{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T01:40:24Z","timestamp":1699753224499},"reference-count":15,"publisher":"Japanese Pharmacological Society","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Folia Pharmacol. Jpn.","Folia Pharmacologica Japonica"],"published-print":{"date-parts":[[2021]]},"DOI":"10.1254\/fpj.21053","type":"journal-article","created":{"date-parts":[[2021,10,31]],"date-time":"2021-10-31T22:10:49Z","timestamp":1635718249000},"page":"364-369","source":"Crossref","is-referenced-by-count":0,"title":["Technology and evaluation best practices for in vivo cardiovascular safety pharmacology studies","In vivo\u5fc3\u8840\u7ba1\u7cfb\u5b89\u5168\u6027\u85ac\u7406\u8a66\u9a13\u306e\u6280\u8853\u3068\u8a55\u4fa1\u306e\u5b9f\u969b"],"prefix":"10.1254","volume":"156","author":[{"given":"Harushige","family":"Ozaki","sequence":"first","affiliation":[{"name":"Takeda Pharmaceutical Company Limited"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"332","reference":[{"key":"1","unstructured":"1) ICH S7A\u300c\u5b89\u5168\u6027\u85ac\u7406\u8a66\u9a13\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u300d\u533b\u85ac\u5be9\u767a\u7b2c902\u53f7. \u5e73\u621013\u5e746\u670821\u65e5."},{"key":"2","unstructured":"2) ICH S7B\u300c\u30d2\u30c8\u7528\u533b\u85ac\u54c1\u306e\u5fc3\u5ba4\u518d\u5206\u6975\u9045\u5ef6\uff08QT\u9593\u9694\u5ef6\u9577\uff09\u306e\u6f5c\u5728\u7684\u53ef\u80fd\u6027\u306b\u95a2\u3059\u308b\u975e\u81e8\u5e8a\u7684\u8a55\u4fa1\u300d\u85ac\u98df\u5be9\u67fb\u767a1023\u7b2c4\u53f7. \u5e73\u621021\u5e7410\u670823\u65e5."},{"key":"3","unstructured":"3) ICH E14&S7B Q&A\u300cQT\/QTc\u9593\u9694\u306e\u5ef6\u9577\u3068\u50ac\u4e0d\u6574\u8108\u4f5c\u7528\u306e\u6f5c\u5728\u7684\u53ef\u80fd\u6027\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u7684\u53ca\u3073\u975e\u81e8\u5e8a\u7684\u8a55\u4fa1\u300d\u306b\u95a2\u3059\u308bQ&A\uff08\u6848\uff09. 2020\u5e746\u670815\u65e5\u30d0\u30fc\u30b8\u30e7\u30f3."},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Darpo B, et al. Clin Pharmacol Ther. 2015;97:326-335.","DOI":"10.1002\/cpt.60"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Komatsu R, et al. J Pharmacol Toxicol Methods. 2019;99:106606.","DOI":"10.1016\/j.vascn.2019.106606"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Park E, et al. Br J Pharmacol. 2018;175:606-617.","DOI":"10.1111\/bph.14101"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Holzgrefe H, et al. J Pharmacol Toxicol Methods. 2014;69:61-101.","DOI":"10.1016\/j.vascn.2013.05.004"},{"key":"8","unstructured":"8) ICH E14\u300c\u975e\u6297\u4e0d\u6574\u8108\u85ac\u306b\u304a\u3051\u308bQT\/QTc\u9593\u9694\u306e\u5ef6\u9577\u3068\u50ac\u4e0d\u6574\u8108\u4f5c\u7528\u306e\u6f5c\u5728\u7684\u53ef\u80fd\u6027\u306b\u95a2\u3059\u308b\u81e8\u5e8a\u7684\u8a55\u4fa1\u306b\u3064\u3044\u3066\u300d\u85ac\u98df\u5be9\u67fb\u767a1023\u7b2c1\u53f7. \u5e73\u621021\u5e7410\u670823\u65e5."},{"key":"9","unstructured":"9) ICH S6\u300c\u30d0\u30a4\u30aa\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u5fdc\u7528\u533b\u85ac\u54c1\u306e\u975e\u81e8\u5e8a\u306b\u304a\u3051\u308b\u5b89\u5168\u6027\u8a55\u4fa1\u300d\u85ac\u98df\u5be9\u67fb\u767a0323\u7b2c1\u53f7. \u5e73\u621024\u5e743\u670823\u65e5."},{"key":"10","unstructured":"10) ICH S9\u300c\u6297\u60aa\u6027\u816b\u760d\u85ac\u306e\u975e\u81e8\u5e8a\u8a55\u4fa1\u306b\u95a2\u3059\u308b\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u300d\u85ac\u98df\u5be9\u67fb\u767a0604\u7b2c1\u53f7. \u5e73\u621022\u5e746\u67084\u65e5."},{"key":"11","unstructured":"11) ICH M3\u300c\u533b\u85ac\u54c1\u306e\u81e8\u5e8a\u8a66\u9a13\u53ca\u3073\u88fd\u9020\u8ca9\u58f2\u627f\u8a8d\u7533\u8acb\u306e\u305f\u3081\u306e\u975e\u81e8\u5e8a\u5b89\u5168\u6027\u8a66\u9a13\u306e\u5b9f\u65bd\u306b\u3064\u3044\u3066\u306e\u30ac\u30a4\u30c0\u30f3\u30b9\u300d\u85ac\u98df\u5be9\u67fb\u767a0219\u7b2c4\u53f7. \u5e73\u621022\u5e742\u670819\u65e5."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Hornberg JJ, et al. Drug Discov Today. 2014;19:1137-1144.","DOI":"10.1016\/j.drudis.2013.12.009"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Lynch JJ 3rd, et al. J Pharmacol Toxicol Methods. 2017;87:108-126.","DOI":"10.1016\/j.vascn.2017.02.020"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Tashibu H, et al. J Pharmacol Sci. 2005;99:473-486.","DOI":"10.1254\/jphs.QT-A3"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Omata T, et al. J Pharmacol Sci. 2005;99:531-541.","DOI":"10.1254\/jphs.QT-C12"}],"container-title":["Folia Pharmacologica Japonica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/fpj\/156\/6\/156_21053\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,12]],"date-time":"2023-11-12T01:13:48Z","timestamp":1699751628000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/fpj\/156\/6\/156_21053\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021]]}},"URL":"https:\/\/doi.org\/10.1254\/fpj.21053","relation":{},"ISSN":["0015-5691","1347-8397"],"issn-type":[{"value":"0015-5691","type":"print"},{"value":"1347-8397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"21053"}}