{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T02:13:52Z","timestamp":1772763232885,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[1999,1,1]],"date-time":"1999-01-01T00:00:00Z","timestamp":915148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":7524,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[1999]]},"DOI":"10.1254\/jjp.79.65","type":"journal-article","created":{"date-parts":[[2002,8,26]],"date-time":"2002-08-26T16:32:11Z","timestamp":1030379531000},"page":"65-73","source":"Crossref","is-referenced-by-count":21,"title":["The Novel Analgesic Compound OT-7100 (5-n-Butyl-7-(3,4,5-trimethoxybenzoylamino)pyrazolo [1,5-a] pyrimidine) Attenuates Mechanical Nociceptive Responses in Animal Models of Acute and Peripheral Neuropathic Hyperalgesia"],"prefix":"10.1016","volume":"79","author":[{"given":"Yasuda","family":"Tsuneo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iwamoto","family":"Takeshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ohara","family":"Masayuki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sato","family":"Seiji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohri","family":"Hideaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noguchi","family":"Koichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Senba","family":"Emiko","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.79.65_bib1","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0304-3959(88)90209-6","article-title":"A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man","volume":"33","author":"Bennett","year":"1988","journal-title":"Pain"},{"key":"10.1254\/jjp.79.65_bib2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/0304-3959(92)90041-9","article-title":"An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat","volume":"50","author":"Kim","year":"1992","journal-title":"Pain"},{"key":"10.1254\/jjp.79.65_bib3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/0304-3959(95)00077-1","article-title":"Fixed-diameter polyethylene cuffs applied to the rat sciatic nerve induce a painful neuropathy: ultrastructural morphometric analysis of axonal alterations","volume":"64","author":"Mosconi","year":"1996","journal-title":"Pain"},{"key":"10.1254\/jjp.79.65_bib4","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0304-3959(93)90136-D","article-title":"Is large myelinated fiber loss associated with hyperalgesia in a model of experimental peripheral neuropathy in the rat?","volume":"52","author":"Coggeshall","year":"1993","journal-title":"Pain"},{"key":"10.1254\/jjp.79.65_bib5","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0304-3959(93)90074-Y","article-title":"Time course of degeneration and regeneration of myelinated nerve fibres following chronic loose ligatures of the rat sciatic nerve: can nerve lesions be linked to the abnormal pain-related behaviours?","volume":"53","author":"Guilbaud","year":"1993","journal-title":"Pain"},{"key":"10.1254\/jjp.79.65_bib6","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00005072-199305000-00006","article-title":"Pathology of experimental compression neuropathy producing hyperesthesia","volume":"52","author":"Sommer","year":"1993","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1254\/jjp.79.65_bib7","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/00005072-199509000-00004","article-title":"Quantitative neuropathology of a focal nerve injury causing hyperalgesia","volume":"54","author":"Sommer","year":"1995","journal-title":"J Neuropathol Exp Neurol"},{"key":"10.1254\/jjp.79.65_bib8","first-page":"113","article-title":"Pathogenetic mechanisms of diabetic neuropathy: Lessons from animal models","volume":"2","author":"Yagihashi","year":"1997","journal-title":"J Periph Nerv Syst"},{"key":"10.1254\/jjp.79.65_bib9","first-page":"824","article-title":"Inhibitory effect of anisodamine on the neuropathic hyperalgesia following peripheral nerve injury (II)","volume":"36","author":"Xie","year":"1993","journal-title":"Sci China B"},{"key":"10.1254\/jjp.79.65_bib10","first-page":"666","article-title":"Synthetic omega-conopeptides applied to the site of nerve injury suppress neuropathic pains in rats","volume":"274","author":"Xiao","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1254\/jjp.79.65_bib11","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0304-3940(95)11844-M","article-title":"The effect of continuous morphine analgesia on chronic thermal hyperalgesia due to sciatic constriction injury in rats","volume":"196","author":"Backonja","year":"1995","journal-title":"Neurosci Lett"},{"key":"10.1254\/jjp.79.65_bib12","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0006-8993(95)00920-L","article-title":"Nerve