{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T04:26:33Z","timestamp":1786767993183,"version":"build-2736575974"},"reference-count":38,"publisher":"Japanese Circulation Society","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Circ Rep"],"published-print":{"date-parts":[[2026,8,10]]},"DOI":"10.1253\/circrep.cr-26-0137","type":"journal-article","created":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T22:09:51Z","timestamp":1781734191000},"page":"1289-1298","source":"Crossref","is-referenced-by-count":0,"title":["Association of Non-Severe Aortic Stenosis With Left Ventricular Reverse Remodeling and Clinical Outcomes After Cardiac Resynchronization Therapy"],"prefix":"10.1253","volume":"8","author":[{"given":"Masaki","family":"Ishiyama","sequence":"first","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuji","family":"Kitano","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Omori","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sasou","sequence":"additional","affiliation":[{"name":"Department of Clinical Engineering, Mie University Hospital"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keishi","family":"Moriwaki","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiyo","family":"Sugiura","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Nakamori","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiko","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tairo","family":"Kurita","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaoru","family":"Dohi","sequence":"additional","affiliation":[{"name":"Department of Cardiology and Nephrology, Mie University Graduate School of Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"330","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1. Khan KR, Khan OA, Chen C, Liu Y, Kandanelly RR, Jamiel PJ, et al. Impact of moderate aortic stenosis in patients with heart failure with reduced ejection fraction. <i>J Am Coll Cardiol<\/i> 2023; 81: 1235\u20131244.","DOI":"10.1016\/j.jacc.2023.01.032"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, et al.; Multicenter InSync Randomized Clinical Evaluation (MIRACLE Study Group). Cardiac resynchronization in chronic heart failure. <i>N Engl J Med<\/i> 2002; 346: 1845\u20131853.","DOI":"10.1056\/NEJMoa013168"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3. Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, et al.; Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. <i>N Engl J Med<\/i> 2004; 350: 2140\u20132150.","DOI":"10.1056\/NEJMoa032423"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4. Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kappenberger L, et al.; Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchronization on morbidity and mortality in heart failure. <i>N Engl J Med<\/i> 2005; 352: 1539\u20131549.","DOI":"10.1056\/NEJMoa050496"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5. Moss AJ, Hall WJ, Cannom DS, Klein H, Brown MW, Daubert JP, et al.; MADIT-CRT Trial Investigators. Cardiac-resynchronization therapy for the prevention of heart-failure events. <i>N Engl J Med<\/i> 2009; 361: 1329\u20131338.","DOI":"10.1056\/NEJMoa0906431"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6. Curtis AB, Worley SJ, Adamson PB, Chung ES, Niazi I, Sherfesee L, et al.; Biventricular versus Right Ventricular Pacing in Heart Failure Patients with Atrioventricular Block (BLOCK HF) Trial Investigators. Biventricular pacing for atrioventricular block and systolic dysfunction. <i>N Engl J Med<\/i> 2013; 368: 1585\u20131593.","DOI":"10.1056\/NEJMoa1210356"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7. van Geldorp IE, Vernooy K, Delhaas T, Prins MH, Crijns HJ, Prinzen FW, et al. Beneficial effects of biventricular pacing in chronically right ventricular paced patients with mild cardiomyopathy. <i>Europace<\/i> 2010; 12: 