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Vollmer M, M\u00f6llmann KP. Infrared Thermal Imaging: Fundamentals, Research and Applications. Weinheim: Wiley-VCH; 2010, doi:10.1002\/9783527630868.","DOI":"10.1002\/9783527630868"},{"key":"2","unstructured":"2. Leung TK, Lee CM, Lin MY, Ho YS, Chen CS, Wu CH, et al. Far infrared ray irradiation induces intracellular generation of nitric oxide in breast cancer cells. <i>J Med Biol Eng<\/i> 2009; 29: 15\u201318."},{"key":"3","doi-asserted-by":"publisher","unstructured":"3. Vatansever F, Hamblin MR. Far infrared radiation (FIR): Its biological effects and medical applications. <i>Photonics Lasers Med<\/i> 2012; 4: 255\u2013266, doi:10.1515\/plm-2012-0034.","DOI":"10.1515\/plm-2012-0034"},{"key":"4","doi-asserted-by":"publisher","unstructured":"4. IkedaY, Biro S, Kamogawa Y, Yoshifuku S, Eto H, Orihara K, et al. Repeated sauna therapy increases arterial endothelial nitric oxide synthase expression and nitric oxide production in cardiomyopathic hamsters. <i>Circ J<\/i> 2005; 69: 722\u2013729, doi:10.1253\/circj.69.722.","DOI":"10.1253\/circj.69.722"},{"key":"5","doi-asserted-by":"publisher","unstructured":"5. Lohr NL, Ninomiya JT, Warltier DC, Weihrauch D. Far red\/near infrared light treatment promotes femoral artery collateralization in the ischemic hindlimb. <i>J Mol Cell Cardiol<\/i> 2013; 62: 36\u201342, doi:10.1016\/j.yjmcc.2013.05.007.","DOI":"10.1016\/j.yjmcc.2013.05.007"},{"key":"6","doi-asserted-by":"publisher","unstructured":"6. Lin CC, Liu XM, Peyton K, Wang H, Yang WC, Lin SJ, et al. Far infrared therapy inhibits vascular endothelial inflammation via the induction of heme oxygenase-1. <i>Arterioscler Thromb Vasc Biol<\/i> 2008; 28: 739\u2013745, doi:10.1161\/ATVBAHA.107.160085.","DOI":"10.1161\/ATVBAHA.107.160085"},{"key":"7","doi-asserted-by":"publisher","unstructured":"7. Akasaki Y, Miyata M, Eto H, Shirasawa T, Hamada N, Ikeda Y, et al. Repeated thermal therapy up-regulates endothelial nitric oxide synthase and augments angiogenesis in a mouse model of hindlimb ischemia. <i>Circ J<\/i> 2006; 70: 463\u2013470, doi:10.1253\/circj.70.463.","DOI":"10.1253\/circj.70.463"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8. Biro S, Masuda A, Kihara T, Tei C. Clinical implications of thermal therapy in lifestyle-related diseases. <i>Exp Biol Med (Maywood)<\/i> 2003; 228: 1245\u20131249, doi:10.1177\/153537020322801023.","DOI":"10.1177\/153537020322801023"},{"key":"9","doi-asserted-by":"publisher","unstructured":"9. Yu SY, Chiu JH, Yang SD, Hsu YC, Lui WY, Wu CW. Biological effect of far-infrared therapy on increasing skin microcirculation in rats. <i>Photodermatol Photoimmunol Photomed<\/i> 2006; 22: 78\u201386, doi:10.1111\/j.1600-0781.2006.00208.x.","DOI":"10.1111\/j.1600-0781.2006.00208.x"},{"key":"10","doi-asserted-by":"publisher","unstructured":"10. Wang HW, Su SH, Wang YL, Chang ST, Liao KH, Lo HH, et al. MicroRNA-134 contributes to glucose-induced endothelial cell dysfunction and this effect can be reversed by far-infrared irradiation. <i>PLoS One<\/i> 2016; 11: e0147067, doi:10.1371\/journal.pone.0147067.","DOI":"10.1371\/journal.pone.0147067"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11. Su LH, Wu KD, Lee