{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T06:47:46Z","timestamp":1745390866936},"reference-count":26,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":10110,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1992]]},"DOI":"10.1254\/jjp.59.427","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T05:07:03Z","timestamp":1201151223000},"page":"427-434","source":"Crossref","is-referenced-by-count":5,"title":["Relationship between Density of Muscarinic Receptors and Nasal Hypersecretion in a Nasal Allergic Model"],"prefix":"10.1016","volume":"59","author":[{"given":"Akio","family":"Namimatsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryohei","family":"Okazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichiro","family":"Go","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeko","family":"Hata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.59.427_bib1","first-page":"60","article-title":"Biology of immunoglobulin E molecular basis of reaginic hypersensitivity","volume":"19","author":"Ishizaka","year":"1974","journal-title":"Prog. Allergy"},{"key":"10.1254\/jjp.59.427_bib2","first-page":"301","article-title":"Mechanisms of nasal allergy","volume":"39","author":"Okuda","year":"1990","journal-title":"Japan. J. Allergol."},{"key":"10.1254\/jjp.59.427_bib3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/BF00454387","article-title":"Important factors in nasal manifestation of allergy","volume":"233","author":"Ohtsuka","year":"1981","journal-title":"Arch. Otorhinolaryngol."},{"key":"10.1254\/jjp.59.427_bib4","first-page":"181","article-title":"The effect of autonomotropic drugs on allergic nasal mucosa","volume":"24","author":"Watase","year":"1986","journal-title":"Rhinology"},{"key":"10.1254\/jjp.59.427_bib5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/BF00454309","article-title":"Adrenergic and cholinergic receptors in human nasal mucosa in cases of nasal allergy","volume":"238","author":"Ishibe","year":"1983","journal-title":"Arch. Otorhinolaryngol."},{"key":"10.1254\/jjp.59.427_bib6","first-page":"1153","article-title":"Autonomic nerve receptors in the allergic nasal mucosa in the human subjects and the sensitized guinea pigs","volume":"88","author":"Terada","year":"1985","journal-title":"J. Otorhinolaryngol. Japon."},{"key":"10.1254\/jjp.59.427_bib7","first-page":"203","article-title":"Adrenergic and cholinergic receptors in human nasal mucosa","volume":"89","author":"Taniguchi","year":"1986","journal-title":"J. Otorhinolaryngol. Japon."},{"key":"10.1254\/jjp.59.427_bib8","first-page":"51","article-title":"Nasal histamine sensitivity in allergic rhinitis","volume":"51","author":"Okuda","year":"1983","journal-title":"Ann. Allergy"},{"key":"10.1254\/jjp.59.427_bib9","first-page":"38","article-title":"Nasal mucosal hypersensitivity to histamine and acetylcholine in pediatric asthma and nasal allergy","volume":"31","author":"Ukai","year":"1982","journal-title":"Japan. J. Allergol."},{"key":"10.1254\/jjp.59.427_bib10","first-page":"228","article-title":"Effect of ammonia on nasal resistance in atopic and non atopic subjects","volume":"88","author":"McLean","year":"1979","journal-title":"Ann. Otol."},{"key":"10.1254\/jjp.59.427_bib11","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1172\/JCI112113","article-title":"Nasal challenge with cold air results in release of inflammatory mediators, possible involvement of mast cells","volume":"76","author":"Togias","year":"1985","journal-title":"J. Clin. Invest."},{"key":"10.1254\/jjp.59.427_bib12","first-page":"847","article-title":"Changes of muscarinic receptors in nasal mucosa in guinea pigs sensitized with ovalbumin and effect of antiallergic drugs to these receptors","volume":"91","author":"Terada","year":"1988","journal-title":"J. Otorhinolaryngol. Japon."},{"key":"10.1254\/jjp.59.427_bib13","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1159\/000231616","article-title":"Characteristics of guinea pig IgE","volume":"51","author":"Ovary","year":"1976","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1254\/jjp.59.427_bib14","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1159\/000235450","article-title":"A new method of the measurement of nasal secretion in guinea pigs","volume":"95","author":"Namimatsu","year":"1991","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1254\/jjp.59.427_bib15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"key":"10.1254\/jjp.59.427_bib16","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1749-6632.1949.tb27297.x","article-title":"The attractions of proteins for small molecules and ions","volume":"51","author":"Scatchard","year":"1949","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1254\/jjp.59.427_bib17","first-page":"183","article-title":"The relationship between the number of the autonomic nerve receptors and degree of hyperreactive nasal symptoms in patients with hyperesthetic rhinitis","volume":"92","author":"Ando","year":"1988","journal-title":"J. Otorhinolaryngol. Japon."},{"key":"10.1254\/jjp.59.427_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1159\/000235480","article-title":"Nasal mucosal hypersensitivity in guinea pigs intermittingly exposed to cold","volume":"96","author":"Namimatsu","year":"1991","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1254\/jjp.59.427_bib19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1159\/000275792","article-title":"Cholinergic muscarinic receptors in the nasal mucosa of guinea pigs with bronchial asthma with and without hypersensitivity nasal symptoms","volume":"47","author":"Konno","year":"1985","journal-title":"ORL"},{"key":"10.1254\/jjp.59.427_bib20","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/0091-6749(73)90022-5","article-title":"Seasonal changes in serum and nasal Ig E concentrations","volume":"51","author":"Yunginger","year":"1973","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1254\/jjp.59.427_bib21","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1159\/000275841","article-title":"Effects of female hormones on the muscarinic and \u03bf\u03b9-adrenergic receptors of the nasal mucosa; An experimental study in guinea pigs","volume":"48","author":"Konno","year":"1986","journal-title":"ORL"},{"key":"10.1254\/jjp.59.427_bib22","first-page":"231","article-title":"Autonomic nerve supply to the nasal mucosa of guinea pig","volume":"30","author":"Furukawa","year":"1991","journal-title":"Japan. J. Rhinol."},{"key":"10.1254\/jjp.59.427_bib23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000236109","article-title":"Mechanism of nasal secretion via nerve reflex in guinea pigs and evaluation of antiallergic drugs","volume":"97","author":"Namimatsu","year":"1992","journal-title":"Int. Arch. Allergy Appl. Immunol."},{"key":"10.1254\/jjp.59.427_bib24","series-title":"Neurotropin; A New Approach to the Treatment of Allergic Inflammation","first-page":"82","article-title":"Changes in autonomic nerve receptors in the nasal mucosa of guinea pigs with nasal allergic symptoms and their regulation by Neurotropin","author":"Namimatsu","year":"1988"},{"key":"10.1254\/jjp.59.427_bib25","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1177\/000348948509400218","article-title":"Histamine H1 receptors and affinity analyses in human nasal mucosa in cases of nasal allergy","volume":"94","author":"Ishibe","year":"1985","journal-title":"Ann. Otol. Rhinol. Laryngol."},{"key":"10.1254\/jjp.59.427_bib26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/0091-6749(82)90044-6","article-title":"Significance of H1 and H2 receptors in the human nose. Rational for topical use of combined antihistamine preparations","volume":"70","author":"Secher","year":"1982","journal-title":"J. Allergy Clin. Immunol."}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819401546?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819401546?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T14:24:30Z","timestamp":1630592670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819401546"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992]]},"references-count":26,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992]]}},"alternative-id":["S0021519819401546"],"URL":"https:\/\/doi.org\/10.1254\/jjp.59.427","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1992]]}}}