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Ambrosy AP, Fonarow GC, Butler J, Chioncel O, Greene SJ, Vaduganathan M, et al. The global health and economic burden of hospitalizations for heart failure: Lessons learned from hospitalized heart failure registries. <i>J Am Coll Cardiol<\/i> 2014; 63: 1123\u20131133.","DOI":"10.1016\/j.jacc.2013.11.053"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Shimokawa H, Miura M, Nochioka K, Sakata Y. Heart failure as a general pandemic in Aisa. <i>Eur J Heart Fail<\/i> 2015; 17: 884\u2013892.","DOI":"10.1002\/ejhf.319"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Chioncel O, Mebazaa A, Harjola VP, Coats AJ, Piepoli MF, Crespo-Leiro MG, et al. Clinical phenotypes and outcome of patients hospitalized for acute heart failure: The ESC Heart Failure Long-Term Registry. <i>Eur J Heart Fail<\/i> 2017; 19: 1242\u20131254.","DOI":"10.1002\/ejhf.890"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Noiri J, Fujimoto W, Takemoto M, Kuroda K, Yamashita S, Imanishi J, et al. Population gap for chronic heart failure patients between randomized controlled trials and Japan\u2019s super-aged society. <i>Circ J<\/i> 2025; 7: 331\u2013340.","DOI":"10.1253\/circrep.CR-25-0002"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Kitai T, Kohsaka S, Kato T, Kato E, Sato K, Teramoto K, et al. JCS\/JHFS 2025 guideline on diagnosis and treatment of heart failure. <i>Circ J<\/i> 2025; 89: 1278\u20131444.","DOI":"10.1253\/circj.CJ-25-0002"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Costanzo MR, Mills RM, Wynne J. Characteristics of \u2018Stage D\u2019 heart failure: Insights from the Acute Decompensated Heart Failure National Registry Longitudinal Module (ADHERE LM). <i>Am Heart J<\/i> 2008; 155: 339\u2013347.","DOI":"10.1016\/j.ahj.2007.10.020"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Conrad N, Judge A, Tran J, Mohseni H, Hedgecott D, Crespillo AP, et al. Temporal trends and patterns in heart failure incidence: A population-based study of 4 million individuals. <i>Lancet<\/i> 2018; 391: 572\u2013580.","DOI":"10.1016\/S0140-6736(17)32520-5"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Unroe KT, Grenier MA, Hernandez AF, Whellan DJ, Kaul P, Schulman KA, et al. Resource use in the last 6 months of life among Medicare beneficiaries with heart failure, 2000\u20132007. <i>Arch Int Med<\/i> 2011; 171: 196.","DOI":"10.1001\/archinternmed.2010.371"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Kaul P, McAlister FA, Ezekowitz J, Bakal JA, Curtis LH, Quan H, et al. Resource use in the last 6 months of life among patients with heart failure in Canada. <i>Arch Int Med<\/i> 2011; 171: 211\u2013217.","DOI":"10.1001\/archinternmed.2010.365"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Yamano E, Sugimoto M, Hirayama A, Kume S, Yamato M, Jin G, et al. Index markers of chronic fatigue syndrome with dysfunction of TCA and urea cycles. <i>Sci Rep<\/i> 2016; 6: 34990.","DOI":"10.1038\/srep34990"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Yoshimi N, Futamura T, Kakumoto K, Salehi AM, Sellgren CM, Larsson JH, et al. Blood metabolomics analysis identifies abnormalities in the citric acid cycle, urea cycle, and amino acid metabolism in bipolar disorder. <i>BBA Clin<\/i> 2016; 5: 151\u2013158.","DOI":"10.1016\/j.bbacli.2016.03.008"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Koike S, Bundo M, Iwamoto K, Suga M, Kuwabara H, Ohashi Y, et al. A snapshot of plasma metabolites in first-episode schizophrenia: A capillary electrophoresis time-of-flight mass