LS, Wang H, Liu CF. Effects of far infrared acupoint stimulation on autonomic activity and quality of life in hemodialysis patients. <i>Am J Chin Med<\/i> 2009; 37: 215\u2013226, doi:10.1142\/S0192415X09006783.","DOI":"10.1142\/S0192415X09006783"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12. Imamura M, Biro S, Kihara T, Yoshifuku S, Takasaki K, Otsuji Y, et al. Repeated thermal therapy improves impaired vascular endothelial function in patients with coronary risk factors. <i>J Am Coll Cardiol<\/i> 2001; 38: 1083\u20131088, doi:10.1016\/s0735-1097(01)01467-x.","DOI":"10.1016\/S0735-1097(01)01467-X"},{"key":"13","doi-asserted-by":"publisher","unstructured":"13. Wu CF, Yeh TP, Lin TC, Huang PH, Huang PJ. Effects of far infrared therapy in hemodialysis arterio-venous fistula maturation: A meta-analysis. <i>PLoS One<\/i> 2024; 19: e0307586, doi:10.1371\/journal.pone.0307586.","DOI":"10.1371\/journal.pone.0307586"},{"key":"14","doi-asserted-by":"publisher","unstructured":"14. Wang YH, Cheng FY, Chao YC, Liu CY, Chang Y. Effects of far-infrared therapy on foot circulation among hemodialysis patients with diabetes mellitus. <i>Biol Res Nurs<\/i> 2020; 22: 403\u2013411, doi:10.1177\/1099800420923730.","DOI":"10.1177\/1099800420923730"},{"key":"15","doi-asserted-by":"publisher","unstructured":"15. Shui S, Wang X, Chiang JY, Zheng L. Far-infrared therapy for cardiovascular, autoimmune, and other chronic health problems: A systematic review. <i>Exp Biol Med (Maywood)<\/i> 2015; 240: 1257\u20131265, doi:10.1177\/1535370215573391.","DOI":"10.1177\/1535370215573391"},{"key":"16","doi-asserted-by":"publisher","unstructured":"16. Wan Q, Yang S, Li L, Chu F. Effects of far infrared therapy on arteriovenous fistulas in hemodialysis patients: A meta-analysis. <i>Ren Fail<\/i> 2017; 39: 613\u2013622, doi:10.1080\/0886022X.2017.1361835.","DOI":"10.1080\/0886022X.2017.1361835"},{"key":"17","doi-asserted-by":"publisher","unstructured":"17. Rau CS, Yang JC, Jeng SF, Chen YC, Lin CJ, Wu CJ, et al. Far-infrared radiation promotes angiogenesis in human microvascular endothelial cells via extracellular signal-regulated kinase activation. <i>Photochem Photobiol<\/i> 2011; 87: 441\u2013446, doi:10.1111\/j.1751-1097.2010.00853.x.","DOI":"10.1111\/j.1751-1097.2010.00853.x"},{"key":"18","doi-asserted-by":"publisher","unstructured":"18. Qin B, Fu SJ, Xu XF, Yang JJ, Wang Y, Wang LN, et al. Far-infrared radiation and its therapeutic parameters: A superior alternative for future regenerative medicine? <i>Pharmacol Res<\/i> 2024; 208: 107349, doi:10.1016\/j.phrs.2024.107349.","DOI":"10.1016\/j.phrs.2024.107349"},{"key":"19","doi-asserted-by":"publisher","unstructured":"19. Huang PH, Chen JW, Lin CP, Chen YH, Wang CH, Leu HB, et al. Far infrared therapy promotes ischemia-induced angiogenesis in diabetic mice and restores high glucose-suppressed endothelial progenitor cell functions. <i>Cardiovasc Diabetol<\/i> 2012; 11: 99, doi:10.1186\/1475-2840-11-99.","DOI":"10.1186\/1475-2840-11-99"},{"key":"20","doi-asserted-by":"publisher","unstructured":"20. Inoue S, Takemoto M, Chishaki A, Ide T, Nishizaka M, Miyazono M, et al. Leg heating using far infra-red radiation in patients with chronic heart failure acutely improves the