{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,6]],"date-time":"2025-07-06T04:01:15Z","timestamp":1751774475714,"version":"3.41.0"},"reference-count":32,"publisher":"Japanese Pharmacological Society","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Folia Pharmacol. Jpn.","Folia Pharmacologica Japonica"],"published-print":{"date-parts":[[2025,7,1]]},"DOI":"10.1254\/fpj.25017","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T22:08:28Z","timestamp":1751321308000},"page":"279-290","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological characteristics and clinical study results of danicopan (Voydeya<sup>\u00ae<\/sup> tablets)","\u30c0\u30cb\u30b3\u30d1\u30f3\uff08\u30dc\u30a4\u30c7\u30e4<sup>\u00ae<\/sup>\u932050 mg\uff09\u306e\u85ac\u7406\u5b66\u7684\u7279\u6027\u53ca\u3073\u81e8\u5e8a\u8a66\u9a13\u6210\u7e3e"],"prefix":"10.1254","volume":"160","author":[{"given":"Hideo","family":"Hayashi","sequence":"first","affiliation":[{"name":"Medical Affairs Division, Alexion Pharma G.K."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"332","reference":[{"key":"1","unstructured":"1) \u767a\u4f5c\u6027\u591c\u9593\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u5c3f\u75c7\uff08PNH\uff09\u306e\u8a3a\u65ad\u57fa\u6e96\u3068\u8a3a\u7642\u306e\u53c2\u7167\u30ac\u30a4\u30c9\u6539\u8a02\u7248\u4f5c\u6210\u306e\u305f\u3081\u306e\u30ef\u30fc\u30ad\u30f3\u30b0\u30b0\u30eb\u30fc\u30d7. \u767a\u4f5c\u6027\u591c\u9593\u30d8\u30e2\u30b0\u30ed\u30d3\u30f3\u5c3f\u75c7\u8a3a\u7642\u306e\u53c2\u7167\u30ac\u30a4\u30c9\u4ee4\u548c4\u5e74\u5ea6\u6539\u8a02\u7248. 2023."},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Kawaguchi T. Nihon Naika Gakkai Zasshi. 2012;101:1891\u20131897.","DOI":"10.2169\/naika.101.1891"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Barratt J, et al. Front Immunol. 2021;12:712572.","DOI":"10.3389\/fimmu.2021.712572"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Lee JW, et al. Expert Rev Clin Pharmacol. 2022;15:851\u2013861.","DOI":"10.1080\/17512433.2022.2109462"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Rother RP, et al. Nat Biotechnol. 2007;25:1256\u20131264.","DOI":"10.1038\/nbt1344"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Schubert J, et al. Br J Haematol. 2008;142:263\u2013272.","DOI":"10.1111\/j.1365-2141.2008.07183.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Kanakura Y, et al. Int J Hematol. 2011;93:36\u201346.","DOI":"10.1007\/s12185-010-0748-9"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Lee JW, et al. Blood. 2019;133:530\u2013539.","DOI":"10.1182\/blood-2018-09-876136"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Kulasekararaj AG, et al. Blood. 2019;133:540\u2013549.","DOI":"10.1182\/blood-2018-09-876805"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Hill A, et al. Br J Haematol. 2010;149:414\u2013425.","DOI":"10.1111\/j.1365-2141.2010.08096.x"},{"key":"11","doi-asserted-by":"crossref","unstructured":"11) Lin Z, et al. Blood. 2015;126:891\u2013894.","DOI":"10.1182\/blood-2015-02-625871"},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Notaro R, et al. Semin Hematol. 2018;55:130\u2013135.","DOI":"10.1053\/j.seminhematol.2018.05.014"},{"key":"13","unstructured":"13) \u6728\u4e0b\u30bf\u30ed\u30a6. \u751f\u5316\u5b66. 2017;89:351\u2013358."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Risitano AM, et al. Blood. 2009;113:4094\u20134100.","DOI":"10.1182\/blood-2008-11-189944"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Tomita A, et al. Ann Hematol. 2012;91:1139\u20131141.","DOI":"10.1007\/s00277-011-1368-z"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Waheed A, et al. Blood Rev. 2024;64:101158.","DOI":"10.1016\/j.blre.2023.101158"},{"key":"17","unstructured":"17) Lee JW, et al. Lancet Haematol. 2023;10:e955\u2013e965."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Harboe M, et al. Clin Exp Immunol. 2004;138:439\u2013446.","DOI":"10.1111\/j.1365-2249.2004.02627.x"},{"key":"19","unstructured":"19) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u52b9\u529b\u3092\u88cf\u4ed8\u3051\u308b\u8a66\u9a13\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.6.2.2\uff09"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Yuan X, et al. Haematologica. 