{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T16:47:32Z","timestamp":1773247652925,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":7890,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1998]]},"DOI":"10.1254\/jjp.78.435","type":"journal-article","created":{"date-parts":[[2002,8,26]],"date-time":"2002-08-26T16:32:11Z","timestamp":1030379531000},"page":"435-441","source":"Crossref","is-referenced-by-count":89,"title":["Anti-ulcer Effects of Antioxidants, Quercetin, \u03b1-Tocopherol, Nifedipine and Tetracycline in Rats"],"prefix":"10.1016","volume":"78","author":[{"given":"Suzuki","family":"Yoshinori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ishihara","family":"Masashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Segami","family":"Tetsuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ito","family":"Mikio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.78.435_bib1","first-page":"159","article-title":"Cytotoxic-free radicals in stress ulcerations","volume":"28","author":"Cochran","year":"1982","journal-title":"Surg Forum"},{"key":"10.1254\/jjp.78.435_bib2","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/BF01965518","article-title":"Oxygen free radicals interact with indomethacin to cause gastrointestinal injury","volume":"17","author":"Del Soldato","year":"1985","journal-title":"Agents Actions"},{"key":"10.1254\/jjp.78.435_bib3","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0016-5085(86)90933-9","article-title":"Role of oxygen radicals in ischemia-induced lesions in cat stomach","volume":"90","author":"Pery","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1254\/jjp.78.435_bib4","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1007\/BF01296666","article-title":"Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric injury","volume":"32","author":"Pihan","year":"1987","journal-title":"Dig Dis Sci"},{"key":"10.1254\/jjp.78.435_bib5","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1136\/gut.34.6.732","article-title":"Role of active oxygen, lipid peroxidation, and antioxidants in pathogenesis of gastric mucosal injury induced by indomethacin in rats","volume":"34","author":"Yoshikawa","year":"1993","journal-title":"Gut"},{"key":"10.1254\/jjp.78.435_bib6","first-page":"105","article-title":"Role of oxygen radicals in the healing process of acetic acid-induced ulcers in rats with limited food-intake-time and effects of oxygen radical scavengers on the ulcer healing","volume":"19","author":"Shii","year":"1992","journal-title":"Exp Ulcer"},{"key":"10.1254\/jjp.78.435_bib7","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1254\/jjp.52.513","article-title":"Effect of N-(3-aminopropionyl)-L-histidinato zinc (Z-103) on the healing and hydrocortisone-induced relapse of acetic acid ulcers in rats with limited food-intake-time","volume":"52","author":"Ito","year":"1990","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.78.435_bib8","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1254\/jjp.59.267","article-title":"Preventive actions of N-(3-aminopropionyl)-L-histidinato zinc (Z-103) through increases in the activities of oxygen-derived free radical scavenging enzymes in the gastric mucosa on ethanol-induced gastric mucosal damage in rats","volume":"59","author":"Ito","year":"1992","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.78.435_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1254\/jjp.68.287","article-title":"Healing-promoting action of the zinc-cimetidine complex on acetic acid-induced gastric ulcers in rats","volume":"68","author":"Ito","year":"1995","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.78.435_bib10","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0014-2999(98)00448-8","article-title":"Anti-ulcer effects of antioxidants: Effect of probucol","volume":"354","author":"Ito","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1254\/jjp.78.435_bib11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0891-5849(87)80033-3","article-title":"Spin trapping: ESR parameters of spin adducts","volume":"3","author":"Buettner","year":"1987","journal-title":"Free Radic Biol Med"},{"key":"10.1254\/jjp.78.435_bib12","doi-asserted-by":"crossref","first-page":"2657","DOI":"10.1016\/S0021-9258(18)93902-5","article-title":"Direct studies on the electron transfer sequence in xanthine oxidase by electron pharmagnetic resonance spectroscopy","volume":"239","author":"Palmer","year":"1964","journal-title":"J Biol Chem"},{"key":"10.1254\/jjp.78.435_bib13","first-page":"450","article-title":"The Fenton reaction between ferrious diethylene triaminepentaacetic acid and hydrogen peroxide","volume":"138","author":"Coheng","year":"1982","journal-title":"FEBS Lett"},{"key":"10.1254\/jjp.78.435_bib14","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxide in animal tissue by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1254\/jjp.78.435_bib15","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0014-2999(94)90719-6","article-title":"Effect of cimetidine and omeprazole on gastric ulcer healing of rats with limited food intake time","volume":"263","author":"Ito","year":"1964","journal-title":"Eur J Pharmacol"},{"key":"10.1254\/jjp.78.435_bib16","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1254\/jjp.19.418","article-title":"A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing","volume":"19","author":"Takagi","year":"1969","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.78.435_bib17","first-page":"393","article-title":"Reactions of linoleic acid peroxyl radicals with phenolic antioxidants: pluse radiolysis study","volume":"52","author":"Erben-Russ","year":"1987","journal-title":"Int J Radiat Biol"},{"key":"10.1254\/jjp.78.435_bib18","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1093\/jn\/107.4.656","article-title":"Protection against carbon tetrachloride-induced lipid peroxidation in the rat by dietary vitamine E, selenium, and methionine as measured by ethane evolution","volume":"107","author":"Hafeman","year":"1977","journal-title":"J Nutr"},{"key":"10.1254\/jjp.78.435_bib19","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/0031-6989(86)90026-3","article-title":"Membrane activity, antioxidant, antiaggregatory and anti-hemolytic properties of four calcium channel blockers","volume":"18","author":"Robak","year":"1986","journal-title":"Pharmacol Res Commun"},{"key":"10.1254\/jjp.78.435_bib20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1365-2133.1987.tb04104.x","article-title":"Tetracyclines are potent scavenger of the super oxide radical","volume":"117","author":"van Baar","year":"1987","journal-title":"Br J Dermatol"},{"key":"10.1254\/jjp.78.435_bib21","first-page":"530","article-title":"Tetracyclines as antioxidants in rheumatoid arthritis: scavenging of hypochlorous acid","volume":"15","author":"Halliwell","year":"1988","journal-title":"J Rheumatol"},{"key":"10.1254\/jjp.78.435_bib22","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/j.1476-5381.1992.tb14230.x","article-title":"Endogenous nitric oxide and sensory neuropeptides interact in the modulation of the rat gastric microcirculation","volume":"105","author":"Tepperman","year":"1992","journal-title":"Br J Pharmacol"},{"key":"10.1254\/jjp.78.435_bib23","first-page":"230","article-title":"The effects of nitric oxide on mucin synthesis in the isolated human colonic cells culture system","volume":"24","author":"Takao","year":"1997","journal-title":"Ulcer Res"},{"key":"10.1254\/jjp.78.435_bib24","first-page":"H815","article-title":"Oxygen-derived free radicals, endothelium and responsiveness of vascular smooth muscle","volume":"250","author":"Rubanyi","year":"1986","journal-title":"Am J Physiol"},{"key":"10.1254\/jjp.78.435_bib25","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1111\/j.2042-7158.1988.tb05290.x","article-title":"Verapamil and nifedipine effects on gastric acid secretion and ulcer formation in rats","volume":"40","author":"Glavin","year":"1988","journal-title":"J Pharm Pharmacol"}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819310078?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819310078?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jjp\/78\/4\/78_4_435\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T05:36:37Z","timestamp":1622093797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819310078"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":25,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998]]}},"alternative-id":["S0021519819310078"],"URL":"https:\/\/doi.org\/10.1254\/jjp.78.435","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1998]]}}}