{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T04:08:53Z","timestamp":1789186133147,"version":"build-2803163510"},"reference-count":28,"publisher":"Japanese Circulation Society","issue":"9","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ Rep"],"published-print":{"date-parts":[[2026,9,10]]},"DOI":"10.1253\/circrep.cr-26-0051","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:14:06Z","timestamp":1784067246000},"page":"1512-1522","source":"Crossref","is-referenced-by-count":0,"title":["High-Intensity Statins and the Post-Discharge Clinical Outcomes at 1 Year After Percutaneous Coronary Intervention\u3000\u2015 Insights From STOPDAPT-3 \u2015"],"prefix":"10.1253","volume":"8","author":[{"given":"Tomoya","family":"Kimura","sequence":"first","affiliation":[{"name":"Department of Cardiology, Mitsubishi Kyoto Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirotoshi","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hirakata Kohsai Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Department of Data Science, Hyogo Medical University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Natsuaki","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Saga University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Obayashi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hamamatsu Rosai Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Kokura Memorial Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoru","family":"Suwa","sequence":"additional","affiliation":[{"name":"Department of Cardiology Juntendo University Shizuoka Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Isawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Sendai Kousei Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Takenaka","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hirakata Kohsai Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Dokkyo Medical University Saitama Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takafumi","family":"Yokomatsu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Mitsubishi Kyoto Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiya","family":"Chinen","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Urasoe General Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuki","family":"Doijiri","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Yamato Seiwa Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Kozuma","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Teikyo University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Kouseikai Takai Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Yamaguchi","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokushima University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kitahara","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsunori","family":"Ishino","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Higashiyamato Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koh","family":"Ono","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Division of Cardiology, Hirakata Kohsai Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of STOPDAPT-3 Investigators","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Rao SV, O\u2019Donoghue ML, Ruel M, Rab T, Tamis-Holland JE, Alexander JH, et al. 2025 ACC\/AHA\/ACEP\/NAEMSP\/SCAI Guideline for the management of patients with acute coronary syndromes: A Report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. <i>J Am Coll Cardiol<\/i> 2025; 85: 2135\u20132237.","DOI":"10.1161\/CIR.0000000000001346"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Virani SS, Newby LK, Arnold SV, Bittner V, Brewer LPC, Demeter SH, et al. 2023 AHA\/ACC\/ACCP\/ASPC\/NLA\/PCNA Guideline for the management of patients with chronic coronary disease: A report of the American Heart Association\/American College of Cardiology Joint Committee on Clinical Practice Guidelines. <i>J Am Coll Cardiol<\/i> 2023; 82: 833\u2013955.","DOI":"10.1016\/j.jacc.2023.04.003"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Nakano S, Kohsaka S, Chikamori T, Fukushima K, Kobayashi Y, Kozuma K, et al. JCS 2022 Guideline focused update on diagnosis and treatment in patients with stable coronary artery disease. <i>Circ J<\/i> 2022; 