{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T04:04:39Z","timestamp":1773461079470,"version":"3.50.1"},"reference-count":37,"publisher":"Japanese Circulation Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ Rep"],"published-print":{"date-parts":[[2026,3,10]]},"DOI":"10.1253\/circrep.cr-25-0186","type":"journal-article","created":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T22:09:09Z","timestamp":1766786949000},"page":"438-446","source":"Crossref","is-referenced-by-count":0,"title":["Association Between Reduction in Loop Diuretics and Heart Failure Rehospitalization After Transcatheter Aortic Valve Replacement"],"prefix":"10.1253","volume":"8","author":[{"given":"Koki","family":"Takegawa","sequence":"first","affiliation":[{"name":"Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center"},{"name":"Department of Cardiovascular Medicine, Institute of Science Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koshiro","family":"Kanaoka","sequence":"additional","affiliation":[{"name":"Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshitaka","family":"Iwanaga","sequence":"additional","affiliation":[{"name":"Department of Medical and Health Information Management, National Cerebral and Cardiovascular Center"},{"name":"Department of Cardiology, Sakurabashi-Watanabe Hospital"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Sasano","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Institute of Science Tokyo"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Nishioka","sequence":"additional","affiliation":[{"name":"Department of Public Health, Health Management and Policy, Nara Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoya","family":"Myojin","sequence":"additional","affiliation":[{"name":"Department of Public Health, Health Management and Policy, Nara Medical University"},{"name":"Department of Community Health and Preventive Medicine, Hamamatsu University School of Medicine"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuya","family":"Noda","sequence":"additional","affiliation":[{"name":"Department of Public Health, Health Management and Policy, Nara Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoaki","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Public Health, Health Management and Policy, Nara Medical University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiro","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Open Innovation Center, National Cerebral and Cardiovascular Center"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Vahanian A, Beyersdorf F, Praz F, Milojevic M, Baldus S, Bauersachs J, et al. 2021 ESC\/EACTS Guidelines for the management of valvular heart disease: Developed by the Task Force for the management of valvular heart disease of the European Society of Cardiology (ESC) and the European Association for Cardio-Thoracic Surgery (EACTS). <i>Eur Heart J<\/i> 2022; 43: 561\u2013632.","DOI":"10.1093\/eurheartj\/ehac051"},{"key":"2","unstructured":"2. Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP 3rd, Gentile F, et al. 2020 ACC\/AHA guideline for the management of patients with valvular heart disease. A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. Developed in collaboration with and endorsed by the American Association for Thoracic Surgery, American Society of Echocardiography, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Anesthesiologists, and Society of Thoracic Surgeons. <i>Circulation<\/i> 2021; 143: e35\u2013e71."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Thyregod HG, J\u00f8rgensen TH, Ihlemann N, Steinbr\u00fcchel DA, Nissen H, Kjeldsen BJ, et al. Transcatheter or surgical aortic valve implantation: 10-year outcomes of the NOTION trial. <i>Eur Heart J<\/i> 2024; 45: 1116\u20131124.","DOI":"10.1093\/eurheartj\/ehae043"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Auffret V, Bakhti A, Leurent G, Bedossa M, Tomasi J, Soulami RB, et al. Determinants and impact of heart failure readmission following transcatheter aortic valve replacement. <i>Circ Cardiovasc Interv<\/i> 2020; 13: e008959.","DOI":"10.1161\/CIRCINTERVENTIONS.120.008959"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Nitsche C, Kammerlander AA, Koschutnik M, Sinnhuber L, Forutan N, Eidenberger A, et al. Fluid overload in patients undergoing TAVR: What we can learn from the nephrologists. <i>ESC Heart Fail<\/i> 2021; 8: 1408\u20131416.","DOI":"10.1002\/ehf2.13226"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Matsushita K, Marchandot B, Trimaille A, Hmadeh S, Kibler M, Heger J, et al. Determinants and treatments of heart failure after transcatheter aortic valve implantation: Moving up a notch. <i>ESC Heart Fail<\/i> 2023; 10: 2183\u20132199.","DOI":"10.1002\/ehf2.14435"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. Sugiyama Y, Moriyama N, Miyashita H, Yokoyama H, Ochiai T, Shishido K, et al. Long-term assessment of survival after transcatheter aortic valve implantation: Insights from the International Transcatheter Aortic Valve Implantation Registry. <i>Circ J<\/i> 2024; 88: 