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Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. <i>N Engl J Med<\/i> 2004; 351: 1296\u20131305.","DOI":"10.1056\/NEJMoa041031"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Hemmelgarn BR, Manns BJ, Lloyd A, James MT, Klarenbach S, Quinn RR, et al. Relation between kidney function, proteinuria, and adverse outcomes. <i>JAMA<\/i> 2010; 303: 423\u2013429.","DOI":"10.1001\/jama.2010.39"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, et al. 2018 AHA\/ACC\/AACVPR\/AAPA\/ABC\/ACPM\/ADA\/AGS\/APhA\/ASPC\/NLA\/PCNA Guideline on the management of blood cholesterol: Executive summary: A report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines. <i>J Am Coll Cardiol<\/i> 2019; 73: 3168\u20133209.","DOI":"10.1016\/j.jacc.2018.11.002"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Wahl P, Ducasa GM, Fornoni A. Systemic and renal lipids in kidney disease development and progression. <i>Am J Physiol Renal Physiol<\/i> 2016; 310: F433\u2013F445.","DOI":"10.1152\/ajprenal.00375.2015"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Tozawa M, Iseki K, Iseki C, Oshiro S, Ikemiya Y, Takishita S. Triglyceride, but not total cholesterol or low-density lipoprotein cholesterol levels, predict development of proteinuria. <i>Kidney Int<\/i> 2002; 62: 1743\u20131749.","DOI":"10.1046\/j.1523-1755.2002.00626.x"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Chen X, Liang M, Zhang J, Xu C, Chen L, Hu R, et al. The non-high-density lipoprotein cholesterol (Non-HDL-C) to HDL-C ratio (NHHR) and its association with chronic kidney disease in Chinese adults with type 2 diabetes: A preliminary study. <i>Nutrients<\/i> 2025; 17: 1125.","DOI":"10.3390\/nu17071125"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Pan J, Gao F, Bao Y, Zhang L, Tu Y, Jia W. Non-high-density lipoprotein cholesterol is associated more closely with albuminuria in Chinese type 2 diabetic patients with normal renal function, compared with traditional lipid parameters. <i>J Clin Lipidol<\/i> 2012; 6: 382\u2013387.","DOI":"10.1016\/j.jacl.2012.01.008"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Osanami A, Tanaka M, Furuhashi M, Ohnishi H, Hanawa N, Yamashita T, et al. Increased LDL-cholesterol level is associated with deterioration of renal function in males. <i>Clin Kidney J<\/i> 2022; 15: 1888\u20131895.","DOI":"10.1093\/ckj\/sfac111"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Kuma A, Uchino B, Ochiai Y, Kawashima M, Enta K, Tamura M, et al. Impact of low-density lipoprotein cholesterol on decline in estimated glomerular filtration rate in apparently healthy young to middle-aged working men. <i>Clin Exp Nephrol<\/i> 2018; 22: 15\u201327.","DOI":"10.1007\/s10157-017-1407-8"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Berneis KK, Krauss RM. Metabolic origins and clinical significance of LDL heterogeneity. <i>J Lipid Res<\/i> 2002; 43: 1363\u20131379.","DOI":"10.1194\/jlr.R200004-JLR200"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Hirano T. Pathophysiology of diabetic dyslipidemia. <i>J Atheroscler Thromb<\/i> 2018; 25: 771\u2013782.","DOI":"10.5551\/jat.RV17023"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Hirano T. Clinical significance of small dense low-density lipoprotein cholesterol measurement in type 2 diabetes. <i>J Diabetes Investig<\/i> 2025; 16: 370\u2013383.","DOI":"10.1111\/jdi.14398"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Hoogeveen RC, Ballantyne CM. Residual cardiovascular risk at low LDL: Remnants, lipoprotein(a), and inflammation. <i>Clin Chem<\/i> 2021; 67: 143\u2013153.","DOI":"10.1093\/clinchem\/hvaa252"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Raposeiras-Roubin S, Rossello X, Oliva B, Fernandez-Friera L, Mendiguren JM, Andres V, et al. Triglycerides and residual atherosclerotic risk. <i>J Am Coll Cardiol<\/i> 2021; 77: 3031\u20133041.","DOI":"10.1016\/j.jacc.2021.04.059"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Ito Y, Fujimura M, Ohta M, Hirano T. Development of a homogeneous assay for measurement of small dense LDL cholesterol. <i>Clin Chem<\/i> 2011; 57: 57\u201365.","DOI":"10.1373\/clinchem.2010.149559"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Sato T, Tanaka M, Furuhashi M. Can small dense LDL cholesterol be estimated from the lipid profile? <i>Curr Opin Lipidol<\/i> 2025; 36: 198\u2013202.","DOI":"10.1097\/MOL.0000000000000989"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Sampson