{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T02:49:37Z","timestamp":1761706177209},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[1998,1,1]],"date-time":"1998-01-01T00:00:00Z","timestamp":883612800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":7890,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1998]]},"DOI":"10.1254\/jjp.78.463","type":"journal-article","created":{"date-parts":[[2002,8,26]],"date-time":"2002-08-26T16:32:11Z","timestamp":1030379531000},"page":"463-469","source":"Crossref","is-referenced-by-count":26,"title":["GTS-21, a Nicotinic Agonist, Attenuates Multiple Infarctions and Cognitive Deficit Caused by Permanent Occlusion of Bilateral Common Carotid Arteries in Rats"],"prefix":"10.1016","volume":"78","author":[{"given":"Naim","family":"Masato","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyake","family":"Hidekazu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murakami","family":"Yukihisa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matsumoto","family":"Kinzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Watanabe","family":"Hiroshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.78.463_bib1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/0197-4580(83)90002-7","article-title":"Biochemical changes in dementia disorders of Alzheimer type (AD\/SDAT)","volume":"4","author":"Gottfries","year":"1983","journal-title":"Neurobiol Aging"},{"key":"10.1254\/jjp.78.463_bib2","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/BF00174504","article-title":"Intravenous nicotine in Alzheimer\u2019s disease: a pilot study","volume":"95","author":"Newhouse","year":"1988","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1254\/jjp.78.463_bib3","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1192\/bjp.154.6.797","article-title":"The effects of nicotine on attention, information processing, and short-term memory in patients with dementia of the Alzheimer type","volume":"154","author":"Sahakian","year":"1989","journal-title":"Br J Psychiatry"},{"key":"10.1254\/jjp.78.463_bib4","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0140-6736(77)91780-9","article-title":"Necropsy evidence of central cholinergic deficits in senile dementia","volume":"1","author":"Perry","year":"1977","journal-title":"Lancet"},{"key":"10.1254\/jjp.78.463_bib5","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1600-0404.1989.tb03807.x","article-title":"Neurotransmitter deficits in a non-multi-infarct category of vascular dementia","volume":"79","author":"Wallin","year":"1989","journal-title":"Acta Neurol Scand"},{"key":"10.1254\/jjp.78.463_bib6","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1254\/jjp.75.443","article-title":"Tacrine improves working memory deficit caused by permanent occlusion of bilateral common carotid arteries in rats","volume":"75","author":"Murakami","year":"1997","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.78.463_bib7","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0006-8993(94)90394-8","article-title":"Progressive cognitive impairment following chronic cerebral hypoperfusion induced by permanent occlusion of bilateral carotid arteries in rats","volume":"653","author":"Ni","year":"1994","journal-title":"Brain Res"},{"key":"10.1254\/jjp.78.463_bib8","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0306-4522(97)00037-7","article-title":"Chronic cerebral hypoperfusion by permanent internal carotid ligation produces learning impairment without brain damage in rats","volume":"79","author":"Ohta","year":"1997","journal-title":"Neuroscience"},{"key":"10.1254\/jjp.78.463_bib9","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0006-8993(94)01436-L","article-title":"Neuronal damage and decrease of central acetylcholine level following permanent occlusion bilateral common carotid arteries in rat","volume":"673","author":"Ni","year":"1995","journal-title":"Brain Res"},{"key":"10.1254\/jjp.78.463_bib10","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1126\/science.7046051","article-title":"The cholinergic hypothesis of geriatric memory dysfunction","volume":"217","author":"Bartus","year":"1982","journal-title":"Science"},{"key":"10.1254\/jjp.78.463_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0022-510X(90)90180-U","article-title":"Arteriolosclerotic leucoencephalopathy in elderly and its relation to white matter lesions in Binswanger\u2019s disease, multi-infarct encephalopathy and Alzheimer\u2019s disease","volume":"98","author":"Ferrer","year":"1990","journal-title":"J Neurol Sci"},{"key":"10.1254\/jjp.78.463_bib12","first-page":"164","article-title":"Characterization of a series of anabaseine-derived compounds reveals that the 3-(4)-dimethylaminocin-namylidine derivative is a selective agonist at neuronal nicotinic \u03b17\/125I-\u03b1-bungarotoxin receptor subtypes","volume":"47","author":"de Fiebre","year":"1995","journal-title":"Mol Pharmacol"},{"key":"10.1254\/jjp.78.463_bib13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1254\/jjp.78.385","article-title":"A comparative study on the effects of nicotine and GTS-21, a new nicotinic agonist, on the locomotor activity and brain monoamine