hemodynamics, vascular endothelial function, and oxidative stress. <i>Intern Med<\/i> 2012; 51: 2263\u20132270, doi:10.2169\/internalmedicine.51.7115.","DOI":"10.2169\/internalmedicine.51.7115"},{"key":"21","doi-asserted-by":"publisher","unstructured":"21. Lin CC, Chang CF, Lai MY, Chen TW, Lee PC. Far-infrared therapy: A novel treatment to improve access blood flow and unassisted patency of arteriovenous fistula in hemodialysis patients. <i>J Am Soc Nephrol<\/i> 2007; 18: 985\u2013992, doi:10.1681\/ASN.2006050534.","DOI":"10.1681\/ASN.2006050534"},{"key":"22","doi-asserted-by":"publisher","unstructured":"22. Chung H, Dai T, Sharma SK, Huang YY, Carroll YJ, Hamblin MR. The nuts and bolts of low-level laser (light) therapy. <i>Ann Biomed Eng<\/i> 2012; 40: 516\u2013533, doi:10.1007\/s10439-011-0454-7.","DOI":"10.1007\/s10439-011-0454-7"},{"key":"23","doi-asserted-by":"publisher","unstructured":"23. Chunyan F, Zhenbin J, Weiyi J, Haiyan M, Jinrong Z, Yue W, et al. The influence of near-infrared therapy on arteriovenous fistula patency in haemodialysis patients: A multicentre, randomised, controlled clinical trial. <i>J Vasc Access<\/i> 2025; 26: 315\u2013321, doi:10.1177\/11297298241251501.","DOI":"10.1177\/11297298241251501"},{"key":"24","doi-asserted-by":"publisher","unstructured":"24. Yen CC, Hsu PC, Lin CC, Chen SC, Hsiao CY, Hwang SJ. Effect of far-infrared radiation therapy on von Willebrand factor in patients with chronic kidney disease. <i>Front Med (Lausanne)<\/i> 2023; 10: 1268212, doi:10.3389\/fmed.2023.1268212.","DOI":"10.3389\/fmed.2023.1268212"},{"key":"25","doi-asserted-by":"publisher","unstructured":"25. Cheng YC, Lung CW, Jan YK, Kuo FC, Lin YS, Lo YC, et al. evaluating the far-infrared radiation bioeffects on micro vascular dysfunction, nervous system, and plantar pressure in diabetes mellitus. <i>Int J Low Extrem Wounds<\/i> 2020; 19: 125\u2013131, doi:10.1177\/1534734619880741.","DOI":"10.1177\/1534734619880741"},{"key":"26","unstructured":"26. Lin TC, Lin CS, Tsai TN, Cheng SM, Lin WS, Cheng CC, et al. Stimulatory influences of far infrared therapy on the transcriptome and genetic networks of endothelial progenitor cells receiving high glucose treatment. <i>Acta Cardiol Sin<\/i> 2015; 31: 414\u2013428, doi:10.6515\/acs20141201c."},{"key":"27","doi-asserted-by":"publisher","unstructured":"27. Chen CF, Yang WC, Lin CC. An update of the effect of far infrared therapy on arteriovenous access in end-stage renal disease patients. <i>J Vasc Access<\/i> 2016; 17: 293\u2013298, doi:10.5301\/jva.5000561.","DOI":"10.5301\/jva.5000561"},{"key":"28","doi-asserted-by":"publisher","unstructured":"28. Lin CC, Yang WC, Chen MC, Liu WS, Yang CY, Lee PC. Effect of far infrared therapy on arteriovenous fistula maturation: An open-label randomized controlled trial. <i>Am J Kidney Dis<\/i> 2013; 62: 304\u2013311, doi:10.1053\/j.ajkd.2013.01.015.","DOI":"10.1053\/j.ajkd.2013.01.015"},{"key":"29","doi-asserted-by":"publisher","unstructured":"29. Lin CC, Yang WC. Prognostic factors influencing the patency of hemodialysis vascular access: Literature review and novel therapeutic modality by far infrared therapy. <i>J Chin Med Assoc<\/i> 2009; 72: 