{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T02:41:38Z","timestamp":1767148898899,"version":"build-2238731810"},"reference-count":32,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2000,1,1]],"date-time":"2000-01-01T00:00:00Z","timestamp":946684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":7159,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[2000]]},"DOI":"10.1016\/s0021-5198(19)30586-4","type":"journal-article","created":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T13:15:03Z","timestamp":1605618903000},"page":"206-214","source":"Crossref","is-referenced-by-count":9,"title":["Calcium Polycarbophil, a Water Absorbing Polymer, Increases Bowel Movement and Prevents Sennoside-Induced Diarrhea in Dogs"],"prefix":"10.1016","volume":"83","author":[{"given":"Takaharu","family":"Saito","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehisa","family":"Yamada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Iwanaga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kouji","family":"Morikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Nagata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiyoshi","family":"Mizumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zen","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/S0021-5198(19)30586-4_bib1","series-title":"Sleisenger and Fordtran\u2019s Gastrointestinal and Liver Disease: Pathophysiology \/ Diagnosis \/ Management","first-page":"1536","article-title":"Irritable bowel syndrome","author":"Olden","year":"1998"},{"key":"10.1016\/S0021-5198(19)30586-4_bib2","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1046\/j.1365-2036.1997.84256000.x","article-title":"Review article: irritable bowel syndrome","volume":"11","author":"Camilleri","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/S0021-5198(19)30586-4_bib3","series-title":"The Functional Gastrointestinal Disorders: Diagnosis, Pathophysiology and Treatment: a Multinational Consensus","first-page":"115","article-title":"the Working Team for Functional Bowel Disorders: Functional Bowel Disorders and Functional Abdominal Pain","author":"Thompson","year":"1994"},{"key":"10.1016\/S0021-5198(19)30586-4_bib4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/j.1875-9114.1982.tb03168.x","article-title":"Pharmacology, toxicology, clinical efficacy, and adverse effects of calcium polycarbophil, an enteral hydrosorptive agent","volume":"2","author":"Danhof","year":"1982","journal-title":"Pharmacotherapy"},{"key":"10.1016\/S0021-5198(19)30586-4_bib5","series-title":"Sleisenger and Fordtran\u2019s Gastrointestinal Disease: Pathophysiology \/ Diagnosis \/ Management","first-page":"837","article-title":"Constipation","author":"Devroede","year":"1993"},{"key":"10.1016\/S0021-5198(19)30586-4_bib6","first-page":"572","article-title":"Effect of calcium polycarbophil (carbophil) suspension on gastrointestinal transit time","volume":"6","author":"Winkelstein","year":"1964","journal-title":"Curr Ther Res"},{"key":"10.1016\/S0021-5198(19)30586-4_bib7","first-page":"443","article-title":"Clinical comparison of calcium polycarbophil and kaolin-pectine suspensions in the treatment of acute childhood diarrhea","volume":"23","author":"Rutledge","year":"1978","journal-title":"Curr Ther Res"},{"key":"10.1016\/S0021-5198(19)30586-4_bib8","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1038\/clpt.1982.108","article-title":"A simple controlled method for the clinical evaluation of antidiarreal drugs","volume":"31","author":"LaCorte","year":"1982","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/S0021-5198(19)30586-4_bib9","first-page":"770","article-title":"Comparison of the laxative efficacy and patient preference of calcium polycarbophil tablets and psyllium suspension","volume":"43","author":"Bass","year":"1988","journal-title":"Curr Ther Res"},{"key":"10.1016\/S0021-5198(19)30586-4_bib10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1365-2036.1993.tb00074.x","article-title":"Calcium polycarbophil compared with placebo in irritable bowel syndrome","volume":"7","author":"Toskes","year":"1993","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1016\/S0021-5198(19)30586-4_bib11","first-page":"937","article-title":"Defecation and the pathophisiology of constipation","volume":"15","author":"Read","year":"1986","journal-title":"Clin Gastroenterol"},{"key":"10.1016\/S0021-5198(19)30586-4_bib12","series-title":"Sleisenger and Fordtran\u2019s Gastrointestinal Disease: Pathophysiology \/ Diagnosis \/ Management","first-page":"1043","article-title":"Diarrhea","author":"Fine","year":"1993"},{"key":"10.1016\/S0021-5198(19)30586-4_bib13","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1248\/cpb.30.1338","article-title":"Metabolism of sennosides by intestinal flora","volume":"30","author":"Hattori","year":"1982","journal-title":"Chem Pharm Bull (Tokyo)"},{"key":"10.1016\/S0021-5198(19)30586-4_bib14","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1159\/000138551","article-title":"Effects of sennoside A + B and bisacodyl on rat large intestine","volume":"38","author":"Elke","year":"1989","journal-title":"Pharmacology"},{"key":"10.1016\/S0021-5198(19)30586-4_bib15","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.2042-7158.1980.tb12930.x","article-title":"Inhibition of intestinal water and electrolyte absorption by senna derivaties in rats","volume":"32","author":"Elke","year":"1980","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/S0021-5198(19)30586-4_bib16","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.2042-7158.1986.tb03089.x","article-title":"Dual