{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T02:42:19Z","timestamp":1767148939545,"version":"build-2238731810"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[1984,1,1]],"date-time":"1984-01-01T00:00:00Z","timestamp":441763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"vor","delay-in-days":13057,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1984]]},"DOI":"10.1016\/s0021-5198(19)53287-5","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T05:08:05Z","timestamp":1605676085000},"page":"339-348","source":"Crossref","is-referenced-by-count":5,"title":["Localized Effects of Naloxone on Local Cerebral Glucose Utilization in Rat Cerebral Nuclei with Met-Enkephalinergic Neurons"],"prefix":"10.1016","volume":"36","author":[{"given":"Tetsuo","family":"HAYASHI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"NAKAMURA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0021-5198(19)53287-5_bib1","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1073\/pnas.75.3.1591","article-title":"Neurons containing \u03b2-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies","volume":"75","author":"Bloom","year":"1978","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S0021-5198(19)53287-5_bib2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/0304-3940(77)90160-4","article-title":"The distribution of enkephalin-immunoreactive cell bodies in the rat central neurons systems","volume":"5","author":"H\u00f6kfelt","year":"1977","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0021-5198(19)53287-5_bib3","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0304-3940(79)95343-6","article-title":"Evidence for enkephalin immuno-reactive neurons in the medulla oblongata projecting to the spinal cord","volume":"14","author":"H\u00f6kfelt","year":"1979","journal-title":"Neurosci. Lett."},{"key":"10.1016\/S0021-5198(19)53287-5_bib4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0006-8993(83)91361-6","article-title":"Development of cerebral methionine-enkephalinergic neurons in rats: Some difference in Wistar-Kyoto rats and spontaneously hypertensive rats","volume":"271","author":"Nakamura","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/S0021-5198(19)53287-5_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/0006-8993(81)90597-7","article-title":"Effect of naloxone upon diffuse noxious inhibitory controls (DNIC) in the rat","volume":"204","author":"Bars","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/S0021-5198(19)53287-5_bib6","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1038\/270620a0","article-title":"Naloxone alters pain perception and somatosensory evoked potentials in normal subjects","volume":"270","author":"Buchsbaum","year":"1977","journal-title":"Nature"},{"key":"10.1016\/S0021-5198(19)53287-5_bib7","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1016\/0024-3205(82)90147-3","article-title":"Periaquductal grey matter stimulation products naloxone sensitive inhibition of reticular neurones in rat caudal medulla","volume":"31","author":"Hill","year":"1982","journal-title":"Life Sci."},{"key":"10.1016\/S0021-5198(19)53287-5_bib8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/BF00431258","article-title":"Naloxone-induced electrographic seizures in the primate","volume":"67","author":"Snyder","year":"1980","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/S0021-5198(19)53287-5_bib9","series-title":"Mechanisms of Blood Pressure Waves","article-title":"Metabolic and met-enkephalin-ergic neuronal responses of cerebral nuclei to baroreceptor alteration in conscious rats","author":"Nakamura","year":"1984"},{"key":"10.1016\/S0021-5198(19)53287-5_bib10","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/BF00495866","article-title":"The effect of opiates on arterial baroreceptor reflex function in the rabbit","volume":"319","author":"Petty","year":"1982","journal-title":"Naunyn Schmiedbergs Arch. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53287-5_bib11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1161\/01.HYP.2.4.395","article-title":"Enkephalin effects on blood pressure, heart rate, and baroreceptor reflex","volume":"2","author":"Schaz","year":"1980","journal-title":"Hypertension"},{"key":"10.1016\/S0021-5198(19)53287-5_bib12","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/0006-8993(81)90360-7","article-title":"Naloxone effects on the blood pressure response Induced by thin-flber muscular afferents","volume":"205","author":"Kumazawa","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/S0021-5198(19)53287-5_bib13","first-page":"441","article-title":"Naloxone treatment of endotoxin shock: stereospecificity of physiologic and pharmacologic effects in the rat","volume":"212","author":"Faden","year":"1980","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0021-5198(19)53287-5_bib14","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0014-2999(80)90214-9","article-title":"Reversal by naloxone of hemorrhagic shock In anephric cats","volume":"65","author":"Feuerstein","year":"1980","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53287-5_bib15","first-page":"295","article-title":"Naloxone acts at central opiate receptors to reverse hypotension","volume":"189","author":"Holaday","year":"1980","journal-title":"hypothermia and hypoventilation in spinal shock. Brain Res."