{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T18:04:21Z","timestamp":1692554661381},"reference-count":23,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1993,1,1]],"date-time":"1993-01-01T00:00:00Z","timestamp":725846400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,4]],"date-time":"2019-09-04T00:00:00Z","timestamp":1567555200000},"content-version":"vor","delay-in-days":9742,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1993]]},"DOI":"10.1254\/jjp.63.513","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T05:09:52Z","timestamp":1201151392000},"page":"513-520","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Repeated Administration of KW-3902, a Novel Adenosine A1-Receptor Antagonist, on Its Pharmacological Actions"],"prefix":"10.1016","volume":"63","author":[{"given":"Hideaki","family":"Kusaka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Karasawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.63.513_bib1","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1021\/jm00094a022","article-title":"Adenosine A, antagonist. 2. Structure-activity relationships on diuretic activities and protective effects against acute renal failure","volume":"35","author":"Suzuki","year":"1992","journal-title":"J. Med. Chem."},{"key":"10.1254\/jjp.63.513_bib2","first-page":"200","article-title":"Diuretic and renal protective effects of KW-3902, a novel adenosine A1-receptor antagonist, via pertussis toxin insensitive mechanism","volume":"266","author":"Mizumoto","year":"1993","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1254\/jjp.63.513_bib3","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1254\/jjp.61.251","article-title":"Renal tubular site of action of KW-3902, a novel adenosine A1-receptor antagonist, in anesthetized rats","volume":"61","author":"Mizumoto","year":"1993","journal-title":"Japan. J. Pharmacol."},{"issue":"Suppl. I","key":"10.1254\/jjp.63.513_bib4","doi-asserted-by":"crossref","first-page":"194P","DOI":"10.1016\/S0021-5198(19)49082-3","article-title":"Renal protective effects of a novel adenosine A1 receptor antagonist, KW-3902","volume":"58","author":"Mizumoto","year":"1992","journal-title":"Japan. J. Pharmacol."},{"key":"10.1254\/jjp.63.513_bib5","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.2042-7158.1991.tb06651.x","article-title":"Diuretic and saliuretic effects of 1,3-dipropyl-8-cyclopentylxanthine, a selective A1-adenosine receptor antagonist","volume":"43","author":"Collis","year":"1991","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1254\/jjp.63.513_bib6","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1111\/j.1476-5381.1989.tb14639.x","article-title":"Amelioration of glycerol-induced acute renal failure in the rat with 8-cyclopentyl-1,3-dipropylxanthinc","volume":"98","author":"Kellett","year":"1989","journal-title":"Br. J. Pharmacol."},{"key":"10.1254\/jjp.63.513_bib7","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/0165-6147(87)90124-6","article-title":"Adenylate cyclase supersensitivity: a general means of cellular adaptation to inhibitory agonist?","volume":"8","author":"Thomas","year":"1987","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1254\/jjp.63.513_bib8","doi-asserted-by":"crossref","first-page":"15702","DOI":"10.1016\/S0021-9258(18)47784-8","article-title":"Adenosine receptor down-regulation and insulin resistance following prolonged incubation of adipocytes with A, adenosine receptor agonist","volume":"262","author":"Green","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1254\/jjp.63.513_bib9","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1172\/JCI112550","article-title":"Desensitization of adenosine receptor-mediated inhibition of lypolysis","volume":"78","author":"Hoffman","year":"1986","journal-title":"J. Clin. Invest."},{"key":"10.1254\/jjp.63.513_bib10","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0021-9258(19)75863-3","article-title":"Heterologous desensitization of the inhibitory A1 adenosine receptor-adenylate cyclase system in rat adipocytes","volume":"262","author":"Parsons","year":"1987","journal-title":"J. Biol. Chem."},{"key":"10.1254\/jjp.63.513_bib11","first-page":"H321","article-title":"Down-regulation and desensitization of A1-adenosine receptor in embryonic chicken heart","volume":"256","author":"Shryock","year":"1989","journal-title":"Am. J. Physiol."},{"key":"10.1254\/jjp.63.513_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/syn.890090203","article-title":"Chronic theophylline treatment increases adenosine A1, but not A2 receptor binding in the rat brain: An autoradiographic study","volume":"9","author":"Lupica","year":"1991","journal-title":"Synapse"},{"key":"10.1254\/jjp.63.513_bib13","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1161\/01.RES.65.4.1066","article-title":"Enhanced sensitivity of heart cells to adenosine and up-regulation of receptor number after treatment of guinea pig with theophylline","volume":"65","author":"Wu","year":"1989","journal-title":"Circ. Res."},{"key":"10.1254\/jjp.63.513_bib14","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/00005344-198704000-00003","article-title":"Evidence that a novel 8-phenyl-substituted xanthine derivative is a cardioselective adenosine receptor antagonist in vivo","volume":"9","author":"Fredholm","year":"1987","journal-title":"J. Cardiovasc. Pharmacol."},{"key":"10.1254\/jjp.63.513_bib15","first-page":"1684","article-title":"Antihypertensive effects of the new calcium antagonist benidipine hydrochloride in rats","volume":"38","author":"Karasawa","year":"1988","journal-title":"Arzneimitlelforschung"},{"key":"10.1254\/jjp.63.513_bib16","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2165\/00003495-197815040-00002","article-title":"Labetalol: a review of its pharmacology and therapeutic use in hypertension","volume":"15","author":"Brogden","year":"1980","journal-title":"Drugs"},{"issue":"Supp. 83","key":"10.1254\/jjp.63.513_bib17","first-page":"413P","article-title":"An investigation of the negative chronotropic effect of adenosine on the guinea-pig atrium","author":"Collis","year":"1984","journal-title":"Br. J. Pharmacol."},{"key":"10.1254\/jjp.63.513_bib18","first-page":"H343","article-title":"Effects of adenosine receptor agonist in isolated perfused rat kidney","volume":"247","author":"Murray","year":"1984","journal-title":"Am. J. Physiol."},{"key":"10.1254\/jjp.63.513_bib19","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/0014-2999(87)90371-2","article-title":"Adenosine induces a calcium-dependent glomerular contraction","volume":"134","author":"Lopez-Novoa","year":"1987","journal-title":"Eur. J. Pharmacol."},{"key":"10.1254\/jjp.63.513_bib20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1254\/jjp.63.257","article-title":"Effects of adenosine A1-agonist and -antagonist on urinary volume and Na excretion in IAP-treated and non-treated rats","volume":"63","author":"Mizumoto","year":"1993","journal-title":"Japan. J. Pharmacol."},{"key":"10.1254\/jjp.63.513_bib21","first-page":"H885","article-title":"Mechanism of adenosine receptor induced renal vasoconstriction in the rat","volume":"255","author":"Rossi","year":"1988","journal-title":"Am. J. Physiol."},{"key":"10.1254\/jjp.63.513_bib22","first-page":"911","article-title":"Further characterization of the renovascular effects of N6-cyclo-hexyladenosine in the isolated perfused rat kidney","volume":"240","author":"Rossi","year":"1987","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1254\/jjp.63.513_bib23","doi-asserted-by":"crossref","first-page":"17E","DOI":"10.1016\/0002-9149(90)90246-W","article-title":"Interaction of diuretics and electrolytes in congestive heart failure","volume":"65","author":"Nicholls","year":"1990","journal-title":"Am. J. Cardiol."}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819359207?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819359207?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T14:23:24Z","timestamp":1630592604000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819359207"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1993]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1993]]}},"alternative-id":["S0021519819359207"],"URL":"https:\/\/doi.org\/10.1254\/jjp.63.513","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1993]]}}}