, predictive factors, and prognosis. <i>Europace<\/i> 2019; 21: 298\u2013305.","DOI":"10.1093\/europace\/euy147"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Tarantino N, Ferraretti A, Ieva R, Musaico F, Guastafierro F, Di Martino L, et al. Serum interleukin 6 and 10 levels in takotsubo cardiomyopathy: Increased admission levels may predict adverse events at follow-up. <i>Atherosclerosis<\/i> 2016; 254: 28\u201334.","DOI":"10.1016\/j.atherosclerosis.2016.09.012"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Nef HM, Mollmann H, Kostin S, Troidl C, Voss S, Weber M, et al. Tako-tsubo cardiomyopathy: Intraindividual structural analysis in the acute phase and after functional recovery. <i>Eur Heart J<\/i> 2007; 28: 2456\u20132464.","DOI":"10.1093\/eurheartj\/ehl570"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Vaudrey B, Mielcarek M, Sauleau E, Meyer N, Marchandot B, Moitry M, et al. Short-term effects of air pollution on coronary events in Strasbourg, France: Importance of seasonal variations. <i>Med Sci<\/i> 2020; 8: 31.","DOI":"10.3390\/medsci8030031"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. R\u00fcckerl R, Greven S, Ljungman P, Aalto P, Antoniades C, Bellander T, et al. Air pollution and inflammation (interleukin-6, C-reactive protein, fibrinogen) in myocardial infarction survivors. <i>Environ Health Perspect<\/i> 2007; 115: 1072\u20131080.","DOI":"10.1289\/ehp.10021"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Fares A. Winter cardiovascular diseases phenomenon. <i>North Am J Med Sci<\/i> 2013; 5: 266\u2013279.","DOI":"10.4103\/1947-2714.110430"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Carbone A, Flacco ME, Manzoli L, Lamberti N, Pigazzani F, Rega S, et al. Chronobiological variation in takotsubo syndrome: An updated systematic review and meta-analysis. <i>Curr Probl Cardiol<\/i> 2024; 49: 102804.","DOI":"10.1016\/j.cpcardiol.2024.102804"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Xue J, Liu P, Xia X, Qi X, Han S, Wang L, et al. Seasonal variation in neurological severity and clinical outcomes in ischemic stroke patients: A 9-year study of 5,238 patients. <i>Circ J<\/i> 2023; 87: 1187\u20131195.","DOI":"10.1253\/circj.CJ-22-0801"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, et al. International expert consensus document on takotsubo syndrome (Part I): Clinical characteristics, diagnostic criteria, and pathophysiology. <i>Eur Heart J<\/i> 2018; 39: 2032\u20132046.","DOI":"10.1093\/eurheartj\/ehy076"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Ghadri JR, Wittstein IS, Prasad A, Sharkey S, Dote K, Akashi YJ, et al. International expert consensus document on takotsubo syndrome (Part II): Diagnostic workup, outcome, and management. <i>Eur Heart J<\/i> 2018; 39: 2047\u20132062.","DOI":"10.1093\/eurheartj\/ehy077"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, B\u00f6hm M, et al. 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. <i>Eur Heart J<\/i> 2021; 42: 3599\u20133726.","DOI":"10.1093\/eurheartj\/ehab368"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Baran DA, Grines CL, Bailey S, Burkhoff D, Hall SA, Henry TD, et al. SCAI clinical expert consensus statement on the classification of cardiogenic shock: This document was endorsed by the American College of Cardiology (ACC), the American Heart Association (AHA), the Society of Critical Care Medicine (SCCM), and the Society of Thoracic Surgeons (STS) in April 2019. <i>Catheter Cardiovasc Interv<\/i> 2019; 94: 29\u201337.","DOI":"10.1002\/ccd.28329"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Dopico XC, Evangelou M, Ferreira RC, Guo H, Pekalski ML, Smyth DJ, et al. Widespread seasonal gene expression reveals annual differences in human immunity and physiology. <i>Nat Commun<\/i> 2015; 6: 7000.","DOI":"10.1038\/ncomms8000"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Wischnewsky MB, Candreva A, Bacchi B, Cammann VL, Kato K, Szawan KA, et al. Prediction of short- and long-term mortality in takotsubo syndrome: The InterTAK prognostic score. <i>Eur J Heart Fail<\/i> 2019; 21: 1469\u20131472.","DOI":"10.1002\/ejhf.1561"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Nguyen TH, Liu S, Ong GJ, Stafford I, Frenneaux MP, Horowitz JD. Glycocalyx shedding is markedly increased during the acute phase of takotsubo cardiomyopathy. <i>Int J Cardiol<\/i> 2017; 243: 296\u2013299.","DOI":"10.1016\/j.ijcard.2017.04.085"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28. Yalta K, Yetkin E, Yalta T. Systemic inflammation in patients with takotsubo syndrome: A review of mechanistic and clinical implications. <i>Monaldi Arch Chest Dis<\/i> 2021, doi:10.4081\/monaldi.2021.1718.","DOI":"10.4081\/monaldi.2021.1718"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Liao X, Chang E, Tang X, Watanabe I, Zhang R, Jeong HW, et al. Cardiac macrophages regulate