spectrometry study. <i>Transl Psychiatry<\/i> 2014; 4: e379.","DOI":"10.1038\/tp.2014.19"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Fan Y, Li Y, Chen Y, Zhao YJ, Liu LW, Li J, et al. Comprehensive metabolomic characterization of coronary artery diseases. <i>J Am Coll Cardiol<\/i> 2016; 68: 1281\u20131293.","DOI":"10.1016\/j.jacc.2016.06.044"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Hage C, L\u00f6fgren L, Michopoulos F, Nilsson R, Davidsson P, Kumar C, et al. Metabolomic profile in HFpEF vs HFrEF patients. <i>J Card Fail<\/i> 2020; 12: 1050\u20131059.","DOI":"10.1016\/j.cardfail.2020.07.010"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Bekfani T, Bekhite M, Meugebauer S, Derlien S, Hamadanchi A, Nisser J, et al. Metabolomic profiling in patients with heart failure and exercise intolerance: Kynurenine as a potential biomarker. <i>Cells<\/i> 2022; 10: 1674.","DOI":"10.3390\/cells11101674"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Wong CN, Gui XY, Rabkin SW. Myeloperoxidase, carnitine, and derivatives of reactive oxidative metabolites in heart failure with preserved versus reduced ejection fraction: A meta-analysis. <i>Int J Cardiol<\/i> 2024; 399: 131657.","DOI":"10.1016\/j.ijcard.2023.131657"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sutton BS, Crosslin DR, Shah SH, Nelson SC, Bassil A, Hale AB, et al. Comprehensive genetic analysis of the platelet activating factor acetylhydrolase (<i>PLA2G7<\/i>) gene and cardiovascular disease in case-control and family datasets. <i>Hum Mol Genet<\/i> 2008; 17: 1318\u20131328.","DOI":"10.1093\/hmg\/ddn020"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Shah SH, Bain JR, Muehlbauer MJ, Stevens RD, Crosslin DR, Haynes C, et al. Association of a peripheral blood metabolic profile with coronary artery disease and risk of subsequent cardiovascular events. <i>Circ Cardiovasc Genet<\/i> 2010; 3: 207\u2013214.","DOI":"10.1161\/CIRCGENETICS.109.852814"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Shah SH, Kraus WE, Newgard CB. Metabolomic profiling for the identification of novel biomarkers and mechanisms related to common cardiovascular diseases: Form and function. <i>Circulation<\/i> 2012; 126: 1110\u20131120.","DOI":"10.1161\/CIRCULATIONAHA.111.060368"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Cheng ML, Wang CH, Shiao MS, Liu MH, Huang CY, Mao CT, et al. Metabolic disturbances identified in plasma are associated with outcomes in patients with heart failure: Diagnostic and prognostic value of metabolomics. <i>J Am Coll Cardiol<\/i> 2015; 65: 1509\u20131520.","DOI":"10.1016\/j.jacc.2015.02.018"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Marcinkiewicz-Siemion M, Ciborowski M, Kretowski A, Musial WJ, Kaminski KA. Metabolomics: A wide-open door to personalized treatment in chronic heart failure? <i>Int J Cardiol<\/i> 2016; 219: 156\u2013163.","DOI":"10.1016\/j.ijcard.2016.06.022"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Wold S, Sj\u00f6strom M, Eriksson L. PLS-regression: A basic tool of chemometrics. <i>Chemometrics and Intelligent Laboratory Systems<\/i> 2001; 58: 109\u2013130.","DOI":"10.1016\/S0169-7439(01)00155-1"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Brereton RG, Lloyd GR. Partial least squares discriminant analysis: Taking the magic away. <i>J Chemom<\/i> 2014; 28: 213\u2013225.","DOI":"10.1002\/cem.2609"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Gromski PS, Muhamadali H, Ellis DI, Xu Y, Correa E, Turner ML, et al. A tutorial review: Metabolomics and partial least squares-discriminant