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Lau J, Antman EM, Jimenez-Silva J, Kupelnick B, Mosteller F, Chalmers TC. Cumulative meta-analysis of therapeutic trials for myocardial infarction. <i>N Engl J Med<\/i> 1992; 327: 248\u2013254, doi:10.1056\/NEJM199207233270406.","DOI":"10.1056\/NEJM199207233270406"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Grines CL, Browne KF, Marco J, Rothbaum D, Stone GW, O\u2019Keefe J, et al. A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction: The Primary Angioplasty in Myocardial Infarction Study Group. <i>N Engl J Med<\/i> 1993; 328: 673\u2013679, doi:10.1056\/NEJM199303113281001.","DOI":"10.1056\/NEJM199303113281001"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Byrne RA, Rossello X, Coughlan JJ, Barbato E, Berry C, Chieffo A, et al. 2023 ESC Guidelines for the management of acute coronary syndromes. <i>Eur Heart J<\/i> 2023; 44: 3720\u20133826, doi:10.1093\/eurheartj\/ehad191.","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4. Rao SV, O\u2019Donoghue ML, Ruel M, Rab T, Tamis-Holland JE, Alexander JH, et al. 2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI Guideline for the management of patients with acute coronary syndromes: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. <i>Circulation<\/i> 2025; 151: e771\u2013e862, doi:10.1161\/CIR.0000000000001309.","DOI":"10.1161\/CIR.0000000000001309"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5. Munkhaugen J, Kristensen AMD, Halvorsen S, Holmager T, Olsen MH, Bakken A, et al. Beta-blockers after myocardial infarction in patients without heart failure. <i>N Engl J Med<\/i> 2025; 393: 1901\u20131911, doi:10.1056\/NEJMoa2505985.","DOI":"10.1056\/NEJMoa2505985"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6. Ibanez B, Latini R, Rossello X, Dominguez-Rodriguez A, Fernandez-Vazquez F, Pelizzoni V, et al. Beta-blockers after myocardial infarction without reduced ejection fraction. <i>N Engl J Med<\/i> 2025; 393: 1889\u20131900, doi:10.1056\/NEJMoa2504735.","DOI":"10.1056\/NEJMoa2504735"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Jeong JC, Park JI, Kim BJ, Kim HJ, Choi KU, Nam JH, et al. Beta-blockers after percutaneous coronary intervention for acute myocardial infarction and non-reduced left ventricular ejection fraction. <i>Front Cardiovasc Med<\/i> 2024; 11: 1447952, doi:10.3389\/fcvm.2024.1447952.","DOI":"10.3389\/fcvm.2024.1447952"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8. Kristensen AMD, Rossello X, Atar D, Yndigegn T, Kimura T, Latini R, et al. Beta-blockers after myocardial infarction with normal ejection fraction. <i>N Engl J Med<\/i> 2026; 394: 540\u2013550, doi:10.1056\/NEJMoa2512686.","DOI":"10.1056\/NEJMoa2512686"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bohm M, et al. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC. <i>Rev Esp Cardiol (Engl Ed)<\/i> 2022; 75: 523, doi:10.1016\/j.rec.2022.05.005.","DOI":"10.1016\/j.rec.2022.05.005"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Nagai S, Nishimori M, Kintsu M, Todo S, Ota E, Odajima S, et al. Left ventricular longitudinal myocardial function of heart failure patients with transition from reduced to preserved ejection fraction and of those with preserved ejection fraction. <i>Circ Rep<\/i> 2024; 6: 161\u2013167, doi:10.1253\/circrep.CR-24-0025.","DOI":"10.1253\/circrep.CR-24-0025"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, Bohm M, et al. 2023 focused update of the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure. <i>Eur Heart J<\/i> 2023; 44: 3627\u20133639, doi:10.1093\/eurheartj\/ehad195.","DOI":"10.1093\/eurheartj\/ehad195"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Feuerstein GZ, Bril A, Ruffolo RR Jr. Protective effects of carvedilol in the myocardium. <i>Am J Cardiol<\/i> 1997; 80: 