{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:43:43Z","timestamp":1792813423755,"version":"4.5.0"},"reference-count":25,"publisher":"Japanese Circulation Society","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ J"],"published-print":{"date-parts":[[2026,10,23]]},"DOI":"10.1253\/circj.cj-26-0427","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T22:11:00Z","timestamp":1787263860000},"page":"1596-1605","source":"Crossref","is-referenced-by-count":3,"title":["Longitudinal Transcriptomic Analysis Identifies Persistent Immune-Related Signature Associated With Restrictive Left Ventricular Filling Patterns After Heart Transplantation"],"prefix":"10.1253","volume":"90","author":[{"given":"Kosuke","family":"Takahari","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Osaka Graduate School of Medicine"},{"name":"Department of Cardiovascular Medicine, Hiroshima University Graduate School of Biomedical and Health Sciences"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Shiraki","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Osaka Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidetaka","family":"Kioka","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Osaka Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Osaka Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Akazawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Osaka Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Nakamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Osaka Keisatsu Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kuramoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Osaka Graduate School of Medicine"},{"name":"Department of Pathophysiology of Heart Failure and Therapeutics, National Cerebral and Cardiovascular Center"},{"name":"Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), The University of Osaka"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hibiki","family":"Mima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Osaka Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fusako","family":"Sera","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Osaka Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuharu","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Osaka Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumasa","family":"Tsukamoto","sequence":"additional","affiliation":[{"name":"Department of Transplant Medicine, National Cerebral and Cardiovascular Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isamu","family":"Mizote","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Osaka Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyo","family":"Hamana","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, Kobe University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohito","family":"Ohtani","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Osaka Graduate School of Medicine"},{"name":"Department of Cardiovascular Medicine, Faculty of Medical Sciences, University of Fukui"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeru","family":"Miyagawa","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, The University of Osaka Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Sakata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, The University of Osaka Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Khush KK, Cherikh WS, Chambers DC, Harhay MO, Hayes D Jr, Hsich E, et al. The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-sixth adult heart transplantation report \u2013 2019; focus theme: Donor and recipient size match. <i>J Heart Lung Transplant<\/i> 2019; 38: 1056\u20131066.","DOI":"10.1016\/j.healun.2019.08.004"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Tallaj JA, Kirklin JK, Brown RN, Rayburn BK, Bourge RC, Benza RL, et al. Post-heart transplant diastolic dysfunction is a risk factor for mortality. <i>J Am Coll Cardiol<\/i> 2007; 50: 1064\u20131069.","DOI":"10.1016\/j.jacc.2007.06.007"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Otsuka K, Takenaka S, Nagai T, Sato T, Konishi T, Tada A, et al. Association of lipid core burden index with early progression of cardiac allograft vasculopathy in patients after heart transplantation. <i>Circ J<\/i> 2026; 90: 752\u2013754, doi:10.1253\/circj.CJ-26-0175.","DOI":"10.1253\/circj.CJ-26-0175"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Shiraki T, Ichibori Y, Ohtani T, Mizote I, Kioka H, Tsukamoto Y, et al. Pathophysiological evaluations of initial plaque development after heart transplantation via serial multimodality imaging and cytokine assessments. <i>J Heart Lung Transplant<\/i> 2022; 41: 877\u2013885.","DOI":"10.1016\/j.healun.2022.03.007"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Vejpongsa P, Torre-Amione G, Marcos-Abdala HG, Kumar S, Youker K, Bhimaraj A, et al. Long term development of diastolic dysfunction and heart failure with preserved left ventricular ejection fraction in heart transplant recipients. <i>Sci Rep<\/i> 2022; 12: 3834.","DOI":"10.1038\/s41598-022-07888-9"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Steding-Ehrenborg K, Nelsson A, Hedstr\u00f6m E, Engblom H, Ingvarsson A, Nilsson J, et al. Diastolic filling in patients after heart transplantation is impaired due to an altered geometrical relationship between the left atrium and ventricle. <i>J Am Heart Assoc<\/i> 2024; 13: e033672.","DOI":"10.1161\/JAHA.123.033672"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Clemmensen TS, Eiskj\u00e6r H, L\u00f8gstrup BB, Ilkj\u00e6r LB, Poulsen SH. Left ventricular global longitudinal strain predicts major adverse cardiac events and all-cause mortality in heart transplant patients. <i>J Heart Lung Transplant<\/i> 2017; 36: 567\u2013576.","DOI":"10.1016\/j.healun.2016.12.002"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Velleca A, Shullo MA, Dhital K, Azeka E, Colvin M, DePasquale E, et al. The International Society for Heart and Lung Transplantation (ISHLT) guidelines for the care of heart transplant recipients. <i>J Heart Lung Transplant<\/i> 2023; 42: e1\u2013e141.","DOI":"10.1016\/j.healun.2022.10.015"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Li X, Turaga D, Li RG, Tsai CR, Quinn JN, Zhao Y, et al. The macrophage landscape