223\u2013229.","DOI":"10.1093\/europace\/eup378"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Goldenberg I, Moss AJ, Hall WJ, Foster E, Goldberger JJ, Santucci P, et al. Predictors of response to cardiac resynchronization therapy in the Multicenter Automatic Defibrillator Implantation Trial With Cardiac Resynchronization Therapy (MADIT-CRT). <i>Circulation<\/i> 2011; 124: 1527\u20131536.","DOI":"10.1161\/CIRCULATIONAHA.110.014324"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9. Prihadi EA, Leung M, Vollema EM, Ng ACT, Ajmone Marsan N, Bax JJ, et al. Prevalence and prognostic relevance of ventricular conduction disturbances in patients with aortic stenosis. <i>Am J Cardiol<\/i> 2017; 120: 2226\u20132232.","DOI":"10.1016\/j.amjcard.2017.08.046"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10. Chen Y, Jia S, Zhang J, Han J, Zhang H, Jiang W. Calcific aortic valve disease: From mechanism to treatment. <i>Circ J<\/i> 2025; 89: 1447\u20131452.","DOI":"10.1253\/circj.CJ-24-0706"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11. Praz F, Borger MA, Lanz J, Marin-Cuartas M, Abreu A, Adamo M, et al.; ESC\/EACTS Scientific Document Group. 2025 ESC\/EACTS Guidelines for the management of valvular heart disease. <i>Eur Heart J<\/i> 2025; 46: 4635\u20134736.","DOI":"10.1093\/ejcts\/ezaf393"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12. Otto CM, Nishimura RA, Bonow RO, Carabello BA, Erwin JP 3rd, Gentile F, et al. 2020 ACC\/AHA Guideline for the management of patients with valvular heart disease: A report of the American College of Cardiology\/American Heart Association Joint Committee on Clinical Practice Guidelines. <i>J Thorac Cardiovasc Surg<\/i> 2021; 162: e183\u2013e353.","DOI":"10.1161\/CIR.0000000000000923"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13. Ypenburg C, van Bommel RJ, Borleffs CJ, Bleeker GB, Boersma E, Schalij MJ, et al. Long-term prognosis after cardiac resynchronization therapy is related to the extent of left ventricular reverse remodeling at midterm follow-up. <i>J Am Coll Cardiol<\/i> 2009; 53: 483\u2013490.","DOI":"10.1016\/j.jacc.2008.10.032"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14. Yu CM, Bleeker GB, Fung JW, Schalij MJ, Zhang Q, van der Wall EE, et al. Left ventricular reverse remodeling but not clinical improvement predicts long-term survival after cardiac resynchronization therapy. <i>Circulation<\/i> 2005; 112: 1580\u20131586.","DOI":"10.1161\/CIRCULATIONAHA.105.538272"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15. Gold MR, Daubert C, Abraham WT, Ghio S, St John Sutton M, Hudnall JH, et al. The effect of reverse remodeling on long-term survival in mildly symptomatic patients with heart failure receiving cardiac resynchronization therapy: Results of the REVERSE study. <i>Heart Rhythm<\/i> 2015; 12: 524\u2013530.","DOI":"10.1016\/j.hrthm.2014.11.014"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16. Kamoshida J, Ueda N, Ishibashi K, Noda T, Kawabata T, Oka S, et al. Elevated B-type natriuretic peptide level as a residual risk factor for ventricular arrhythmias among patients undergoing cardiac resynchronization therapy with improved left ventricular ejection fraction. <i>Circ Rep<\/i> 2024; 6: 407\u2013414.","DOI":"10.1253\/circrep.CR-24-0065"},{"key":"17","doi-asserted-by":"crossref","unstructured":"17. Stassen J, Ewe SH, Pio SM, Pibarot P, Redfors B, Leipsic J, et al. Managing patients with moderate aortic stenosis. <i>JACC Cardiovasc Imaging<\/i> 2023; 16: 837\u2013855.","DOI":"10.1016\/j.jcmg.2022.12.013"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18. Jean G, Van Mieghem NM, Gegenava T, van Gils L, Bernard J, Geleijnse ML, et al. Moderate aortic stenosis in patients with heart failure and reduced ejection fraction. <i>J Am Coll Cardiol<\/i> 2021; 77: 2796\u20132803.","DOI":"10.1016\/j.jacc.2021.04.014"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19. Mizutani