M, Ling C, Sun Q, Harb R, Ashmaig M, Warnick R, et al. A new equation for calculation of low-density lipoprotein cholesterol in patients with normolipidemia and\/or hypertriglyceridemia. <i>JAMA Cardiol<\/i> 2020; 5: 540\u2013548.","DOI":"10.1001\/jamacardio.2020.0013"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Sampson M, Wolska A, Warnick R, Lucero D, Remaley AT. A new equation based on the standard lipid panel for calculating small dense low-density lipoprotein-cholesterol and its use as a risk-enhancer test. <i>Clin Chem<\/i> 2021; 67: 987\u2013997.","DOI":"10.1093\/clinchem\/hvab048"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Hirano T, Ito Y. Accuracy of small dense low-density lipoprotein-cholesterol concentration estimated via Sampson\u2019s equation in healthy subjects and patients with diabetes. <i>J Atheroscler Thromb<\/i> 2023; 30: 979\u2013989.","DOI":"10.5551\/jat.63865"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Endo K, Kobayashi R, Tanaka M, Tanaka M, Akiyama Y, Sato T, et al. Validation of estimated small dense low-density lipoprotein cholesterol concentration in a Japanese general population. <i>J Atheroscler Thromb<\/i> 2024; 31: 931\u2013952.","DOI":"10.5551\/jat.64578"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Inyaku M, Tanaka M, Sato T, Endo K, Mori K, Hosaka I, et al. Calculated small dense low-density lipoprotein cholesterol level is a predominant predictor for new onset of ischemic heart disease. <i>J Atheroscler Thromb<\/i> 2024; 31: 232\u2013248.","DOI":"10.5551\/jat.64369"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Tanaka M, Sato T, Endo K, Inyaku M, Mori K, Hosaka I, et al. An increase in calculated small dense low-density lipoprotein cholesterol predicts new onset of hypertension in a Japanese cohort. <i>Hypertens Res<\/i> 2023; 46: 2635\u20132645.","DOI":"10.1038\/s41440-023-01392-x"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Endo K, Tanaka M, Sato T, Inyaku M, Nakata K, Kawaharata W, et al. High level of estimated small dense low-density lipoprotein cholesterol as an independent risk factor for the development of ischemic heart disease regardless of low-density lipoprotein cholesterol level: A 10-year cohort study. <i>Circ J<\/i> 2025; 89: 1182\u20131189.","DOI":"10.1253\/circj.CJ-24-0770"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Aida H, Tanaka M, Sato T, Kawaharata W, Matsumori R, Hosaka I, et al. Elevated level of estimated small dense LDL cholesterol is independently associated with the development of hypertension, regardless of LDL cholesterol level. <i>Hypertens Res<\/i> 2025; 48: 3091\u20133100.","DOI":"10.1038\/s41440-025-02374-x"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Vaziri ND. Role of dyslipidemia in impairment of energy metabolism, oxidative stress, inflammation and cardiovascular disease in chronic kidney disease. <i>Clin Exp Nephrol<\/i> 2014; 18: 265\u2013268.","DOI":"10.1007\/s10157-013-0847-z"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Tanaka M, Sato T, Kawaharata W, Aida H, Furuhashi M. Small dense low-density lipoprotein cholesterol and renal function: A missing link in cardiovascular risk assessment for chronic kidney disease patients: Reply. <i>Circ J<\/i> 2025; 89: 848\u2013849.","DOI":"10.1253\/circj.CJ-25-0326"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, et al. Revised equations for estimated GFR from serum creatinine in Japan. <i>Am J Kidney Dis<\/i> 2009; 53: 982\u2013992.","DOI":"10.1053\/j.ajkd.2008.12.034"},{"key":"28","unstructured":"28. Kidney Disease: Improving Global Outcomes (KDIGO) CKD Work Group. KDIGO 2024 clinical practice guideline for the evaluation and management of chronic kidney disease. <i>Kidney Int<\/i> 2024; 105(4S): S117\u2013S314."},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. DeLong ER, DeLong DM, Clarke-Pearson DL. Comparing the areas under two or more correlated receiver operating characteristic curves: A nonparametric approach. <i>Biometrics<\/i> 1988; 44: 837\u2013845.","DOI":"10.2307\/2531595"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Pencina MJ, D\u2019Agostino RB, Pencina KM, Janssens AC, Greenland P. Interpreting incremental value of markers added to risk prediction models. <i>Am J Epidemiol<\/i> 2012; 176: 473\u2013481.","DOI":"10.1093\/aje\/kws207"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Pencina MJ, D\u2019Agostino RB Sr, Steyerberg EW. Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers. <i>Stat Med<\/i> 2011; 30: 11\u201321.","DOI":"10.1002\/sim.4085"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Kanda Y. Investigation of the freely available easy-to-use software \u201cEZR\u201d for medical statistics. <i>Bone Marrow Transplant<\/i> 2013; 48: 452\u2013458.","DOI":"10.1038\/bmt.2012.244"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Hattori Y, Suzuki M, Tsushima M, Yoshida M, Tokunaga Y, Wang Y, et al. Development of approximate formula for LDL-chol, LDL-apo B and LDL-chol\/LDL-apo B as indices of hyperapobetalipoproteinemia and small dense LDL. <i>Atherosclerosis<\/i> 1998; 138: 289\u2013299.","DOI":"10.1016\/S0021-9150(98)00034-3"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Bae JC, Han JM, Kwon S, Jee JH, Yu TY, Lee MK, et al. LDL-C\/apoB and HDL-C\/apoA-1 ratios predict incident chronic kidney disease in a large apparently healthy cohort. <i>Atherosclerosis<\/i> 2016; 251: 170\u2013176.","DOI":"10.1016\/j.atherosclerosis.2016.06.029"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Higashioka M, Sakata S, Honda T, Hata J, Shibata M, Yoshida D, et al. The association of small dense low-density lipoprotein cholesterol and coronary heart disease in subjects at high cardiovascular risk. <i>J Atheroscler Thromb<\/i> 2021; 28: 79\u201389.","DOI":"10.5551\/jat.55350"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Rangaswami J, Bhalla V, Blair JEA, Chang TI, Costa S, Lentine KL, et al. Cardiorenal syndrome: Classification, pathophysiology, diagnosis, and treatment strategies: A scientific statement from the American Heart Association. <i>Circulation<\/i> 2019; 139: e840\u2013e878.","DOI":"10.1161\/CIR.0000000000000664"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Ndumele CE, Neeland IJ, Tuttle KR, Chow SL, Mathew RO, Khan SS, et al. A synopsis of the evidence for the science and clinical management of cardiovascular-kidney-metabolic (CKM) syndrome: A scientific statement from the American Heart Association. <i>Circulation<\/i> 2023; 148: 1636\u20131664.","DOI":"10.1161\/CIR.0000000000001186"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Khan SS, Coresh J, Pencina MJ, Ndumele CE, Rangaswami J, Chow SL, et al. Novel prediction equations for absolute risk assessment of total cardiovascular disease incorporating cardiovascular-kidney-metabolic health: A scientific statement from the American Heart Association. <i>Circulation<\/i> 2023; 148: 1982\u20132004.","DOI":"10.1161\/CIR.0000000000001191"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Choi SH, Ginsberg HN. Increased very low density lipoprotein (VLDL) secretion, hepatic steatosis, and insulin resistance. <i>Trends Endocrinol Metab<\/i> 2011; 22: 353\u2013363.","DOI":"10.1016\/j.tem.2011.04.007"},{"key":"40","doi-asserted-by":"crossref","unstructured":"40. Anumas S, Inagi R. Mitigating lipotoxicity: A potential mechanism to delay chronic kidney disease progression using current pharmacological therapies. <i>Nephrology (Carlton)<\/i> 2025; 30: e70098.","DOI":"10.1111\/nep.70098"},{"key":"41","doi-asserted-by":"crossref","unstructured":"41. Nishi H, Higashihara T, Inagi R. Lipotoxicity in kidney, heart, and skeletal muscle dysfunction. <i>Nutrients<\/i> 2019; 11: 1664.","DOI":"10.3390\/nu11071664"},{"key":"42","doi-asserted-by":"crossref","unstructured":"42. Goulinet S, Chapman MJ. Plasma LDL and HDL subspecies are heterogenous in particle content of tocopherols and oxygenated and hydrocarbon carotenoids. Relevance to oxidative resistance and atherogenesis. <i>Arterioscler Thromb Vasc Biol<\/i> 1997; 17: 786\u2013796.","DOI":"10.1161\/01.ATV.17.4.786"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Chancharme L, Therond P, Nigon F, Lepage S, Couturier M, Chapman MJ. Cholesteryl ester hydroperoxide lability is a key feature of the oxidative susceptibility of small, dense LDL. <i>Arterioscler Thromb Vasc Biol<\/i> 1999; 19: 810\u2013820.","DOI":"10.1161\/01.ATV.19.3.810"},{"key":"44","doi-asserted-by":"crossref","unstructured":"44. Packard CJ, Demant T, Stewart JP, Bedford D, Caslake MJ, Schwertfeger G, et al. Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions. <i>J Lipid Res<\/i> 2000; 41: 305\u2013318.","DOI":"10.1016\/S0022-2275(20)32065-4"},{"key":"45","doi-asserted-by":"crossref","unstructured":"45. Ruan XZ, Varghese Z, Moorhead JF. 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