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Activation of autophagy ameliorates cardiomyopathy in <i>Mybpc3<\/i>-targeted knockin mice. <i>Circ Heart Fail<\/i> 2017; 10: e004140, doi:10.1161\/circheartfailure.117.004140.","DOI":"10.1161\/CIRCHEARTFAILURE.117.004140"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5. Daniels BH, McComb RD, Mobley BC, Gultekin SH, Lee HS, Margeta M. LC3 and p62 as diagnostic markers of drug-induced autophagic vacuolar cardiomyopathy: A study of 3 cases. <i>Am J Surg Pathol<\/i> 2013; 37: 1014\u20131021, doi:10.1097\/PAS.0b013e3182863fa8.","DOI":"10.1097\/PAS.0b013e3182863fa8"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6. Otsuka K, Terasaki F, Shimomura H, Tsukada B, Horii T, Isomura T, et al. Enhanced expression of the ubiquitin-proteasome system in the myocardium from patients with dilated cardiomyopathy referred for left ventriculoplasty: An immunohistochemical study with special reference to oxidative stress. <i>Heart Vessels<\/i> 2010; 25: 474\u2013484, doi:10.1007\/s00380-010-0006-3.","DOI":"10.1007\/s00380-010-0006-3"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Weekes J, Morrison K, Mullen A, Wait R, Barton P, Dunn MJ. Hyperubiquitination of proteins in dilated cardiomyopathy. <i>Proteomics<\/i> 2003; 3: 208\u2013216, doi:10.1002\/pmic.200390029.","DOI":"10.1002\/pmic.200390029"},{"key":"8","doi-asserted-by":"publisher","unstructured":"8. Ji XY, Zheng D, Ni R, Wang JX, Shao JQ, Vue Z, et al. Sustained over-expression of calpain-2 induces age-dependent dilated cardiomyopathy in mice through aberrant autophagy. <i>Acta Pharmacol Sin<\/i> 2022; 43: 2873\u20132884, doi:10.1038\/s41401-022-00965-9.","DOI":"10.1038\/s41401-022-00965-9"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Corsetti G, Chen-Scarabelli C, Romano C, Pasini E, Dioguardi FS, Onorati F, et al. Autophagy and oncosis\/necroptosis are enhanced in cardiomyocytes from heart failure patients. <i>Med Sci Monit Basic Res<\/i> 2019; 25: 33\u201344, doi:10.12659\/msmbr.913436.","DOI":"10.12659\/MSMBR.913436"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Kanamori H, Yoshida A, Naruse G, Endo S, Minatoguchi S, Watanabe T, et al. Impact of autophagy on prognosis of patients with dilated cardiomyopathy. <i>J Am Coll Cardiol<\/i> 2022; 79: 789\u2013801, doi:10.1016\/j.jacc.2021.11.059.","DOI":"10.1016\/j.jacc.2021.11.059"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Kassiotis C, Ballal K, Wellnitz K, Vela D, Gong M, Salazar R, et al. Markers of autophagy are downregulated in failing human heart after mechanical unloading. <i>Circulation<\/i> 2009; 120(Suppl): S191\u2013S197, doi:10.1161\/circulationaha.108.842252.","DOI":"10.1161\/CIRCULATIONAHA.108.842252"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Caragnano A, Aleksova A, Bulfoni M, Cervellin C, Rolle IG, Veneziano C, et al. Autophagy and inflammasome activation in dilated cardiomyopathy. <i>J Clin Med<\/i> 2019; 8: 1519, doi:10.3390\/jcm8101519.","DOI":"10.3390\/jcm8101519"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. van der Klooster ZJ, Sepehrkhouy S, Dooijes D, Te Rijdt WP, Schuiringa F, Lingeman J, et al. 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