462\u2013471.","DOI":"10.1253\/circj.CJ-23-0593"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Lauck SB, Yu M, Ding L, Hardiman S, Wong D, Sathananthan J, et al. Quality-of-life outcomes after transcatheter aortic valve implantation in a \u201creal world\u201d population: Insights from a prospective Canadian database. <i>CJC Open<\/i> 2021; 3: 1033\u20131042.","DOI":"10.1016\/j.cjco.2021.04.006"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Begun X, Butt JH, Kristensen SL, Weeke PE, Backer OD, Schou M, et al. Diuretic treatment before and after transcatheter aortic valve implantation: A Danish nationwide study. <i>PLoS ONE<\/i> 2023; 18: e0282636.","DOI":"10.1371\/journal.pone.0282636"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. McDonagh TA, Metra M, Adamo M, Gardner RS, Baumbach A, B\u00f6hm M, et al. 2023 focused update of the 2021 ESC guidelines for the diagnosis and treatment of acute and chronic heart failure: Developed by the task force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) with the special contribution of the Heart Failure Association (HFA) of the ESC. <i>Eur J Heart Fail<\/i> 2023; 44: 3627\u20133639.","DOI":"10.1093\/eurheartj\/ehad195"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Friday JM, Cleland JGF, Pellicori P, Wolters MK, McMurray JJV, Jhund PS, et al. Loop diuretic therapy with or without heart failure: impact on prognosis. <i>Eur Heart J<\/i> 2024; 45: 3837\u20133849.","DOI":"10.1093\/eurheartj\/ehae345"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Okoye C, Mazzarone T, Cargiolli C, Guarino D. Discontinuation of loop diuretics in older patients with chronic stable heart failure: A narrative review. <i>Drugs Aging<\/i> 2023; 40: 981\u2013990.","DOI":"10.1007\/s40266-023-01061-1"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Laszczy\u0144ska O, Severo M, Fri\u00f5es F, Louren\u00e7o P, Silva S, Bettencourt P, et al. Prognostic effect of the dose of loop diuretic over 5 years in chronic heart failure. <i>J Card Fail<\/i> 2017; 23: 589\u2013593.","DOI":"10.1016\/j.cardfail.2017.04.001"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Rohde LE, Rover MM, Neto JAF, Danzmann LC, Bertoldi EG, Sim\u00f5es MV, et al. Short-term diuretic withdrawal in stable outpatients with mild heart failure and no fluid retention receiving optimal therapy: A double-blind, multicentre, randomized trial. <i>Eur Heart J<\/i> 2019; 40: 3605\u20133612.","DOI":"10.1093\/eurheartj\/ehz554"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Cantey EP, Chang KY, Blair JEA, Brummel K, Sweis RN, Pham DT, et al. Impact of loop diuretic use on outcomes following transcatheter aortic valve implantation. <i>Am J Cardiol<\/i> 2020; 131: 67\u201373.","DOI":"10.1016\/j.amjcard.2020.06.033"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Myojin T, Noda T, Kubo S, Nishioka Y, Higashino T, Imamura T. Development of a new method to trace patient data using the national database in Japan. <i>Adv Biomed Eng<\/i> 2022; 11: 203\u2013217.","DOI":"10.14326\/abe.11.203"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Biegus J, Cotter G, Metra M, Ponikowski P. Decongestion in acute heart failure: Is it time to change diuretic-centred paradigm? <i>Eur J Heart Fail<\/i> 2024; 26: 2094\u20132106.","DOI":"10.1002\/ejhf.3423"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. DeVore AD, Hasselblad V, Mentz RJ, O\u2019Connor CM, Armstrong PW, McMurray JJ, et al. Loop diuretic dose adjustments after a hospitalization for heart failure: Insights from ASCEND-HF. <i>Eur J Heart Fail<\/i> 2015; 17: 340\u2013346.","DOI":"10.1002\/ejhf.235"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Croset F, Ll\u00e0cer P, N\u00fa\u00f1ez J, Campos J, Garc\u00eda M, P\u00e9rez A, et al. Loop diuretic down-titration at discharge in patients hospitalized for acute heart failure. <i>ESC Heart Fail<\/i> 2024; 11: 1739\u20131747.","DOI":"10.1002\/ehf2.14749"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Pellicori P, Fitchett D, Kosiborod MN, Ofstad AP, Seman L, Zinman B, et al. Use of diuretics and outcomes in patients with type 2 diabetes: Findings from the EMPA-REG OUTCOME trial. <i>Eur J Heart Fail<\/i> 2021; 23: 1085\u20131093.","DOI":"10.1002\/ejhf.2220"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. vanPoelgeest E, Paoletti L, \u00d6zk\u00f6k S, Pinar E, Bahat G, Vuong V, et al. The effects of diuretic deprescribing in adult patients: A systematic review to inform an evidence-based diuretic deprescribing guideline. <i>Br J Clin Pharmacol<\/i> 2025; 91: 38\u201354.","DOI":"10.1111\/bcp.16189"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Eshaghian S, Horwich TB, Fonarow GC. Relation of loop diuretic dose to mortality in advanced heart failure. <i>Am J Cardiol<\/i> 2006; 97: 1759\u20131764.","DOI":"10.1016\/j.amjcard.2005.12.072"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Nakano I, Tsuda M, Kinugawa S, Fukushima A, Kakutani N, Takada S, et al. Loop diuretic use is associated with skeletal muscle wasting in patients with heart failure. <i>J Cardiol<\/i> 2020; 76: 