{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T23:24:28Z","timestamp":1697498668305},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":6793,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[2001]]},"DOI":"10.1254\/jjp.85.35","type":"journal-article","created":{"date-parts":[[2002,8,26]],"date-time":"2002-08-26T16:38:09Z","timestamp":1030379889000},"page":"35-40","source":"Crossref","is-referenced-by-count":2,"title":["(\u00b1)-Pindolol Acts as a Partial Agonist at Atypical \u03b2 -Adrenoceptors in the Guinea Pig Duodenum"],"prefix":"10.1016","volume":"85","author":[{"given":"Takahiro","family":"Horinouchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuo","family":"Koike","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.85.35_bib1","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/214597a0","article-title":"Differentiation of receptor systems activated by sympathomimetic amines","volume":"214","author":"Lands","year":"1967","journal-title":"Nature"},{"key":"10.1254\/jjp.85.35_bib2","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/med.2610130604","article-title":"\u03b23 And atypical \u03b2-adrenoceptors","volume":"13","author":"Arch","year":"1993","journal-title":"Med Res Rev"},{"key":"10.1254\/jjp.85.35_bib3","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1046\/j.1365-2036.1996.71245000.x","article-title":"\u03b23-Adrenoceptor agonists: future anti-inflammatory drugs for the gastrointestinal tract?","volume":"10","author":"Anthony","year":"1996","journal-title":"Aliment Pharmacol Ther"},{"key":"10.1254\/jjp.85.35_bib4","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1476-5381.1996.tb15230.x","article-title":"Comparison of the profiles of agonists as stimulants of the \u03b23-adrenoceptor in vitro with their gastroprotective effects in the conscious rat","volume":"117","author":"Bahl","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib5","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1254\/jjp.74.109","article-title":"FR149175, a \u03b23-adrenoceptor-selective agonist, is a possible therapeutic agent for non-insulin-dependent diabetes mellitus","volume":"74","author":"Yamamoto","year":"1997","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib6","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1111\/j.1476-5381.1996.tb15648.x","article-title":"Differences between the third cardiac \u03b2-adrenoceptor and the colonic \u03b23-adrenoceptor in the rat","volume":"118","author":"Kaumann","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib7","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1476-5381.1996.tb15285.x","article-title":"Mediation of the positive chro-notropic effect of CGP 12177 and cyanopindolol in the pithed rat by atypical \/-adrenoceptors, different from \u03b23-adrenocep-tors","volume":"117","author":"Malinowska","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib8","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/sj.bjp.0701523","article-title":"Lipolytic effects of conventional \u03b23-adrenoceptor agonists and of CGP 12,177 in rat and human fat cells: preliminary pharmacological evidence for a putative \u03b24-adrenoceptor","volume":"122","author":"Galitzky","year":"1997","journal-title":"Br J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0014-2999(99)00355-6","article-title":"Characterization of atypical \u03b2-adrenoceptors in the guinea pig duodenum","volume":"376","author":"Horinouchi","year":"1999","journal-title":"Eur J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib10","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1476-5381.1996.tb15248.x","article-title":"Atypical responses of rat ileum to pindolol, cyanopindolol and iodocyanopindolol","volume":"117","author":"Hoey","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib11","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1111\/j.1476-5381.1996.tb15709.x","article-title":"Characteristics of cyanopindolol analogues active at the \u03b23-adrenoceptor in rat ileum","volume":"119","author":"Hoey","year":"1996","journal-title":"Br J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib12","first-page":"1094","article-title":"Structural and conformational features determining selective signal transduc-tion in the Zradrenergic receptor","volume":"44","author":"Blin","year":"1993","journal-title":"Mol Pharmacol"},{"key":"10.1254\/jjp.85.35_bib13","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1126\/science.2570461","article-title":"Molecular characterization of the human \/3adrenergic receptor","volume":"245","author":"Emorine","year":"1989","journal-title":"Science"},{"key":"10.1254\/jjp.85.35_bib14","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1111\/j.1476-5381.1991.tb09792.x","article-title":"Characterization of cat-echolamine-mediated relaxations in rat isolated gastric fundus: evidence for an atypical \u03b2-adrenoceptor","volume":"103","author":"McLaughlin","year":"1991","journal-title":"Br J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-2007-1004839","article-title":"Discrepancies in lipolytic activities induced by \u03b2-adrenoceptor agonists in human and rat adipocytes","volume":"22","author":"Hollenga","year":"1990","journal-title":"Horm Metab Res"},{"key":"10.1254\/jjp.85.35_bib16","first-page":"299","article-title":"Cumulative dose-response curves, II. Technique for the making of dose-response curves in isolated organs and the evaluation of drug parameters","volume":"143","author":"Van Rossum","year":"1963","journal-title":"Arch Int Pharmacodyn"},{"key":"10.1254\/jjp.85.35_bib17","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/0163-7258(81)90089-9","article-title":"Beta-adreno-ceptor antagonists in psychiatry and neurology","volume":"12","author":"Middlemiss","year":"1981","journal-title":"Pharmacol Ther"},{"key":"10.1254\/jjp.85.35_bib18","first-page":"107P","article-title":"Interactions of \u03b2-adrenoceptor antagonists with 5-hydroxytryptamine receptor subtypes in rat cerebral cortex","volume":"78","author":"Nahorski","year":"1983","journal-title":"Br J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib19","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/0165-6147(86)90377-9","article-title":"Are there selective ligands for 5-HTia and 5-HTib receptor binding sites in brain?","volume":"7","author":"Hamon","year":"1986","journal-title":"Trends Pharmacol Sci"},{"key":"10.1254\/jjp.85.35_bib20","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0922-4106(93)90061-D","article-title":"Structural analysis by the comparative molecular field analysis method of the affinity of \u03b2-adrenoceptor blocking agents for 5-HTia and 5-HTib receptors","volume":"244","author":"Langlois","year":"1993","journal-title":"Eur J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib21","first-page":"R42","article-title":"A classification of heart serotonin receptors","volume":"332","author":"Kaumann","year":"1983","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1254\/jjp.85.35_bib22","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/0165-6147(89)90065-5","article-title":"Is there a third heart \u03b2-adrenoceptor?","volume":"10","author":"Kaumann","year":"1989","journal-title":"Trends Pharmacol Sci"},{"key":"10.1254\/jjp.85.35_bib23","first-page":"379","article-title":"A modification of receptor theory","volume":"11","author":"Stephenson","year":"1956","journal-title":"Br J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib24","first-page":"459","article-title":"Receptor reserve and threshold phenomena. I. Theory and experiments with auto-nomic drugs tested on isolated organs","volume":"127","author":"Ari\u00ebns","year":"1960","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"10.1254\/jjp.85.35_bib25","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/j.1476-5381.1994.tb13167.x","article-title":"Mediation of most atypical effects by species homologues of the \u03b23-adrenoceptor","volume":"112","author":"Blin","year":"1994","journal-title":"Br J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib26","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0014-2999(98)00809-7","article-title":"Genomic cloning and species-specific properties of the recombinant canine \u03b23-adrenoceptor","volume":"363","author":"Lenzen","year":"1998","journal-title":"Eur J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib27","first-page":"446","article-title":"Is there \u2018atypical\u2019 \u03b2-receptor in the rat stomach fundus the rat \u03b23-receptor?","volume":"272","author":"Cohen","year":"1995","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1254\/jjp.85.35_bib28","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0014-2999(91)90492-9","article-title":"Coexistence of three \u03b2-adrenoceptor subtypes in white fat cells of various mammalian species","volume":"199","author":"Langin","year":"1991","journal-title":"Eur J Pharmacol"},{"key":"10.1254\/jjp.85.35_bib29","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1159\/000139338","article-title":"Functional evidence for the presence of \u03b23-adrenoceptors in the guinea-pig common bile duct and colon","volume":"51","author":"De Ponti","year":"1995","journal-title":"Pharmacology"}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819304688?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819304688?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T18:19:08Z","timestamp":1605637148000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819304688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2001]]}},"alternative-id":["S0021519819304688"],"URL":"https:\/\/doi.org\/10.1254\/jjp.85.35","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[2001]]}}}