109\u2013116, doi:10.1016\/S1726-4901(09)70035-8.","DOI":"10.1016\/S1726-4901(09)70035-8"},{"key":"30","doi-asserted-by":"publisher","unstructured":"30. Huang J, Zheng P, Chen X, Zheng F, He B. Effect of far-infrared therapy device on arteriovenous fistula maturation and lifespan in hemodialysis patients: A randomized controlled clinical trial. <i>Front Surg<\/i> 2023; 10: 1260979, doi:10.3389\/fsurg.2023.1260979.","DOI":"10.3389\/fsurg.2023.1260979"},{"key":"31","doi-asserted-by":"publisher","unstructured":"31. Lindhard K, Rix M, Heaf JG, Hansen HP, Pedersen BL, Jensen BL, et al. Effect of far infrared therapy on arteriovenous fistula maturation, survival and stenosis in hemodialysis patients: A randomized, controlled clinical trial: The FAITH on fistula trial. <i>BMC Nephrol<\/i> 2021; 22: 283, doi:10.1186\/s12882-021-02476-x.","DOI":"10.1186\/s12882-021-02476-x"},{"key":"32","doi-asserted-by":"publisher","unstructured":"32. Ramesh S, Tripathy S, Sen M, Nandi D. Effects of far infrared radiation and sitz bath on perineal wound healing and pain in primiparous women undergoing an episiotomy: A randomized prospective parallel arm study. <i>Cureus<\/i> 2024; 16: e67477, doi:10.7759\/cureus.67477.","DOI":"10.7759\/cureus.67477"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33. Chang CN, Niu CY, Tan AC, Chan CH, Chen CF, Chen TH, et al. The effect of far-infrared therapy on the peritoneal expression of glucose degradation products in diabetic patients on peritoneal dialysis. <i>Int J Mol Sci<\/i> 2021; 22: 3732, doi:10.3390\/ijms22073732.","DOI":"10.3390\/ijms22073732"},{"key":"34","doi-asserted-by":"publisher","unstructured":"34. Chen CF, Chen FA, Tan AC, Lee TL, Chan CH, Lin CC. Far-infrared therapy improves ankle brachial index in hemodialysis patients with peripheral artery disease. <i>Heart Vessels<\/i> 2019; 34: 435\u2013441, doi:10.1007\/s00380-018-1259-5.","DOI":"10.1007\/s00380-018-1259-5"},{"key":"35","doi-asserted-by":"publisher","unstructured":"35. Lai YT, Chan HL, Lin SH, Lin CC, Li SY, Liu CK, et al. Far-infrared ray patches relieve pain and improve skin sensitivity in myofascial pain syndrome: A double-blind randomized controlled study. <i>Complement Ther Med<\/i> 2017; 35: 127\u2013132, doi:10.1016\/j.ctim.2017.10.007.","DOI":"10.1016\/j.ctim.2017.10.007"},{"key":"36","doi-asserted-by":"publisher","unstructured":"36. Wang HW, Huang TS, Lo HH, Huang PH, Lin CC, Chang SJ, et al. Deficiency of the microRNA-31-microRNA-720 pathway in the plasma and endothelial progenitor cells from patients with coronary artery disease. <i>Arterioscler Thromb Vasc Biol<\/i> 2014; 34: 857\u2013869, doi:10.1161\/ATVBAHA.113.303001.","DOI":"10.1161\/ATVBAHA.113.303001"},{"key":"37","doi-asserted-by":"crossref","unstructured":"37. Lin CC, Chung MY, Yang WC, Lin SJ, Lee PC. Length polymorphisms of heme oxygenase-1 determine the effect of far-infrared therapy on the function of arteriovenous fistula in hemodialysis patients: A novel physicogenomic study. <i>Nephrol Dial Transplant<\/i> 2013; 28: 1284\u20131293, doi:10.1093\/ndt\/gfs608.","DOI":"10.1093\/ndt\/gfs608"},{"key":"38","doi-asserted-by":"crossref","unstructured":"38. Tei C, Tanaka N. Thermal therapy for CHF: Improving functional capacity and quality of life. <i>J Cardiol<\/i> 2004; 