{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T15:51:07Z","timestamp":1786809067381,"version":"build-2736575974"},"reference-count":18,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":7159,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[2000]]},"DOI":"10.1254\/jjp.82.218","type":"journal-article","created":{"date-parts":[[2002,8,26]],"date-time":"2002-08-26T16:38:09Z","timestamp":1030379889000},"page":"218-225","source":"Crossref","is-referenced-by-count":57,"title":["Anti-ulcer Effects of Chitin and Chitosan, Healthy Foods, in Rats"],"prefix":"10.1016","volume":"82","author":[{"given":"Mikio","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Ban","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Ishihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.82.218_bib1","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1002\/app.1983.070280607","article-title":"Highly deacetylated chitosan and its properties","volume":"28","author":"Mima","year":"1983","journal-title":"J Appl Polym Sci"},{"key":"10.1254\/jjp.82.218_bib2","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1248\/cpb.36.784","article-title":"Growth-inhibitory effect of hexa-N-acetylchitohexaose and chitohexaose against Meth-A solid tumor","volume":"36","author":"Tokoro","year":"1988","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1254\/jjp.82.218_bib3","first-page":"127","article-title":"Immunoadjuvant properties of chitosan","volume":"39","author":"Marcinkicwicz","year":"1991","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"10.1254\/jjp.82.218_bib4","first-page":"198","article-title":"Anti-hypertensive effect of chitosan in rats and humans","volume":"11","author":"Kato","year":"1994","journal-title":"J Tradit Chin Med"},{"key":"10.1254\/jjp.82.218_bib5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/BF02535456","article-title":"Hypocholesterolemication of chitosans with different viscosity in rats","volume":"23","author":"Sugano","year":"1988","journal-title":"Lipids"},{"key":"10.1254\/jjp.82.218_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S0021-9150(98)00045-8","article-title":"Dietary chitosan inhibits hypercholesterolemia and atherogenesis in the apolipoprotein E-deficient mouse model of atherosclerosis","volume":"138","author":"Ormrod","year":"1998","journal-title":"Atherosclerosis"},{"key":"10.1254\/jjp.82.218_bib7","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1271\/bbb.63.833","article-title":"Modification of chitosan to improve its hypocholesterolemic capacity","volume":"63","author":"Lee","year":"1999","journal-title":"Biosci Biotechnol Biochem"},{"key":"10.1254\/jjp.82.218_bib8","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1128\/AEM.53.3.603-605.1987","article-title":"Effects of chitin and its soluble derivatives on survival of Vibrio cholerae 01 at low temperature","volume":"53","author":"Amako","year":"1987","journal-title":"Appl Environ Microbiol"},{"key":"10.1254\/jjp.82.218_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.4315\/0362-028X-62.3.239","article-title":"Antibact\u00e8rial activity of shrimp chitosan against Escherichia coli","volume":"62","author":"Tsai","year":"1999","journal-title":"J Food Prot"},{"key":"10.1254\/jjp.82.218_bib10","first-page":"283","article-title":"The acceleration of wound healing with cartilage-surgery","volume":"105","author":"Prudden","year":"1957","journal-title":"Gynecol Obstet"},{"key":"10.1254\/jjp.82.218_bib11","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1292\/jvms.57.851","article-title":"Evaluation of chitin and chitosan on open wound healing in dogs","volume":"57","author":"Okamoto","year":"1995","journal-title":"J Vet Med Sci"},{"key":"10.1254\/jjp.82.218_bib12","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/02844319709085478","article-title":"Heparin-chitosan complexs stimulate wound healing in human skin","volume":"31","author":"Kratz","year":"1997","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"key":"10.1254\/jjp.82.218_bib13","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0014-2999(98)00448-8","article-title":"Anti-ulcer effects of antioxidants: effect of probucol","volume":"354","author":"Ito","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1254\/jjp.82.218_bib14","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/0014-2999(94)90719-6","article-title":"Effect of cimetidine and omeprazole on gastric ulcer healing of rats with limited food intake time","volume":"263","author":"Ito","year":"1994","journal-title":"Eur J Pharmacol"},{"key":"10.1254\/jjp.82.218_bib15","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1254\/jjp.19.418","article-title":"A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing","volume":"19","author":"Takagi","year":"1969","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.82.218_bib16","first-page":"1240","article-title":"A simple method for estimation of gastric mucus and effects of antiulcerogenic agents on the decrease in mucus during water-immersion stress in rats","volume":"36","author":"Kitagawa","year":"1986","journal-title":"Arzneimittelforschung"},{"key":"10.1254\/jjp.82.218_bib17","first-page":"43","article-title":"The new application of gastric protective agents to wound healing","volume":"14","author":"Yanagawa","year":"1994","journal-title":"Jpn J Inflamm"},{"issue":"Suppl 2","key":"10.1254\/jjp.82.218_bib18","first-page":"117","article-title":"Mechanisms of action of sucralfate","volume":"3","author":"Nagashima","year":"1981","journal-title":"J Clin Gastroenterol"}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819306870?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819306870?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jjp\/82\/3\/82_3_218\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T18:16:36Z","timestamp":1605636996000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819306870"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000]]}},"alternative-id":["S0021519819306870"],"URL":"https:\/\/doi.org\/10.1254\/jjp.82.218","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[2000]]}}}