H, Fujimoto N, Ito H, Sato T, Moriwaki K, Takasaki A, et al. Prognostic impact of peak aortic jet velocity on patients with acute myocardial infarction. <i>Circ J<\/i> 2022; 86: 1539\u20131546.","DOI":"10.1253\/circj.CJ-22-0217"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20. Ypenburg C, Schalij MJ, Bleeker GB, Steendijk P, Boersma E, Dibbets-Schneider P, et al. Impact of viability and scar tissue on response to cardiac resynchronization therapy in ischaemic heart failure patients. <i>European Heart Journal<\/i> 2007; 28: 33\u201341.","DOI":"10.1093\/eurheartj\/ehl379"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21. Everett RJ, Tastet L, Clavel MA, Chin CWL, Capoulade R, Vassiliou VS, et al. Progression of hypertrophy and myocardial fibrosis in aortic stenosis: A multicenter cardiac magnetic resonance study. <i>Circ Cardiovasc Imaging<\/i> 2018; 11: e007451.","DOI":"10.1161\/CIRCIMAGING.117.007451"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22. Chen Z, Ma X, Gao Y, Wu S, Xu N, Chen F, et al. Cardiac magnetic resonance-derived myocardial scar is associated with echocardiographic response and clinical prognosis of left bundle branch area pacing for cardiac resynchronization therapy. <i>Europace<\/i> 2023; 25: euad326.","DOI":"10.1093\/europace\/euad326"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23. Sade LE, Saba S, Marek JJ, Onishi T, Schwartzman D, Adelstein EC, et al. The association of left ventricular lead position related to regional scar by speckle-tracking echocardiography with clinical outcomes in patients receiving cardiac resynchronization therapy. <i>J Am Soc Echocardiogr<\/i> 2014; 27: 648\u2013656.","DOI":"10.1016\/j.echo.2014.01.025"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24. Song Y, Chen X, Yang K, Dong Z, Cui C, Zhao K, et al. Cardiac MRI-derived myocardial fibrosis and ventricular dyssynchrony predict response to cardiac resynchronization therapy in patients with nonischemic dilated cardiomyopathy. <i>Radiol Cardiothorac Imaging<\/i> 2023; 5: e220127.","DOI":"10.1148\/ryct.220127"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25. Kim SE, Oh J, Hong YJ, Kim D, Yu HT, Lee CJ, et al. Tissue characterization using cardiac magnetic resonance imaging and response to cardiac resynchronization therapy. <i>Europace<\/i> 2025; 27: euaf043.","DOI":"10.1093\/europace\/euaf043"},{"key":"26","doi-asserted-by":"crossref","unstructured":"26. Ferri-Certi\u0107 J, Zavrl-D\u017eananovi\u0107 D, Le\u017eai\u0107 L, \u017di\u017eek D. Impact of left ventricular pacing threshold on ventricular arrhythmia occurrence in cardiac resynchronization therapy. <i>J Cardiol<\/i> 2019; 74: 353\u2013359.","DOI":"10.1016\/j.jjcc.2019.03.015"},{"key":"27","doi-asserted-by":"crossref","unstructured":"27. Naqvi SY, Jawaid A, Vermilye K, Biering-S\u00f8rensen T, Goldenberg I, Zareba W, et al. Left ventricular reverse remodeling in cardiac resynchronization therapy and long-term outcomes. <i>JACC Clin Electrophysiol<\/i> 2019; 9: 1001\u20131010.","DOI":"10.1016\/j.jacep.2019.07.012"},{"key":"28","doi-asserted-by":"crossref","unstructured":"28. Leyva F, Zegard A, Patel P, Stegemann B, Marshall H, Ludman P, et al. Timing of cardiac resynchronization therapy implantation. <i>Europace<\/i> 2023; 25: euad059.","DOI":"10.1093\/europace\/euad059"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29. Van Mieghem NM, Elmariah S, Spitzer E, Pibarot P, Nazif TM, Bax JJ, et al. Transcatheter aortic valve replacement in patients with systolic heart failure and moderate aortic stenosis: TAVR UNLOAD. <i>J Am Coll Cardiol<\/i> 2025; 85: 878\u2013890.","DOI":"10.1016\/j.jacc.2024.10.070"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30. Wagener M, Reuthebuch O, Heg D, T\u00fcller D, Ferrari E, Gr\u00fcnenfelder J, et