44: 55\u201356.","DOI":"10.5136\/lifesupport.16.Supplement_55"},{"key":"39","doi-asserted-by":"crossref","unstructured":"39. Miyata M, Tei C. Waon therapy for cardiovascular disease: Innovative therapy for the 21<sup>st<\/sup> century. <i>Circ J<\/i> 2010; 74: 617\u2013621, doi:10.1253\/circj.CJ-09-0939.","DOI":"10.1253\/circj.CJ-09-0939"},{"key":"40","doi-asserted-by":"publisher","unstructured":"40. Laukkanen T, Kunutsor S, Zaccardi F, Laukkanen JA. Acute effects of sauna bathing on cardiovascular function. <i>J Hum Hypertens<\/i> 2018; 32: 129\u2013138, doi:10.1038\/s41371-017-0008-z.","DOI":"10.1038\/s41371-017-0008-z"},{"key":"41","doi-asserted-by":"publisher","unstructured":"41. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher A M. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. <i>Nature<\/i> 1999; 399: 601\u2013605, doi:10.1038\/21224.","DOI":"10.1038\/21224"},{"key":"42","doi-asserted-by":"publisher","unstructured":"42. Fulton D, Gratton JP, McCabe TJ, Fontana J, Fujio Y, Walsh K, et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. <i>Nature<\/i> 1999; 399: 597\u2013601, doi:10.1038\/21218.","DOI":"10.1038\/21218"},{"key":"43","doi-asserted-by":"crossref","unstructured":"43. Ko CM, Then CK, Kuo YM, Lin YK, Shen SC. Far-infrared ameliorates Pb-induced renal toxicity via voltage-gated calcium channel-mediated calcium influx. <i>Int J Mol Sci<\/i> 2023; 24: 15828, doi:10.3390\/ijms242115828.","DOI":"10.3390\/ijms242115828"},{"key":"44","doi-asserted-by":"publisher","unstructured":"44. Mendoza SA, Fang J, Gutterman DD, Wilcox DA, Bubolz AH, Li R, et al. TRPV4-mediated endothelial Ca<sup>2+<\/sup> influx and vasodilation in response to shear stress. <i>Am J Physiol Heart Circ Physiol<\/i> 2010; 298: H466\u2013H476, doi:10.1152\/ajpheart.00854.2009.","DOI":"10.1152\/ajpheart.00854.2009"},{"key":"45","doi-asserted-by":"publisher","unstructured":"45. Tran TH, Mai HN, Shin EJ, Nam Y, Nguyen BT, Lee YJ, et al. Repeated exposure to far infrared ray attenuates acute restraint stress in mice via inhibition of JAK2\/STAT3 signaling pathway by induction of glutathione peroxidase-1. <i>Neurochem Int<\/i> 2016; 94: 9\u201322, doi:10.1016\/j.neuint.2016.02.001.","DOI":"10.1016\/j.neuint.2016.02.001"},{"key":"46","doi-asserted-by":"publisher","unstructured":"19. Huang PH, Chen JW, Lin CP, Chen YH, Wang CH, Leu HB, et al. Far infrared therapy promotes ischemia-induced angiogenesis in diabetic mice and restores high glucose-suppressed endothelial progenitor cell functions. <i>Cardiovasc Diabetol<\/i> 2012; 11: 99, doi:10.1186\/1475-2840-11-99.","DOI":"10.1186\/1475-2840-11-99"},{"key":"47","doi-asserted-by":"publisher","unstructured":"47. F\u00f6rstermann U, Sessa WC. Nitric oxide synthases: Regulation and function. <i>Eur Heart J<\/i> 2012; 33: 829\u2013837, doi:10.1093\/eurheartj\/ehr304.","DOI":"10.1093\/eurheartj\/ehr304"},{"key":"48","doi-asserted-by":"publisher","unstructured":"48. Passarella S, Karu T. Absorption of monochromatic and narrow band radiation in the visible and near IR by both mitochondrial and non-mitochondrial photoacceptors results in photobiomodulation. <i>J Photochem Photobiol B<\/i> 2014; 140: 