2017;102:466\u2013475.","DOI":"10.3324\/haematol.2016.153312"},{"key":"21","unstructured":"21) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u85ac\u7269\u52d5\u614b\u53ca\u3073\u85ac\u529b\u5b66\u7684\u4f5c\u7528\u3092\u8a55\u4fa1\u3059\u308b\u8a66\u9a13\uff08ACH471-001\uff09\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.7.6.1\uff09"},{"key":"22","unstructured":"22) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u81e8\u5e8a\u85ac\u7406\u306e\u6982\u8981\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.7.2.3\uff09"},{"key":"23","unstructured":"23) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u85ac\u7269\u52d5\u614b\u53ca\u3073\u85ac\u529b\u5b66\u7684\u4f5c\u7528\u3092\u8a55\u4fa1\u3059\u308b\u8a66\u9a13\uff08ACH471-002\uff09\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.7.6.2\uff09"},{"key":"24","unstructured":"24) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u6bd2\u6027\u8a66\u9a13\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.4.4\uff09"},{"key":"25","unstructured":"25) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u6bd2\u6027\u8a66\u9a13\u306e\u6982\u8981\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.6.6\uff09"},{"key":"26","unstructured":"26) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u65e5\u672c\u4eba\u5065\u5eb7\u6210\u4eba\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2c\u2160\u76f8\u8a66\u9a13\uff08ALXN2040-HV-101\uff09\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.7.6.13\uff09"},{"key":"27","unstructured":"27) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u81e8\u5e8a\u85ac\u7406\u306e\u6982\u8981\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.7.2.2\uff09"},{"key":"28","unstructured":"28) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u6bcd\u96c6\u56e3PK\/PD\u89e3\u6790\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.7.2.3.4\uff09"},{"key":"29","unstructured":"29) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u30c0\u30cb\u30b3\u30d1\u30f3\u306e\u85ac\u7269\u52d5\u614b\uff08PK\uff09\u306b\u53ca\u307c\u3059\u98df\u4e8b\u306e\u5f71\u97ff\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.7.1.2.2\uff09"},{"key":"30","unstructured":"30) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u5065\u5eb7\u88ab\u9a13\u8005\uff0c\u814e\u6a5f\u80fd\u969c\u5bb3\u3092\u6709\u3059\u308b\u88ab\u9a13\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2c\u2160\u76f8\u8a66\u9a13\uff08ACH471-009\uff09\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.7.6.5\uff09"},{"key":"31","unstructured":"31) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u5065\u5eb7\u88ab\u9a13\u8005\uff0c\u809d\u6a5f\u80fd\u969c\u5bb3\u3092\u6709\u3059\u308b\u88ab\u9a13\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u7b2c\u2160\u76f8\u8a66\u9a13\uff08ACH471-012\uff09\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.7.6.8\uff09"},{"key":"32","unstructured":"32) \u30a2\u30ec\u30af\u30b7\u30aa\u30f3\u30d5\u30a1\u30fc\u30de\u5408\u540c\u4f1a\u793e \u793e\u5185\u8cc7\u6599\uff1a\u30e9\u30d6\u30ea\u30ba\u30de\u30d6\u53c8\u306f\u30a8\u30af\u30ea\u30ba\u30de\u30d6\u304c\u6295\u4e0e\u3055\u308c\u3066\u304a\u308a\u8840\u7ba1\u5916\u6eb6\u8840\u304c\u8a8d\u3081\u3089\u308c\u308bPNH\u60a3\u8005\u3092\u5bfe\u8c61\u3068\u3057\u305f\u56fd\u969b\u5171\u540c\u7b2c\u2162\u76f8\u8a66\u9a13\uff08ALXN2040-PNH-301\uff09\uff082024\u5e741\u670818\u65e5\u627f\u8a8d\uff0cCTD2.7.6.18\uff09"}],"container-title":["Folia Pharmacologica Japonica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/fpj\/160\/4\/160_25017\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T04:10:17Z","timestamp":1751688617000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/fpj\/160\/4\/160_25017\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7,1]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1254\/fpj.25017","relation":{},"ISSN":["0015-5691","1347-8397"],"issn-type":[{"type":"print","value":"0015-5691"},{"type":"electronic","value":"1347-8397"}],"subject":[],"published":{"date-parts":[[2025,7,1]]},"article-number":"25017"}}