{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T10:44:00Z","timestamp":1776422640718,"version":"3.51.2"},"reference-count":34,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2001,1,1]],"date-time":"2001-01-01T00:00:00Z","timestamp":978307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T00:00:00Z","timestamp":1565222400000},"content-version":"vor","delay-in-days":6793,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Japanese Journal of Pharmacology"],"published-print":{"date-parts":[[2001]]},"DOI":"10.1254\/jjp.85.416","type":"journal-article","created":{"date-parts":[[2002,8,26]],"date-time":"2002-08-26T16:44:18Z","timestamp":1030380258000},"page":"416-422","source":"Crossref","is-referenced-by-count":20,"title":["Involvement of Angiotensin II in Progression of Renal Injury in Rats With Genetic Non-insulin-Dependent Diabetes Mellitus (Wistar Fatty Rats)"],"prefix":"10.1016","volume":"85","author":[{"given":"Masakuni","family":"Noda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Nagano-Tsuge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Sekiguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumiko","family":"Shibouta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiko","family":"Naka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimi","family":"Imura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1254\/jjp.85.416_bib1","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1172\/JCI117251","article-title":"Angiotensin II stimulates extracellular matrix protein synthesis through induction of transforming growth factor-\u03b2 expression in rat glomerular mesangial cells","volume":"93","author":"Kagami","year":"1994","journal-title":"J Clin Invest"},{"key":"10.1254\/jjp.85.416_bib2","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1681\/ASN.V7102025","article-title":"Angiotensin in progressive renal diseases: Theory and practice","volume":"7","author":"Matsusaka","year":"1996","journal-title":"J Am Soc Nephrol"},{"key":"10.1254\/jjp.85.416_bib3","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1056\/NEJM199311113292004","article-title":"The effect of angiotensin-converting-enzyme inhibition on diabetic ne-phropathy","volume":"329","author":"Lewis","year":"1993","journal-title":"N Engl J Med"},{"key":"10.1254\/jjp.85.416_bib4","doi-asserted-by":"crossref","first-page":"76","DOI":"10.2337\/diacare.39.1.76","article-title":"Effects of converting-enzyme inhibition on barrier function in diabetic glomerulopathy","volume":"39","author":"Morelli","year":"1990","journal-title":"Diabetes"},{"key":"10.1254\/jjp.85.416_bib5","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1136\/bmj.297.6656.1086","article-title":"Protection of kidney function and decrease in albuminuria by captopril in insulin dependent diabetics with nephropathy","volume":"297","author":"Parving","year":"1988","journal-title":"BMJ"},{"key":"10.1254\/jjp.85.416_bib6","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1681\/ASN.V4140","article-title":"Short- and long-term effect of angiotensin II receptor blockade in rats with experimental diabetes","volume":"4","author":"Remuzzi","year":"1993","journal-title":"J Am Soc Nephrol"},{"key":"10.1254\/jjp.85.416_bib7","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1097\/00004872-199917080-00023","article-title":"The effect of losartan and captopril on glomerular basement membrane anionic charge in a diabetic rat model","volume":"17","author":"Yavuz","year":"1999","journal-title":"J Hypertens"},{"key":"10.1254\/jjp.85.416_bib8","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S1056-8727(97)00076-7","article-title":"Protective effects of a small dose of captopril on the reduction of glomerular basement membrane anionic sites in spontaneously hypertensive rats with streptozotocin-induced diabetes","volume":"12","author":"Isogai","year":"1998","journal-title":"J Diabetes Complications"},{"key":"10.1254\/jjp.85.416_bib9","first-page":"220","article-title":"Angiotensin-converting enzyme inhibition and calcium channel blockade both normalize early hyperfiltration in experimental diabetes, but only the former prevents late renal structural damage","volume":"2","author":"Perico","year":"1994","journal-title":"Exp Nephrol"},{"key":"10.1254\/jjp.85.416_bib10","first-page":"F496","article-title":"Renal injury in obese Zucker rats: glomerular hemodynam-ics alterations and effects of enalapril","volume":"263","author":"Schmitz","year":"1992","journal-title":"Am J Physiol"},{"key":"10.1254\/jjp.85.416_bib11","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1681\/ASN.V641295","article-title":"The angiotensin II receptor antagonist losartan reduces blood pressure but not renal injury in obese Zucker rats","volume":"6","author":"Crary","year":"1995","journal-title":"J Am Soc Nephrol"},{"key":"10.1254\/jjp.85.416_bib12","first-page":"S218","article-title":"Irbesartan lowers blood pressure and ameliorates renal injury in experimental non-insulin-dependent diabetes mellitus","volume":"63","author":"O\u2019Donnell","year":"1997","journal-title":"Kidney Int 52, Suppl"},{"key":"10.1254\/jjp.85.416_bib13","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/ki.1992.383","article-title":"Bradykinin-mediated effects of ACE inhibition","volume":"42","author":"Gavras","year":"1992","journal-title":"Kidney Int"},{"key":"10.1254\/jjp.85.416_bib14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1161\/01.HYP.23.4.439","article-title":"Effects of converting enzyme inhibitors on angiotensin and bradykinin peptides","volume":"23","author":"Campbell","year":"1994","journal-title":"Hypertension"},{"key":"10.1254\/jjp.85.416_bib15","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.2337\/diab.41.11.1422","article-title":"Spontaneous long-term hyperglycemic rat with diabetic complications. Otsuka Long-Evans Tokushima Fatty (OLETF) strain","volume":"41","author":"Kawano","year":"1992","journal-title":"Diabetes"},{"key":"10.1254\/jjp.85.416_bib16","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1161\/01.HYP.30.5.1054","article-title":"Angiotensin blockade improves cardiac and