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Effectiveness and safety of novel oral anticoagulants as compared with vitamin K antagonists in the treatment of acute symptomatic venous thromboembolism: A systematic review and meta-analysis. <i>J Thromb Haemost<\/i> 2014; 12: 320\u2013328, doi:10.1111\/jth.12485.","DOI":"10.1111\/jth.12485"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6. Cohen AT, Hamilton M, Mitchell SA, Phatak H, Liu X, Bird A, et al. Comparison of the novel oral anticoagulants apixaban, dabigatran, edoxaban, and rivaroxaban in the initial and long-term treatment and prevention of venous thromboembolism: Systematic review and network meta-analysis. <i>PLoS One<\/i> 2015; 10: e0144856, doi:10.1371\/journal.pone.0144856.","DOI":"10.1371\/journal.pone.0144856"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Di Micco P, Monreal M. Platelet count and bleeding in patients receiving anticoagulant therapy for venous thromboembolism: Lesson from the RIETE Registry. <i>J Blood Med<\/i> 2019; 10: 453\u2013456, doi:10.2147\/jbm.s234053.","DOI":"10.2147\/JBM.S234053"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8. Riva N, Bellesini M, Di Minno MN, Mumoli N, Pomero F, Franchini M, et al. Poor predictive value of contemporary bleeding risk scores during long-term treatment of venous thromboembolism: A multicentre retrospective cohort study. <i>Thromb Haemost<\/i> 2014; 112: 511\u2013521, doi:10.1160\/th14-01-0081.","DOI":"10.1160\/TH14-01-0081"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. Piovella C, Dalla Valle F, Trujillo-Santos J, Pesavento R, L\u00f3pez L, Font L, et al. 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Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY. A novel user-friendly score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial fibrillation: The Euro Heart Survey. <i>Chest<\/i> 2010; 138: 1093\u20131100, doi:10.1378\/chest.10-0134.","DOI":"10.1378\/chest.10-0134"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Gage BF, Yan Y, Milligan PE, Waterman AD, Culverhouse R, Rich MW, et al. Clinical classification schemes for predicting hemorrhage: Results from the National Registry of Atrial Fibrillation (nRAF). <i>Am Heart J<\/i> 2006; 151: 713\u2013719, doi:10.1016\/j.ahj.2005.04.017.","DOI":"10.1016\/j.ahj.2005.04.017"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Kaneda K, Yamashita Y, Morimoto T, Chatani R, Nishimoto Y, Ikeda N, et al. Anticoagulation strategies and long-term recurrence in patients with venous thromboembolism in the era of direct oral anticoagulants. <i>Eur J Intern Med<\/i> 2023; 118: 59\u201372, doi:10.1016\/j.ejim.2023.08.007.","DOI":"10.1016\/j.ejim.2023.08.007"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Goldhaber SZ, Visani L, De Rosa M. Acute pulmonary embolism: Clinical outcomes in the International Cooperative Pulmonary Embolism Registry (ICOPER). <i>Lancet<\/i> 1999; 353: 1386\u20131389, doi:10.1016\/s0140-6736(98)07534-5.","DOI":"10.1016\/S0140-6736(98)07534-5"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18. Chatani R, Yamashita Y, Morimoto T, Mushiake K, Kadota K, Kaneda K, et al. Cancer-associated venous thromboembolism in the direct oral anticoagulants era: Insight from the COMMAND VTE Registry-2. <i>Thromb Res<\/i> 2024; 234: 86\u201393, doi:10.1016\/j.thromres.2023.12.016.","DOI":"10.1016\/j.thromres.2023.12.016"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Schulman S, Kearon C; Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Definition of major bleeding in clinical investigations of antihemostatic medicinal products in non-surgical patients. <i>J Thromb Haemost<\/i> 2005; 3: 692\u2013694, doi:10.1111\/j.1538-7836.2005.01204.x.","DOI":"10.1111\/j.1538-7836.2005.01204.x"},{"key":"20","unstructured":"20. Nutritional anaemias. Report of a WHO scientific group. <i>World Health Organ Tech Rep Ser<\/i> 1968; 405: 5\u201337."