{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T09:25:45Z","timestamp":1763457945339},"reference-count":26,"publisher":"Japanese Circulation Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ Rep"],"published-print":{"date-parts":[[2020,9,10]]},"DOI":"10.1253\/circrep.cr-20-0055","type":"journal-article","created":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T18:07:13Z","timestamp":1596823633000},"page":"531-535","source":"Crossref","is-referenced-by-count":5,"title":["Rationale and Design of Therapeutic Angiogenesis by Cell Transplantation Using Adipose-Derived Regenerative Cells in Patients With Critical Limb Ischemia\u3000\u2015 TACT-ADRC Multicenter Trial \u2015"],"prefix":"10.1253","volume":"2","author":[{"given":"Yuuki","family":"Shimizu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Nagoya University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhisa","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nagoya University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Fukumoto","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Internal Medicine, Kurume University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Takamura","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Graduate School of Medical Science, Kanazawa University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teruo","family":"Inoue","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Dokkyo Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tokuichiro","family":"Nagata","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, St. Marianna University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro J.","family":"Akashi","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Department of Internal Medicine, St. Marianna University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Yamada","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Fukuoka Tokushukai Medical Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Kuwahara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Shinshu University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rei","family":"Shibata","sequence":"additional","affiliation":[{"name":"Department of Advanced Cardiovascular Therapeutics, Nagoya University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyoaki","family":"Murohara","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Nagoya University Graduate School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"on behalf of the TACT-ADRC Multicenter Trial Group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Aboyans V, Ricco JB, Bartelink MEL, Bjorck M, Brodmann M, Cohnert T, et al. and Group ESCSD. 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS). <i>Eur Heart J<\/i> 2018; 39: 763\u2013816.","DOI":"10.1093\/eurheartj\/ehx095"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Beckman JA, Duncan MS, Damrauer SM, Wells QS, Barnett JV, Wasserman DH, et al. Microvascular disease, peripheral artery disease, and amputation. <i>Circulation<\/i> 2019; 140: 449\u2013458.","DOI":"10.1161\/CIRCULATIONAHA.119.040672"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Bevan GH, White Solaru KT. Evidence-based medical management of peripheral artery disease. <i>Arterioscler Thromb Vasc Biol<\/i> 2020; 40: 541\u2013553.","DOI":"10.1161\/ATVBAHA.119.312142"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Gerhard-Herman MD, Gornik HL, Barrett C, Barshes NR, Corriere MA, Drachman DE, et al. 2016 AHA\/ACC guideline on the management of patients with lower extremity peripheral artery disease. <i>Circulation<\/i> 2017; 135: e726\u2013e779.","DOI":"10.1161\/CIR.0000000000000470"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Miyahara T, Suhara M, Nemoto Y, Shirasu T, Haga M, Mochizuki Y, et al. Long-term results of treatment for critical limb ischemia. <i>Ann Vasc Dis<\/i> 2015; 8: 192\u2013197.","DOI":"10.3400\/avd.oa.15-00074"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Tateishi-Yuyama E, Matsubara H, Murohara T, Ikeda U, Shintani S, Masaki H, et al. Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: A pilot study and a randomised controlled trial. <i>Lancet<\/i> 2002; 360: 427\u2013435.","DOI":"10.1016\/S0140-6736(02)09670-8"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Kondo K, Yanishi K, Hayashida R, Shintani S, Shibata R, Murotani K, et al. Long-term clinical outcomes survey of bone marrow-derived cell therapy in critical limb ischemia in Japan. <i>Circ J<\/i> 2018; 82: 1168\u20131178.","DOI":"10.1253\/circj.CJ-17-0510"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Zuk PA, Zhu M, Mizuno H, Huang J, Futrell JW, Katz AJ, et al. Multilineage cells from human adipose tissue: Implications for cell-based therapies. <i>Tissue Eng<\/i> 2001; 7: 211\u2013228.","DOI":"10.1089\/107632701300062859"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Rehman J, Traktuev D, Li J, Merfeld-Clauss S, Temm-Grove CJ, Bovenkerk JE, et al. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. <i>Circulation<\/i> 2004; 109: 1292\u20131298.","DOI":"10.1161\/01.CIR.0000121425.42966.F1"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Nakagami H, Maeda K, Morishita R, Iguchi S, Nishikawa T, Takami Y, et al. Novel autologous cell therapy in ischemic limb disease through growth factor secretion by cultured adipose tissue-derived stromal cells. <i>Arterioscler Thromb Vasc Biol<\/i> 2005; 25: 2542\u20132547.","DOI":"10.1161\/01.ATV.0000190701.92007.6d"},{"key":"11","unstructured":"11. Wang JH, Liu N, Du HW, Weng JS, Chen RH, Xiao YC, et al. Effects of adipose-derived stem cell transplantation on the angiogenesis and the expression of bFGF and VEGF in the brain post focal cerebral ischemia in rats. <i>Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi<\/i> 2008; 24: 958\u2013961 (in Chinese)."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Kondo K, Shintani S, Shibata R, Murakami H, Murakami R, Imaizumi M, et al. Implantation of adipose-derived regenerative cells enhances ischemia-induced angiogenesis. <i>Arterioscler Thromb Vasc Biol<\/i> 2009; 29: 61\u201366.","DOI":"10.1161\/ATVBAHA.108.166496"},{"key":"13","unstructured":"13. Kesten S, Fraser JK. Autologous adipose derived regenerative cells: A platform for therapeutic applications. <i>Surg Technol Int<\/i> 2016; 29: 38\u201344."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Lee HC, An SG, Lee HW, Park JS, Cha KS, Hong TJ, et al. Safety and effect of adipose tissue-derived stem cell implantation in patients with critical limb ischemia: A pilot study. <i>Circ J<\/i> 2012; 76: 1750\u20131760.","DOI":"10.1253\/circj.CJ-11-1135"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Bura A, Planat-Benard V, Bourin P, Silvestre JS, Gross F, Grolleau JL, et al. Phase I trial: The use of autologous cultured adipose-derived stroma\/stem cells to treat patients with non-revascularizable critical limb ischemia. <i>Cytotherapy<\/i> 2014; 16: 245\u2013257.","DOI":"10.1016\/j.jcyt.2013.11.011"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Rigato M, Monami M, Fadini GP. Autologous cell therapy for peripheral arterial disease: Systematic review and meta-analysis of randomized, nonrandomized, and noncontrolled studies. <i>Circ Res<\/i> 2017; 120: 1326\u20131340.","DOI":"10.1161\/CIRCRESAHA.116.309045"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Yamamoto T, Gotoh M, Kato M, Majima T, Toriyama K, Kamei Y, et al. Periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress urinary incontinence: Report of three initial cases. <i>Int J Urol<\/i> 2012; 19: 652\u2013659.","DOI":"10.1111\/j.1442-2042.2012.02999.x"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Lin K, Matsubara Y, Masuda Y, Togashi K, Ohno T, Tamura T, et al. Characterization of adipose tissue-derived cells isolated with the Celution system. <i>Cytotherapy<\/i> 2008; 10: 417\u2013426.","DOI":"10.1080\/14653240801982979"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Aronowitz JA and Ellenhorn JD. Adipose stromal vascular fraction isolation: A head-to-head comparison of four commercial cell separation systems. <i>Plast Reconstr Surg<\/i> 2013; 132: 932e\u2013939e.","DOI":"10.1097\/PRS.0b013e3182a80652"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Adam DJ, Beard JD, Cleveland T, Bell J, Bradbury AW, Forbes JF, et al. Bypass versus angioplasty in severe ischaemia of the leg (BASIL): Multicentre, randomised controlled trial. <i>Lancet<\/i> 2005; 366: 1925\u20131934.","DOI":"10.1016\/S0140-6736(05)67704-5"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Abu Dabrh AM, Steffen MW, Undavalli C, Asi N, Wang Z, Elamin MB, et al. The natural history of untreated severe or critical limb ischemia. <i>J Vasc Surg<\/i> 2015; 62: 1642\u20131651.e3.","DOI":"10.1016\/j.jvs.2015.07.065"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Uccioli L, Meloni M, Izzo V, Giurato L, Merolla S, Gandini R. Critical limb ischemia: Current challenges and future prospects. <i>Vasc Health Risk Manag<\/i> 2018; 14: 63\u201374.","DOI":"10.2147\/VHRM.S125065"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Norgren L, Hiatt WR, Dormandy JA, Nehler MR, Harris KA, Fowkes FG, et al. Inter-Society consensus for the management of peripheral arterial disease (TASC II). <i>J Vasc Surg<\/i> 2007; 45(Suppl S): S5\u2013S67.","DOI":"10.1016\/j.jvs.2006.12.037"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Lee YJ. Quick and simple approximation of sample sizes for comparing two independent binomial distributions: Different-sample-size case. <i>Biometrics<\/i> 1984; 40: 239\u2013241.","DOI":"10.2307\/2530765"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Harvey BJ, Lang TA. Hypothesis testing, study power, and sample size. <i>Chest<\/i> 2010; 138: 734\u2013737.","DOI":"10.1378\/chest.10-0067"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Kajiguchi M, Kondo T, Izawa H, Kobayashi M, Yamamoto K, Shintani S, et al. Safety and efficacy of autologous progenitor cell transplantation for therapeutic angiogenesis in patients with critical limb ischemia. <i>Circ J<\/i> 2007; 71: 196\u2013201.","DOI":"10.1253\/circj.71.196"}],"container-title":["Circulation Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circrep\/2\/9\/2_CR-20-0055\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T23:23:06Z","timestamp":1599866586000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circrep\/2\/9\/2_CR-20-0055\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,10]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020]]}},"URL":"https:\/\/doi.org\/10.1253\/circrep.cr-20-0055","relation":{},"ISSN":["2434-0790"],"issn-type":[{"type":"electronic","value":"2434-0790"}],"subject":[],"published":{"date-parts":[[2020,9,10]]}}}