344\u2013358, doi:10.1016\/j.jphotobiol.2014.07.010.","DOI":"10.1016\/j.jphotobiol.2014.07.010"},{"key":"49","doi-asserted-by":"crossref","unstructured":"49. Palikaras K, Lionaki E, Tavernarakis N. Mechanisms of mitophagy in cellular homeostasis, physiology and pathology. <i>Nat Cell Biol<\/i> 2018; 20: 1013\u20131022, doi:10.1038\/s41556-018-0176-2.","DOI":"10.1038\/s41556-018-0176-2"},{"key":"50","doi-asserted-by":"publisher","unstructured":"50. Yamamoto M, Kensler TW, Motohashi H. The KEAP1-NRF2 system: A thiol-based sensor\u2013effector apparatus for maintaining redox homeostasis. <i>Physiol Rev<\/i> 2018; 98: 1169\u20131203, doi:10.1152\/physrev.00023.2017.","DOI":"10.1152\/physrev.00023.2017"},{"key":"51","doi-asserted-by":"publisher","unstructured":"51. Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J. Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: An evolutionarily conserved mechanism. <i>Cell Mol Life Sci<\/i> 2016; 73: 3221\u20133247, doi:10.1007\/s00018-016-2223-0.","DOI":"10.1007\/s00018-016-2223-0"},{"key":"52","doi-asserted-by":"publisher","unstructured":"52. Peng HB, Libby P, Liao JK. Induction and stabilization of I\u03baB\u03b1 by nitric oxide mediates inhibition of NF-\u03baB. <i>J Biol Chem<\/i> 1995; 270: 14214\u201314219, doi:10.1074\/jbc.270.23.14214.","DOI":"10.1074\/jbc.270.23.14214"},{"key":"53","doi-asserted-by":"publisher","unstructured":"53. Cave AC, Brewer AC, Narayanapanicker A, Ray R, Grieve DJ, Walker S, et al. NADPH oxidases in cardiovascular health and disease. <i>Antioxid Redox Signal<\/i> 2006; 8: 691\u2013728, doi:10.1089\/ars.2006.8.691.","DOI":"10.1089\/ars.2006.8.691"},{"key":"54","doi-asserted-by":"publisher","unstructured":"54. Cracowski JL, Minson CT, Salvat-Melis M, Halliwill JR. Methodological issues in the assessment of skin microvascular endothelial function in humans. <i>Trends Pharmacol Sci<\/i> 2006; 27: 503\u2013508, doi:10.1016\/j.tips.2006.07.008.","DOI":"10.1016\/j.tips.2006.07.008"},{"key":"55","doi-asserted-by":"publisher","unstructured":"55. Tu YP, Chen SC, Liu YH, Chen CF, Hour TC. Postconditioning with far-infrared irradiation increases heme oxygenase-1 expression and protects against ischemia\/reperfusion injury in rat testis. <i>Life Sci<\/i> 2013; 92: 35\u201341, doi:10.1016\/j.lfs.2012.10.019.","DOI":"10.1016\/j.lfs.2012.10.019"},{"key":"56","doi-asserted-by":"publisher","unstructured":"56. Russu E, Arbanasi EM, Chirila TV, Muresan AV. Therapeutic strategies based on non-ionizing radiation to prevent venous neointimal hyperplasia: The relevance for stenosed arteriovenous fistula, and the role of vascular compliance. <i>Front Cardiovasc Med<\/i> 2024; 11: 1356671, doi:10.3389\/fcvm.2024.1356671.","DOI":"10.3389\/fcvm.2024.1356671"},{"key":"57","doi-asserted-by":"publisher","unstructured":"57. Shemilt R, Bagabir H, Lang C, Khan F. Potential mechanisms for the effects of far-infrared on the cardiovascular system: A review. <i>Vasa<\/i> 2019; 48: 303\u2013312, doi:10.1024\/0301-1526\/a000752.","DOI":"10.1024\/0301-1526\/a000752"},{"key":"58","doi-asserted-by":"publisher","unstructured":"58. Mussbacher M, Derler M, Bas\u00edlio J, Schmid JA. NF-\u03baB in monocytes and macrophages: An inflammatory master regulator in multitalented immune cells. <i>Front Immunol<\/i> 2023; 14: 1134661, doi:10.3389\/fimmu.2023.1134661.","DOI":"10.3389\/fimmu.2023.1134661"},{"key":"59","doi-asserted-by":"crossref","unstructured":"59. Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. <i>Nature<\/i> 2000; 407: 249\u2013257, doi:10.1038\/35025220.","DOI":"10.1038\/35025220"},{"key":"60","doi-asserted-by":"publisher","unstructured":"60. Brunt VE, Eymann TM, Francisco MA, Howard MJ, Minson CT. Passive heat therapy improves cutaneous microvascular function in sedentary humans via improved nitric oxide-dependent dilation. <i>J Appl Physiol (1985)<\/i> 2016; 121: 716\u2013723, doi:10.1152\/japplphysiol.00424.2016.","DOI":"10.1152\/japplphysiol.00424.2016"},{"key":"61","doi-asserted-by":"crossref","unstructured":"61. Chen CH, Chen MC, Hsu YH, Chou TC. Far-infrared radiation alleviates cisplatin-induced vascular damage and impaired circulation via activation of HIF-1alpha. <i>Cancer Sci<\/i> 2022; 113: 2194\u20132206, doi:10.1111\/cas.15371.","DOI":"10.1111\/cas.15371"},{"key":"62","doi-asserted-by":"publisher","unstructured":"62. Hsu YH, Lin YF, Chen CH, Chiu YJ, Chiu HW. Far infrared promotes wound healing through activation of Notch1 signaling. <i>J Mol Med (Berl)<\/i> 2017; 95: 1203\u20131213, doi:10.1007\/s00109-017-1580-y.","DOI":"10.1007\/s00109-017-1580-y"},{"key":"63","doi-asserted-by":"publisher","unstructured":"63. Athonvarangkul D, Wang K, Deng Y, Inzucchi SE, Mayerson A. Improved extremity tissue oxygenation with short-term exposure to textiles embedded with far infrared light emitting thermoactive particles in patients with diabetes mellitus. <i>Diab Vasc Dis Res<\/i> 2023; 20: 14791641231170282, doi:10.1177\/14791641231170282.","DOI":"10.1177\/14791641231170282"},{"key":"64","doi-asserted-by":"publisher","unstructured":"64. Che Yusof R, Norhayati MN, Azman MY. Far-infrared therapy on arteriovenous fistula among hemodialysis patients: A systematic review and meta-analysis. <i>J Chin Med Assoc<\/i> 2025; 88: 425\u2013432, doi:10.1097\/JCMA.0000000000001236.","DOI":"10.1097\/JCMA.0000000000001236"},{"key":"65","doi-asserted-by":"publisher","unstructured":"53. Cave AC, Brewer AC, Narayanapanicker A, Ray R, Grieve DJ, Walker S, et al. NADPH oxidases in cardiovascular health and disease. <i>Antioxid Redox Signal<\/i> 2006; 8: 691\u2013728, doi:10.1089\/ars.2006.8.691.","DOI":"10.1089\/ars.2006.8.691"},{"key":"66","doi-asserted-by":"crossref","unstructured":"66. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. <i>Physiol Rev<\/i> 2004; 84: 767\u2013801, doi:10.1152\/physrev.00041.2003.","DOI":"10.1152\/physrev.00041.2003"},{"key":"67","doi-asserted-by":"publisher","unstructured":"67. Raines EW. PDGF and cardiovascular disease. <i>Cytokine Growth Factor Rev<\/i> 2004; 15: 237\u2013254, doi:10.1016\/j.cytogfr.2004.03.004.","DOI":"10.1016\/j.cytogfr.2004.03.004"},{"key":"68","doi-asserted-by":"publisher","unstructured":"68. Chiu HW, Chen CH, Chen YJ, Hsu YH. Far-infrared suppresses skin photoaging in ultraviolet B-irradiated mice. <i>PLoS One<\/i> 2017; 12: e0174042, doi:10.1371\/journal.pone.0174042.","DOI":"10.1371\/journal.pone.0174042"},{"key":"69","doi-asserted-by":"publisher","unstructured":"69. Xu T, Fu H, Zhao W, Shan S. 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