{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T19:04:02Z","timestamp":1757617442625,"version":"3.44.0"},"reference-count":38,"publisher":"Japanese Pharmacological Society","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Folia Pharmacol. Jpn.","Folia Pharmacologica Japonica"],"published-print":{"date-parts":[[2025,9,1]]},"DOI":"10.1254\/fpj.25025","type":"journal-article","created":{"date-parts":[[2025,7,9]],"date-time":"2025-07-09T22:07:35Z","timestamp":1752098855000},"page":"360-370","source":"Crossref","is-referenced-by-count":0,"title":["Pharmacological characteristics and clinical trial results of garadacimab (anti-activated factor XII monoclonal antibody) for long-term prophylaxis of hereditary angioedema","\u907a\u4f1d\u6027\u8840\u7ba1\u6027\u6d6e\u816b\u306e\u9577\u671f\u767a\u4f5c\u6291\u5236\u6cbb\u7642\u85ac\u30ac\u30e9\u30c0\u30b7\u30de\u30d6\uff08\u30a2\u30ca\u30a8\u30d6\u30ea&lt;sup&gt;\u00ae&lt;\/sup&gt;\u76ae\u4e0b\u6ce8200\u00a0mg\u30da\u30f3\uff09\u306e\u85ac\u7406\u5b66\u7684\u7279\u5fb4\u304a\u3088\u3073\u81e8\u5e8a\u8a66\u9a13\u6210\u7e3e"],"prefix":"10.1254","volume":"160","author":[{"given":"Yumi","family":"Ito","sequence":"first","affiliation":[{"name":"Medical Affairs, CSL Behring"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Medical Affairs, CSL Behring"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Akiyama","sequence":"additional","affiliation":[{"name":"Medical Affairs, CSL Behring"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"332","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Bork K, et al. J Allergy Clin Immunol. 2012;130:692\u2013697.","DOI":"10.1016\/j.jaci.2012.05.055"},{"key":"2","unstructured":"2) Maurer M, et al. Allergy. 2022;77:1961\u20131990."},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Zanichelli A, et al. Clin Rev Allergy Immunol. 2021;61:77\u201383.","DOI":"10.1007\/s12016-021-08855-4"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Pappalardo E, et al. J Allergy Clin Immunol. 2000;106:1147\u20131154.","DOI":"10.1067\/mai.2000.110471"},{"key":"5","unstructured":"5) \u5800\u5185\u5b5d\u5f66, \u4ed6. \u907a\u4f1d\u6027\u8840\u7ba1\u6027\u6d6e\u816b\uff08Hereditary angioedema\uff1aHAE\uff09\u8a3a\u7642\u30ac\u30a4\u30c9\u30e9\u30a4\u30f3\u6539\u8a022023\u5e74\u7248\uff1a\u88dc\u4f53. 2023:60:103-131."},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Agostoni A, et al. J Allergy Clin Immunol. 2004;114:S51\u2013S131.","DOI":"10.1016\/j.jaci.2004.06.047"},{"key":"7","unstructured":"7) Reshef A, et al. J Allergy Clin Immunol. 2024;154:398\u2013411.e391."},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Han ED, et al. J Clin Invest. 2002;109:1057\u20131063.","DOI":"10.1172\/JCI14211"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) Miyata T, et al. Allergol Int. 2023;72:375\u2013384.","DOI":"10.1016\/j.alit.2023.04.004"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Cohn DM, et al. J Intern Med. 2024;296:311\u2013326.","DOI":"10.1111\/joim.20008"},{"key":"11","unstructured":"11) L\u00f3pez Lera A. Balkan Med J. 2021;38:82\u201388."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Rosi-Schumacher M, et al. Laryngoscope Investig Otolaryngol. 2021;6:394\u2013403.","DOI":"10.1002\/lio2.555"},{"key":"13","doi-asserted-by":"crossref","unstructured":"13) Caballero T, et al. Allergy Asthma Proc. 2014;35:47\u201353.","DOI":"10.2500\/aap.2013.34.3685"},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Bork K, et al. Am J Med. 2006;119:267\u2013274.","DOI":"10.1016\/j.amjmed.2005.09.064"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Altman KA, et al. Curr Med Res Opin. 2014;30:923\u2013930.","DOI":"10.1185\/03007995.2013.879441"},{"key":"16","doi-asserted-by":"crossref","unstructured":"16) Agostoni A, et al. Medicine (Baltimore). 1992;71:206\u2013215.","DOI":"10.1097\/00005792-199207000-00003"},{"key":"17","unstructured":"17) \u6c38\u7530\u529f\uff0c\u4ed6. \u65e5\u672c\u6551\u6025\u533b\u5b66\u4f1a\u96d1\u8a8c. 2012;23:21\u201325."