{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T22:31:41Z","timestamp":1694212301731},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[1991,1,1]],"date-time":"1991-01-01T00:00:00Z","timestamp":662688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T00:00:00Z","timestamp":1568246400000},"content-version":"vor","delay-in-days":10481,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1991]]},"DOI":"10.1254\/jjp.57.153","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T05:07:03Z","timestamp":1201151223000},"page":"153-165","source":"Crossref","is-referenced-by-count":16,"title":["Pharmacological Profile of the 2-Alkynyladenosine Derivative 2-Octynyladenosine (YT-146) in the Cardiovascular System"],"prefix":"10.1016","volume":"57","author":[{"given":"Kentaro","family":"Kogi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Uchibori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Aihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toichi","family":"Abiru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.57.153_bib1","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0301-0082(86)90015-8","article-title":"Adenosine receptors and calcium: Basis for proposing a third (A3) adenosine receptor","volume":"26","author":"Ribeiro","year":"1986","journal-title":"Prog. Neurobiol."},{"key":"10.1254\/jjp.57.153_bib2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1111\/j.1471-4159.1979.tb05236.x","article-title":"Adenosine regulates via two different types of receptors the accumulation of cyclic AMP in cultured brain cell","volume":"33","author":"Van Calker","year":"1979","journal-title":"J. Neurochem."},{"key":"10.1254\/jjp.57.153_bib3","doi-asserted-by":"crossref","first-page":"5547","DOI":"10.1073\/pnas.77.9.5547","article-title":"Adenosine receptors in brain membranes: Binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthin","volume":"77","author":"Bruns","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1254\/jjp.57.153_bib4","first-page":"316","article-title":"Ligand selectivity of dog coronary adenosine receptor resembles that of adenylate cyclase stimulatory (Ra) receptors","volume":"227","author":"Kusachi","year":"1983","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1254\/jjp.57.153_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0014-2999(83)90529-0","article-title":"Adenosine relaxes the aorta by interacting with an A2 receptor and an intracellular site","volume":"96","author":"Collis","year":"1983","journal-title":"Eur. J. Pharmacol."},{"key":"10.1254\/jjp.57.153_bib6","first-page":"49","article-title":"Evidence suggesting an Ra-type adenosine receptor in bovine coronary arteries","volume":"232","author":"Mustafa","year":"1985","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1254\/jjp.57.153_bib7","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1016\/0024-3205(82)90746-9","article-title":"Adenosine receptor mediated cardiac depression","volume":"31","author":"Evans","year":"1982","journal-title":"Life Sci."},{"key":"10.1254\/jjp.57.153_bib8","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1476-5381.1983.tb09381.x","article-title":"Evidence for an A1-adenosine receptor in the guinea-pig atrium","volume":"78","author":"Collis","year":"1983","journal-title":"Br. J. Pharmacol."},{"key":"10.1254\/jjp.57.153_bib9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/j.1476-5381.1983.tb11060.x","article-title":"Inhibition by purines of the inotropic action of isoprenaline in rat atria","volume":"80","author":"Hughes","year":"1983","journal-title":"Br. J. Pharmacol."},{"key":"10.1254\/jjp.57.153_bib10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1248\/cpb.23.759","article-title":"Synthesis and coronany vasodilating activity of 2-substituted adenosines","volume":"23","author":"Marumoto","year":"1975","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1254\/jjp.57.153_bib11","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1021\/jm00269a022","article-title":"Ethyl adenosine-5\u2019-carboxylate: A potent vasoactive agent in the dog","volume":"16","author":"Stain","year":"1973","journal-title":"J. Med. Chem."},{"key":"10.1254\/jjp.57.153_bib12","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1021\/jm00149a016","article-title":"Dog coronary artery adenosine receptor: Structure of the N6-alkyl subregion","volume":"28","author":"Kusachi","year":"1985","journal-title":"J. Med. Chem."},{"key":"10.1254\/jjp.57.153_bib13","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1248\/cpb.33.1766","article-title":"Palladium-catalyzed crosscoupling of 2-iodoadenosine with terminal alkynes: synthesis and biological activities of 2-alkynyladenosines","volume":"33","author":"Matsuda","year":"1985","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"10.1254\/jjp.57.153_bib14","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1080\/07328318708056182","article-title":"The synthesis, mutagenic and pharmacological activities of 2-carbon-substituted adenosines","volume":"6","author":"Matsuda","year":"1987","journal-title":"Nucleosides Nucleotides"},{"issue":"Supp. II","key":"10.1254\/jjp.57.153_bib15","doi-asserted-by":"crossref","first-page":"92P","DOI":"10.1016\/S0021-5198(19)32967-1","article-title":"2-Alkynyladenosine analogs as potent and selective adenosine-A2 receptor agonists","volume":"52","author":"Abiru","year":"1990","journal-title":"Japan. J. Pharmacol."