{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:37:25Z","timestamp":1776893845919,"version":"3.51.2"},"reference-count":10,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1992,1,1]],"date-time":"1992-01-01T00:00:00Z","timestamp":694224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,6]],"date-time":"2019-09-06T00:00:00Z","timestamp":1567728000000},"content-version":"vor","delay-in-days":10110,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1992]]},"DOI":"10.1254\/jjp.59.457","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T05:07:03Z","timestamp":1201151223000},"page":"457-459","source":"Crossref","is-referenced-by-count":27,"title":["Tizanidine May Discriminate between Imidazoline-Receptors and \u03b12-Adrenoceptors"],"prefix":"10.1016","volume":"59","author":[{"given":"Ikunobu","family":"Muramatsu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeru","family":"Kigoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.59.457_bib1","series-title":"Die Klinische Wertung der Spastizit\u00e4t","first-page":"61","article-title":"Pharmacological properties of tizanidine (DS103-282)","author":"Coward","year":"1984"},{"key":"10.1254\/jjp.59.457_bib2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0306-4522(90)90311-Q","article-title":"Concomitant depression of locus coeruleus neurons and of flexor reflexes by an a 2-adrenergic agonist in rats: a possible mechanism for an 02-mediated muscle relaxation","volume":"34","author":"Paimeri","year":"1990","journal-title":"Neuroscience"},{"key":"10.1254\/jjp.59.457_bib3","first-page":"232","article-title":"Central cardiovascular effects of \u03b1-adrenergic drugs: differences between catecholamines and imidazolines","volume":"230","author":"Bousquet","year":"1984","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1254\/jjp.59.457_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(87)90125-7","article-title":"Clonidine binds to imidazole binding sites as well as \u03b12-adrenoceptors in the ventrolateral medulla","volume":"134","author":"Ernsberger","year":"1987","journal-title":"Eur. J. Pharmacol."},{"key":"10.1254\/jjp.59.457_bib5","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1016\/0024-3205(89)90270-1","article-title":"The imidazoline-preferring receptor","volume":"45","author":"Lehmann","year":"1989","journal-title":"Life Sci."},{"key":"10.1254\/jjp.59.457_bib6","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1016\/0006-2952(91)90152-U","article-title":"Clonidine-displacing substance (CDS) and its putative imidazoline receptor","volume":"41","author":"Atlas","year":"1991","journal-title":"Biochem. Pharmacol."},{"key":"10.1254\/jjp.59.457_bib7","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0006-8993(91)91675-Q","article-title":"Autoradiographic distribution of \u03b12 adrenoceptors, NAIBS, and 5-HT1a receptors in human brain using [3H]idazoxan and [3H]rauwolscine","volume":"566","author":"Vos","year":"1991","journal-title":"Brain Res."},{"key":"10.1254\/jjp.59.457_bib8","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1111\/j.1476-5381.1991.tb12533.x","article-title":"Three distinct binding sites for [3H]-prazosin in the rat cerebral cortex","volume":"104","author":"Oshita","year":"1991","journal-title":"Br. J. Pharmacol."},{"key":"10.1254\/jjp.59.457_bib9","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1093\/ajh\/3.2.90","article-title":"Characterization and visualization of clonidine-sensitive imidazole sites in rat kidney which recognize clonidine-displacing substance","volume":"3","author":"Ernsberger","year":"1990","journal-title":"Am. J. Hypertens."},{"key":"10.1254\/jjp.59.457_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/BF00251126","article-title":"Involvement of presynaptic imidazoline receptors in the \u03b12-adrenoceptor-independent inhibition of noradrenaline release by imidazoline derivatives","volume":"343","author":"G\u00f6thert","year":"1991","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819401583?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819401583?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T04:26:54Z","timestamp":1605673614000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819401583"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1992]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1992]]}},"alternative-id":["S0021519819401583"],"URL":"https:\/\/doi.org\/10.1254\/jjp.59.457","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1992]]}}}