},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Shibuya M, et al. Allergol Int. 2014;63:493\u2013494.","DOI":"10.2332\/allergolint.13-LE-0655"},{"key":"19","doi-asserted-by":"crossref","unstructured":"19) Zotter Z, et al. Orphanet J Rare Dis. 2014;9:44.","DOI":"10.1186\/s13023-014-0205-6"},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Fijen LM, et al. J Allergy Clin Immunol Pract. 2023;11:2468\u20132475 e2462.","DOI":"10.1016\/j.jaip.2023.03.032"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Craig TJ, et al. Lancet. 2023;401:1079\u20131090.","DOI":"10.1016\/S0140-6736(23)00350-1"},{"key":"22","doi-asserted-by":"crossref","unstructured":"22) Riedl MA, et al. Allergy Asthma Proc. 2021;42:S17\u2013S25.","DOI":"10.2500\/aap.2021.42.210017"},{"key":"23","doi-asserted-by":"crossref","unstructured":"23) Riedl MA, et al. Allergy Asthma Proc. 2023;44:275\u2013282.","DOI":"10.2500\/aap.2023.44.230026"},{"key":"24","doi-asserted-by":"crossref","unstructured":"24) Cowan R, et al. J Headache Pain. 2019;20:50.","DOI":"10.1186\/s10194-019-0998-8"},{"key":"25","unstructured":"25) Grumach AS, et al. Clin Transl Allergy. 2023;13:e12243."},{"key":"26","doi-asserted-by":"crossref","unstructured":"26) Bork K, et al. Allergy Asthma Clin Immunol. 2021;17:40.","DOI":"10.1186\/s13223-021-00537-2"},{"key":"27","unstructured":"27) CSL\u30d9\u30fc\u30ea\u30f3\u30b0\u682a\u5f0f\u4f1a\u793e. \u30a2\u30ca\u30a8\u30d6\u30ea<sup>\u00ae<\/sup>\u76ae\u4e0b\u6ce8200mg\u30da\u30f3\u6dfb\u4ed8\u6587\u66f8\u7b2c1\u7248. 2025."},{"key":"28","doi-asserted-by":"crossref","unstructured":"28) Oschatz C, et al. Immunity. 2011;34:258\u2013268.","DOI":"10.1016\/j.immuni.2011.02.008"},{"key":"29","doi-asserted-by":"crossref","unstructured":"29) Cao H, et al. J Allergy Clin Immunol. 2018;142:1355\u20131358.","DOI":"10.1016\/j.jaci.2018.06.014"},{"key":"30","doi-asserted-by":"crossref","unstructured":"30) Yu J, et al. J Hematol Oncol. 2020;13:45.","DOI":"10.1186\/s13045-020-00962-7"},{"key":"31","unstructured":"31) CSL\u30d9\u30fc\u30ea\u30f3\u30b0\u682a\u5f0f\u4f1a\u793e. \u793e\u5185\u8cc7\u6599: \u81e8\u5e8a\u85ac\u7406\u8a66\u9a13 CTD2.7.2. 2025."},{"key":"32","doi-asserted-by":"crossref","unstructured":"32) Glassman F, et al. J Clin Pharmacol. 2025;65:466\u2013477.","DOI":"10.1002\/jcph.6162"},{"key":"33","doi-asserted-by":"crossref","unstructured":"33) McKenzie A, et al. Clin Transl Sci. 2022;15:626\u2013637.","DOI":"10.1111\/cts.13180"},{"key":"34","doi-asserted-by":"crossref","unstructured":"34) Craig T, et al. Lancet. 2022;399:945\u2013955.","DOI":"10.1016\/S0140-6736(21)02225-X"},{"key":"35","doi-asserted-by":"crossref","unstructured":"35) Craig TJ, et al. Lancet Haematol. 2024;11:e436\u2013e447.","DOI":"10.1016\/S2352-3026(24)00081-4"},{"key":"36","unstructured":"36) CSL\u30d9\u30fc\u30ea\u30f3\u30b0\u682a\u5f0f\u4f1a\u793e. \u30a2\u30ca\u30a8\u30d6\u30ea<sup>\u00ae<\/sup>\u76ae\u4e0b\u6ce8200mg\u30da\u30f3\u30a4\u30f3\u30bf\u30d3\u30e5\u30fc\u30d5\u30a9\u30fc\u30e0\u7b2c1\u7248. 2025."},{"key":"37","unstructured":"37) CSL\u30d9\u30fc\u30ea\u30f3\u30b0\u682a\u5f0f\u4f1a\u793e. \u793e\u5185\u8cc7\u6599: \u81e8\u5e8a\u7684\u6709\u52b9\u6027 CTD 2.7.3. 2025."},{"key":"38","doi-asserted-by":"crossref","unstructured":"38) Reshef A, et al. Allergy. 2025;80:545\u2013556.","DOI":"10.1111\/all.16351"}],"container-title":["Folia Pharmacologica Japonica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/fpj\/160\/5\/160_25025\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T04:06:05Z","timestamp":1757131565000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/fpj\/160\/5\/160_25025\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,1]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.1254\/fpj.25025","relation":{},"ISSN":["0015-5691","1347-8397"],"issn-type":[{"type":"print","value":"0015-5691"},{"type":"electronic","value":"1347-8397"}],"subject":[],"published":{"date-parts":[[2025,9,1]]},"article-number":"25025"}}