{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:33:40Z","timestamp":1757702020816},"reference-count":37,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1996,1,1]],"date-time":"1996-01-01T00:00:00Z","timestamp":820454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T00:00:00Z","timestamp":1565913600000},"content-version":"vor","delay-in-days":8628,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1996]]},"DOI":"10.1254\/jjp.70.313","type":"journal-article","created":{"date-parts":[[2008,1,24]],"date-time":"2008-01-24T05:13:33Z","timestamp":1201151613000},"page":"313-320","source":"Crossref","is-referenced-by-count":22,"title":["Effects of the Endothelin ETA-Receptor Antagonist FR139317 on Development of Hypertension and Cardiovascular Hypertrophy in Deoxycorticosterone Acetate-Salt Hypertensive Rats"],"prefix":"10.1016","volume":"70","author":[{"given":"Katsuya","family":"Fujita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuo","family":"Matsumura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohko","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masanori","family":"Takaoka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiro","family":"Morimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.70.313_bib1","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/332411a0","article-title":"A novel potent vasoconstrictor peptide produced by vascular endothelial cells","volume":"332","author":"Yanagisawa","year":"1988","journal-title":"Nature"},{"key":"10.1254\/jjp.70.313_bib2","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/0002-9343(90)90527-K","article-title":"Plasma immunoreactive endothelin in essential hypertension","volume":"88","author":"Kohno","year":"1990","journal-title":"Am J Med"},{"key":"10.1254\/jjp.70.313_bib3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/cs0780261","article-title":"A sensitive radioimmunoassay measuring endothelin-like immunoreactivity in human plasma: comparison of levels in patients with essential hypertension and normotensive control subjects","volume":"78","author":"Davenport","year":"1990","journal-title":"Clin Sci"},{"key":"10.1254\/jjp.70.313_bib4","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1097\/00004872-198911000-00011","article-title":"Endothelin sensitivity and receptor binding in the aorta of spontaneously hypertensive rats","volume":"7","author":"Clozel","year":"1989","journal-title":"J Hypertens"},{"key":"10.1254\/jjp.70.313_bib5","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1161\/01.HYP.18.1.93","article-title":"Plasma immunoreactive endothelin-1 in experimental malignant hypertension","volume":"18","author":"Kohno","year":"1991","journal-title":"Hypertension"},{"issue":"Suppl 5","key":"10.1254\/jjp.70.313_bib6","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1097\/00005344-199322005-00007","article-title":"Peptide vasoconstrictor, vessel structure, and vascular smooth muscle proliferation","volume":"22","author":"Hahn","year":"1993","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1254\/jjp.70.313_bib7","first-page":"150","article-title":"Endothelin, a potent vasoconstrictor, is a vascular smooth muscle mitogen","volume":"1","author":"Dubin","year":"1989","journal-title":"J Vasc Med Biol"},{"key":"10.1254\/jjp.70.313_bib8","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0021-9150(89)90227-X","article-title":"Endothelin is a potent mitogen for vascular smooth muscle cells","volume":"78","author":"Hirata","year":"1989","journal-title":"Atherosclerosis"},{"key":"10.1254\/jjp.70.313_bib9","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/0922-4106(92)90109-9","article-title":"The selective endothelin ETA receptor antagonist BQ123 antagonizes endothelin-1-mediated mitogenesis","volume":"225","author":"Ohlstein","year":"1992","journal-title":"Eur J Pharmacol"},{"key":"10.1254\/jjp.70.313_bib10","first-page":"1040","article-title":"Pharmacological profile of FR139317, a novel, potent endothelin ETA receptor antagonist","volume":"264","author":"Sogabe","year":"1993","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1254\/jjp.70.313_bib11","first-page":"127","article-title":"Subtype selectivity of a novel endothelin antagonist, FR139317, for the two endothelin receptors in transfected