al. Clinical outcomes in high-gradient, classical low-flow, low-gradient, and paradoxical low-flow, low-gradient aortic stenosis after transcatheter aortic valve implantation: A report from the SwissTAVI Registry. <i>J Am Heart Assoc<\/i> 2023; 12: e029489.","DOI":"10.1161\/JAHA.123.029489"},{"key":"31","doi-asserted-by":"crossref","unstructured":"31. Puls M, Korte KP, Bleckmann A, Huenlich M, Danner BC, Schoendube F, et al. Long-term outcomes after TAVI in patients with different types of aortic stenosis: The conundrum of low flow, low gradient and low ejection fraction. <i>EuroIntervention<\/i> 2017; 13: 286\u2013293.","DOI":"10.4244\/EIJ-D-16-00801"},{"key":"32","doi-asserted-by":"crossref","unstructured":"32. Nagata H, Miyagi A, Shiohira S, Toma Y, Ikemiyagi H, Nagano T, et al. Incidence and prognostic impact of acute kidney injury after transcatheter aortic valve replacement in patients with low-flow and low-gradient aortic stenosis. <i>Circ Rep<\/i> 2025; 7: 1269\u20131278.","DOI":"10.1253\/circrep.CR-25-0120"},{"key":"33","doi-asserted-by":"publisher","unstructured":"33. Ahmed M, Kumar A, Ridham FNU, Azad IF, Lohana RR, Qadir Z, et al. A history that matters: A systematic review and meta-analysis on prior heart failure hospitalization and outcomes after transcatheter aortic valve implantation. <i>J Echocardiogr<\/i> 2026, doi:10.1007\/s12574-026-00729-y.","DOI":"10.1007\/s12574-026-00729-y"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34. Yagi N, Ogawa M, Kuwajima K, Hasegawa H, Yamane T, Shiota T. Impact of stroke volume assessment by 3-dimensional transesophageal echocardiography on the classification of low-gradient aortic stenosis. <i>J Echocardiogr<\/i> 2024; 22: 152\u2013161.","DOI":"10.1007\/s12574-023-00638-4"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35. Izumi C, Eishi K, Ashihara K, Arita T, Otsuji Y, Kunihara T, et al.; Japanese Circulation Society Joint Working Group. JCS\/JSCS\/JATS\/JSVS 2020 Guidelines on the management of valvular heart disease. <i>Circ J<\/i> 2020; 84: 2037\u20132119.","DOI":"10.1253\/circj.CJ-20-0135"},{"key":"36","doi-asserted-by":"crossref","unstructured":"36. Matsukawa R, Kabu K, Koga E, Hara A, Kisanuki H, Sada M, et al. Optimizing guideline-directed medical therapy during hospitalization improves prognosis in patients with worsening heart failure requiring readmissions. <i>Circ J<\/i> 2024; 88: 1416\u20131424.","DOI":"10.1253\/circj.CJ-24-0265"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Fujimoto Y, Kitai T, Horiuchi Y, Kondo T, Murai R, Matsukawa R, et al. Contemporary guideline-directed medical therapy and outpatient worsening heart failure events in hospitalized patients with heart failure: Preliminary Observational Study on Utilizing Predischarge Period for Optimizing Medications in Hospitalized Patients With Heart Failure (PRE-UPFRONT-HF). <i>Circ J<\/i> 2025; 89: 912\u2013920.","DOI":"10.1253\/circj.CJ-24-1020"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Mizutani H, Fujimoto N, Nakamori S, Kokawa T, Ishiyama M, Omori T, et al. Effects of sacubitril\/valsartan on myocardial tissue in heart failure with left ventricular ejection fraction below 50. <i>Circ J<\/i> 2025; 89: 901\u2013911.","DOI":"10.1253\/circj.CJ-24-0934"}],"container-title":["Circulation Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circrep\/8\/8\/8_CR-26-0137\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T03:29:25Z","timestamp":1786764565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/circrep\/8\/8\/8_CR-26-0137\/_article"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,10]]},"references-count":38,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1253\/circrep.cr-26-0137","relation":{},"ISSN":["2434-0790"],"issn-type":[{"value":"2434-0790","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,10]]},"article-number":"CR-26-0137"}}