analysis, a marriage of convenience or a shotgun wedding. <i>Anal Chim Acta<\/i> 2015; 879: 10\u201323.","DOI":"10.1016\/j.aca.2015.02.012"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Want E, Masson P. Processing and analysis of GC\/LC\u2013MS-based metabolomics data. <i>Methods Mol Biol<\/i> 2011; 708: 277\u2013298.","DOI":"10.1007\/978-1-61737-985-7_17"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Worley B, Halouska S, Powers R. Utilities for quantifying separation in PCA\/PLS-DA scores plots. <i>Anal Biochem<\/i> 2013; 433: 102\u2013104.","DOI":"10.1016\/j.ab.2012.10.011"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Machida K, Minamisawa M, Motoki H, Teramoto K, Okuma Y, Kanai M, et al. Clinical profile and prognosis of dementia in patients with acute decompensated heart failure: From the CURE-HF registry. <i>Circ J<\/i> 2023; 88: 93\u2013102.","DOI":"10.1253\/circj.CJ-23-0129"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Kanai M, Minamisawa M, Motoki H, Seko Y, Kimura K, Okano T, et al. Prognostic impact of hyperpolypharmacy due to noncardiovascular medications in patients after acute decompensated heart failure: Insights from the Clue of Risk Stratification in the Elderly Patients With Heart Failure (CURE-HF) registry. <i>Circ J<\/i> 2023; 88: 33\u201342.","DOI":"10.1253\/circj.CJ-22-0712"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Stanley WC, Recchia FA, Lopaschuk GD. Myocardial substrate metabolism in the normal and failing heart. <i>Physiol Rev<\/i> 2005; 85: 1093\u20131129.","DOI":"10.1152\/physrev.00006.2004"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Neubauer S. The failing heart: An engine out of fuel. <i>N Engl J Med<\/i> 2007; 356: 1140\u20131151.","DOI":"10.1056\/NEJMra063052"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Murashige D, Jang C, Neinast M, Edwards JJ, Cowan A, Hyman MC, et al. Comprehensive quantification of fuel use by the failing and nonfailing human heart. <i>Science<\/i> 2020; 370: 364\u2013368.","DOI":"10.1126\/science.abc8861"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Nickel A, L\u00f6ffler J, Maack C. Myocardial energetics in heart failure. <i>Basic Res Cardiol<\/i> 2013; 108: 358.","DOI":"10.1007\/s00395-013-0358-9"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Soukoulis V, Dihu JB, Sole M, Anker SD, Cleland J, Fonarow GC, et al. Micronutrient deficiencies an unmet need in heart failure. <i>J Am Coll Cardiol<\/i> 2009; 54: 1660\u20131673.","DOI":"10.1016\/j.jacc.2009.08.012"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Ujiro S, Fujimoto W, Takemoto M, Kuroda K, Yamashita S, Imanishi J, et al. Impact of cardiorenal anemia syndrome on the prognosis of patients with chronic heart failure in Japan: Insights from the KUNIUMI registry chronic cohort. <i>Circ J<\/i> 2025; 89: 463\u2013469.","DOI":"10.1253\/circj.CJ-24-0957"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Michael H, Szlosek D, Clements C, Mack R. Symmetrical dimethylarginine: Evaluating chronic kidney disease in the era of multiple kidney biomarkers. <i>Vet Clin North Am Small Anim Pract<\/i> 2022; 52: 609\u2013629.","DOI":"10.1016\/j.cvsm.2022.01.003"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Esteban-Fern\u00e1ndez A, Villar-Taibo R, Alejo M, Arroyo D, Bonilla Palomas JL, Cachero M, et al. Diagnosis and management of malnutrition in patients with heart failure. <i>J Clin Med<\/i> 2023; 12: 3320.","DOI":"10.3390\/jcm12093320"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. 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