{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T13:15:40Z","timestamp":1778591740962,"version":"3.51.4"},"reference-count":19,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,13]],"date-time":"2019-09-13T00:00:00Z","timestamp":1568332800000},"content-version":"vor","delay-in-days":10482,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1991]]},"DOI":"10.1016\/s0021-5198(19)39987-1","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T04:23:20Z","timestamp":1605673400000},"page":"139-146","source":"Crossref","is-referenced-by-count":9,"title":["Mechanisms of Veratramine-Induced 5-HT Syndrome in Mice"],"prefix":"10.1016","volume":"55","author":[{"given":"Ryoichi","family":"Nagata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kanji","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shin-ichi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeo","family":"Fukuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0021-5198(19)39987-1_bib1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1254\/jjp.5.102","article-title":"Actions of veratramine on the central nervous system","volume":"5","author":"Fukuma","year":"1956","journal-title":"Japan. J. Pharmacol."},{"issue":"Supp.","key":"10.1016\/S0021-5198(19)39987-1_bib2","doi-asserted-by":"crossref","first-page":"86P","DOI":"10.1016\/S0021-5198(19)59011-4","article-title":"Veratramine-induced behavior in mice: effects of benzodiazepines and other drugs affecting GABAergic or serotonergic functions","volume":"40","author":"Nagata","year":"1986","journal-title":"Japan. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)39987-1_bib3","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1016\/0014-2999(90)92258-K","article-title":"Studies on veratramine in producing \u201c5-HT syndrome\u201d in mice","volume":"183","author":"Nagata","year":"1990","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)39987-1_bib4","first-page":"89","article-title":"Studies on alkaloids. XX. Actions of veratrum alkaloids upon the central nervous system of mice","volume":"113","author":"Tanaka","year":"1955","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0021-5198(19)39987-1_bib5","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1471-4159.1971.tb12034.x","article-title":"Studies in vivo on the relationship between brain tryptophan, brain 5-HT synthesis and hyperactivity in rats treated with a monoamine oxidase inhibitor and L-tryptophan","volume":"18","author":"Grahame-Smith","year":"1971","journal-title":"J. Neurochem."},{"key":"10.1016\/S0021-5198(19)39987-1_bib6","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0024-3205(76)90303-9","article-title":"An animal behavioral model for studying central serotonergic synapses","volume":"19","author":"Jacobs","year":"1976","journal-title":"Life Sci."},{"key":"10.1016\/S0021-5198(19)39987-1_bib7","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1212\/WNL.23.11.1234","article-title":"5-Hydroxytryptophan-induced myoclonus in guinea pigs and the possible role of serotonin in infantile myoclonus","volume":"23","author":"Klawans","year":"1973","journal-title":"Neurology"},{"key":"10.1016\/S0021-5198(19)39987-1_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/0361-9230(78)90120-X","article-title":"Possible serotonin-agonist action of veratramine","volume":"3","author":"Izumi","year":"1978","journal-title":"Brain Res. Bull."},{"issue":"Supp.","key":"10.1016\/S0021-5198(19)39987-1_bib9","doi-asserted-by":"crossref","first-page":"63P","DOI":"10.1016\/S0021-5198(19)32221-8","article-title":"Relationship between struggling movement induced by veratramine and brain monoamines","volume":"24","author":"Koga","year":"1974","journal-title":"Japan. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)39987-1_bib10","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1471-4159.1966.tb09873.x","article-title":"Regional studies of catecholamines in the rat brain. I. The disposition of [3H] norepinephrine, [3H] dopamine and [5H] dopa in various regions of the brain","volume":"13","author":"Glowinski","year":"1966","journal-title":"J. Neurochem."},{"key":"10.1016\/S0021-5198(19)39987-1_bib11","first-page":"404","article-title":"Kinetics of serotonin accumulation into slices from rat brain: relationship to catecholamine uptake","volume":"175","author":"Shaskan","year":"1970","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/S0021-5198(19)39987-1_bib12","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1021\/ja01318a036","article-title":"The determination of enzyme dissociation constants","volume":"56","author":"Linewcaver","year":"1934","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/S0021-5198(19)39987-1_bib13","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0014-2999(81)90103-5","article-title":"Multiple serotonin receptors: regional distribution and effect of raphe leisons","volume":"76","author":"Blackshear","year":"1981","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)39987-1_bib14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0006-8993(81)90562-X","article-title":"Two distinct serotonin receptors: regional variations in receptor binding in mammalian brain","volume":"208","author":"Peroutka","year":"1981","journal-title":"Brain Res."},{"key":"10.1016\/S0021-5198(19)39987-1_bib15","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/0091-3057(86)90477-6","article-title":"Differential effects of 5-hydroxytryptamine1A selective drugs on the 5-HT behavioral syndrome","volume":"24","author":"Smith","year":"1986","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0021-5198(19)39987-1_bib16","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/0006-8993(78)91110-1","article-title":"Biochemical and behavioural effects of serotonin neurotoxins on the nigrostriatal dopamine system: comparison of injection sites","volume":"152","author":"Giambalvo","year":"1978","journal-title":"Brain Res."},{"key":"10.1016\/S0021-5198(19)39987-1_bib17","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0014-2999(79)90492-8","article-title":"Interactions between serotonergic and dopaminergic systems in rat brain demonstrated by small unilateral lesions of the raphe nuclei","volume":"57","author":"Nicolaou","year":"1979","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/S0021-5198(19)39987-1_bib18","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0091-3057(88)90089-5","article-title":"Mechanisms of effects of d-fenfluramine on brain serotonin metabolism in rats: uptake inhibition versus release","volume":"30","author":"Fuller","year":"1988","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/S0021-5198(19)39987-1_bib19","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1111\/j.1476-5381.1988.tb11725.x","article-title":"The mechanism by which monoamine oxidase inhibitors give rise to a non-calcium-dependent component in the depolarization-induced release of 5-HT from rat brain synaptosomes","volume":"95","author":"Evans","year":"1988","journal-title":"Br. J. Pharmacol."}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819399871?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819399871?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T17:07:21Z","timestamp":1618420041000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819399871"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991]]},"references-count":19,"aliases":["10.1254\/jjp.55.139"],"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991]]}},"alternative-id":["S0021519819399871"],"URL":"https:\/\/doi.org\/10.1016\/s0021-5198(19)39987-1","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1991]]}}}