{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T23:35:44Z","timestamp":1777937744938,"version":"3.51.4"},"reference-count":21,"publisher":"Japanese Pharmacological Society","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Folia Pharmacol. Jpn.","Folia Pharmacologica Japonica"],"published-print":{"date-parts":[[2026,5,1]]},"DOI":"10.1254\/fpj.25096","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T22:12:50Z","timestamp":1777587170000},"page":"192-197","source":"Crossref","is-referenced-by-count":0,"title":["The preclinical profiles and the clinical efficacy and safety of vornorexant (Vorzzz&lt;sup&gt;\u00ae&lt;\/sup&gt; tablets), a new orexin receptor antagonist","\u65b0\u898f\u30aa\u30ec\u30ad\u30b7\u30f3\u53d7\u5bb9\u4f53\u62ee\u6297\u85ac\u30dc\u30eb\u30ce\u30ec\u30ad\u30b5\u30f3\u30c8\uff08\u30dc\u30eb\u30ba\u30a3&lt;sup&gt;\u00ae&lt;\/sup&gt;\u93202.5 mg\uff0c5 mg\uff0c10 mg\uff09\u306e\u85ac\u7406\u5b66\u7684\u7279\u5fb4\u3068\u81e8\u5e8a\u8a66\u9a13\u6210\u7e3e"],"prefix":"10.1254","volume":"161","author":[{"given":"Haruka","family":"Yokota","sequence":"first","affiliation":[{"name":"Medical Information, Taisho Pharmaceutical Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Chino","sequence":"additional","affiliation":[{"name":"Medical Information, Taisho Pharmaceutical Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kayoko","family":"Shibayama","sequence":"additional","affiliation":[{"name":"Medical Information, Taisho Pharmaceutical Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeyuki","family":"Chaki","sequence":"additional","affiliation":[{"name":"Medical Information, Taisho Pharmaceutical Co., Ltd."},{"name":"Research Headquarters, Taisho Pharmaceutical Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Imadera","sequence":"additional","affiliation":[{"name":"Medical Information, Taisho Pharmaceutical Co., Ltd."}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"332","reference":[{"key":"1","doi-asserted-by":"crossref","unstructured":"1) Riemann D, et al. Lancet Neurol. 2015;14:547\u2013558.","DOI":"10.1016\/S1474-4422(15)00021-6"},{"key":"2","doi-asserted-by":"crossref","unstructured":"2) Roth T. J Clin Sleep Med. 2007;3:S7\u2013S10.","DOI":"10.5664\/jcsm.26929"},{"key":"3","doi-asserted-by":"crossref","unstructured":"3) Chan NY, et al. Neurotherapeutics. 2021;18:32\u201343.","DOI":"10.1007\/s13311-021-01029-2"},{"key":"4","doi-asserted-by":"crossref","unstructured":"4) Lader M. Br J Clin Pharmacol. 2014;77:295\u2013301.","DOI":"10.1111\/j.1365-2125.2012.04418.x"},{"key":"5","doi-asserted-by":"crossref","unstructured":"5) Gravielle MC, et al. Pharmacol Res. 2016;109:92\u2013100.","DOI":"10.1016\/j.phrs.2015.12.030"},{"key":"6","doi-asserted-by":"crossref","unstructured":"6) Hindmarch I. Int J Clin Pract. 2009;63:1085\u20131094.","DOI":"10.1111\/j.1742-1241.2009.02085.x"},{"key":"7","doi-asserted-by":"crossref","unstructured":"7) Capiau A, et al. Eur Geriatr Med. 2023;14:697\u2013708.","DOI":"10.1007\/s41999-022-00731-4"},{"key":"8","doi-asserted-by":"crossref","unstructured":"8) Sakurai T, et al. Cell. 1998;92:573\u2013585.","DOI":"10.1016\/S0092-8674(00)80949-6"},{"key":"9","doi-asserted-by":"crossref","unstructured":"9) de Lecea L, et al. Proc Natl Acad Sci U S A. 1998;95:322\u2013327.","DOI":"10.1073\/pnas.95.1.322"},{"key":"10","doi-asserted-by":"crossref","unstructured":"10) Jones BE. Trends Pharmacol Sci. 2005;26:578\u2013586.","DOI":"10.1016\/j.tips.2005.09.009"},{"key":"11","unstructured":"11) De Luca R, et al. Nat Commun. 2022;13:4163."},{"key":"12","doi-asserted-by":"crossref","unstructured":"12) Muehlan C, et al. J Sleep Res. 2023;32:e13902.","DOI":"10.1111\/jsr.13902"},{"key":"13","unstructured":"13) Suzuki R, et al. Bioorg Med Chem. 2015;23:1260\u20131275."},{"key":"14","doi-asserted-by":"crossref","unstructured":"14) Futamura A, et al. Bioorg Med Chem. 2020;28:115489.","DOI":"10.1016\/j.bmc.2020.115489"},{"key":"15","doi-asserted-by":"crossref","unstructured":"15) Hikichi H, et al. J Pharmacol Exp Ther. 2025;392:103624.","DOI":"10.1016\/j.jpet.2025.103624"},{"key":"16","unstructured":"16) Konno Y, et al. Pharmacol Res Perspect. 2024;12:e1183."},{"key":"17","unstructured":"17) \u30dc\u30eb\u30ba\u30a3<sup>\u00ae<\/sup>\u9320 \u7533\u8acb\u8cc7\u6599"},{"key":"18","doi-asserted-by":"crossref","unstructured":"18) Kambe D, et al. Basic Clin Pharmacol Toxicol. 2023;133:576\u2013591.","DOI":"10.1111\/bcpt.13930"},{"key":"19","unstructured":"19) Uchiyama M, et al. Sleep. 2026;49:zsaf291."},{"key":"20","doi-asserted-by":"crossref","unstructured":"20) Uchiyama M, et al. Psychopharmacology (Berl). 2022;239:2143\u20132154.","DOI":"10.1007\/s00213-022-06089-6"},{"key":"21","doi-asserted-by":"crossref","unstructured":"21) Miyazaki Y, et al. Psychiatry Clin Neurosci. 2025;79:757\u2013764.","DOI":"10.1111\/pcn.13888"}],"container-title":["Folia Pharmacologica Japonica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/fpj\/161\/3\/161_25096\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:12:15Z","timestamp":1777695135000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/fpj\/161\/3\/161_25096\/_article\/-char\/ja\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,1]]},"references-count":21,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026]]}},"URL":"https:\/\/doi.org\/10.1254\/fpj.25096","relation":{},"ISSN":["0015-5691","1347-8397"],"issn-type":[{"value":"0015-5691","type":"print"},{"value":"1347-8397","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,1]]},"article-number":"25096"}}