effect of orally administered sennoside on large intestine transit and fluid absorption in the rat","volume":"38","author":"Elke","year":"1986","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/S0021-5198(19)30586-4_bib17","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1159\/000138421","article-title":"Sennoside and human colonic motility","volume":"36","author":"Staunnont","year":"1988","journal-title":"Pharmacology"},{"key":"10.1016\/S0021-5198(19)30586-4_bib18","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1136\/gut.25.9.931","article-title":"Loperamide has anti-secretory activity in the human jejunum in vivo","volume":"25","author":"Hughes","year":"1984","journal-title":"Gut"},{"key":"10.1016\/S0021-5198(19)30586-4_bib19","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/S0016-5085(84)80161-4","article-title":"Mechanism of the antidiarrheal effect of loperamide","volume":"86","author":"Lawrence","year":"1984","journal-title":"Gastroenterology"},{"key":"10.1016\/S0021-5198(19)30586-4_bib20","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0016-5085(86)90079-X","article-title":"Human intestinal motor activity and transport: effect of a synthetic opiate","volume":"90","author":"Kachel","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/S0021-5198(19)30586-4_bib21","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/BF01295711","article-title":"Loperamide survey of studies on mechanism of its anti-diarrheal activity","volume":"38","author":"Awouters","year":"1993","journal-title":"Dig Dis Sci"},{"key":"10.1016\/S0021-5198(19)30586-4_bib22","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1007\/BF01296099","article-title":"Loperamide abolishes exercise-induced orocecal liquid transit acceleration","volume":"38","author":"William","year":"1993","journal-title":"Dig Dis Sci"},{"key":"10.1016\/S0021-5198(19)30586-4_bib23","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.2042-7158.1987.tb03409.x","article-title":"Interactions of trimebutine with guinea-pig opioid receptors","volume":"39","author":"Roman","year":"1987","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/S0021-5198(19)30586-4_bib24","first-page":"836","article-title":"Interaction of trimebutine and Jo-1196 (fedotozine) with opioid receptors in the canine ileum","volume":"257","author":"Allescher","year":"1991","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/S0021-5198(19)30586-4_bib25","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1016\/0016-5085(91)90395-2","article-title":"Dual effect of trimebutine on contractivity of the guinea pig ileum via the opioid receptors","volume":"101","author":"Taniyama","year":"1991","journal-title":"Gastroenterology"},{"key":"10.1016\/S0021-5198(19)30586-4_bib26","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1540\/jsmr.28.87","article-title":"Effects of trimebutine on colonic propulsion in mice","volume":"28","author":"Yamada","year":"1992","journal-title":"J Smooth Muscle Res"},{"key":"10.1016\/S0021-5198(19)30586-4_bib27","first-page":"631","article-title":"General pharmacology of the four gastrointestinal motility stimulants bethanechol, metoclopramide, trimebutine, and cisapride","volume":"41","author":"Megens","year":"1991","journal-title":"Arzneimittelforschung"},{"key":"10.1016\/S0021-5198(19)30586-4_bib28","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0014-2999(93)90395-X","article-title":"Comparison of the effects of trimebutine and YM-114 (KAE-393), a novel 5-HT3 receptor antagonist, on stress-induced defecation","volume":"250","author":"Miyata","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/S0021-5198(19)30586-4_bib29","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1007\/BF02053934","article-title":"Effects of trimebutine on colonic function in patients with chronic idiopathic constipation: evidence for the need of a physiologic rather than clinical selection","volume":"36","author":"Schang","year":"1993","journal-title":"Dis Colon Rectum"},{"key":"10.1016\/S0021-5198(19)30586-4_bib30","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1248\/bpb.20.275","article-title":"Decalcification of calcium polycarbophil in rats","volume":"20","author":"Yamada","year":"1997","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/S0021-5198(19)30586-4_bib31","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.2042-7158.1996.tb03947.x","article-title":"Physicochemical properties of calcium polycarbophil, a water-absorbing polymer","volume":"48","author":"Yamada","year":"1996","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/S0021-5198(19)30586-4_bib32","first-page":"149","article-title":"The effect of polycarbophil on water transport in rat intestine","volume":"2","author":"Yamada","year":"1996","journal-title":"Pharm Sci"}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819305864?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819305864?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T13:15:24Z","timestamp":1605618924000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819305864"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000]]},"references-count":32,"aliases":["10.1254\/jjp.83.206"],"journal-issue":{"issue":"3","published-print":{"date-parts":[[2000]]}},"alternative-id":["S0021519819305864"],"URL":"https:\/\/doi.org\/10.1016\/s0021-5198(19)30586-4","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[2000]]}}}