41L\u201345L, doi:10.1016\/s0002-9149(97)00847-3.","DOI":"10.1016\/S0002-9149(97)00847-3"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. Dargie HJ. Effect of carvedilol on outcome after myocardial infarction in patients with left-ventricular dysfunction: The CAPRICORN randomised trial. <i>Lancet<\/i> 2001; 357: 1385\u20131390, doi:10.1016\/s0140-6736(00)04560-8.","DOI":"10.1016\/S0140-6736(00)04560-8"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Frohlich H, Torres L, Tager T, Schellberg D, Corletto A, Kazmi S, et al. Bisoprolol compared with carvedilol and metoprolol succinate in the treatment of patients with chronic heart failure. <i>Clin Res Cardiol<\/i> 2017; 106: 711\u2013721, doi:101007\/s00392-017-1115-0.","DOI":"10.1007\/s00392-017-1115-0"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15. Poirier L, Tobe SW. Contemporary use of beta-blockers: Clinical relevance of subclassification. <i>Can J Cardiol<\/i> 2014; 30: S9\u2013S15, doi:10.1016\/j.cjca.2013.12.001.","DOI":"10.1016\/j.cjca.2013.12.001"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. 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Laskey WK, Yancy CW, Maisel WH. Thrombosis in coronary drug-eluting stents: Report from the meeting of the Circulatory System Medical Devices Advisory Panel of the Food and Drug Administration Center for Devices and Radiologic Health, December 7\u20138, 2006. <i>Circulation<\/i> 2007; 115: 2352\u20132357, doi:10.1161\/CIRCULATIONAHA.107.688416.","DOI":"10.1161\/CIRCULATIONAHA.107.688416"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J, et al. Standardized bleeding definitions for cardiovascular clinical trials: A consensus report from the Bleeding Academic Research Consortium. <i>Circulation<\/i> 2011; 123: 2736\u20132747, doi:10.1161\/CIRCULATIONAHA.110.009449.","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"26","doi-asserted-by":"publisher","unstructured":"26. Nam H, Cha JH, Choi KH, Chung CR, Yang JH, Suh GY, et al. Association between initial left ventricular systolic dysfunction and clinical outcome in sepsis: A multicenter cohort study. <i>Crit Care Med<\/i> 2025; 53: e1759\u2013e1769, doi:10.1097\/CCM.0000000000006771.","DOI":"10.1097\/CCM.0000000000006771"},{"key":"27","doi-asserted-by":"publisher","unstructured":"27. Kim S, Lee JD, Kim BK, Kim YH, Kim JH. Association between left ventricular systolic dysfunction and mortality in patients with septic shock. <i>J Korean Med Sci<\/i> 2020; 35: e24, doi:10.3346\/jkms.2020.35.e24.","DOI":"10.3346\/jkms.2020.35.e24"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28. Forner J, Weidner K, Rusnak J, Dudda J, Behnes M, Akin I, et al. Prognostic impact of left compared to right heart function in sepsis and septic shock. <i>ASAIO J<\/i> 2024; 70: 502\u2013509, doi:10.1097\/MAT.0000000000002131.","DOI":"10.1097\/MAT.0000000000002131"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29. Ziff OJ, Samra M, Howard JP, Bromage DI, Ruschitzka F, Francis DP, et al. Beta-blocker efficacy across different cardiovascular indications: An umbrella review and meta-analytic assessment. <i>BMC Med<\/i> 2020; 18: 103, doi:10.1186\/s12916-020-01564-3.","DOI":"10.1186\/s12916-020-01564-3"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30. do Vale GT, Ceron CS, Gonzaga NA, Simplicio JA, Padovan JC. Three generations of beta-blockers: History, class differences and clinical applicability. <i>Curr Hypertens Rev<\/i> 2019; 15: 22\u201331, doi:10.2174\/1573402114666180918102735.","DOI":"10.2174\/1573402114666180918102735"},{"key":"31","doi-asserted-by":"publisher","unstructured":"31. Prichard BN. Alpha- and beta-blocking agents: Pharmacology and properties. <i>Cleve Clin J Med<\/i> 1991; 58: 337\u2013350, doi:10.3949\/ccjm.58.4.337.","DOI":"10.3949\/ccjm.58.4.337"},{"key":"32","doi-asserted-by":"publisher","unstructured":"32. 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