86: 882\u2013915.","DOI":"10.1253\/circj.CJ-21-1041"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Kimura K, Kimura T, Ishihara M, Nakagawa Y, Nakao K, Miyauchi K, et al. JCS 2018 Guideline on diagnosis and treatment of acute coronary syndrome. <i>Circ J<\/i> 2019; 83: 1085\u20131196.","DOI":"10.1253\/circj.CJ-19-0133"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Cannon CP, Braunwald E, McCabe CH, Rader DJ, Rouleau JL, Belder R, et al.; Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis in Myocardial Infarction 22 Investigators. Intensive versus moderate lipid lowering with statins after acute coronary syndromes. <i>N Engl J Med<\/i> 2004; 350: 1495\u20131504.","DOI":"10.1056\/NEJMoa040583"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. De Lemos JA, Blazing MA, Wiviott SD, Lewis EF, Fox KA, White HD, et al. Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: Phase Z of the A to Z trial. <i>JAMA<\/i> 2004; 292: 1307\u20131316.","DOI":"10.1001\/jama.292.11.1307"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. <i>N Engl J Med<\/i> 2005; 352: 1425\u20131435.","DOI":"10.1056\/NEJMoa050461"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Pedersen TR, Faergeman O, Kastelein JJP, Olsson AG, Tikkanen MJ, Holme I, et al.; Incremental Decrease in End Points Through Aggressive Lipid Lowering (IDEAL) Study Group. High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: The IDEAL study: A randomized controlled trial. <i>JAMA<\/i> 2005; 294: 2437\u20132445.","DOI":"10.1001\/jama.294.19.2437"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Armitage J, Bowman L, Wallendszus K, Bulbulia R, Rahimi K, Haynes R, et al. Intensive lowering of LDL cholesterol with 80 mg versus 20 mg simvastatin daily in 12,064 survivors of myocardial infarction: A double-blind randomised trial. <i>Lancet<\/i> 2010; 376: 1658\u20131669.","DOI":"10.1016\/S0140-6736(10)60310-8"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, Bhala N, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: A meta-analysis of data from 170 000 participants in 26 randomised trials. <i>Lancet<\/i> 2010; 376: 1670\u20131681.","DOI":"10.1016\/S0140-6736(10)61350-5"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Taguchi I, Iimuro S, Iwata H, Takashima H, Abe M, Amiya E, et al. High-dose versus low-dose pitavastatin in Japanese patients with stable coronary artery disease (REAL-CAD). <i>Circulation<\/i> 2018; 137: 1997\u20132009.","DOI":"10.1161\/CIRCULATIONAHA.117.032615"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Watanabe H, Morimoto T, Yamamoto K, Obayashi Y, Natsuaki M, Yamaji K, et al. Prevalence and effects of high-intensity statins for Japanese Patients presenting with acute coronary syndrome: A post hoc secondary analysis of STOPDAPT-2 ACS. <i>Circ J<\/i> 2023; 87: 657\u2013668.","DOI":"10.1253\/circj.CJ-22-0650"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Natsuaki M, Watanabe H, Morimoto T, Yamamoto K, Obayashi Y, Nishikawa R, et al. An aspirin-free versus dual antiplatelet strategy for coronary stenting: STOPDAPT-3 randomized trial. <i>Circulation<\/i> 2024; 149: 585\u2013600.","DOI":"10.1161\/CIRCULATIONAHA.123.066720"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Watanabe H, Natsuaki M, Morimoto T, Yamamoto K, Obayashi Y, Nishikawa R, et al. Aspirin vs. clopidogrel monotherapy after percutaneous coronary intervention: 1-Year follow-up of the STOPDAPT-3 trial. <i>Eur Heart J<\/i> 2024; 45: 5042\u20135054.","DOI":"10.1093\/eurheartj\/ehae617"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Urban P, Mehran R, Colleran R, Angiolillo DJ, Byrne RA, Capodanno D, et al. Defining high bleeding risk in patients undergoing percutaneous coronary intervention. <i>Circulation<\/i> 2019; 140: 240\u2013261.","DOI":"10.1161\/CIRCULATIONAHA.119.040167"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. <i>Clin Chem<\/i> 1972; 18: 499\u2013502.","DOI":"10.1093\/clinchem\/18.6.499"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Mehran R, Rao SV, Bhatt DL, Gibson CM, Caixeta A, Eikelboom J, et al. Standardized bleeding definitions for cardiovascular clinical trials: A consensus report from the Bleeding Academic Research Consortium. <i>Circulation<\/i> 2011; 123: 