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Macfarlane PW, Antzelevitch C, Haissaguerre M, Huikuri HV, Potse M, Rosso R, et al. The early repolarization pattern: A consensus paper. <i>J Am Coll Cardiol<\/i> 2015; 66: 470\u2013477.","DOI":"10.1016\/j.jacc.2015.05.033"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Takase B, Ikeda T, Shimizu W, Abe H, Aiba T, Chinushi M, et al. JCS\/JHRS 2022 guideline on diagnosis and risk assessment of arrhythmia. <i>Circ J<\/i> 2024; 88: 1509\u20131595.","DOI":"10.1253\/circj.CJ-22-0827"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Wu SH, Lin XX, Cheng YJ, Qiang CC, Zhang J. Early repolarization pattern and risk for arrhythmia death: A meta-analysis. <i>J Am Coll Cardiol<\/i> 2013; 61: 645\u2013650.","DOI":"10.1016\/j.jacc.2012.11.023"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Junttila MJ, Tikkanen JT, Kentt\u00e4 T, Anttonen O, Aro AL, Porthan K, et al. Early repolarization as a predictor of arrhythmic and nonarrhythmic cardiac events in middle-aged subjects. <i>Heart Rhythm<\/i> 2014; 11: 1701\u20131706.","DOI":"10.1016\/j.hrthm.2014.05.024"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Siebermair J, Sinner MF, Beckmann BM, Laubender RP, Martens E, Sattler S, et al. Early repolarization pattern is the strongest predictor of arrhythmia recurrence in patients with idiopathic ventricular fibrillation: Results from a single centre long-term follow-up over 20 years. <i>Europace<\/i> 2016; 18: 718\u2013725.","DOI":"10.1093\/europace\/euv301"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Kitamura T, Fukamizu S, Hojo R, Aoyama Y, Komiyama K, Nishizaki M, et al. Early repolarization pattern and its day-to-day dynamic change as markers for ventricular fibrillation in patients with vasospastic angina. <i>Europace<\/i> 2016; 18: 1252\u20131258.","DOI":"10.1093\/europace\/euv281"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Hasegawa Y, Watanabe H, Ikami Y, Otsuki S, Iijima K, Yagihara N, et al. Early repolarization and risk of lone atrial fibrillation. <i>J Cardiovasc Electrophysiol<\/i> 2019; 30: 565\u2013568.","DOI":"10.1111\/jce.13848"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Uberoi A, Jain NA, Perez M, Weinkopff A, Ashley E, Hadley D, et al. Early repolarization in an ambulatory clinical population. <i>Circulation<\/i> 2011; 124: 2208\u20132214.","DOI":"10.1161\/CIRCULATIONAHA.111.047191"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Serra-Grima R, Do\u00f1ate M, \u00c1lvarez-Garc\u00eda J, Barradas-Pires A, Ferrero A, Carballeira L, et al. Long-term follow-up of early repolarization pattern in elite athletes. <i>Am J Med<\/i> 2015; 128: 192.e1\u20139.","DOI":"10.1016\/j.amjmed.2014.06.017"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Patton KK, Ellinor PT, Ezekowitz M, Kowey P, Lubitz SA, Perez M, et al. Electrocardiographic early repolarization: A scientific statement from the American Heart Association. <i>Circulation<\/i> 2016; 133: 1520\u20131529.","DOI":"10.1161\/CIR.0000000000000388"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Halasz G, Cattaneo M, Piepoli M, Biagi A, Romano S, Biasini V, et al. Early repolarization in pediatric athletes: A dynamic electrocardiographic pattern with benign prognosis. <i>J Am Heart Assoc<\/i> 2021; 10: e020776.","DOI":"10.1161\/JAHA.121.020776"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. The Atherosclerosis Risk in Communities (ARIC) study: Design and objectives. The ARIC investigators. <i>Am J Epidemiol<\/i> 1989; 129: 687\u2013702.","DOI":"10.1093\/oxfordjournals.aje.a115184"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Wright JD, Folsom AR, Coresh J, Sharrett AR, Couper D, Wagenknecht LE, et al. The ARIC (Atherosclerosis Risk In Communities) study: JACC focus seminar 3\/8. <i>J Am Coll Cardiol<\/i> 2021; 77: 