Chinese hamster ovary cells","volume":"43","author":"Aramori","year":"1993","journal-title":"Mol Pharmacol"},{"key":"10.1254\/jjp.70.313_bib12","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1111\/j.1476-5381.1995.tb13292.x","article-title":"Role of endothelin-1 and the ETA receptor in the maintenance of deoxycorticosterone acetate-salt-induced hypertension","volume":"114","author":"Fujita","year":"1995","journal-title":"Br J Pharmacol"},{"key":"10.1254\/jjp.70.313_bib13","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1006\/bbrc.1993.1616","article-title":"C-type natriuretic peptide inhibits intimal thickening after vascular injury","volume":"193","author":"Furuya","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1254\/jjp.70.313_bib14","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0024-3205(93)90233-S","article-title":"Antihypertensive effect of newly synthesized endothelin antagonist, BQ123, in a genetic hypertensive model","volume":"52","author":"Nishikibe","year":"1993","journal-title":"Life Sci"},{"key":"10.1254\/jjp.70.313_bib15","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1097\/00005344-199212000-00014","article-title":"Pharmacological characterization of an endothelinA (ETA) receptor antagonist in conscious rats","volume":"20","author":"Bazil","year":"1992","journal-title":"J Cardiovasc Pharmacol"},{"key":"10.1254\/jjp.70.313_bib16","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1021\/jm00029a001","article-title":"The discovery of sulfonamide endothelin antagonists and the development of the orally active ETA antagonist 5-(dimethylamino)-N-3,4-dimethyl-5-isoxazolyl)-1-naphthalenesulfonamide","volume":"37","author":"Stein","year":"1994","journal-title":"J Med Chem"},{"key":"10.1254\/jjp.70.313_bib17","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/0014-2999(94)90665-3","article-title":"Antihypertensive effects of BQ123, a selective endothelin ETA receptor antagonist, in spontaneously hypertensive rats treated with DOCA-salt","volume":"259","author":"Okada","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1254\/jjp.70.313_bib18","first-page":"H1802","article-title":"Hemodynamic studies in DOCA salt hypertensive rats after opening on an arteriovenous fistula","volume":"262","author":"Huang","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1254\/jjp.70.313_bib19","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1161\/01.HYP.21.3.294","article-title":"Increased endothelin-1 content in blood vessels of deoxycorticosterone acetate-salt hypertensive but not in spontaneously hypertensive rats","volume":"21","author":"Larivi\u00e8re","year":"1993","journal-title":"Hypertension"},{"key":"10.1254\/jjp.70.313_bib20","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1016\/0006-291X(89)92252-3","article-title":"Endothelin enhances adrenergic vasoconstriction in perfused rat mesenteric arteries","volume":"159","author":"Tabuchi","year":"1989","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1254\/jjp.70.313_bib21","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1161\/01.HYP.19.2.131","article-title":"Endothelin stimulated by angiotensin II augments contractility of SHR resistance arteries","volume":"19","author":"Dohi","year":"1992","journal-title":"Hypertension"},{"key":"10.1254\/jjp.70.313_bib22","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1097\/00004872-198908000-00001","article-title":"Salt-induced hypertension: the interactive role of vasopressin and of the sympathetic nervous system","volume":"7","author":"Garvas","year":"1989","journal-title":"J Hypertens"},{"key":"10.1254\/jjp.70.313_bib23","first-page":"PL1","article-title":"ETA receptor-mediated role of endothelin in the kidney of DOCA-salt hypertensive rats","volume":"58","author":"Fujita","year":"1996","journal-title":"Life Sci"},{"key":"10.1254\/jjp.70.313_bib24","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1152\/physrev.1982.62.2.347","article-title":"Physiological aspects of primary hypertension","volume":"62","author":"Folkow","year":"1982","journal-title":"Physiol Rev"},{"key":"10.1254\/jjp.70.313_bib25","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1161\/01.RES.36.2.300","article-title":"Malignant hypertension resulting from deoxycorticosterone