across the lifespan of a human cardiac allograft. <i>Circulation<\/i> 2024; 149: 1650\u20131666.","DOI":"10.1161\/CIRCULATIONAHA.123.065294"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Amancherla K, Qin J, Hulke ML, Pfeiffer RD, Agrawal V, Sheng Q, et al. Single-nuclear RNA sequencing of endomyocardial biopsies identifies persistence of donor-recipient chimerism with distinct signatures in severe cardiac allograft vasculopathy. <i>Circ Heart Fail<\/i> 2023; 16: e010119.","DOI":"10.1161\/CIRCHEARTFAILURE.122.010119"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Stewart S, Winters GL, Fishbein MC, Tazelaar HD, Kobashigawa J, Abrams J, et al. Revision of the 1990 working formulation for the standardization of nomenclature in the diagnosis of heart rejection. <i>J Heart Lung Transplant<\/i> 2005; 24: 1710\u20131720.","DOI":"10.1016\/j.healun.2005.03.019"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Berry GJ, Burke MM, Andersen C, Bruneval P, Fedrigo M, Fishbein MC, et al. The 2013 International Society for Heart and Lung Transplantation Working Formulation for the standardization of nomenclature in the pathologic diagnosis of antibody-mediated rejection in heart transplantation. <i>J Heart Lung Transplant<\/i> 2013; 32: 1147\u20131162.","DOI":"10.1016\/j.healun.2013.08.011"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Lang RM, Badano LP, Mor-Avi V, Afilalo J, Armstrong A, Ernande L, et al. Recommendations for cardiac chamber quantification by echocardiography in adults: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. <i>J Am Soc Echocardiogr<\/i> 2015; 28: 1\u201339.e14.","DOI":"10.1016\/j.echo.2014.10.003"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Nagueh SF, Smiseth OA, Appleton CP, Byrd BF 3rd, Dokainish H, Edvardsen T, et al. Recommendations for the evaluation of left ventricular diastolic function by echocardiography: An update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. <i>J Am Soc Echocardiogr<\/i> 2016; 29: 277\u2013314.","DOI":"10.1016\/j.echo.2016.01.011"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Mehra MR, Crespo-Leiro MG, Dipchand A, Ensminger SM, Hiemann NE, Kobashigawa JA, et al. International Society for Heart and Lung Transplantation working formulation of a standardized nomenclature for cardiac allograft vasculopathy \u2013 2010. <i>J Heart Lung Transplant<\/i> 2010; 29: 717\u2013727.","DOI":"10.1016\/j.healun.2010.05.017"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kobashigawa JA, Itagaki BK, Razi RR, Patel JK, Chai W, Kawano MA, et al. Correlation between myocardial fibrosis and restrictive cardiac physiology in patients undergoing retransplantation. <i>Clin Transplant<\/i> 2013; 27: E679\u2013E684.","DOI":"10.1111\/ctr.12250"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Valantine HA, Appleton CP, Hatle LK, Hunt SA, Billingham ME, Shumway NE, et al. A hemodynamic and Doppler echocardiographic study of ventricular function in long-term cardiac allograft recipients: Etiology and prognosis of restrictive-constrictive physiology. <i>Circulation<\/i> 1989; 79: 66\u201375.","DOI":"10.1161\/01.CIR.79.1.66"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Chamberlain R, Edwards NFA, Scalia GM, Chan J. Novel left and right ventricular strain analysis to detect subclinical myocardial dysfunction in cardiac allograft rejection. <i>Int J Cardiovasc Imaging<\/i> 2022; 38: 1077\u20131088.","DOI":"10.1007\/s10554-021-02486-8"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Barber DL, Wherry EJ, Masopust D, Zhu B, Allison JP, Sharpe AH, et al. Restoring function in exhausted CD8 T cells during chronic viral infection. <i>Nature<\/i> 2006; 439: 682\u2013687.","DOI":"10.1038\/nature04444"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Eleid MF, Caracciolo G, Cho EJ, Scott RL, Steidley DE, Wilansky S, et al. Natural history of left ventricular mechanics in transplanted hearts: Relationships with clinical variables and genetic expression profiles of allograft rejection. <i>JACC Cardiovasc Imaging<\/i> 2010; 3: 989\u20131000.","DOI":"10.1016\/j.jcmg.2010.07.009"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Nakano K, Yamamoto M, Yamada Y, Nakatsukasa T, Kawamatsu N, Sato K, et al. Mitochondrial structural abnormalities and cardiac reverse remodeling in patients with systolic dysfunction. <i>Circ J<\/i> 2024; 89: 101\u2013108.","DOI":"10.1253\/circj.CJ-24-0451"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Lichscheidt ED, Jespersen NR, Nielsen BRR, Berg K, Seefeldt J, Nyengaard JR, et al. Abnormal mitochondrial function and morphology in heart transplanted patients with cardiac allograft vasculopathy. <i>J Heart Lung Transplant<\/i> 2022; 41: 732\u2013741.","DOI":"10.1016\/j.healun.2022.01.1376"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Zhou B, Tian R. Mitochondrial dysfunction in pathophysiology of heart failure. <i>J Clin Invest<\/i> 2018; 128: 3716\u20133726.","DOI":"10.1172\/JCI120849"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Frisk C, Das S, Eriksson MJ, Walentinsson A, Corbascio M, Hage C, et al. Cardiac biopsies reveal differences in transcriptomics between left and right ventricle in patients with or without diagnostic signs of heart failure. <i>Sci Rep<\/i> 2024; 14: 5811.","DOI":"10.1038\/s41598-024-56025-1"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Daud A, Xu D, Revelo MP, Shah Z, Drakos SG, Dranow E, et al. Microvascular loss and diastolic dysfunction in severe symptomatic cardiac allograft vasculopathy. <i>Circ Heart Fail<\/i> 2018; 11: e004759.","DOI":"10.1161\/CIRCHEARTFAILURE.117.004759"}],"container-title":["Circulation Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/90\/11\/90_CJ-26-0427\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T03:23:42Z","timestamp":1792812222000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circj\/90\/11\/90_CJ-26-0427\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,23]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1253\/circj.cj-26-0427","relation":{},"ISSN":["1346-9843","1347-4820"],"issn-type":[{"value":"1346-9843","type":"print"},{"value":"1347-4820","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,23]]},"article-number":"CJ-26-0427"}}