{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T02:53:13Z","timestamp":1767149593810,"version":"build-2238731810"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1990,1,1]],"date-time":"1990-01-01T00:00:00Z","timestamp":631152000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,20]],"date-time":"2019-09-20T00:00:00Z","timestamp":1568937600000},"content-version":"vor","delay-in-days":10854,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1990]]},"DOI":"10.1016\/s0021-5198(19)53747-7","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T05:11:49Z","timestamp":1605676309000},"page":"363-370","source":"Crossref","is-referenced-by-count":3,"title":["Anticholinergic Action of Disopyramide in Intestinal Smooth Muscle of the Guinea Pig: Inhibition of Muscarinic Receptors (M1 and M2)"],"prefix":"10.1016","volume":"52","author":[{"given":"Yukisato","family":"ISHIDA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masami","family":"MIZUKAMI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"TANIGUCHI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuhiro","family":"SATAKE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohatsu","family":"FUJIWARA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shoji","family":"SHIBATA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0021-5198(19)53747-7_bib1","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1002\/cpt1974162330","article-title":"Disopyramide phosphate: Clinical efficacy of a new oral antiarrhythmic drug","volume":"16","author":"Vismara","year":"1974","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/S0021-5198(19)53747-7_bib2","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1161\/01.RES.46.5.660","article-title":"Electrophysiological effects of disopyramide and quinidine on guinea pig atria and canine Purkinje fibers","volume":"46","author":"Mirro","year":"1980","journal-title":"Circ. Res."},{"key":"10.1016\/S0021-5198(19)53747-7_bib3","series-title":"Pharmacological and Biochemical Properties of Drug Substances, Vol. 2","first-page":"168","article-title":"Disopyramide","author":"Dean","year":"1979"},{"key":"10.1016\/S0021-5198(19)53747-7_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1399-6576.1981.tb01650.x","article-title":"Disopyramide anticholinergic action","volume":"25","author":"Byrne","year":"1981","journal-title":"Acta Anaesth. Scand."},{"key":"10.1016\/S0021-5198(19)53747-7_bib5","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/323411a0","article-title":"Cloning, sequencing and expression of complementary DNA encoding the muscarinic acetylcholine receptor","volume":"323","author":"Kubo","year":"1986","journal-title":"Nature"},{"key":"10.1016\/S0021-5198(19)53747-7_bib6","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1126\/science.3107123","article-title":"Primary structure and biochemical properties of an M2 muscarinic receptor","volume":"236","author":"Peralta","year":"1987","journal-title":"Science"},{"key":"10.1016\/S0021-5198(19)53747-7_bib7","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/0896-6273(88)90190-0","article-title":"Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes","volume":"1","author":"Bonner","year":"1988","journal-title":"Neuron"},{"key":"10.1016\/S0021-5198(19)53747-7_bib8","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.1016\/0024-3205(82)90066-2","article-title":"Muscarinic receptor subtype M1 and M2 biochemical and functional characterization","volume":"31","author":"Hammer","year":"1982","journal-title":"Life Sci."},{"key":"10.1016\/S0021-5198(19)53747-7_bib9","unstructured":"Mitchelson, F.: Heterogeneity in muscarinic receptors: Evidence from pharmacologic studies with antagonists. TIPS 5, Symposium Supp. 12-16 (1984)"},{"key":"10.1016\/S0021-5198(19)53747-7_bib10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1476-5381.1985.tb08879.x","article-title":"The relative potencies of some agonists at M2 muscarinic receptors in guinea-pig ileum, atria and bronchi","volume":"85","author":"Barlow","year":"1985","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53747-7_bib11","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1476-5381.1988.tb11516.x","article-title":"Comparison of effects of some muscarinic agonists on smooth muscle function and phos-phatidylinositol turnover in the guinea-pig taenia caeci","volume":"94","author":"Gardner","year":"1988","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53747-7_bib12","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1016\/S0021-5198(19)53747-7_bib13","first-page":"48","article-title":"Some quantitative use of drug antagonists","volume":"14","author":"Arunlakshana","year":"1959","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53747-7_bib14","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1111\/j.2042-7158.1986.tb04615.x","article-title":"Interactions of muscarinic drugs with their receptors in single cells of guinea-pig taenia caecum","volume":"38","author":"Takayanagi","year":"1986","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53747-7_bib15","first-page":"861","article-title":"Muscarinic cholinergic receptor binding in the longitudinal muscle of the guinea pig ileum with [3H]-quinuclidinyl benzilate","volume":"10","author":"Yamamura","year":"1974","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53747-7_bib16","first-page":"227","article-title":"Structural and stereochemical requirements for muscarinic receptor binding","volume":"15","author":"Aronstam","year":"1979","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53747-7_bib17","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1161\/01.RES.47.6.855","article-title":"Anticholinergic effects of disopyramide and quinidine on guinea pig myocardium","volume":"47","author":"Mirro","year":"1980","journal-title":"Circ. Res."},{"key":"10.1016\/S0021-5198(19)53747-7_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/0014-2999(84)90439-4","article-title":"Intrinsic activity and effects of. guanyl-5\u2019-yl irnidodiphosphate. Gpp(NH)p on the affinity of partial agonists to the muscarinic receptor","volume":"99","author":"Takayanagi","year":"1984","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)53747-7_bib19","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1111\/j.2042-7158.1985.tb05106.x","article-title":"Comparison of the affinity constant of some muscarinic receptor antagonists with their displacement of [3H]-quinuclidinyl benzilate binding in atrial and ileal longitudinal muscle of the guinea-pig","volume":"37","author":"Choo","year":"1985","journal-title":"J. Pharm. Pharmacol."},{"issue":"Supp. (1)","key":"10.1016\/S0021-5198(19)53747-7_bib20","first-page":"5","article-title":"Some pharmacological effects of disopyramide and a metabolite","volume":"4","author":"Bains","year":"1976","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/S0021-5198(19)53747-7_bib21","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/0024-3205(80)90471-3","article-title":"Comparative anticholinergic potencies of R- and S-disopyramide in longitudinal muscle strips from guinea pig ileum","volume":"27","author":"Giacomini","year":"1980","journal-title":"Life Sci."},{"key":"10.1016\/S0021-5198(19)53747-7_bib22","first-page":"747","article-title":"Pharmacological differences between the high-affinity muscarinic agonist binding states of the rat heart and cerebral cortex labeled with (+)-[3H]cismethyldioxolane","volume":"229","author":"Vickroy","year":"1984","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0021-5198(19)53747-7_bib23","first-page":"411","article-title":"[3H]Pirenzepine and (\u2212)-[3H]quinuclidinyl benzilate binding to rat cerebral cortical and cardiac muscarinic cholinergic sites. I. Characterization and regulation of agonist binding to putative muscarinic subtypes","volume":"237","author":"Watson","year":"1986","journal-title":"J. Pharmacol. Exp. Ther."}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819537477?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819537477?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T14:05:01Z","timestamp":1618409101000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819537477"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990]]},"references-count":23,"aliases":["10.1254\/jjp.52.363"],"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990]]}},"alternative-id":["S0021519819537477"],"URL":"https:\/\/doi.org\/10.1016\/s0021-5198(19)53747-7","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1990]]}}}