2736\u20132747.","DOI":"10.1161\/CIRCULATIONAHA.110.009449"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Cutlip DE, Windecker S, Mehran R, Boam A, Cohen DJ, van Es GA, et al. Clinical end points in coronary stent trials: A case for standardized definitions. <i>Circulation<\/i> 2007; 115: 2344\u20132351.","DOI":"10.1161\/CIRCULATIONAHA.106.685313"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Giustino G, Chieffo A, Palmerini T, Valgimigli M, Feres F, Abizaid A, et al. Efficacy and safety of dual antiplatelet therapy after complex PCI. <i>J Am Coll Cardiol<\/i> 2016; 68: 1851\u20131864.","DOI":"10.1016\/j.jacc.2016.07.760"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D, et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: The MIRACL study: A randomized controlled trial. <i>JAMA<\/i> 2001; 285: 1711\u20131718.","DOI":"10.1001\/jama.285.13.1711"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Rosenson RS, Kent ST, Brown TM, Farkouh ME, Levitan EB, Yun H, et al. Underutilization of high-intensity statin therapy after hospitalization for coronary heart disease. <i>J Am Coll Cardiol<\/i> 2015; 65: 270\u2013277.","DOI":"10.1016\/j.jacc.2014.09.088"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Cannon CP, de Lemos JA, Rosenson RS, Ballantyne CM, Liu Y, Gao Q, et al. Use of lipid-lowering therapies over 2 years in GOULD, a registry of patients with atherosclerotic cardiovascular disease in the US. <i>JAMA Cardiol<\/i> 2021; 6: 1060\u20131068.","DOI":"10.1001\/jamacardio.2021.1810"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Krychtiuk KA, Ahrens I, Drexel H, Halvorsen S, Hassager C, Huber K, et al. Acute LDL-C reduction post ACS: Strike early and strike strong: From evidence to clinical practice. A clinical consensus statement of the Association for Acute CardioVascular Care (ACVC), in collaboration with the European Association of Preventive Cardiology (EAPC) and the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy. <i>Eur Heart J Acute Cardiovasc Care<\/i> 2022; 11: 939\u2013949.","DOI":"10.1093\/ehjacc\/zuac123"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Smith SC Jr, Grundy SM. 2013 ACC\/AHA Guideline recommends fixed-dose strategies instead of targeted goals to lower blood cholesterol. <i>J Am Coll Cardiol<\/i> 2014; 64: 601\u2013612.","DOI":"10.1016\/j.jacc.2014.06.1159"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Boekholdt SM, Hovingh GK, Mora S, Arsenault BJ, Amarenco P, Pedersen TR, et al. Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: A meta-analysis of statin trials. <i>J Am Coll Cardiol<\/i> 2014; 64: 485\u2013494.","DOI":"10.1016\/j.jacc.2014.02.615"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Amarenco P, Bogousslavsky J, Callahan A, Goldstein LB, Hennerici M, Rudolph AE, et al. High-dose atorvastatin after stroke or transient ischemic attack. <i>N Engl J Med<\/i> 2006; 355: 549\u2013559.","DOI":"10.1056\/NEJMoa061894"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Goldstein LB, Amarenco P, Szarek M, Callahan A, Hennerici M, Sillesen H, et al. Hemorrhagic stroke in the Stroke Prevention by Aggressive Reduction in Cholesterol Levels study. <i>Neurology<\/i> 2008; 70: 2364\u20132370.","DOI":"10.1212\/01.wnl.0000296277.63350.77"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Lee M, Cheng CY, Wu YL, Lee JD, Hsu CY, Ovbiagele B. Association between intensity of low-density lipoprotein cholesterol reduction with statin-based therapies and secondary stroke prevention: A meta-analysis of randomized clinical trials. <i>JAMA Neurol<\/i> 2022; 79: 349\u2013358.","DOI":"10.1001\/jamaneurol.2021.5578"}],"container-title":["Circulation Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circrep\/8\/9\/8_CR-26-0051\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T03:25:36Z","timestamp":1789183536000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circrep\/8\/9\/8_CR-26-0051\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,10]]},"references-count":28,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1253\/circrep.cr-26-0051","relation":{},"ISSN":["2434-0790"],"issn-type":[{"value":"2434-0790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,10]]},"article-number":"CR-26-0051"}}