109\u2013114.","DOI":"10.1016\/j.jjcc.2020.01.003"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Uemura Y, Shibata R, Sawada K, Ishikawa S, Takemoto K, Murohara T, et al. Prognostic impact of polypharmacy and discharge medications in octogenarians and nonagenarian patients with acute heart failure. <i>Heart Vessels<\/i> 2024; 39: 514\u2013523.","DOI":"10.1007\/s00380-024-02366-w"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Damman K, Kjekshus J, Wikstrand J, Cleland JGF, Komajda M, Wedel H, et al. Loop diuretics, renal function and clinical outcome in patients with heart failure and reduced ejection fraction. <i>Eur J Heart Fail<\/i> 2016; 18: 328\u2013336.","DOI":"10.1002\/ejhf.462"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Mullens W, Damman K, Harjola VP, Mebazaa A, Brunner-La Rocca HP, Martens P, et al. The use of diuretics in heart failure with congestion: A position statement from the Heart Failure Association of the European Society of Cardiology. <i>Eur J Heart Fail<\/i> 2019; 21: 137\u2013155.","DOI":"10.1002\/ejhf.1369"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Fudim M, O\u2019Connor CM, Mulder H, Coles A, Bhatt AS, Ambrosy AP, et al. Loop diuretic adjustments in patients with chronic heart failure: Insights from HF-ACTION. <i>Am Heart J<\/i> 2018; 205: 133\u2013141.","DOI":"10.1016\/j.ahj.2018.06.017"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Martens P, Verbrugge FH, Boonen L, Nijst P, Dupont M, Mullens W. Value of routine investigations to predict loop diuretic down-titration success in stable heart failure. <i>Int J Cardiol<\/i> 2018; 250: 171\u2013175.","DOI":"10.1016\/j.ijcard.2017.10.018"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Scholte NT, Aydin D, Linssen GC, Koudstaal S, Rademaker PC, Geerlings PR, et al. Use of loop diuretics in patients with chronic heart failure: An observational overview. <i>Open Heart<\/i> 2023; 10: e002497.","DOI":"10.1136\/openhrt-2023-002497"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Kapelios CJ, Laroche C, Crespo-Leiro MG, Anker SD, Coats AJS, D\u00edaz-Molina B, et al. Association between loop diuretic dose changes and outcomes in chronic heart failure: Observations from the ESC-EORP Heart Failure Long-Term Registry. <i>Eur J Heart Fail<\/i> 2020; 22: 1424\u20131437.","DOI":"10.1002\/ejhf.1796"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. G\u00e9n\u00e9reux P, Pibarot P, Redfors B, Mack MJ, Makkar RR, Jaber WA, et al. Staging classification of aortic stenosis based on the extent of cardiac damage. <i>Eur Heart J<\/i> 2017; 38: 3351\u20133358.","DOI":"10.1093\/eurheartj\/ehx381"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. G\u00e9n\u00e9reux P, Pibarot P, Redfors B, Bax JJ, Zhao Y, Makkar RR, et al. Evolution and prognostic impact of cardiac damage after aortic valve replacement. <i>J Am Coll Cardiol<\/i> 2022; 80: 783\u2013800.","DOI":"10.1016\/j.jacc.2022.05.006"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Fukui M, Gutpa A, Abdelkarim I, Sharbaugh MS, Althouse AD, Elzomor H, et al. Association of structural and functional cardiac changes with transcatheter aortic valve replacement outcomes in patients with aortic stenosis. <i>JAMA Cardiol<\/i> 2019; 4: 215\u2013222.","DOI":"10.1001\/jamacardio.2018.4830"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Ikenaga T, Kato Y, Kawahira Y, Miyazaki M, Hirata T, Teratani H, et al. Early changes in left ventricular myocardial mechanics after transcatheter aortic valve replacement for severe aortic stenosis. <i>Circ Rep<\/i> 2025; 7: 365\u2013371.","DOI":"10.1253\/circrep.CR-24-0139"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. G\u00e9n\u00e9reux P, Cohen DJ, Pibarot P, Redfors B, Bax JJ, Zhao Y, et al. Cardiac damage and quality of life after aortic valve replacement in the PARTNER Trials. <i>J Am Coll Cardiol<\/i> 2023; 81: 743\u2013752.","DOI":"10.1016\/j.jacc.2022.11.059"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Hirasawa K, vanRosendael PJ, Fortuni F, Singh GK, Kuneman JH, Vollema EM, et al. Prognostic implications of cardiac damage classification based on computed tomography in severe aortic stenosis. <i>Eur Heart J Cardiovasc Imaging<\/i> 2022; 23: 578\u2013585.","DOI":"10.1093\/ehjci\/jeab071"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. G\u00e9n\u00e9reux P, Schwartz A, Oldemeyer JB, Pibarot P, Cohen DJ, Blanke P, et al. Transcatheter aortic-valve replacement for asymptomatic severe aortic stenosis. <i>N Engl J Med<\/i> 2025; 392: 217\u2013227.","DOI":"10.1056\/NEJMoa2405880"}],"container-title":["Circulation Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circrep\/8\/3\/8_CR-25-0186\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T03:20:36Z","timestamp":1773458436000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circrep\/8\/3\/8_CR-25-0186\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,10]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1253\/circrep.cr-25-0186","relation":{},"ISSN":["2434-0790"],"issn-type":[{"value":"2434-0790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,10]]},"article-number":"CR-25-0186"}}