isoproterenol-induced takotsubo-like cardiomyopathy. <i>JCI Insight<\/i> 2022; 7: e156236.","DOI":"10.1172\/jci.insight.156236"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Faucher L, Matsushita K, Kikuchi S, Tatarcheh T, Marchandot B, Granier A, et al. Mortality risk stratification for Takotsubo syndrome: Evaluating CRP measurement alongside the InterTAK prognostic score. <i>ESC Heart Fail<\/i> 2025; 12: 1427\u20131436.","DOI":"10.1002\/ehf2.15161"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Sung KC. Seasonal variation of C-reactive protein in apparently healthy Koreans. <i>Int J Cardiol<\/i> 2006; 107: 338\u2013342.","DOI":"10.1016\/j.ijcard.2005.03.045"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Wucher V, Sodaei R, Amador R, Irimia M, Guig\u00f3 R. Day-night and seasonal variation of human gene expression across tissues. <i>PLoS Biol<\/i> 2023; 21: e3001986.","DOI":"10.1371\/journal.pbio.3001986"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Murray PJ, Wynn TA. Protective and pathogenic functions of macrophage subsets. <i>Nat Rev Immunol<\/i> 2011; 11: 723\u2013737.","DOI":"10.1038\/nri3073"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Santoro F, Costantino MD, Guastafierro F, Triggiani G, Ferraretti A, Tarantino N, et al. Inflammatory patterns in takotsubo cardiomyopathy and acute coronary syndrome: A propensity score matched analysis. <i>Atherosclerosis<\/i> 2018; 274: 157\u2013161.","DOI":"10.1016\/j.atherosclerosis.2018.05.017"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Surikow SY, Raman B, Licari J, Singh K, Nguyen TH, Horowitz JD. Evidence of nitrosative stress within hearts of patients dying of tako-tsubo cardiomyopathy. <i>Int J Cardiol<\/i> 2015; 189: 112\u2013114.","DOI":"10.1016\/j.ijcard.2015.03.416"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Surikow SY, Nguyen TH, Stafford I, Chapman M, Chacko S, Singh K, et al. Nitrosative stress as a modulator of inflammatory change in a model of takotsubo syndrome. <i>JACC Basic Transl Sci<\/i> 2018; 3: 213\u2013226.","DOI":"10.1016\/j.jacbts.2017.10.002"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Nguyen TH, Neil CJ, Sverdlov AL, Mahadavan G, Chirkov YY, Kucia AM, et al. N-Terminal pro-brain natriuretic protein levels in takotsubo cardiomyopathy. <i>Am J Cardiol<\/i> 2011; 108: 1316\u20131321.","DOI":"10.1016\/j.amjcard.2011.06.047"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Liu S, Chirkov Y, Horowitz J. Neutrophil-initiated myocardial inflammation and its modulation by B-type natriuretic peptide: A potential therapeutic target. <i>Int J Mol Sci<\/i> 2018; 20: 129.","DOI":"10.3390\/ijms20010129"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Mezzasoma L, Talesa VN, Romani R, Bellezza I. ANP and BNP exert anti-inflammatory action via NPR-1\/cGMP axis by interfering with canonical, non-canonical, and alternative routes of inflammasome activation in human THP1 cells. <i>Int J Mol Sci<\/i> 2020; 22: 24.","DOI":"10.3390\/ijms22010024"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Mroueh A, Fakih W, Carmona A, Trimaille A, Matsushita K, Marchandot B, et al. COVID-19 promotes endothelial dysfunction and thrombogenicity: Role of proinflammatory cytokines\/SGLT2 prooxidant pathway. <i>J Thromb Haemost<\/i> 2024; 22: 286\u2013299.","DOI":"10.1016\/j.jtha.2023.09.022"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Mroueh A, Algara-Suarez P, Fakih W, Gong DS, Matsushita K, Park SH, et al. SGLT2 expression in human vasculature and heart correlates with low-grade inflammation and causes eNOS-NO\/ROS imbalance. <i>Cardiovasc Res<\/i> 2025; 121: 643\u2013657.","DOI":"10.1093\/cvr\/cvae257"},{"key":"42","doi-asserted-by":"publisher","unstructured":"42. Tatartech T. Takotsubo syndrome induced oxidative stress and endothelial dysfunction in left ventricle of rat model: Association with NADPH oxidases\/SGLT2 pro-oxidant pathway. <i>Eur Heart J<\/i> 2024; 45(Supplement_1): ehae666.3732, doi:10.1093\/eurheartj\/ehae666.3732.","DOI":"10.1093\/eurheartj\/ehae666.3732"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Matsukawa R, Okahara A, Tokutome M, Itonaga J, Hara A, Kisanuki H, et al. Early initiation of sodium-glucose cotransporter 2 inhibitor leads to a shorter hospital stay in patients with acute decompensated heart failure. <i>Circ Rep<\/i> 2023; 5: 187\u2013197.","DOI":"10.1253\/circrep.CR-22-0118"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/89\/10\/89_CJ-24-0762\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T03:37:19Z","timestamp":1758944239000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/89\/10\/89_CJ-24-0762\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,25]]},"references-count":43,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-24-0762","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9,25]]},"article-number":"CJ-24-0762"}}