},{"key":"10.1016\/S0021-5198(19)53287-5_bib16","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/0024-3205(82)90118-7","article-title":"Naloxone reversal of ischemic neurologic deficits in baboons is not mediated by systemic effects","volume":"31","author":"Baskin","year":"1982","journal-title":"Life Sci."},{"key":"10.1016\/S0021-5198(19)53287-5_bib17","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1126\/science.6274019","article-title":"Reversal of induced ischemic neurologic deficit in gerbils by the opiate antagonist naloxone","volume":"215","author":"Hosobuchi","year":"1982","journal-title":"Science"},{"key":"10.1016\/S0021-5198(19)53287-5_bib18","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/0006-8993(79)90797-2","article-title":"The opiate antagonist naloxone modifies the effects of electroconvulsive shock (ECS) on respiration, blood pressure and heart rate","volume":"177","author":"Belenky","year":"1979","journal-title":"Brain Res."},{"key":"10.1016\/S0021-5198(19)53287-5_bib19","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0024-3205(81)90110-7","article-title":"Naloxone blocks the effect of 5-hydroxytryptophan on passive avoidance learning in rats: implication of endogenous opioid peptides","volume":"29","author":"Garz\u00f3n","year":"1981","journal-title":"Life Sci."},{"key":"10.1016\/S0021-5198(19)53287-5_bib20","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1177\/28.8.7003009","article-title":"The distribution and functions of the enkephalins","volume":"28","author":"Miller","year":"1980","journal-title":"J. Histochem. Cytochem."},{"key":"10.1016\/S0021-5198(19)53287-5_bib21","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/0024-3205(83)90786-5","article-title":"Naloxone-induced hypodipsia: a CNS mapping study","volume":"33","author":"Czech","year":"1983","journal-title":"Life Sci."},{"key":"10.1016\/S0021-5198(19)53287-5_bib22","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0024-3205(80)90183-6","article-title":"The neuroendocrine control of appetite: the role of the endogenous opiates, cholecystokinin, TRH, gamma-amino-butyric-acid and the diazepam receptor","volume":"27","author":"Morley","year":"1980","journal-title":"Life Sci."},{"key":"10.1016\/S0021-5198(19)53287-5_bib23","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1016\/0024-3205(76)90068-0","article-title":"Effect of naloxone on antinociceptive activity of phenoxybenzamine","volume":"19","author":"Elliott","year":"1976","journal-title":"Life Sci"},{"key":"10.1016\/S0021-5198(19)53287-5_bib24","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0091-3057(81)90348-8","article-title":"Naloxone blocks the effect of diazepam and meprobamate on conflict behaviour in rats","volume":"15","author":"Duka","year":"1981","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0021-5198(19)53287-5_bib25","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1159\/000117834","article-title":"R\u00e9cepteurs de l\u2019opium et sommeil","volume":"7","author":"Tissot","year":"1981","journal-title":"Neuropsychobiol"},{"key":"10.1016\/S0021-5198(19)53287-5_bib26","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1476-5381.1980.tb10862.x","article-title":"Release of opioid peptides in anesthetized cats","volume":"68","author":"Dashwood","year":"1980","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53287-5_bib27","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/0006-8993(81)91110-0","article-title":"Dose-dependent analgesic and hyperalgesic effects of systemic naloxone in arthritic rats","volume":"226","author":"Kayser","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/S0021-5198(19)53287-5_bib28","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/j.1476-5381.1981.tb09960.x","article-title":"Potentiation by naloxone of pressor reflexes","volume":"74","author":"Montastruc","year":"1981","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53287-5_bib29","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/0024-3205(83)90085-1","article-title":"Cardiovascular effects of naloxone, naltrexone and morphine in the squirrel monkey","volume":"32","author":"Byrd","year":"1983","journal-title":"Life Sci."},{"key":"10.1016\/S0021-5198(19)53287-5_bib30","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1016\/0024-3205(82)90116-3","article-title":"Cardiovascular responses to opioid agonists injected into the nucleus of tractus solitarius of anesthetized cats","volume":"31","author":"Hassen","year":"1982","journal-title":"Life Sci."},{"key":"10.1016\/S0021-5198(19)53287-5_bib31","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1111\/j.1399-6576.1979.tb01460.x","article-title":"Circulatory pattern and duration of action of naloxone in dogs with and without opioid pretreatment","volume":"23","author":"Schweichel","year":"1979","journal-title":"Acta Anaesthesiol. Scand."