{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T03:14:36Z","timestamp":1767150876205,"version":"build-2238731810"},"reference-count":15,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1984,1,1]],"date-time":"1984-01-01T00:00:00Z","timestamp":441763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T00:00:00Z","timestamp":1570147200000},"content-version":"vor","delay-in-days":13060,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1984]]},"DOI":"10.1016\/s0021-5198(19)52298-3","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T04:35:51Z","timestamp":1605674151000},"page":"435-440","source":"Crossref","is-referenced-by-count":7,"title":["Structure-Affinity Relationships Between Several New Benzodiazepine Derivatives and 3H-Diazepam Receptor Sites"],"prefix":"10.1016","volume":"34","author":[{"given":"Takeshi","family":"SHIBUYA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"FIELD","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"WATANABE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhiko","family":"SATO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernard","family":"SALAFSKY","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0021-5198(19)52298-3_bib1","doi-asserted-by":"crossref","first-page":"102P","DOI":"10.1016\/S0021-5198(19)66030-0","article-title":"Effects of benzodiazepines on brain monoamines","volume":"26","author":"Shibuya","year":"1976","journal-title":"Japan. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)52298-3_bib2","first-page":"297","article-title":"Simultaneous measurement of biogenic amines and related compounds by high performance liquid chromatography (HPLC)","volume":"20","author":"Shibuya","year":"1982","journal-title":"Int. J. Clin. Pharmacol."},{"key":"10.1016\/S0021-5198(19)52298-3_bib3","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1126\/science.918669","article-title":"Benzodiazepine receptor: Demonstration in the central nervous system","volume":"198","author":"M\u00f6hler","year":"1977","journal-title":"Science"},{"key":"10.1016\/S0021-5198(19)52298-3_bib4","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/266732a0","article-title":"Benzodiazepine receptors in rat brain","volume":"266","author":"Squires","year":"1977","journal-title":"Nature"},{"key":"10.1016\/S0021-5198(19)52298-3_bib5","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1016\/0024-3205(77)90191-6","article-title":"Properties of 3H-diazepam binding to benzodiazepine receptors in rat cerebral cortex","volume":"20","author":"M\u00f6hler","year":"1977","journal-title":"Life Sci."},{"key":"10.1016\/S0021-5198(19)52298-3_bib6","series-title":"In The Benzodiazepines","first-page":"443","article-title":"Chemistry of 1,4-benzodiaze-pines and some aspects of the structure-activity relationship","author":"Sternbach","year":"1973"},{"key":"10.1016\/S0021-5198(19)52298-3_bib7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1021\/jm00176a016","article-title":"Values and structure activity relationship of benzodiazepines","volume":"23","author":"Biagi","year":"1980","journal-title":"J. Med. Chem."},{"key":"10.1016\/S0021-5198(19)52298-3_bib8","first-page":"628","article-title":"Structure-activity relationship in 1,4 benzodiazepines","volume":"57","author":"Borea","year":"1981","journal-title":"Boll. Soc. Ital. Biol. Sper."},{"key":"10.1016\/S0021-5198(19)52298-3_bib9","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1126\/science.6101294","article-title":"Receptors for the age of anxiety: Pharmacology of the benzodiazepines","volume":"207","author":"Tallman","year":"1980","journal-title":"Science"},{"key":"10.1016\/S0021-5198(19)52298-3_bib10","first-page":"3032","article-title":"The benzodiazepine receptor of mammalian brain","volume":"39","author":"Speth","year":"1980","journal-title":"Fed. Proc."},{"key":"10.1016\/S0021-5198(19)52298-3_bib11","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-5198(19)52298-3_bib12","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/clpt.1981.169","article-title":"Pharmacoelectro-encephalographic study of brotizolam, a novel hypnotic","volume":"30","author":"Fink","year":"1981","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/S0021-5198(19)52298-3_bib13","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1365-2125.1980.tb00504.x","article-title":"Studies on sleep and performance with a triazolo-1.4-thienodiazepam (brotizolam)","volume":"10","author":"Nicholson","year":"1980","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/S0021-5198(19)52298-3_bib14","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000400084","article-title":"Confirmation of pharmaco-EEG predictions concerning pharmacodynamic properties of an anxiolytic sedative by sleep studies","volume":"6","author":"Saletu","year":"1981","journal-title":"Adv. Biol. Psychiat."},{"key":"10.1016\/S0021-5198(19)52298-3_bib15","first-page":"603","article-title":"Anxiolytic effects of a new triazoio-benzodiazepine","volume":"15","author":"Itil","year":"1973","journal-title":"Curr. Ther. Res. Clin. Exp."}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819522983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819522983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T14:04:20Z","timestamp":1618409060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819522983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984]]},"references-count":15,"aliases":["10.1254\/jjp.34.435"],"journal-issue":{"issue":"4","published-print":{"date-parts":[[1984]]}},"alternative-id":["S0021519819522983"],"URL":"https:\/\/doi.org\/10.1016\/s0021-5198(19)52298-3","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1984]]}}}