{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T04:19:43Z","timestamp":1683433183172},"reference-count":25,"publisher":"Japanese Pharmacological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Folia Pharmacol. Jpn.","Folia Pharmacologica Japonica"],"published-print":{"date-parts":[[2023,5,1]]},"DOI":"10.1254\/fpj.22156","type":"journal-article","created":{"date-parts":[[2023,4,30]],"date-time":"2023-04-30T22:14:16Z","timestamp":1682892856000},"page":"273-281","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological and clinical profile of asciminib hydrochloride, a novel first-in-class tyrosine kinase inhibitor specifically targeting ABL myristoyl pocket","\u30a2\u30b7\u30df\u30cb\u30d6\u5869\u9178\u5869\uff08\u30bb\u30e0\u30d6\u30ea\u30c3\u30af\u30b9&lt;sup&gt;\u00ae&lt;\/sup&gt;\u932020\u2005mg\/40\u2005mg\uff09\u306e\u85ac\u7406\u5b66\u7684\u7279\u6027\u53ca\u3073\u81e8\u5e8a\u8a66\u9a13\u6210\u7e3e"],"prefix":"10.1254","volume":"158","author":[{"given":"Jihye","family":"Chung","sequence":"first","affiliation":[{"name":"Novartis Pharma KK, Medical Affairs Division"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taisuke","family":"Ariyoshi","sequence":"additional","affiliation":[{"name":"Novartis Pharma KK, Global Drug Development Division"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiro","family":"Yoneda","sequence":"additional","affiliation":[{"name":"Novartis Pharma KK, Global Drug Development Division"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Novartis Pharma KK, Global Drug Development Division"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Kawakita","sequence":"additional","affiliation":[{"name":"Novartis Pharma KK, Global Drug Development Division"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akio","family":"Maki","sequence":"additional","affiliation":[{"name":"Novartis Pharma KK, Global Drug Development Division"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"332","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Jabbour E, et al. Am J Hematol. 2018;93:442-459.","DOI":"10.1002\/ajh.25011"},{"key":"2","doi-asserted-by":"publisher","unstructured":"2) Apperley JF. Lancet. 2015;385:1447-1459.","DOI":"10.1016\/S0140-6736(13)62120-0"},{"key":"3","doi-asserted-by":"publisher","unstructured":"3) Hochhaus A, et al. Leukemia. 2020;34:966-984.","DOI":"10.1038\/s41375-020-0776-2"},{"key":"4","unstructured":"4) NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines<sup>\u00ae<\/sup>) Chronic Myeloid Leukemia. Version 3. 2022."},{"key":"5","unstructured":"5) \u65e5\u672c\u8840\u6db2\u5b66\u4f1a\u7de8. \u9020\u8840\u5668\u816b\u760d\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3 2018\u5e74\u7248\u88dc\u8a02\u7248. \u91d1\u539f\u51fa\u7248; 2020."},{"key":"6","doi-asserted-by":"publisher","unstructured":"6) Wylie AA, et al. Nature. 2017;543:733-737.","DOI":"10.1038\/nature21702"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Manley PW, et al. Leuk Res. 2020;98:106458.","DOI":"10.1016\/j.leukres.2020.106458"},{"key":"8","unstructured":"8) \u793e\u5185\u8cc7\u6599\uff1a\u56fd\u969b\u5171\u540c\u7b2c\u2160\u76f8\u8a66\u9a13\uff08X2101 \u8a66\u9a13\uff09\u306b\u304a\u3051\u308b\u6709\u52b9\u6027\u53ca\u3073\u5b89\u5168\u6027\uff082022\u5e743\u670828\u65e5\u627f\u8a8d\uff0cCTD2.7.6-4.2.1\uff09"},{"key":"9","unstructured":"9) Hughes TP, et al. N Engl J Med. 2019;381:2315-2326."