growth factor alleviates a painful peripheral neuropathy in rats","volume":"699","author":"Ren","year":"1995","journal-title":"Brain Res"},{"key":"10.1254\/jjp.79.65_bib13","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/0304-3940(94)11154-B","article-title":"Role of peri-axonal inflammation in the development of thermal hyperalgesia and guarding behavior in a rat model of neuropathic pain","volume":"184","author":"Clatworthy","year":"1995","journal-title":"Neurosci Lett"},{"key":"10.1254\/jjp.79.65_bib14","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S1098-7339(06)80057-X","article-title":"Effect of local methylprednisolone on pain in a nerve injury model: A pilot study","volume":"22","author":"Johansson","year":"1997","journal-title":"Reg Anesth"},{"key":"10.1254\/jjp.79.65_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/0304-3940(94)90714-5","article-title":"Pretreatment with MK-801, a non-competitive NMD A antagonist, prevents development of mechanical hyperalgesia in a rat model of chronic neuropathy, but not in a model of chronic inflammation","volume":"165","author":"Smith","year":"1994","journal-title":"Neurosci Lett"},{"key":"10.1254\/jjp.79.65_bib16","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0304-3940(96)12670-7","article-title":"Application of nitric oxide synthase inhibitor, N\u03c9-nitro-L-arginine methyl ester, on injured nerve attenuates neuropathy-induced thermal hyperalgesia in rats","volume":"210","author":"Thomas","year":"1996","journal-title":"Neurosci Lett"},{"key":"10.1254\/jjp.79.65_bib17","first-page":"409","article-title":"A method for measurement of analgesic activity on inflamed tissue","volume":"111","author":"Randall","year":"1957","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1254\/jjp.79.65_bib18","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1146\/annurev.iy.03.040185.001403","article-title":"Interleukin 1: an immunological perspective","volume":"3","author":"Durum","year":"1985","journal-title":"Annu Rev Immunol"},{"key":"10.1254\/jjp.79.65_bib19","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/0306-4522(96)00127-3","article-title":"Schwann cells produce tumor necrosis factor alpha: expression in injured and non-injured nerves","volume":"73","author":"Wagner","year":"1996","journal-title":"Neuroscience"},{"key":"10.1254\/jjp.79.65_bib20","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1038\/330658a0","article-title":"Interleukin-1 regulates synthesis of nerve growth factor in non-neuronal cells of rat sciatic nerve","volume":"330","author":"Lindholm","year":"1987","journal-title":"Nature"},{"key":"10.1254\/jjp.79.65_bib21","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1097\/00001756-199611250-00018","article-title":"Endoneurial injection of TNF-alpha produces neuropathic pain behaviors","volume":"7","author":"Wagner","year":"1996","journal-title":"Neuroreport"},{"key":"10.1254\/jjp.79.65_bib22","series-title":"Proceedings of the 8th World Congress on Pain, Progress in Pain Research and Management","first-page":"155","article-title":"Central consequences of persistent pain state","volume":"8","author":"Price","year":"1997"},{"key":"10.1254\/jjp.79.65_bib23","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/BF01965026","article-title":"Lack of sensitization of primary afferent receptors by prostaglandins in a rat model of causalgic chronic pains","volume":"25","author":"Seltzer","year":"1988","journal-title":"Agents Actions"},{"key":"10.1254\/jjp.79.65_bib24","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0304-3959(95)00155-7","article-title":"Topical aspirin\/diethyl ether mixture versus indomethacin and diclofenac\/diethyl ether mixtures for acute herpetic neuralgia and postherpetic neuralgia: a double-blind crossover placebo-controlled study","volume":"65","author":"De Benedittis","year":"1996","journal-title":"Pain"},{"key":"10.1254\/jjp.79.65_bib25","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1177\/082585979401000409","article-title":"Neuropathic pain","volume":"10","author":"Billings","year":"1994","journal-title":"J Palliat Care"}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819309904?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819309904?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jjp\/79\/1\/79_1_65\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T18:24:18Z","timestamp":1605637458000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819309904"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999]]}},"alternative-id":["S0021519819309904"],"URL":"https:\/\/doi.org\/10.1254\/jjp.79.65","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[1999]]}}}