renal complications of type II diabetic rats","volume":"30","author":"Kim","year":"1997","journal-title":"Hypertension"},{"key":"10.1254\/jjp.85.416_bib17","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1177\/107424849800300408","article-title":"Angiotensin-converting enzyme inhibition delays onset of glucosuria with regression of renal injuries in genetic rat model of non-insulin-dependent diabetes mellitus","volume":"3","author":"Uehara","year":"1998","journal-title":"J Cardiovasc Pharmacol Ther"},{"key":"10.1254\/jjp.85.416_bib18","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0895-7061(98)00276-3","article-title":"Angiotensin II subtype-1 receptor antagonists improve hemodynamic and renal changes without affecting glucose metabolisms in genetic rat model of non-insulin-dependent diabetes mellitus","volume":"12","author":"Uehara","year":"1999","journal-title":"Am J Hypertens"},{"key":"10.1254\/jjp.85.416_bib19","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.2337\/diab.30.12.1045","article-title":"A new genetically obese-hyperglycemic rat (Wistar fatty)","volume":"30","author":"Ikeda","year":"1981","journal-title":"Diabetes"},{"key":"10.1254\/jjp.85.416_bib20","first-page":"E989","article-title":"Anti-hypertensive and vasculo- and renoprotective effects of pio-glitazone in genetically obese diabetic rats","volume":"272","author":"Yoshimoto","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1254\/jjp.85.416_bib21","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s101570070023","article-title":"Blockade of renin-angiotensin system ameliorates diabetic nephropathy in NIDDM model","volume":"4","author":"Ohta","year":"2000","journal-title":"Clin Exp Nephrol"},{"key":"10.1254\/jjp.85.416_bib22","first-page":"121","article-title":"Angiotensin II receptor antagonistic action of candesartan (CV-11974) in the rabbit aorta","volume":"24","author":"Noda","year":"1996","journal-title":"Jpn Pharmacol Ther"},{"key":"10.1254\/jjp.85.416_bib23","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1021\/jm00068a011","article-title":"Nonpeptide angiotensin II receptor antagonists: synthesis and biological activity of potential prodrugs of benzimidazole-7-carboxylic acids","volume":"36","author":"Kubo","year":"1993","journal-title":"J Med Chem"},{"key":"10.1254\/jjp.85.416_bib24","first-page":"1540","volume":"268","author":"Inada","year":"1994","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1254\/jjp.85.416_bib25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1254\/jjp.73.185","article-title":"Regional hemodynamic effects of candesartan cilexetil (TCV-116), an angiotensin II AT1-receptor antagonist, in conscious spontaneously hypertensive rats","volume":"73","author":"Kanagawa","year":"1997","journal-title":"Jpn J Pharmacol"},{"key":"10.1254\/jjp.85.416_bib26","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1046\/j.1523-1755.1999.00614.x","article-title":"Effect of candesartan cilexetil (TCV-116) in rats with chronic renal failure","volume":"56","author":"Noda","year":"1999","journal-title":"Kidney Int"},{"key":"10.1254\/jjp.85.416_bib27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF02479929","article-title":"New aspects of podocyte structure, function and pathology","volume":"2","author":"Kriz","year":"1998","journal-title":"Clin Exp Nephrol"},{"key":"10.1254\/jjp.85.416_bib28","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1159\/000188505","article-title":"On the progression of chronic renal disease","volume":"69","author":"Strutz","year":"1995","journal-title":"Nephron"},{"key":"10.1254\/jjp.85.416_bib29","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1097\/00004872-199917080-00023","article-title":"The effect of losartan and captopril on glomerular basement membrane anionic charge in a diabetic rat model","volume":"17","author":"Yavuz","year":"1999","journal-title":"J Hypertens"},{"key":"10.1254\/jjp.85.416_bib30","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/ki.1988.16","article-title":"Glomerular size and charge selectivity in insulin-dependent diabetes mellitus","volume":"33","author":"Deckert","year":"1988","journal-title":"Kidney Int"},{"key":"10.1254\/jjp.85.416_bib31","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1007\/BF00401371","article-title":"Glomerular charge selectivity and the influence of improved blood glucose control in type 1 (insulin-dependent) diabetic patients with microalbuminuria","volume":"35","author":"Bangstad","year":"1992","journal-title":"Diabetologia"},{"key":"10.1254\/jjp.85.416_bib32","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1007\/BF00399958","article-title":"Size- and charge selectivity of glomerular filtration in Type 1 (insulin-dependent) diabetic patients with and without albuminuria","volume":"36","author":"Deckert","year":"1993","journal-title":"Diabetologia"},{"key":"10.1254\/jjp.85.416_bib33","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1038\/ki.1994.349","article-title":"Lipids and the kidney","volume":"46","author":"Keane","year":"1994","journal-title":"Kidney Int"},{"key":"10.1254\/jjp.85.416_bib34","first-page":"S18","article-title":"Modulation of glomerular sclerosis and interstitial fibrosis by native and modified lipo-proteins","volume":"54","author":"Grone","year":"1996","journal-title":"Kidney Int 49, Suppl"}],"container-title":["Japanese Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819304111?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0021519819304111?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.jstage.jst.go.jp\/article\/jjp\/85\/4\/85_4_416\/_pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T05:40:14Z","timestamp":1622094014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0021519819304111"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001]]},"references-count":34,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2001]]}},"alternative-id":["S0021519819304111"],"URL":"https:\/\/doi.org\/10.1254\/jjp.85.416","relation":{},"ISSN":["0021-5198"],"issn-type":[{"value":"0021-5198","type":"print"}],"subject":[],"published":{"date-parts":[[2001]]}}}