2939\u20132959.","DOI":"10.1016\/j.jacc.2021.04.035"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Wang YG, Wu HT, Daubechies I, Li Y, Estes EH, Soliman EZ. Automated J wave detection from digital 12-lead electrocardiogram. <i>J Electrocardiol<\/i> 2015; 48: 21\u201328.","DOI":"10.1016\/j.jelectrocard.2014.10.006"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Devereux RB, Casale PN, Eisenberg RR, Miller DH, Kligfield P. Electrocardiographic detection of left ventricular hypertrophy using echocardiographic determination of left ventricular mass as the reference standard: Comparison of standard criteria, computer diagnosis and physician interpretation. <i>J Am Coll Cardiol<\/i> 1984; 3: 82\u201387.","DOI":"10.1016\/S0735-1097(84)80433-7"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Cheng YJ, Deng H, Liao YJ, Fang XH, Liao HT, Liu FZ, et al. Role of ideal cardiovascular health metrics in reducing risk of incident arrhythmias. <i>Eur J Prev Cardiol<\/i> 2024; 31: 658\u2013666.","DOI":"10.1093\/eurjpc\/zwad357"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Zhao D, Post WS, Blasco-Colmenares E, Cheng A, Zhang Y, Deo R, et al. Racial differences in sudden cardiac death. <i>Circulation<\/i> 2019; 139: 1688\u20131697.","DOI":"10.1161\/CIRCULATIONAHA.118.036553"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Zhang J, Liu J, Ye M, Zhang M, Yao F, Cheng Y. Incidence and risk factors associated with atrioventricular block in the general population: The atherosclerosis risk in communities study and Cardiovascular Health Study. <i>BMC Cardiovasc Disord<\/i> 2024; 24: 509.","DOI":"10.1186\/s12872-024-04163-9"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Jensen PN, Gronroos NN, Chen LY, Folsom AR, deFilippi C, Heckbert SR, et al. Incidence of and risk factors for sick sinus syndrome in the general population. <i>J Am Coll Cardiol<\/i> 2014; 64: 531\u2013538.","DOI":"10.1016\/j.jacc.2014.03.056"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Rooney MR, Soliman EZ, Lutsey PL, Norby FL, Loehr LR, Mosley TH, et al. Prevalence and characteristics of subclinical atrial fibrillation in a community-dwelling elderly population: The ARIC study. <i>Circ Arrhythm Electrophysiol<\/i> 2019; 12: e007390.","DOI":"10.1161\/CIRCEP.119.007390"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Mou L, Norby FL, Chen LY, O\u2019Neal WT, Lewis TT, Loehr LR, et al. Lifetime risk of atrial fibrillation by race and socioeconomic status: ARIC study (Atherosclerosis Risk in Communities). <i>Circ Arrhythm Electrophysiol<\/i> 2018; 11: e006350.","DOI":"10.1161\/CIRCEP.118.006350"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Antzelevitch C, Yan GX. J wave syndromes. <i>Heart Rhythm<\/i> 2010; 7: 549\u2013558.","DOI":"10.1016\/j.hrthm.2009.12.006"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Tikkanen JT, Anttonen O, Junttila MJ, Aro AL, Kerola T, Rissanen HA, et al. Long-term outcome associated with early repolarization on electrocardiography. <i>N Engl J Med<\/i> 2009; 361: 2529\u20132537.","DOI":"10.1056\/NEJMoa0907589"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Barra S, Provid\u00eancia R, Paiva L, Nascimento J. Early repolarization patterns and the role of additional proarrhythmic triggers. <i>Europace<\/i> 2013; 15: 482\u2013485.","DOI":"10.1093\/europace\/eus421"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Sinner MF, Porthan K, Noseworthy PA, Havulinna AS, Tikkanen JT, M\u00fcller-Nurasyid M, et al. A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern. <i>Heart Rhythm<\/i> 2012; 9: 1627\u20131634.","DOI":"10.1016\/j.hrthm.2012.06.008"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Imai Y, Kusano K, Aiba T, Ako J, Asano Y, Harada-Shiba M, et al. JCS\/JCC\/JSPCCS 2024 guideline on genetic testing and counseling in cardiovascular disease. <i>Circ J<\/i> 2024; 88: 