acetate and salt excess","volume":"36","author":"Garvas","year":"1975","journal-title":"Circ Res"},{"key":"10.1254\/jjp.70.313_bib26","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1097\/00000441-198804000-00023","article-title":"Hemodynamic and neurohormonal changes in the development of DOC hypertension in the dog","volume":"295","author":"Ferrario","year":"1988","journal-title":"Am J Med Sci"},{"key":"10.1254\/jjp.70.313_bib27","first-page":"137","article-title":"Vascular changes associated with deoxycorticosterone-NaCl-induced hypertension","volume":"26","author":"Lee","year":"1989","journal-title":"Blood Vessels"},{"key":"10.1254\/jjp.70.313_bib28","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1097\/00004872-198912000-00004","article-title":"Remodelling of the heart in DOCA-salt hypertensive rats by propranolol and by an alpha-2 agonist, rilmenidine","volume":"7","author":"Amrani","year":"1989","journal-title":"J Hypertens"},{"key":"10.1254\/jjp.70.313_bib29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1006\/bbrc.1993.1291","article-title":"Endothelin-1 is produced and secreted by neonatal rat cardiac myocytes in vitro","volume":"191","author":"Suzuki","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1254\/jjp.70.313_bib30","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1172\/JCI116579","article-title":"Endothelin-1 is an auto-crine\/paracrine factor in the mechanism of angiotensin Il-induced hypertrophy in cultured rat cardiomyocytes","volume":"92","author":"Ito","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1254\/jjp.70.313_bib31","doi-asserted-by":"crossref","first-page":"20555","DOI":"10.1016\/S0021-9258(17)30538-0","article-title":"Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A para-crine mechanism for myocardial cell hypertrophy","volume":"265","author":"Shubeita","year":"1990","journal-title":"J Biol Chem"},{"key":"10.1254\/jjp.70.313_bib32","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1161\/01.RES.69.1.209","article-title":"Endothelin induces hypertrophy with enhanced expression of muscle-specific genes in cultured neonatal rat cardiomyocytes","volume":"69","author":"Ito","year":"1991","journal-title":"Circ Res"},{"key":"10.1254\/jjp.70.313_bib33","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/0014-5793(93)80476-B","article-title":"Increased production of endothelin-1 in the hypertrophied rat heart due to pressure overload","volume":"332","author":"Yorikane","year":"1993","journal-title":"FEBS Lett"},{"issue":"Suppl I","key":"10.1254\/jjp.70.313_bib34","doi-asserted-by":"crossref","first-page":"261P","DOI":"10.1016\/S0021-5198(19)50677-1","article-title":"Possible role of endothelin-1 in volume overload cardiac hypertrophy","volume":"64","author":"Ishiye","year":"1994","journal-title":"Jpn J Phramacol"},{"key":"10.1254\/jjp.70.313_bib35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1161\/01.HYP.24.2.183","article-title":"Effect of a nonselective endothelin antagonist on vascular remodeling in deoxycorticosterone acetate-salt hypertensive rats: Evidence for a role of endothelin in vascular hypertrophy","volume":"24","author":"Li","year":"1994","journal-title":"Hypertension"},{"key":"10.1254\/jjp.70.313_bib36","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/0006-291X(92)90826-7","article-title":"The endothelin ETB receptor mediates both vasodilation and vasoconstriction in vivo","volume":"186","author":"Clozel","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1254\/jjp.70.313_bib37","doi-asserted-by":"crossref","first-page":"C479","DOI":"10.1152\/ajpcell.1993.264.2.C479","article-title":"ETB receptors on aortic smooth muscle cells of spontaneously hypertensive rats","volume":"264","author":"Batra","year":"1993","journal-title":"Am J Physiol"}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819353302?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819353302?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T14:24:40Z","timestamp":1630592680000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819353302"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1996]]}},"alternative-id":["S0021519819353302"],"URL":"https:\/\/doi.org\/10.1254\/jjp.70.313","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1996]]}}}