level","volume":"78","author":"Nanri","year":"1998","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.78.463_bib14","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1254\/jjp.74.285","article-title":"GTS-21, a nicotinic agonist, protects against neocortical neuronal cell loss induced by the nucleus basalis magnocellularis lesion in rats","volume":"74","author":"Nanri","year":"1997","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.78.463_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1254\/jjp.76.23","article-title":"Protective effect of GTS-21, a novel nicotinic receptor agonist, on delayed neuronal death induced by ischemia in gerbils","volume":"76","author":"Nanri","year":"1998","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.78.463_bib16","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"key":"10.1254\/jjp.78.463_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3987\/COM-92-S3","article-title":"Long range transmission of polar effects in cholinergic 3-arylidene anabaseines. Conformations calculated by molecular modeling","volume":"35","author":"Zoltewicz","year":"1993","journal-title":"Heterocycles"},{"key":"10.1254\/jjp.78.463_bib18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0006-8993(82)90833-2","article-title":"Delayed neuronal death in the gerbil hippocampus following ischemia","volume":"239","author":"Kirino","year":"1982","journal-title":"Brain Res"},{"key":"10.1254\/jjp.78.463_bib19","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/ana.410190306","article-title":"A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study","volume":"19","author":"Brun","year":"1986","journal-title":"Ann Neurol"},{"key":"10.1254\/jjp.78.463_bib20","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1136\/jnnp.57.11.1347","article-title":"Effect of white matter disease of functional connections in the aging brain","volume":"57","author":"Leuchter","year":"1994","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"10.1254\/jjp.78.463_bib21","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0149-7634(88)80008-3","article-title":"Psychopharmacological effects in the radial-arm maze","volume":"12","author":"Levin","year":"1988","journal-title":"Neurosci Behav Rev"},{"key":"10.1254\/jjp.78.463_bib22","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1001\/archneur.1989.00520430102025","article-title":"Dementia. A review emphasizing clinicopathologic correlation and brain-behavior relationships","volume":"46","author":"Chui","year":"1989","journal-title":"Arch Neurol"},{"key":"10.1254\/jjp.78.463_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1254\/jjp.72.57","article-title":"Effects of Bifemelane on muscarinic receptors and choline acetyltransferase in the brains of aged rats following chronic cerebral hypoperfusion induced by permanent occlusion on bilateral carotid arteries","volume":"72","author":"Egashira","year":"1996","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.78.463_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0006-8993(96)00400-3","article-title":"Relationship between cholinergic dysfunction and discrimination learning disabilities in Wistar rats following chronic cerebral hypoperfusion","volume":"729","author":"Tanaka","year":"1996","journal-title":"Brain Res"},{"key":"10.1254\/jjp.78.463_bib25","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0006-8993(94)91678-0","article-title":"Nicotine-induced protection of cultured cortical neurons against N-methyl-D-aspartate receptor-mediated glutamate cytotoxicity","volume":"644","author":"Akaike","year":"1994","journal-title":"Brain Res"},{"issue":"Suppl I","key":"10.1254\/jjp.78.463_bib26","doi-asserted-by":"crossref","first-page":"171P","DOI":"10.1016\/S0021-5198(19)36924-0","article-title":"Protective effects of \u03b17 neuronal nicotinic receptor agonist on glutamate-induced neurotoxicity in cultured cortical neurons","volume":"71","author":"Kaneko","year":"1996","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.78.463_bib27","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/BF00294175","article-title":"Glial activation and white matter changes in the rat brain induced by chronic cerebral hypoperfusion: an immunohistochemical study","volume":"87","author":"Wakita","year":"1994","journal-title":"Acta Neuropathol"},{"key":"10.1254\/jjp.78.463_bib28","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1212\/WNL.44.7.1246","article-title":"Cerebral white matter lesions, vascular risk factors, and cognitive function in a population-based study: the Rotterdam Study","volume":"44","author":"Breteler","year":"1994","journal-title":"Neurology"}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819310108?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819310108?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jjp\/78\/4\/78_4_463\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T05:36:34Z","timestamp":1622093794000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819310108"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1998]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1998]]}},"alternative-id":["S0021519819310108"],"URL":"https:\/\/doi.org\/10.1254\/jjp.78.463","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1998]]}}}