},{"key":"10.1016\/S0021-5198(19)53287-5_bib32","first-page":"2333","article-title":"Limitations on the antagonistic actions of opioid antagonists","volume":"41","author":"Young","year":"1982","journal-title":"Fed. Proc."},{"key":"10.1016\/S0021-5198(19)53287-5_bib33","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1111\/j.1471-4159.1977.tb10649.x","article-title":"The [14C]-deoxygiucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat","volume":"28","author":"Sokoloff","year":"1977","journal-title":"J. Neurochem."},{"key":"10.1016\/S0021-5198(19)53287-5_bib34","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/cne.901570104","article-title":"Topographic atlas of catecholamine and acetylcholinesterase-containing neurons in the rat brain-II. Hindbrain (mesencephalon, rhombencephalon)","volume":"157","author":"Palkovits","year":"1984","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/S0021-5198(19)53287-5_bib35","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/BF00501366","article-title":"Cerebral neuronal activity in spontaneously hypertensive rats as demonstrated by the 14C-deoxyglucose method","volume":"316","author":"Hayashi","year":"1981","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53287-5_bib36","first-page":"1209","article-title":"Alteration of methionine enkephalin immunoreactivity in cerebral nuclei of young spontaneously hypertensive rats","volume":"4","author":"Nakamura","year":"1982","journal-title":"Clin. Exp. Hypertension"},{"key":"10.1016\/S0021-5198(19)53287-5_bib37","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/S0021-5198(19)52622-1","article-title":"Cerebral acting maps of hydralazine, clonidine, and a-methyl-dopa in spontaneously hypertensive rats as demonstrated by the 14C-deoxy-D-glucose method","volume":"32","author":"Hayashi","year":"1982","journal-title":"Japan. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53287-5_bib38","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1161\/01.HYP.4.5.662","article-title":"Methionine en-kephalinergic neuronal activity in cerebral nuclei of spontaneously hypertensive rats","volume":"4","author":"Nakamura","year":"1982","journal-title":"Hypertension"},{"key":"10.1016\/S0021-5198(19)53287-5_bib39","series-title":"The Rat Brain","author":"K\u00f6nig","year":"1970"},{"key":"10.1016\/S0021-5198(19)53287-5_bib40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1038\/jcbfm.1981.4","article-title":"Localization of functional activity in the central nervous system by measurement of glucose utilization with radioactive deoxy-glucose","volume":"1","author":"Sokoloff","year":"1981","journal-title":"J. Cereb. Blood. Flow Metabol."},{"key":"10.1016\/S0021-5198(19)53287-5_bib41","first-page":"266","article-title":"Discrimination of three opiate receptor binding sites with the use of a computerized curve-fitting technique","volume":"21","author":"Pfeiffer","year":"1982","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53287-5_bib42","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1073\/pnas.74.5.2167","article-title":"Opioid peptide enkephalin: Immunohistochemical mapping in rat central nervous system","volume":"74","author":"Simantov","year":"1977","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/S0021-5198(19)53287-5_bib43","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/0024-3205(82)90378-2","article-title":"Visualization of opiate receptors and opioid peptides in sequential brain sections","volume":"31","author":"Lewis","year":"1982","journal-title":"Life Sci."},{"key":"10.1016\/S0021-5198(19)53287-5_bib44","first-page":"234","article-title":"Quantitative film autoradiography of opiate agonist and antagonist binding in rat brain","volume":"225","author":"Geary","year":"1983","journal-title":"J. Pharmcol. Exp. Ther."},{"key":"10.1016\/S0021-5198(19)53287-5_bib45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/0006-8993(82)91209-4","article-title":"Effect of naltrexone on regional brain oxygen consumption in the cat","volume":"233","author":"Grandison","year":"1982","journal-title":"Brain Res."},{"key":"10.1016\/S0021-5198(19)53287-5_bib46","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0006-8993(82)91207-0","article-title":"Influence of \u03b1-receptor blocking agents upon metabolic activity in nuclei Involved in central control of blood pressure","volume":"233","author":"Savaki","year":"1982","journal-title":"Brain Res."}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819532875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819532875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,11,28]],"date-time":"2022-11-28T10:44:27Z","timestamp":1669632267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819532875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984]]},"references-count":46,"aliases":["10.1254\/jjp.36.339"],"journal-issue":{"issue":"3","published-print":{"date-parts":[[1984]]}},"alternative-id":["S0021519819532875"],"URL":"https:\/\/doi.org\/10.1016\/s0021-5198(19)53287-5","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1984]]}}}