{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T09:53:01Z","timestamp":1700301181029},"reference-count":14,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1994,1,1]],"date-time":"1994-01-01T00:00:00Z","timestamp":757382400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,23]],"date-time":"2019-08-23T00:00:00Z","timestamp":1566518400000},"content-version":"vor","delay-in-days":9365,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1994]]},"DOI":"10.1254\/jjp.66.433","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T05:13:33Z","timestamp":1201151613000},"page":"433-438","source":"Crossref","is-referenced-by-count":5,"title":["Antitumor Effects and Distribution of Adriamycin Incorporated into Hydroxyapatite Implants in a Cancer Rat Model Bearing Swarm Rat Chondrosarcoma"],"prefix":"10.1016","volume":"66","author":[{"given":"Keiko","family":"Yamamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hisashi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Osada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Yotsuyanagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshitaka","family":"Nabeshima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.66.433_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2106\/00004623-196749010-00008","article-title":"Osteogenic sarcoma\u2013a study of 6000 cases","volume":"49","author":"Dahlin","year":"1967","journal-title":"J Bone Joint Surg"},{"key":"10.1254\/jjp.66.433_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1056\/NEJM198107163050305","article-title":"The anthracycline antineoplastic drug","volume":"305","author":"Young","year":"1981","journal-title":"N Engl J Med"},{"key":"10.1254\/jjp.66.433_bib3","first-page":"195","article-title":"Adriamycin (NSC-123127) cardiomyooathy: an overview with determination of risk factors","volume":"6","author":"Minow","year":"1975","journal-title":"Cancer Chemother Rep"},{"key":"10.1254\/jjp.66.433_bib4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0142-9612(90)90008-E","article-title":"Quantitative study on osteoconduction of apatite-wollastonite containing glass ceramic granules, hydroxyapatite granules and alumina granules","volume":"11","author":"Ono","year":"1990","journal-title":"Biomaterials"},{"key":"10.1254\/jjp.66.433_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1254\/jjp.65.289","article-title":"Anticancer effects of adriamycin-loaded hydroxy apatite implants using a Swarm rat chondrosarcoma model","volume":"65","author":"Yamamura","year":"1994","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.66.433_bib6","first-page":"362","article-title":"Transplantable osteogenic tumor in the rat","volume":"27","author":"Maibenco","year":"1967","journal-title":"Cancer Res"},{"key":"10.1254\/jjp.66.433_bib7","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1002\/1097-0142(19800201)45:3<582::AID-CNCR2820450326>3.0.CO;2-#","article-title":"The diagnosis and grading of chondrosarcoma of bone","volume":"45","author":"Sanerkin","year":"1980","journal-title":"Cancer"},{"key":"10.1254\/jjp.66.433_bib8","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1002\/jbm.820260807","article-title":"Synthesis of antibiotic-loaded hydroxyapatite beads and in vitro drug release testing","volume":"26","author":"Yamamura","year":"1992","journal-title":"J Biomed Mater Res"},{"key":"10.1254\/jjp.66.433_bib9","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1111\/j.1349-7006.1989.tb01697.x","article-title":"Antitumor activity of ME2303, a fluorine-containing anthracycline, against human tumors implanted in nude mice","volume":"80","author":"Tsuruo","year":"1989","journal-title":"Jpn J Cancer Res"},{"key":"10.1254\/jjp.66.433_bib10","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1248\/yakushi1947.104.6_620","article-title":"Determination of adriamycin and its metabolites in biological samples using high performance liquid chromatography. II. Analysis of tissue by extraction method","volume":"104","author":"Masuike","year":"1984","journal-title":"Yakugaku Zasshi"},{"key":"10.1254\/jjp.66.433_bib11","first-page":"2505","article-title":"Enhanced lymphatic delivery of mytomycin C conjugated with dextran","volume":"44","author":"Takakura","year":"1984","journal-title":"Cancer Res"},{"key":"10.1254\/jjp.66.433_bib12","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1002\/1097-0142(197906)43:6<2163::AID-CNCR2820430602>3.0.CO;2-S","article-title":"Primary osteogenic sarcoma \u2013 the rationale for pre-operative chemotherapy and delayed surgery","volume":"43","author":"Rosen","year":"1979","journal-title":"Cancer"},{"key":"10.1254\/jjp.66.433_bib13","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/0277-5379(87)90106-4","article-title":"The rationale for intra-arterial chemotherapy","volume":"23","author":"Lee","year":"1987","journal-title":"Br J Cancer Clin Oncol"},{"key":"10.1254\/jjp.66.433_bib14","first-page":"387","article-title":"Experimental research on the use of an antineoplastic drug with a bone implant","volume":"14","author":"Guan","year":"1990","journal-title":"Int Orthop"}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819356525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819356525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T23:23:56Z","timestamp":1605655436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819356525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1994]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1994]]}},"alternative-id":["S0021519819356525"],"URL":"https:\/\/doi.org\/10.1254\/jjp.66.433","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1994]]}}}