},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. Yamashita Y, Morimoto T, Amano H, Takase T, Hiramori S, Kim K, et al. Influence of baseline platelet count on outcomes in patients with venous thromboembolism (from the COMMAND VTE Registry). <i>Am J Cardiol<\/i> 2018; 122: 2131\u20132141, doi:10.1016\/j.amjcard.2018.08.053.","DOI":"10.1016\/j.amjcard.2018.08.053"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Ortel TL, Neumann I, Ageno W, Beyth R, Clark NP, Cuker A, et al. American Society of Hematology 2020 guidelines for management of venous thromboembolism: Treatment of deep vein thrombosis and pulmonary embolism. <i>Blood Adv<\/i> 2020; 4: 4693\u20134738, doi:10.1182\/bloodadvances.2020001830.","DOI":"10.1182\/bloodadvances.2020001830"},{"key":"23","unstructured":"23. National Institute for Health and Care Excellence (NICE). Venous thromboembolic diseases: Diagnosis, management and thrombophilia testing. 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Length of anticoagulation in provoked venous thromboembolism: A multicenter study of how real-world practice mirrors guideline recommendations. <i>J Am Heart Assoc<\/i> 2022; 11: e025471, doi:10.1161\/jaha.122.025471.","DOI":"10.1161\/JAHA.122.025471"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26. Kaneda K, Yamashita Y, Morimoto T, Chatani R, Nishimoto Y, Ikeda N, et al. Temporal changes in long-term outcomes of venous thromboembolism from the warfarin era to the direct oral anticoagulant era. <i>J Am Heart Assoc<\/i> 2024; 13: e034412, doi:10.1161\/jaha.124.034412.","DOI":"10.1161\/JAHA.124.034412"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Kearon C, Akl EA, Comerota AJ, Prandoni P, Bounameaux H, Goldhaber SZ, et al. Antithrombotic therapy for VTE disease: Antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. <i>Chest<\/i> 2012; 141(Suppl): e419S\u2013e496S, doi:10.1378\/chest.11-2301.","DOI":"10.1378\/chest.11-2301"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28. Nieto JA, Solano R, Ruiz-Rib\u00f3 MD, Ruiz-Gimenez N, Prandoni P, Kearon C, et al. Fatal bleeding in patients receiving anticoagulant therapy for venous thromboembolism: Findings from the RIETE registry. <i>J Thromb Haemost<\/i> 2010; 8: 1216\u20131222, doi:10.1111\/j.1538-7836.2010.03852.x.","DOI":"10.1111\/j.1538-7836.2010.03852.x"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29. Kuijer PM, Hutten BA, Prins MH, B\u00fcller HR. 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Direct oral anticoagulant use in older adults with atrial fibrillation: Challenges and solutions. <i>Eur Cardiol<\/i> 2025; 20: e03, doi:10.15420\/ecr.2024.17.","DOI":"10.15420\/ecr.2024.17"},{"key":"46","doi-asserted-by":"publisher","unstructured":"46. Ito S, Inoko M, Yamashita Y, Morimoto T, Kimura T. Thrombocytopenia and bleeding events in patients with venous thromboembolism. <i>Eur J Intern Med<\/i> 2024; 122: 132\u2013134, doi:10.1016\/j.ejim.2024.01.007.","DOI":"10.1016\/j.ejim.2024.01.007"},{"key":"47","doi-asserted-by":"publisher","unstructured":"47. Decousus H, Tapson VF, Bergmann JF, Chong BH, Froehlich JB, Kakkar AK, et al. Factors at admission associated with bleeding risk in medical patients: Findings from the IMPROVE Investigators. <i>Chest<\/i> 2011; 139: 69\u201379, doi:10.1378\/chest.09-3081.","DOI":"10.1378\/chest.09-3081"},{"key":"48","doi-asserted-by":"publisher","unstructured":"48. Tamargo J, Kaski JC, Kimura T, Barton JC, Yamamoto K, Komiyama M, et al. 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