},{"key":"10.1254\/jjp.57.153_bib16","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1254\/jjp.19.502","article-title":"The negative inotropic action of norepinephrine in the presence of ouabain","volume":"19","author":"Nakashima","year":"1969","journal-title":"Japan. J. Pharmacol."},{"key":"10.1254\/jjp.57.153_bib17","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1073\/pnas.77.5.2551","article-title":"Subclasses of external adenosine receptors","volume":"77","author":"Londos","year":"1980","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1254\/jjp.57.153_bib18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/BF00511410","article-title":"Evaluation of the binding of the A1 selective adenosine radioligand, cyclopentyladenosine (CPA), to rat brain tissue","volume":"332","author":"Williams","year":"1986","journal-title":"Naunyn Schmiedebergs. Arch. Pharmacol."},{"key":"10.1254\/jjp.57.153_bib19","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1021\/jm00402a004","article-title":"N6-[2-(3,5-Dimethoxyphenyl)-2-(2-methylphenyl)-ethyl] adenosine and its uronamide derivatives. Novel adenosine agonists with both high affinity and high selectivity for the adenosine A2 receptor","volume":"31","author":"Bridges","year":"1988","journal-title":"J. Med. Chem."},{"key":"10.1254\/jjp.57.153_bib20","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1021\/jm00393a003","article-title":"N6-(2,2-Diphenylethyl) adenosine, a novel adenosine receptor agonists with antipsychotic-like activity","volume":"30","author":"Bridges","year":"1987","journal-title":"J. Med. Chem."},{"key":"10.1254\/jjp.57.153_bib21","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1021\/jm00396a044","article-title":"N6-(Arylalkyl)adenosines. Identification of N6-(9-fluorenylmethyl) adenosine as a highly potent agonist for the adenosine A2 receptor","volume":"31","author":"Trivedi","year":"1988","journal-title":"J. Med. Chem."},{"key":"10.1254\/jjp.57.153_bib22","first-page":"70","article-title":"Effect of nitrates and other coronary dilators of large and small coronary vessels","volume":"168","author":"Winbury","year":"1969","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1254\/jjp.57.153_bib23","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1152\/ajplegacy.1967.212.5.1062","article-title":"Effect of nitrates on nutritional circulation of heart and hindlimb","volume":"212","author":"Winbury","year":"1967","journal-title":"Am. J. Physiol."},{"key":"10.1254\/jjp.57.153_bib24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1161\/01.RES.22.5.649","article-title":"Effect of nitroglycerin and dipyridamole on regional coronary resistance","volume":"22","author":"Fam","year":"1968","journal-title":"Circ. Res."},{"key":"10.1254\/jjp.57.153_bib25","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/BF00586218","article-title":"Effects of adenosine on isolated coronary vascular smooth muscle","volume":"335","author":"Norton","year":"1972","journal-title":"Pflugers Arch."},{"key":"10.1254\/jjp.57.153_bib26","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1152\/ajplegacy.1972.223.1.223","article-title":"Response of large and small coronary arteries to nitroglycerin, NaN02, and adenosine","volume":"223","author":"Schnaar","year":"1972","journal-title":"Am. J. Physiol."},{"key":"10.1254\/jjp.57.153_bib27","first-page":"342","article-title":"Adenosine-mediated relaxation and activation of cyclic AMP-dependent protein kinase in coronary arterial smooth muscle","volume":"228","author":"Silver","year":"1984","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1254\/jjp.57.153_bib28","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1161\/01.RES.47.5.684","article-title":"Atrioventricular conduction disturbances during hypoxia: Possible role of adenosine in rabbit and guinea pig heart","volume":"47","author":"Belardinelli","year":"1980","journal-title":"Circ. Res."},{"key":"10.1254\/jjp.57.153_bib29","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1254\/jjp.27.689","article-title":"Effects of 2-substituted adenosine derivative, 2-(p-methoxyphenyl)-adenosine (CV-1674) on coronary and cardiohemodynamics, and myocardial energetics","volume":"27","author":"Hirata","year":"1977","journal-title":"Japan. J. Pharmacol."},{"key":"10.1254\/jjp.57.153_bib30","series-title":"Adenosine: Receptors and Modulation of Cell Function","first-page":"357","article-title":"Some cardiovascular effects of adenosine","author":"Berne","year":"1985"}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819327210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819327210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T14:24:10Z","timestamp":1630592650000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819327210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991]]}},"alternative-id":["S0021519819327210"],"URL":"https:\/\/doi.org\/10.1254\/jjp.57.153","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1991]]}}}