2022\u20132099.","DOI":"10.1253\/circj.CJ-23-0926"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Delaney JT, Muhammad R, Blair MA, Kor K, Fish FA, Roden DM, et al. A KCNJ8 mutation associated with early repolarization and atrial fibrillation. <i>Europace<\/i> 2012; 14: 1428\u20131432.","DOI":"10.1093\/europace\/eus150"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Teumer A, Trenkwalder T, Kessler T, Jamshidi Y, van den Berg ME, Kaess B, et al. <i>KCND3<\/i> potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern. <i>JCI Insight<\/i> 2019; 4: e131156.","DOI":"10.1172\/jci.insight.131156"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Watanabe H, Nogami A, Ohkubo K, Kawata H, Hayashi Y, Ishikawa T, et al. Electrocardiographic characteristics and <i>SCN5A<\/i> mutations in idiopathic ventricular fibrillation associated with early repolarization. <i>Circ Arrhythm Electrophysiol<\/i> 2011; 4: 874\u2013881.","DOI":"10.1161\/CIRCEP.111.963983"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Walsh JA 3rd, Ilkhanoff L, Soliman EZ, Prineas R, Liu K, Ning H, et al. Natural history of the early repolarization pattern in a biracial cohort: CARDIA (Coronary Artery Risk Development in Young Adults) study. <i>J Am Coll Cardiol<\/i> 2013; 61: 863\u2013869.","DOI":"10.1016\/j.jacc.2012.11.053"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Junttila MJ, Tikkanen JT, Porthan K, Oikarinen L, Jula A, Kentt\u00e4 T, et al. Relationship between testosterone level and early repolarization on 12-lead electrocardiograms in men. <i>J Am Coll Cardiol<\/i> 2013; 62: 1633\u20131634.","DOI":"10.1016\/j.jacc.2013.07.015"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Fukuda T, Shinohara T, Yonezu K, Mitarai K, Hirota K, Kondo H, et al. Vagal response is involved in the occurrence of ventricular fibrillation in patients with early repolarization syndrome. <i>Heart Rhythm<\/i> 2023; 20: 879\u2013885.","DOI":"10.1016\/j.hrthm.2023.02.029"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Ilkhanoff L, Soliman EZ, Prineas RJ, Walsh JA 3rd, Ning H, Liu K, et al. Clinical characteristics and outcomes associated with the natural history of early repolarization in a young, biracial cohort followed to middle age: The Coronary Artery Risk Development in Young Adults (CARDIA) study. <i>Circ Arrhythm Electrophysiol<\/i> 2014; 7: 392\u2013399.","DOI":"10.1161\/CIRCEP.113.000874"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Olson KA, Viera AJ, Soliman EZ, Crow RS, Rosamond WD. Long-term prognosis associated with J-point elevation in a large middle-aged biracial cohort: The ARIC study. <i>Eur Heart J<\/i> 2011; 32: 3098\u20133106.","DOI":"10.1093\/eurheartj\/ehr264"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Kamakura T, Wada M, Ishibashi K, Inoue YY, Miyamoto K, Okamura H, et al. Differences in the onset mode of ventricular tachyarrhythmia between patients with J wave in anterior leads and those with J wave in inferolateral leads. <i>Heart Rhythm<\/i> 2017; 14: 553\u2013561.","DOI":"10.1016\/j.hrthm.2016.11.027"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Nademanee K, Haissaguerre M, Hocini M, Nogami A, Cheniti G, Duchateau J, et al. Mapping and ablation of ventricular fibrillation associated with early repolarization syndrome. <i>Circulation<\/i> 2019; 140: 1477\u20131490.","DOI":"10.1161\/CIRCULATIONAHA.118.039022"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Sabbag A, Sidi Y, Kivity S, Beinart R, Glikson M, Segev S, et al. Obesity and exercise-induced ectopic ventricular arrhythmias in apparently healthy middle aged adults. <i>Eur J Prev Cardiol<\/i> 2016; 23: 511\u2013517.","DOI":"10.1177\/2047487315591442"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Liu P, Wang Y, Zhang X, Zhang Z, Zhao N, Ou W, et al. 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