},{"key":"10","unstructured":"10) \u793e\u5185\u8cc7\u6599\uff1a\u56fd\u969b\u5171\u540c\u7b2c\u2162\u76f8\u8a66\u9a13\uff08A2301\/ASCEMBL\u8a66\u9a13\uff09\uff08\u627f\u8a8d\u6642\u8a55\u4fa1\u8cc7\u6599\uff09\uff082022\u5e743\u670828\u65e5\u627f\u8a8d\uff0cCTD2.7.6-4.1.1\uff09"},{"key":"11","doi-asserted-by":"publisher","unstructured":"11) R\u00e9a D, et al. Blood. 2021;138:2031-2041.","DOI":"10.1182\/blood.2020009984"},{"key":"12","doi-asserted-by":"publisher","unstructured":"12) Nagar B, et al. Cell. 2003;112:859-871.","DOI":"10.1016\/S0092-8674(03)00194-6"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Schoepfer J, et al. J Med Chem. 2018;61:8120-8135.","DOI":"10.1021\/acs.jmedchem.8b01040"},{"key":"14","unstructured":"14) \u793e\u5185\u8cc7\u6599\uff1aIn vitro\u306b\u304a\u3051\u308b\u7d30\u80de\u5897\u6b96\u6291\u5236\u4f5c\u7528\u306e\u691c\u8a0e\uff082022\u5e743\u670828\u65e5\u627f\u8a8d\uff0cCTD2.6.2-2.2.1\uff09"},{"key":"15","unstructured":"15) \u793e\u5185\u8cc7\u6599\uff1aIn vitro\u306b\u304a\u3051\u308b\u751f\u5316\u5b66\u7684\u6d3b\u6027\u306e\u691c\u8a0e\uff082022\u5e743\u670828\u65e5\u627f\u8a8d\uff0cCTD2.6.2-2.2.3\uff09"},{"key":"16","unstructured":"16) \u793e\u5185\u8cc7\u6599\uff1aIn vivo KCL-22\u7d30\u80de\u7570\u7a2e\u79fb\u690d\u30e2\u30c7\u30eb\u85ac\u7406\u8a66\u9a13\uff081\u65e52\u56de\u6295\u4e0e\uff09\uff082022\u5e743\u670828\u65e5\u627f\u8a8d\uff0cCTD2.6.2-2.3.2\uff09"},{"key":"17","unstructured":"17) \u793e\u5185\u8cc7\u6599\uff1aIn vivo T315I\u5909\u7570\u682aKCL-22\u7d30\u80de\u7570\u7a2e\u79fb\u690d\u30e2\u30c7\u30eb\u85ac\u7406\u8a66\u9a13\uff082022\u5e743\u670828\u65e5\u627f\u8a8d\uff0cCTD2.6.2-2.3.3\uff09"},{"key":"18","unstructured":"18) \u793e\u5185\u8cc7\u6599\uff1a\u85ac\u7269\u52d5\u614b\u5b66\uff08PK\uff09\uff0f\u85ac\u529b\u5b66\uff08PD\uff09\u8a66\u9a13\uff082022\u5e743\u670828\u65e5\u627f\u8a8d\uff0cCTD2.6.2-2.7\uff09"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Hoch M, et al. Clin Transl Sci. 2022;15:1698-1712.","DOI":"10.1111\/cts.13285"},{"key":"20","unstructured":"20) \u793e\u5185\u8cc7\u6599\uff1a\u56fd\u969b\u5171\u540c\u7b2c\u2160\u76f8\u8a66\u9a13\uff08X2101\u8a66\u9a13\uff09\uff08\u627f\u8a8d\u6642\u8a55\u4fa1\u8cc7\u6599\uff09\uff082022\u5e743\u670828\u65e5\u627f\u8a8d\uff0cCTD2.7.2-2.4.1\uff09"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Li YF, et al. Clin Pharmacokinet. 2022;61:1393-1403.","DOI":"10.1007\/s40262-022-01148-9"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Hoch M, et al. Clin Pharmacol Drug Dev. 2022;11:207-219.","DOI":"10.1002\/cpdd.1019"},{"key":"23","unstructured":"23) R\u00e9a D, et al. HemaSphere. 2022;6:56-57."},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Yuda J, et al. Cancer Med. 2023;12:2990-2998.","DOI":"10.1002\/cam4.5212"},{"key":"25","doi-asserted-by":"crossref","unstructured":"25) Mughal TI, et al. Haematologica. 2016;101:541-558.","DOI":"10.3324\/haematol.2015.139337"}],"container-title":["Folia Pharmacologica Japonica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/fpj\/158\/3\/158_22156\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,6]],"date-time":"2023-05-06T04:12:05Z","timestamp":1683346325000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/fpj\/158\/3\/158_22156\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,1]]},"references-count":25,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1254\/fpj.22156","relation":{},"ISSN":["0015-5691","1347-8397"],"issn-type":[{"value":"0015-5691","type":"print"},{"value":"1347-8397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,1]]},"article-number":"22156"}}